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Fusion gene ID: 38819 |
FusionGeneSummary for TMTC4_FGF14 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TMTC4_FGF14 | Fusion gene ID: 38819 | Hgene | Tgene | Gene symbol | TMTC4 | FGF14 | Gene ID | 84899 | 2259 |
| Gene name | transmembrane and tetratricopeptide repeat containing 4 | fibroblast growth factor 14 | |
| Synonyms | - | FGF-14|FHF-4|FHF4|SCA27 | |
| Cytomap | 13q32.3 | 13q33.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | transmembrane and TPR repeat-containing protein 4 | fibroblast growth factor 14bA397O8.2fibroblast growth factor homologous factor 4 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q5T4D3 | Q92915 | |
| Ensembl transtripts involved in fusion gene | ENST00000376234, ENST00000342624, ENST00000328767, ENST00000462211, | ENST00000376131, ENST00000376143, ENST00000468052, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 4 X 3 X 4=48 |
| # samples | 1 | 4 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TMTC4 [Title/Abstract] AND FGF14 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-A2-A0D2-01A | TMTC4 | chr13 | 101277789 | - | FGF14 | chr13 | 102527646 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000376234 | ENST00000376131 | TMTC4 | chr13 | 101277789 | - | FGF14 | chr13 | 102527646 | - |
| Frame-shift | ENST00000376234 | ENST00000376143 | TMTC4 | chr13 | 101277789 | - | FGF14 | chr13 | 102527646 | - |
| In-frame | ENST00000376234 | ENST00000468052 | TMTC4 | chr13 | 101277789 | - | FGF14 | chr13 | 102527646 | - |
| Frame-shift | ENST00000342624 | ENST00000376131 | TMTC4 | chr13 | 101277789 | - | FGF14 | chr13 | 102527646 | - |
| Frame-shift | ENST00000342624 | ENST00000376143 | TMTC4 | chr13 | 101277789 | - | FGF14 | chr13 | 102527646 | - |
| Frame-shift | ENST00000342624 | ENST00000468052 | TMTC4 | chr13 | 101277789 | - | FGF14 | chr13 | 102527646 | - |
| Frame-shift | ENST00000328767 | ENST00000376131 | TMTC4 | chr13 | 101277789 | - | FGF14 | chr13 | 102527646 | - |
| Frame-shift | ENST00000328767 | ENST00000376143 | TMTC4 | chr13 | 101277789 | - | FGF14 | chr13 | 102527646 | - |
| In-frame | ENST00000328767 | ENST00000468052 | TMTC4 | chr13 | 101277789 | - | FGF14 | chr13 | 102527646 | - |
