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Fusion gene ID: 38798 |
FusionGeneSummary for TMTC2_HERC1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TMTC2_HERC1 | Fusion gene ID: 38798 | Hgene | Tgene | Gene symbol | TMTC2 | HERC1 | Gene ID | 160335 | 8925 |
| Gene name | transmembrane and tetratricopeptide repeat containing 2 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 | |
| Synonyms | IBDBP1 | MDFPMR|p532|p619 | |
| Cytomap | 12q21.31 | 15q22.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | transmembrane and TPR repeat-containing protein 2 | probable E3 ubiquitin-protein ligase HERC1HECT domain and RCC1-like domain-containing protein 1HECT-type E3 ubiquitin transferase HERC1guanine nucleotide exchange factor p532hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q8N394 | Q15751 | |
| Ensembl transtripts involved in fusion gene | ENST00000321196, ENST00000548305, ENST00000549919, | ENST00000443617, | |
| Fusion gene scores | * DoF score | 9 X 6 X 4=216 | 8 X 8 X 5=320 |
| # samples | 8 | 8 | |
| ** MAII score | log2(8/216*10)=-1.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/320*10)=-2 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TMTC2 [Title/Abstract] AND HERC1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-DX-A1L4-01A | TMTC2 | chr12 | 83081448 | + | HERC1 | chr15 | 63956793 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000321196 | ENST00000443617 | TMTC2 | chr12 | 83081448 | + | HERC1 | chr15 | 63956793 | - |
| In-frame | ENST00000548305 | ENST00000443617 | TMTC2 | chr12 | 83081448 | + | HERC1 | chr15 | 63956793 | - |
| intron-3CDS | ENST00000549919 | ENST00000443617 | TMTC2 | chr12 | 83081448 | + | HERC1 | chr15 | 63956793 | - |
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FusionProtFeatures for TMTC2_HERC1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TMTC2 | HERC1 |
| Involved in membrane trafficking via some guaninenucleotide exchange factor (GEF) activity and its ability to bindclathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDPfor free GTP. Binds phosphatidylinositol 4,5-bisphosphate, whichis required for GEF activity. May also act as a E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directlytransfers the ubiquitin to targeted substrates.{ECO:0000269|PubMed:15642342, ECO:0000269|PubMed:8861955,ECO:0000269|PubMed:9233772}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >HERC1 | chr12:83081448 | chr15:63956793 | ENST00000443617 | - | 41 | 78 | 4501_4848 | 2851 | 4862 | Domain | HECT |