| intron-3CDS | ENST00000462211 | ENST00000376131 | TMTC4 | chr13 | 101277789 | - | FGF14 | chr13 | 102527646 | - |
| intron-3CDS | ENST00000462211 | ENST00000376143 | TMTC4 | chr13 | 101277789 | - | FGF14 | chr13 | 102527646 | - |
| intron-3CDS | ENST00000462211 | ENST00000468052 | TMTC4 | chr13 | 101277789 | - | FGF14 | chr13 | 102527646 | - |
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FusionProtFeatures for TMTC4_FGF14 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TMTC4 | FGF14 |
| Probably involved in nervous system development andfunction. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TMTC4_FGF14 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_TMTC4_ENST00000376234_chr13_101277789_-_FGF14_ENST00000468052_chr13_102527646_-_593aa MAVLDTDLDHILPSSVLPPFWAKLVVGSVAIVCFARSYDGDFVFDDSEAIVNNKDLQAETPLGDLWHHDFWGSRLSSNTSHKSYRPLTVL TFRINYYLSGGFHPVGFHVVNILLHSGISVLMVDVFSVLFGGLQYTSKGRRLHLAPRASLLAALLFAVHPVHTECVAGVVGRADLLCALF FLLSFLGYCKAFRESNKEGAHSSTFWVLLSIFLGAVAMLCKEQGITVLGLNAVFDILVIGKFNVLEIVQKVLHKDKSLENLGMLRNGGLL FRMTLLTSGGAGMLYVRWRIMGTGPPAFTEVDNPASFADSMLVRAVNYNYYYSLNAWLLLCPWWLCFDWSMGCIPLIKSISDWRVIALAA LWFCLIGLICQALCSEDGHKRRILTLGLGFLVIPFLPASNLFFRVGFVVAERVLYLPSVGYCVLLTFGFGALSKHTKKKKLIAAVVLGIL FINTLRCVLRSGEWRSEEQLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKYVHAMNNLGNILKERNELQEAEELLS >In-frame_TMTC4_ENST00000328767_chr13_101277789_-_FGF14_ENST00000468052_chr13_102527646_-_482aa MAVLDTDLDHILPSSVLPPFWAKLVVGSVAIVCFARSYDGDFVFDDSEAIVNNKVAGVVGRADLLCALFFLLSFLGYCKAFRESNKEGAH SSTFWVLLSIFLGAVAMLCKEQGITVLGLNAVFDILVIGKFNVLEIVQKVLHKDKSLENLGMLRNGGLLFRMTLLTSGGAGMLYVRWRIM GTGPPAFTEVDNPASFADSMLVRAVNYNYYYSLNAWLLLCPWWLCFDWSMGCIPLIKSISDWRVIALAALWFCLIGLICQALCSEDGHKR RILTLGLGFLVIPFLPASNLFFRVGFVVAERVLYLPSVGYCVLLTFGFGALSKHTKKKKLIAAVVLGILFINTLRCVLRSGEWRSEEQLF RSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKYVHAMNNLGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIVQN |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_TMTC4_ENST00000376234_chr13_101277789_-_FGF14_ENST00000468052_chr13_102527646_-_1779nt ATGGCCGTGTTGGACACTGATTTGGATCACATTCTTCCATCTTCTGTTCTTCCTCCATTCTGGGCTAAGTTAGTAGTGGGATCGGTTGCC