| Tgene | >HERC1 | chr12:83081448 | chr15:63956793 | ENST00000443617 | - | 41 | 78 | 3426_3465 | 2851 | 4862 | Repeat | Note=WD 1 |
| Tgene | >HERC1 | chr12:83081448 | chr15:63956793 | ENST00000443617 | - | 41 | 78 | 3484_3522 | 2851 | 4862 | Repeat | Note=WD 2 |
| Tgene | >HERC1 | chr12:83081448 | chr15:63956793 | ENST00000443617 | - | 41 | 78 | 3524_3572 | 2851 | 4862 | Repeat | Note=WD 3 |
| Tgene | >HERC1 | chr12:83081448 | chr15:63956793 | ENST00000443617 | - | 41 | 78 | 3580_3619 | 2851 | 4862 | Repeat | Note=WD 4 |
| Tgene | >HERC1 | chr12:83081448 | chr15:63956793 | ENST00000443617 | - | 41 | 78 | 3624_3663 | 2851 | 4862 | Repeat | Note=WD 5 |
| Tgene | >HERC1 | chr12:83081448 | chr15:63956793 | ENST00000443617 | - | 41 | 78 | 3667_3713 | 2851 | 4862 | Repeat | Note=WD 6 |
| Tgene | >HERC1 | chr12:83081448 | chr15:63956793 | ENST00000443617 | - | 41 | 78 | 3745_3784 | 2851 | 4862 | Repeat | Note=WD 7 |
| Tgene | >HERC1 | chr12:83081448 | chr15:63956793 | ENST00000443617 | - | 41 | 78 | 3996_4044 | 2851 | 4862 | Repeat | Note=RCC1 8 |
| Tgene | >HERC1 | chr12:83081448 | chr15:63956793 | ENST00000443617 | - | 41 | 78 | 4046_4099 | 2851 | 4862 | Repeat | Note=RCC1 9 |
| Tgene | >HERC1 | chr12:83081448 | chr15:63956793 | ENST00000443617 | - | 41 | 78 | 4101_4151 | 2851 | 4862 | Repeat | Note=RCC1 10 |
| Tgene | >HERC1 | chr12:83081448 | chr15:63956793 | ENST00000443617 | - | 41 | 78 | 4153_4203 | 2851 | 4862 | Repeat | Note=RCC1 11 |
| Tgene | >HERC1 | chr12:83081448 | chr15:63956793 | ENST00000443617 | - | 41 | 78 | 4205_4256 | 2851 | 4862 | Repeat | Note=RCC1 12 |
| Tgene | >HERC1 | chr12:83081448 | chr15:63956793 | ENST00000443617 | - | 41 | 78 | 4258_4308 | 2851 | 4862 | Repeat | Note=RCC1 13 |
| Tgene | >HERC1 | chr12:83081448 | chr15:63956793 | ENST00000443617 | - | 41 | 78 | 4310_4360 | 2851 | 4862 | Repeat | Note=RCC1 14 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >TMTC2 | chr12:83081448 | chr15:63956793 | ENST00000321196 | + | 1 | 12 | 462_492 | 27 | 837 | Repeat | Note=TPR 1 |
| Hgene | >TMTC2 | chr12:83081448 | chr15:63956793 | ENST00000321196 | + | 1 | 12 | 493_526 | 27 | 837 | Repeat | Note=TPR 2 |
| Hgene | >TMTC2 | chr12:83081448 | chr15:63956793 | ENST00000321196 | + | 1 | 12 | 527_560 | 27 | 837 | Repeat | Note=TPR 3 |
| Hgene | >TMTC2 | chr12:83081448 | chr15:63956793 | ENST00000321196 | + | 1 | 12 | 562_594 | 27 | 837 | Repeat | Note=TPR 4 |
| Hgene | >TMTC2 | chr12:83081448 | chr15:63956793 | ENST00000321196 | + | 1 | 12 | 606_639 | 27 | 837 | Repeat | Note=TPR 5 |
| Hgene | >TMTC2 | chr12:83081448 | chr15:63956793 | ENST00000321196 | + | 1 | 12 | 643_676 | 27 | 837 | Repeat | Note=TPR 6 |
| Hgene | >TMTC2 | chr12:83081448 | chr15:63956793 | ENST00000321196 | + | 1 | 12 | 677_710 | 27 | 837 | Repeat | Note=TPR 7 |
| Hgene | >TMTC2 | chr12:83081448 | chr15:63956793 | ENST00000321196 | + | 1 | 12 | 712_744 | 27 | 837 | Repeat | Note=TPR 8 |
| Hgene | >TMTC2 | chr12:83081448 | chr15:63956793 | ENST00000321196 | + | 1 | 12 | 746_778 | 27 | 837 | Repeat | Note=TPR 9 |
| Hgene | >TMTC2 | chr12:83081448 | chr15:63956793 | ENST00000321196 | + | 1 | 12 | 779_812 | 27 | 837 | Repeat | Note=TPR 10 |
| Hgene | >TMTC2 | chr12:83081448 | chr15:63956793 | ENST00000321196 | + | 1 | 12 | 108_128 | 27 | 837 | Transmembrane | Helical |
| Hgene | >TMTC2 | chr12:83081448 | chr15:63956793 | ENST00000321196 | + | 1 | 12 | 133_153 | 27 | 837 | Transmembrane | Helical |
| Hgene | >TMTC2 | chr12:83081448 | chr15:63956793 | ENST00000321196 | + | 1 | 12 | 163_183 | 27 | 837 | Transmembrane | Helical |
| Hgene | >TMTC2 | chr12:83081448 | chr15:63956793 | ENST00000321196 | + | 1 | 12 | 184_204 | 27 | 837 | Transmembrane | Helical |
| Hgene | >TMTC2 | chr12:83081448 | chr15:63956793 | ENST00000321196 | + | 1 | 12 | 222_241 | 27 | 837 | Transmembrane | Helical |
| Hgene | >TMTC2 | chr12:83081448 | chr15:63956793 | ENST00000321196 | + | 1 | 12 | 313_333 | 27 | 837 | Transmembrane | Helical |
| Hgene | >TMTC2 | chr12:83081448 | chr15:63956793 | ENST00000321196 | + | 1 | 12 | 400_420 | 27 | 837 | Transmembrane | Helical |
| Hgene | >TMTC2 | chr12:83081448 | chr15:63956793 | ENST00000321196 | + | 1 | 12 | 423_443 | 27 | 837 | Transmembrane | Helical |
| Hgene | >TMTC2 | chr12:83081448 | chr15:63956793 | ENST00000321196 | + | 1 | 12 | 450_470 | 27 | 837 | Transmembrane | Helical |
| Hgene | >TMTC2 | chr12:83081448 | chr15:63956793 | ENST00000321196 | + | 1 | 12 | 85_105 | 27 | 837 | Transmembrane | Helical |
| Tgene | HERC1 | chr12:83081448 | chr15:63956793 | ENST00000443617 | - | 41 | 78 | 1349_1378 | 2851 | 4862 | Compositional bias | Note=Glu-rich |