ATTGTGTGTTTTGCACGCAGCTATGATGGAGACTTTGTCTTTGATGACTCAGAAGCTATTGTTAACAATAAGGACCTCCAAGCAGAAACG CCCCTGGGGGACCTGTGGCATCATGACTTCTGGGGCAGTAGACTGAGCAGCAACACCAGCCACAAGTCCTACCGGCCTCTCACCGTCCTG ACTTTCAGGATTAACTACTACCTCTCGGGAGGCTTCCACCCCGTGGGCTTTCACGTGGTCAACATCCTCCTGCACAGTGGCATCTCTGTC CTCATGGTGGACGTCTTCTCGGTTCTGTTTGGCGGCCTGCAGTACACCAGTAAAGGCCGGAGGCTGCACCTCGCCCCCAGGGCGTCCCTG CTGGCCGCGCTGCTGTTTGCTGTCCATCCTGTGCACACCGAGTGTGTTGCTGGTGTTGTCGGCCGTGCAGACCTCCTGTGTGCCCTGTTC TTCTTGTTATCTTTCCTTGGCTACTGTAAAGCATTTAGAGAAAGTAACAAGGAGGGAGCGCATTCTTCCACCTTCTGGGTGCTGCTGAGT ATCTTTCTGGGAGCAGTGGCCATGCTGTGCAAAGAGCAAGGGATCACTGTGCTGGGTTTAAATGCGGTATTTGACATCTTGGTGATAGGC AAATTCAATGTTCTGGAAATTGTCCAGAAGGTACTACATAAGGACAAGTCATTAGAGAATCTCGGCATGCTCAGGAACGGGGGCCTCCTC TTCAGAATGACCCTGCTCACCTCTGGAGGGGCTGGGATGCTCTACGTGCGCTGGAGGATCATGGGCACGGGCCCGCCGGCCTTCACCGAG GTGGACAACCCGGCCTCCTTTGCTGACAGCATGCTGGTGAGGGCCGTAAACTACAATTACTACTATTCATTGAATGCCTGGCTGCTGCTG TGTCCCTGGTGGCTGTGTTTTGATTGGTCAATGGGCTGCATCCCCCTCATTAAGTCCATCAGCGACTGGAGGGTAATTGCACTTGCAGCA CTCTGGTTCTGCCTAATTGGCCTGATATGCCAAGCCCTGTGCTCTGAAGACGGCCACAAGAGAAGGATCCTTACTCTGGGCCTGGGATTT CTCGTTATCCCATTTCTCCCCGCGAGTAACCTGTTCTTCCGAGTGGGCTTCGTGGTCGCAGAGCGTGTCCTCTACCTCCCCAGCGTTGGG TACTGTGTGCTGCTGACTTTTGGATTCGGAGCCCTGAGCAAACATACCAAGAAAAAGAAACTCATTGCCGCTGTCGTGCTGGGAATCTTA TTCATCAACACGCTGAGATGTGTGCTGCGCAGCGGCGAGTGGCGGAGTGAGGAACAGCTTTTCAGAAGTGCTCTGTCTGTGTGTCCCCTC AATGCTAAGGTTCACTACAACATTGGCAAAAACCTGGCTGATAAAGGCAACCAGACAGCTGCCATCAGATACTACCGGGAAGCTGTAAGA TTAAATCCCAAGTATGTTCATGCCATGAATAATCTTGGAAATATCTTAAAAGAAAGGAATGAGCTACAGGAAGCTGAGGAGCTGCTGTCT TTGGCTGTTCAAATACAGCCAGACTTTGCCGCTGCGTGGATGAATCTAGGCATAGTGCAGAATAGCCTGAAACGGTTTGAAGCAGCAGAG >In-frame_TMTC4_ENST00000328767_chr13_101277789_-_FGF14_ENST00000468052_chr13_102527646_-_1446nt ATGGCCGTGTTGGACACTGATTTGGATCACATTCTTCCATCTTCTGTTCTTCCTCCATTCTGGGCTAAGTTAGTAGTGGGATCGGTTGCC ATTGTGTGTTTTGCACGCAGCTATGATGGAGACTTTGTCTTTGATGACTCAGAAGCTATTGTTAACAATAAGGTTGCTGGTGTTGTCGGC CGTGCAGACCTCCTGTGTGCCCTGTTCTTCTTGTTATCTTTCCTTGGCTACTGTAAAGCATTTAGAGAAAGTAACAAGGAGGGAGCGCAT TCTTCCACCTTCTGGGTGCTGCTGAGTATCTTTCTGGGAGCAGTGGCCATGCTGTGCAAAGAGCAAGGGATCACTGTGCTGGGTTTAAAT GCGGTATTTGACATCTTGGTGATAGGCAAATTCAATGTTCTGGAAATTGTCCAGAAGGTACTACATAAGGACAAGTCATTAGAGAATCTC GGCATGCTCAGGAACGGGGGCCTCCTCTTCAGAATGACCCTGCTCACCTCTGGAGGGGCTGGGATGCTCTACGTGCGCTGGAGGATCATG GGCACGGGCCCGCCGGCCTTCACCGAGGTGGACAACCCGGCCTCCTTTGCTGACAGCATGCTGGTGAGGGCCGTAAACTACAATTACTAC TATTCATTGAATGCCTGGCTGCTGCTGTGTCCCTGGTGGCTGTGTTTTGATTGGTCAATGGGCTGCATCCCCCTCATTAAGTCCATCAGC GACTGGAGGGTAATTGCACTTGCAGCACTCTGGTTCTGCCTAATTGGCCTGATATGCCAAGCCCTGTGCTCTGAAGACGGCCACAAGAGA AGGATCCTTACTCTGGGCCTGGGATTTCTCGTTATCCCATTTCTCCCCGCGAGTAACCTGTTCTTCCGAGTGGGCTTCGTGGTCGCAGAG CGTGTCCTCTACCTCCCCAGCGTTGGGTACTGTGTGCTGCTGACTTTTGGATTCGGAGCCCTGAGCAAACATACCAAGAAAAAGAAACTC ATTGCCGCTGTCGTGCTGGGAATCTTATTCATCAACACGCTGAGATGTGTGCTGCGCAGCGGCGAGTGGCGGAGTGAGGAACAGCTTTTC AGAAGTGCTCTGTCTGTGTGTCCCCTCAATGCTAAGGTTCACTACAACATTGGCAAAAACCTGGCTGATAAAGGCAACCAGACAGCTGCC ATCAGATACTACCGGGAAGCTGTAAGATTAAATCCCAAGTATGTTCATGCCATGAATAATCTTGGAAATATCTTAAAAGAAAGGAATGAG CTACAGGAAGCTGAGGAGCTGCTGTCTTTGGCTGTTCAAATACAGCCAGACTTTGCCGCTGCGTGGATGAATCTAGGCATAGTGCAGAAT AGCCTGAAACGGTTTGAAGCAGCAGAGCAAAGTTACCGGACAGCAATTAAACACAGAAGGAAATACCCAGACTGTTACTACAACCTCGGG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_TMTC4_ENST00000376234_chr13_101277789_-_FGF14_ENST00000468052_chr13_102527646_-_2535nt GCGGGAGGCGCGGCGCGGGGGGGGTCGGGTGCGCGGCGGGCGGCCCCTCCCCCTGCCAGGTCCGGGCGGGTGCCTGGAGCCGCCAGAGTT TCCGCACCCGGGAGGGAGATGCGGCCGGGGCTCAGGCTCCTTGCAGATTCCTAACCAGCATAATGCTGGAGCCGGGAGCCACCAACCTGC AGTTTTCAGAATGGCCGTGTTGGACACTGATTTGGATCACATTCTTCCATCTTCTGTTCTTCCTCCATTCTGGGCTAAGTTAGTAGTGGG ATCGGTTGCCATTGTGTGTTTTGCACGCAGCTATGATGGAGACTTTGTCTTTGATGACTCAGAAGCTATTGTTAACAATAAGGACCTCCA AGCAGAAACGCCCCTGGGGGACCTGTGGCATCATGACTTCTGGGGCAGTAGACTGAGCAGCAACACCAGCCACAAGTCCTACCGGCCTCT CACCGTCCTGACTTTCAGGATTAACTACTACCTCTCGGGAGGCTTCCACCCCGTGGGCTTTCACGTGGTCAACATCCTCCTGCACAGTGG CATCTCTGTCCTCATGGTGGACGTCTTCTCGGTTCTGTTTGGCGGCCTGCAGTACACCAGTAAAGGCCGGAGGCTGCACCTCGCCCCCAG GGCGTCCCTGCTGGCCGCGCTGCTGTTTGCTGTCCATCCTGTGCACACCGAGTGTGTTGCTGGTGTTGTCGGCCGTGCAGACCTCCTGTG TGCCCTGTTCTTCTTGTTATCTTTCCTTGGCTACTGTAAAGCATTTAGAGAAAGTAACAAGGAGGGAGCGCATTCTTCCACCTTCTGGGT GCTGCTGAGTATCTTTCTGGGAGCAGTGGCCATGCTGTGCAAAGAGCAAGGGATCACTGTGCTGGGTTTAAATGCGGTATTTGACATCTT GGTGATAGGCAAATTCAATGTTCTGGAAATTGTCCAGAAGGTACTACATAAGGACAAGTCATTAGAGAATCTCGGCATGCTCAGGAACGG GGGCCTCCTCTTCAGAATGACCCTGCTCACCTCTGGAGGGGCTGGGATGCTCTACGTGCGCTGGAGGATCATGGGCACGGGCCCGCCGGC