| Tgene | HERC1 | chr12:83081448 | chr15:63956793 | ENST00000443617 | - | 41 | 78 | 2002_2193 | 2851 | 4862 | Domain | B30.2/SPRY |
| Tgene | HERC1 | chr12:83081448 | chr15:63956793 | ENST00000443617 | - | 41 | 78 | 371_420 | 2851 | 4862 | Repeat | Note=RCC1 1 |
| Tgene | HERC1 | chr12:83081448 | chr15:63956793 | ENST00000443617 | - | 41 | 78 | 421_475 | 2851 | 4862 | Repeat | Note=RCC1 2 |
| Tgene | HERC1 | chr12:83081448 | chr15:63956793 | ENST00000443617 | - | 41 | 78 | 476_528 | 2851 | 4862 | Repeat | Note=RCC1 3 |
| Tgene | HERC1 | chr12:83081448 | chr15:63956793 | ENST00000443617 | - | 41 | 78 | 529_578 | 2851 | 4862 | Repeat | Note=RCC1 4 |
| Tgene | HERC1 | chr12:83081448 | chr15:63956793 | ENST00000443617 | - | 41 | 78 | 580_631 | 2851 | 4862 | Repeat | Note=RCC1 5 |
| Tgene | HERC1 | chr12:83081448 | chr15:63956793 | ENST00000443617 | - | 41 | 78 | 633_682 | 2851 | 4862 | Repeat | Note=RCC1 6 |
| Tgene | HERC1 | chr12:83081448 | chr15:63956793 | ENST00000443617 | - | 41 | 78 | 683_735 | 2851 | 4862 | Repeat | Note=RCC1 7 |
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FusionGeneSequence for TMTC2_HERC1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_TMTC2_ENST00000321196_chr12_83081448_+_HERC1_ENST00000443617_chr15_63956793_-_2038aa MIAELVSSALGLALYLNTLSADFCYDDSPDNLDHTENAASGSGPSARGRSAVTRRHKFDLAARTLLARAAGLYRSVQAHRNQSRREGISL QQDPGALYDFNLDEELEIDLDDEAMEAMFGQDLTSDNDILGMWIPEVLDWPTWHVCESEDREEVVVCELCECSVVSFNQHMKRNHPGCGR SANRQGYRSNGSYVDGWFGGECGSGNPYYLLCGTCREKYLAMKTKSKSTSSERYKGQAPDLIGKQDSVYEEDWDMLDVDEDEKLTGEEEF ELLAGPLGLNDRRIVPEPVQFPDSDPLGASVAMVTATNSMEETLMQIGCHGSVEKSSSGRITLGEQAAALANPHDRVVALRRVTAAAQVL LARTMVMRALSLLSVSGSSCSLAAGLESLGLTDIRTLVRLMCLAAAGRAGLSTSPSAMASTSERSRGGHSKANKPISCLAYLSTAVGCLA SNAPSAAKLLVQLCTQNLISAATGVNLTTVDDSIQRKFLPSFLRGIAEENKLVTSPNFVVTQALVALLADKGAKLRPNYDKSEVEKKGPL ELANALAACCLSSRLSSQHRQWAAQQLVRTLAAHDRDNQTTLQTLADMGGDLRKCSFIKLEAHQNRVMTCVWCNKKGLLATSGNDGTIRV WNVTKKQYSLQQTCVFNRLEGDAEESLGSPSDPSFSPVSWSISGKYLAGALEKMVNIWQVNGGKGLVDIQPHWVSALAWPEEGPATAWSG ESPELLLVGRMDGSLGLIEVVDVSTMHRRELEHCYRKDVSVTCIAWFSEDRPFAVGYFDGKLLLGTKEPLEKGGIVLIDAHKDTLISMKW DPTGHILMTCAKEDSVKLWGSISGCWCCLHSLCHPSIVNGIAWCRLPGKGSKLQLLMATGCQSGLVCVWRIPQDTTQTNVTSAEGWWEQE SNCQDGYRKSSGAKCVYQLRGHITPVRTVAFSSDGLALVSGGLGGLMNIWSLRDGSVLQTVVIGSGAIQTTVWIPEVGVAACSNRSKDVL VVNCTAEWAAANHVLATCRTALKQQGVLGLNMAPCMRAFLERLPMMLQEQYAYEKPHVVCGDQLVHSPYMQCLASLAVGLHLDQLLCNPP VPPHHQNCLPDPASWNPNEWAWLECFSTTIKAAEALTNGAQFPESFTVPDLEPVPEDELVFLMDNSKWINGMDEQIMSWATSRPEDWHLG GKCDVYLWGAGRHGQLAEAGRNVMVPAAAPSFSQAQQVICGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQL VTSCGSDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNK KLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAKSSPQKIDVLCGIGIKKVACGTQFSVALTKDGHVYTFG QDRLIGLPEGRARNHNRPQQIPVLAGVIIEDVAVGAEHTLALASNGDVYAWGSNSEGQLGLGHTNHVREPTLVTGLQGKNVRQISAGRCH SAAWTAPPVPPRAPGVSVPLQLGLPDTVPPQYGALREVSIHTVRARLRLLYHFSDLMYSSWRLLNLSPNNQNSTSHYNAGTWGIVQGQLR PLLAPRVYTLPMVRSIGKTMVQGKNYGPQITVKRISTRGRKCKPIFVQIARQVVKLNASDLRLPSRAWKVKLVGEGADDAGGVFDDTITE MCQELETGIVDLLIPSPNATAEVGYNRDRFLFNPSACLDEHLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQLCCVPLTLEDLEEVDLL YVQTLNSILHIEDSGITEESFHEMIPLDSFVGQSADGKMVPIIPGGNSIPLTFSNRKEYVERAIEYRLHEMDRQVAAVREGMSWIVPVPL LSLLTAKQLEQMVCGMPEISVEVLKKVVRYREVDEQHQLVQWFWHTLEEFSNEERVLFMRFVSGRSRLPANTADISQRFQIMKVDRPYDS >In-frame_TMTC2_ENST00000548305_chr12_83081448_+_HERC1_ENST00000443617_chr15_63956793_-_2038aa MIAELVSSALGLALYLNTLSADFCYDDSPDNLDHTENAASGSGPSARGRSAVTRRHKFDLAARTLLARAAGLYRSVQAHRNQSRREGISL QQDPGALYDFNLDEELEIDLDDEAMEAMFGQDLTSDNDILGMWIPEVLDWPTWHVCESEDREEVVVCELCECSVVSFNQHMKRNHPGCGR SANRQGYRSNGSYVDGWFGGECGSGNPYYLLCGTCREKYLAMKTKSKSTSSERYKGQAPDLIGKQDSVYEEDWDMLDVDEDEKLTGEEEF ELLAGPLGLNDRRIVPEPVQFPDSDPLGASVAMVTATNSMEETLMQIGCHGSVEKSSSGRITLGEQAAALANPHDRVVALRRVTAAAQVL LARTMVMRALSLLSVSGSSCSLAAGLESLGLTDIRTLVRLMCLAAAGRAGLSTSPSAMASTSERSRGGHSKANKPISCLAYLSTAVGCLA SNAPSAAKLLVQLCTQNLISAATGVNLTTVDDSIQRKFLPSFLRGIAEENKLVTSPNFVVTQALVALLADKGAKLRPNYDKSEVEKKGPL ELANALAACCLSSRLSSQHRQWAAQQLVRTLAAHDRDNQTTLQTLADMGGDLRKCSFIKLEAHQNRVMTCVWCNKKGLLATSGNDGTIRV WNVTKKQYSLQQTCVFNRLEGDAEESLGSPSDPSFSPVSWSISGKYLAGALEKMVNIWQVNGGKGLVDIQPHWVSALAWPEEGPATAWSG ESPELLLVGRMDGSLGLIEVVDVSTMHRRELEHCYRKDVSVTCIAWFSEDRPFAVGYFDGKLLLGTKEPLEKGGIVLIDAHKDTLISMKW DPTGHILMTCAKEDSVKLWGSISGCWCCLHSLCHPSIVNGIAWCRLPGKGSKLQLLMATGCQSGLVCVWRIPQDTTQTNVTSAEGWWEQE SNCQDGYRKSSGAKCVYQLRGHITPVRTVAFSSDGLALVSGGLGGLMNIWSLRDGSVLQTVVIGSGAIQTTVWIPEVGVAACSNRSKDVL VVNCTAEWAAANHVLATCRTALKQQGVLGLNMAPCMRAFLERLPMMLQEQYAYEKPHVVCGDQLVHSPYMQCLASLAVGLHLDQLLCNPP VPPHHQNCLPDPASWNPNEWAWLECFSTTIKAAEALTNGAQFPESFTVPDLEPVPEDELVFLMDNSKWINGMDEQIMSWATSRPEDWHLG GKCDVYLWGAGRHGQLAEAGRNVMVPAAAPSFSQAQQVICGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQL VTSCGSDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNK KLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAKSSPQKIDVLCGIGIKKVACGTQFSVALTKDGHVYTFG