CTTCACCGAGGTGGACAACCCGGCCTCCTTTGCTGACAGCATGCTGGTGAGGGCCGTAAACTACAATTACTACTATTCATTGAATGCCTG GCTGCTGCTGTGTCCCTGGTGGCTGTGTTTTGATTGGTCAATGGGCTGCATCCCCCTCATTAAGTCCATCAGCGACTGGAGGGTAATTGC ACTTGCAGCACTCTGGTTCTGCCTAATTGGCCTGATATGCCAAGCCCTGTGCTCTGAAGACGGCCACAAGAGAAGGATCCTTACTCTGGG CCTGGGATTTCTCGTTATCCCATTTCTCCCCGCGAGTAACCTGTTCTTCCGAGTGGGCTTCGTGGTCGCAGAGCGTGTCCTCTACCTCCC CAGCGTTGGGTACTGTGTGCTGCTGACTTTTGGATTCGGAGCCCTGAGCAAACATACCAAGAAAAAGAAACTCATTGCCGCTGTCGTGCT GGGAATCTTATTCATCAACACGCTGAGATGTGTGCTGCGCAGCGGCGAGTGGCGGAGTGAGGAACAGCTTTTCAGAAGTGCTCTGTCTGT GTGTCCCCTCAATGCTAAGGTTCACTACAACATTGGCAAAAACCTGGCTGATAAAGGCAACCAGACAGCTGCCATCAGATACTACCGGGA AGCTGTAAGATTAAATCCCAAGTATGTTCATGCCATGAATAATCTTGGAAATATCTTAAAAGAAAGGAATGAGCTACAGGAAGCTGAGGA GCTGCTGTCTTTGGCTGTTCAAATACAGCCAGACTTTGCCGCTGCGTGGATGAATCTAGGCATAGTGCAGAATAGCCTGAAACGGTTTGA AGCAGCAGAGCAAAGTTACCGGACAGCAATTAAACACAGAAGGAAATACCCAGACTGTTACTACAACCTCGGGCGTCTGCCCCAGCTCAA GGGTATAGTGACCAGGTTATATTGCAGGCAAGGCTACTACTTGCAAATGCACCCCGATGGAGCTCTCGATGGAACCAAGGATGACAGCAC TAATTCTACACTCTTCAACCTCATACCAGTGGGACTACGTGTTGTTGCCATCCAGGGAGTGAAAACAGGGTTGTATATAGCCATGAATGG AGAAGGTTACCTCTACCCATCAGTAAGTAAGACGCCAAAGATCTCGGCCATTCGTTCAATGCATGTAAAATAACAATGGCAGCAACAACA AAAAGAAAGTTCTATGTCTGTTGTTTCTGCCAGTTTTTGCCTTAGTATTTGATCTTTGCGAGAATGCTTAGAAGCTGTTTATTATTCACC AGTGTTTAGTAATATGAGTTTATCTAAAGGAAGTGTAATACTATGTCTTAAATAGTGCTTTTGCCATATTTTAAAAAATAACCTAGTATA CACGTGAATCTAATCTTTTGTATTTCTAGTTAGAAATGCACTTATCTTAGAGAGTTTCTTATAATGTTTTTAAAAGAAACAATATGAATT >In-frame_TMTC4_ENST00000328767_chr13_101277789_-_FGF14_ENST00000468052_chr13_102527646_-_2097nt GAGATGCGGCCGGGGCTCAGGCTCCTTGCAGATTCCTAACCAGCATAATGCTGGAGCCGGGAGCCACCAACCTGCAGTTTTCAGAATGGC CGTGTTGGACACTGATTTGGATCACATTCTTCCATCTTCTGTTCTTCCTCCATTCTGGGCTAAGTTAGTAGTGGGATCGGTTGCCATTGT GTGTTTTGCACGCAGCTATGATGGAGACTTTGTCTTTGATGACTCAGAAGCTATTGTTAACAATAAGGTTGCTGGTGTTGTCGGCCGTGC AGACCTCCTGTGTGCCCTGTTCTTCTTGTTATCTTTCCTTGGCTACTGTAAAGCATTTAGAGAAAGTAACAAGGAGGGAGCGCATTCTTC CACCTTCTGGGTGCTGCTGAGTATCTTTCTGGGAGCAGTGGCCATGCTGTGCAAAGAGCAAGGGATCACTGTGCTGGGTTTAAATGCGGT ATTTGACATCTTGGTGATAGGCAAATTCAATGTTCTGGAAATTGTCCAGAAGGTACTACATAAGGACAAGTCATTAGAGAATCTCGGCAT GCTCAGGAACGGGGGCCTCCTCTTCAGAATGACCCTGCTCACCTCTGGAGGGGCTGGGATGCTCTACGTGCGCTGGAGGATCATGGGCAC