QDRLIGLPEGRARNHNRPQQIPVLAGVIIEDVAVGAEHTLALASNGDVYAWGSNSEGQLGLGHTNHVREPTLVTGLQGKNVRQISAGRCH SAAWTAPPVPPRAPGVSVPLQLGLPDTVPPQYGALREVSIHTVRARLRLLYHFSDLMYSSWRLLNLSPNNQNSTSHYNAGTWGIVQGQLR PLLAPRVYTLPMVRSIGKTMVQGKNYGPQITVKRISTRGRKCKPIFVQIARQVVKLNASDLRLPSRAWKVKLVGEGADDAGGVFDDTITE MCQELETGIVDLLIPSPNATAEVGYNRDRFLFNPSACLDEHLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQLCCVPLTLEDLEEVDLL YVQTLNSILHIEDSGITEESFHEMIPLDSFVGQSADGKMVPIIPGGNSIPLTFSNRKEYVERAIEYRLHEMDRQVAAVREGMSWIVPVPL LSLLTAKQLEQMVCGMPEISVEVLKKVVRYREVDEQHQLVQWFWHTLEEFSNEERVLFMRFVSGRSRLPANTADISQRFQIMKVDRPYDS |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_TMTC2_ENST00000321196_chr12_83081448_+_HERC1_ENST00000443617_chr15_63956793_-_6114nt ATGATTGCAGAGTTGGTGAGCAGCGCTCTGGGGCTCGCCTTGTATCTCAACACCCTGAGTGCGGATTTCTGCTATGATGACAGCCCTGAT AATTTGGATCATACAGAGAATGCAGCTTCTGGAAGTGGACCATCAGCTAGAGGTCGCTCAGCGGTAACAAGAAGACACAAGTTTGACTTA GCTGCTCGCACACTGCTAGCAAGAGCAGCGGGATTATACCGCTCTGTGCAGGCCCACAGGAATCAAAGTCGGAGAGAAGGAATATCTTTG CAGCAAGACCCAGGGGCGTTGTATGACTTTAATTTAGATGAGGAATTGGAAATTGATCTTGATGATGAGGCGATGGAAGCTATGTTTGGA CAAGACCTGACCAGTGACAATGATATTCTGGGAATGTGGATCCCAGAGGTACTGGATTGGCCTACCTGGCATGTTTGTGAGTCTGAAGAC AGGGAAGAAGTGGTGGTGTGTGAACTGTGTGAATGCAGCGTCGTCAGCTTCAATCAGCACATGAAGAGAAACCATCCAGGCTGTGGGCGC AGTGCAAACCGCCAGGGCTATCGCAGCAATGGTTCCTATGTGGATGGCTGGTTTGGCGGTGAATGTGGGAGTGGAAATCCGTACTACCTG TTATGTGGCACCTGCAGGGAGAAGTACTTAGCCATGAAGACCAAATCTAAGTCAACAAGTTCTGAAAGGTACAAGGGACAAGCTCCAGAT CTAATTGGCAAGCAAGACAGTGTGTATGAAGAAGACTGGGACATGTTGGATGTTGATGAAGATGAAAAGCTAACTGGTGAAGAAGAATTT GAATTACTTGCTGGACCGCTTGGTTTAAATGACCGGCGCATTGTACCAGAACCAGTTCAGTTCCCTGACAGCGATCCACTGGGAGCATCA GTAGCAATGGTCACAGCCACCAACAGTATGGAAGAGACTCTGATGCAAATAGGTTGCCATGGCTCCGTAGAAAAGAGCTCCTCTGGGAGA ATAACGTTAGGAGAGCAGGCAGCTGCCCTAGCAAACCCTCATGACCGTGTGGTGGCTTTAAGGAGAGTGACTGCTGCTGCTCAGGTTCTT CTGGCCAGAACCATGGTCATGAGAGCGCTGTCTCTTCTCTCAGTCAGTGGTTCCAGTTGTAGCCTGGCTGCTGGTCTTGAGTCTCTGGGG CTAACAGATATCCGAACGCTAGTTCGATTAATGTGCTTGGCAGCAGCAGGGAGAGCTGGCCTCTCCACCAGCCCTTCTGCCATGGCTAGC ACCTCAGAACGATCACGAGGTGGGCATAGCAAGGCTAACAAGCCTATCTCTTGCCTGGCCTATTTGAGCACAGCAGTGGGATGTCTGGCA TCAAATGCTCCTAGTGCTGCCAAACTGCTTGTACAGTTGTGTACACAGAACTTGATTTCTGCTGCAACAGGTGTAAATCTAACCACAGTT GATGACTCAATTCAGCGAAAGTTTCTACCCAGCTTTCTCCGAGGAATTGCTGAAGAGAACAAGCTTGTGACCTCCCCAAACTTTGTTGTA ACACAGGCCCTTGTGGCATTGCTAGCAGACAAAGGGGCCAAACTAAGACCTAACTATGATAAGTCAGAAGTTGAAAAGAAAGGCCCTCTG