GGGCCCGCCGGCCTTCACCGAGGTGGACAACCCGGCCTCCTTTGCTGACAGCATGCTGGTGAGGGCCGTAAACTACAATTACTACTATTC ATTGAATGCCTGGCTGCTGCTGTGTCCCTGGTGGCTGTGTTTTGATTGGTCAATGGGCTGCATCCCCCTCATTAAGTCCATCAGCGACTG GAGGGTAATTGCACTTGCAGCACTCTGGTTCTGCCTAATTGGCCTGATATGCCAAGCCCTGTGCTCTGAAGACGGCCACAAGAGAAGGAT CCTTACTCTGGGCCTGGGATTTCTCGTTATCCCATTTCTCCCCGCGAGTAACCTGTTCTTCCGAGTGGGCTTCGTGGTCGCAGAGCGTGT CCTCTACCTCCCCAGCGTTGGGTACTGTGTGCTGCTGACTTTTGGATTCGGAGCCCTGAGCAAACATACCAAGAAAAAGAAACTCATTGC CGCTGTCGTGCTGGGAATCTTATTCATCAACACGCTGAGATGTGTGCTGCGCAGCGGCGAGTGGCGGAGTGAGGAACAGCTTTTCAGAAG TGCTCTGTCTGTGTGTCCCCTCAATGCTAAGGTTCACTACAACATTGGCAAAAACCTGGCTGATAAAGGCAACCAGACAGCTGCCATCAG ATACTACCGGGAAGCTGTAAGATTAAATCCCAAGTATGTTCATGCCATGAATAATCTTGGAAATATCTTAAAAGAAAGGAATGAGCTACA GGAAGCTGAGGAGCTGCTGTCTTTGGCTGTTCAAATACAGCCAGACTTTGCCGCTGCGTGGATGAATCTAGGCATAGTGCAGAATAGCCT GAAACGGTTTGAAGCAGCAGAGCAAAGTTACCGGACAGCAATTAAACACAGAAGGAAATACCCAGACTGTTACTACAACCTCGGGCGTCT GCCCCAGCTCAAGGGTATAGTGACCAGGTTATATTGCAGGCAAGGCTACTACTTGCAAATGCACCCCGATGGAGCTCTCGATGGAACCAA GGATGACAGCACTAATTCTACACTCTTCAACCTCATACCAGTGGGACTACGTGTTGTTGCCATCCAGGGAGTGAAAACAGGGTTGTATAT AGCCATGAATGGAGAAGGTTACCTCTACCCATCAGTAAGTAAGACGCCAAAGATCTCGGCCATTCGTTCAATGCATGTAAAATAACAATG GCAGCAACAACAAAAAGAAAGTTCTATGTCTGTTGTTTCTGCCAGTTTTTGCCTTAGTATTTGATCTTTGCGAGAATGCTTAGAAGCTGT TTATTATTCACCAGTGTTTAGTAATATGAGTTTATCTAAAGGAAGTGTAATACTATGTCTTAAATAGTGCTTTTGCCATATTTTAAAAAA TAACCTAGTATACACGTGAATCTAATCTTTTGTATTTCTAGTTAGAAATGCACTTATCTTAGAGAGTTTCTTATAATGTTTTTAAAAGAA |
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FusionGenePPI for TMTC4_FGF14 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TMTC4 | ELAVL1, NXF1, NRG1, PEX19, TXNDC15, COL1A1, HERC3, C1orf186, CD79B, OS9, SCN3B, PCDH12, GORASP1, NEUROG3, NR4A1, SLC6A15, CCDC40, CDH8, SYP, CSGALNACT2, CES3, PMEL, EDEM2 | FGF14 | SCN8A |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TMTC4_FGF14 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TMTC4_FGF14 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | FGF14 | C1836383 | SPINOCEREBELLAR ATAXIA 27 | 2 | CTD_human;ORPHANET;UNIPROT |
| Tgene | FGF14 | C0007302 | Cartilage Diseases | 1 | CTD_human |
| Tgene | FGF14 | C0009241 | Cognition Disorders | 1 | CTD_human |
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