GAGTTGGCTAATGCCCTGGCAGCCTGCTGCCTCTCCTCCAGGCTGTCCTCACAGCATCGGCAATGGGCAGCTCAGCAACTCGTGCGCACT CTTGCTGCACACGACCGTGACAACCAAACTACTCTGCAGACACTTGCTGATATGGGAGGAGATCTTAGAAAATGCTCCTTTATCAAATTG GAGGCTCATCAGAACAGAGTAATGACATGTGTTTGGTGTAATAAAAAAGGTCTTTTGGCTACAAGTGGCAATGATGGCACCATCCGCGTA TGGAATGTTACCAAGAAGCAATATTCACTGCAACAGACCTGTGTGTTCAACAGATTGGAAGGGGATGCTGAGGAAAGCCTGGGATCACCC AGTGATCCAAGTTTCTCACCAGTTTCCTGGAGTATCAGTGGCAAATATCTAGCAGGCGCTTTGGAAAAGATGGTGAATATCTGGCAAGTT AATGGAGGAAAAGGATTAGTAGATATTCAGCCTCATTGGGTATCTGCCCTGGCTTGGCCAGAAGAGGGTCCGGCTACAGCCTGGTCAGGA GAGTCTCCAGAATTGTTGTTGGTGGGACGGATGGATGGATCTCTGGGACTGATTGAAGTTGTTGATGTGTCCACCATGCACCGTCGAGAA TTGGAGCATTGCTATCGAAAGGATGTGTCTGTTACTTGCATTGCATGGTTCAGTGAAGACAGACCATTTGCAGTGGGATATTTTGATGGA AAACTGTTACTGGGAACAAAGGAACCACTTGAGAAAGGAGGCATTGTTCTAATTGATGCACATAAGGATACTCTTATTAGCATGAAGTGG GACCCTACAGGTCATATTCTTATGACATGTGCCAAAGAAGACAGTGTGAAACTCTGGGGCTCTATTTCGGGATGCTGGTGCTGTCTACAT TCACTCTGCCATCCATCTATTGTAAATGGCATTGCTTGGTGCCGCCTTCCAGGGAAAGGATCCAAGTTGCAGTTACTGATGGCTACTGGC TGTCAGAGTGGCTTAGTATGTGTTTGGCGCATTCCTCAAGATACTACACAGACCAATGTGACTAGTGCAGAAGGATGGTGGGAGCAGGAA TCAAATTGCCAGGATGGATATAGGAAATCATCAGGAGCCAAGTGTGTTTATCAGCTGCGGGGACACATCACTCCTGTTCGGACTGTTGCC TTTAGTTCTGATGGGTTGGCCCTGGTGTCTGGTGGACTAGGTGGGCTCATGAACATTTGGTCTTTAAGGGATGGCTCTGTCTTGCAAACT GTTGTGATAGGCTCTGGAGCTATTCAGACCACAGTATGGATTCCAGAAGTTGGAGTAGCTGCTTGCTCAAATAGATCAAAGGATGTTTTG GTCGTGAATTGTACAGCAGAATGGGCAGCTGCCAATCATGTTTTGGCAACCTGTAGGACAGCATTGAAACAGCAGGGTGTTCTGGGATTG AACATGGCTCCCTGCATGAGAGCATTTTTGGAGCGGCTCCCCATGATGCTTCAGGAGCAGTATGCCTATGAAAAGCCTCATGTGGTTTGT GGTGACCAACTTGTTCATAGCCCCTATATGCAATGCTTGGCTTCCCTTGCTGTGGGACTTCATCTGGATCAGCTGTTGTGTAACCCTCCA GTGCCACCACACCACCAGAACTGTCTCCCTGACCCTGCATCCTGGAATCCAAATGAATGGGCCTGGTTAGAATGTTTCTCAACCACTATA AAAGCTGCCGAAGCCCTGACCAATGGAGCCCAGTTTCCAGAATCTTTTACCGTTCCAGATCTAGAACCTGTTCCAGAGGATGAACTTGTA TTTCTAATGGATAACAGTAAATGGATTAACGGCATGGATGAACAAATTATGTCTTGGGCAACTTCCAGACCTGAGGACTGGCACCTGGGA GGTAAATGTGATGTCTACTTATGGGGTGCTGGTAGGCATGGACAGCTGGCAGAAGCTGGAAGAAATGTAATGGTACCTGCAGCAGCTCCC TCATTCTCACAGGCCCAACAGGTCATTTGTGGTCAGAATTGTACCTTTGTCATCCAGGCCAATGGCACAGTGTTGGCTTGTGGGGAAGGA AGTTATGGCAGATTAGGACAAGGAAATTCAGATGACCTTCATGTGCTGACAGTTATTTCAGCCTTACAAGGCTTTGTGGTGACCCAGCTG GTGACTTCCTGTGGTTCTGATGGGCACTCTATGGCCCTAACTGAAAGTGGTGAGGTCTTTAGCTGGGGAGATGGTGACTATGGTAAACTT GGCCATGGGAACAGCGACAGGCAGCGGCGGCCCAGGCAGATCGAGGCCTTACAAGGAGAAGAAGTGGTGCAGATGTCTTGTGGCTTCAAG CACTCAGCAGTGGTCACTTCAGATGGCAAACTGTTCACCTTTGGGAATGGTGACTATGGTCGTCTGGGTCTTGGAAATACCTCTAACAAA AAACTTCCAGAGAGAGTGACTGCACTGGAGGGATATCAGATTGGACAGGTGGCCTGTGGATTAAACCACACTTTGGCAGTGTCAGCAGAT GGTTCCATGGTGTGGGCTTTTGGAGATGGAGACTATGGAAAACTAGGCTTAGGAAATTCCACTGCAAAATCTTCACCTCAGAAAATTGAC GTCCTTTGTGGAATTGGAATAAAAAAGGTTGCTTGTGGAACTCAGTTTTCTGTTGCTTTGACCAAAGATGGTCATGTGTATACCTTTGGT CAAGATCGCCTGATAGGCTTGCCAGAGGGGCGTGCTCGCAATCACAATCGACCGCAACAAATCCCTGTCCTGGCTGGAGTAATCATAGAA GATGTGGCAGTTGGAGCTGAACACACACTTGCTTTGGCATCAAATGGAGATGTGTATGCCTGGGGGAGCAATTCAGAAGGGCAGCTCGGC TTAGGCCATACCAACCATGTTCGAGAACCAACCCTGGTAACAGGTCTGCAAGGGAAAAATGTTCGGCAGATCTCGGCTGGCCGCTGCCAC AGTGCTGCATGGACAGCACCACCTGTCCCACCAAGAGCACCAGGTGTGTCAGTACCTCTGCAGCTGGGCCTGCCTGACACAGTGCCCCCC CAGTATGGGGCGCTGAGAGAAGTCAGCATTCACACGGTGCGGGCCAGGCTCCGGCTGCTCTACCACTTCTCTGACCTCATGTACTCATCC TGGAGACTGCTGAACCTTAGCCCCAACAACCAGAACAGCACATCCCATTATAATGCTGGAACTTGGGGCATTGTACAGGGACAACTTCGG CCTTTGTTAGCCCCAAGAGTCTACACTCTGCCAATGGTGCGCTCCATAGGAAAAACCATGGTTCAAGGCAAAAACTATGGACCTCAGATA ACTGTAAAGAGGATATCAACCAGAGGACGGAAGTGTAAGCCTATTTTTGTCCAAATAGCGAGACAAGTAGTTAAGCTGAATGCTTCAGAC CTCCGCCTGCCTTCCCGAGCGTGGAAGGTTAAGCTGGTTGGAGAAGGGGCTGATGATGCTGGAGGAGTGTTTGATGACACCATCACAGAG ATGTGCCAGGAACTTGAAACTGGTATTGTTGACCTTCTTATACCCTCTCCCAATGCCACCGCAGAAGTGGGTTACAATAGGGACAGGTTC CTTTTTAACCCTTCTGCCTGCCTCGATGAACACTTAATGCAGTTTAAGTTTTTAGGAATTTTAATGGGGGTTGCCATTCGCACAAAGAAG CCTCTGGACCTCCACTTGGCCCCTCTGGTGTGGAAGCAGCTGTGCTGTGTCCCACTCACCCTAGAGGACCTGGAGGAGGTGGATCTGCTC TACGTGCAGACTCTCAACAGCATTCTTCACATTGAAGACAGTGGGATTACCGAGGAGAGTTTCCATGAGATGATTCCTCTTGATTCTTTT GTTGGCCAGAGTGCTGATGGCAAAATGGTTCCTATAATCCCTGGTGGAAATAGTATCCCACTCACATTTTCCAACAGGAAGGAATATGTG GAGAGGGCCATTGAATATCGACTTCATGAGATGGACAGACAGGTGGCTGCAGTCCGAGAAGGGATGTCCTGGATTGTTCCTGTGCCGCTG CTGTCCCTCCTCACAGCAAAACAACTGGAGCAGATGGTGTGTGGGATGCCCGAGATCTCTGTGGAAGTCTTGAAGAAAGTGGTGCGGTAC CGTGAGGTGGATGAGCAGCATCAGCTGGTGCAGTGGTTCTGGCACACGCTGGAAGAGTTCTCCAATGAGGAGCGGGTGCTTTTCATGAGG TTTGTGTCAGGAAGATCTCGACTACCAGCCAACACTGCTGACATTTCTCAGAGATTTCAAATCATGAAGGTTGATAGGCCTTACGACAGT CTGCCTACCTCACAGACCTGCTTCTTCCAGCTGAGGCTGCCCCCGTACTCCAGCCAGCTGGTCATGGCCGAGCGCCTGCGCTATGCCATC >In-frame_TMTC2_ENST00000548305_chr12_83081448_+_HERC1_ENST00000443617_chr15_63956793_-_6114nt ATGATTGCAGAGTTGGTGAGCAGCGCTCTGGGGCTCGCCTTGTATCTCAACACCCTGAGTGCGGATTTCTGCTATGATGACAGCCCTGAT AATTTGGATCATACAGAGAATGCAGCTTCTGGAAGTGGACCATCAGCTAGAGGTCGCTCAGCGGTAACAAGAAGACACAAGTTTGACTTA GCTGCTCGCACACTGCTAGCAAGAGCAGCGGGATTATACCGCTCTGTGCAGGCCCACAGGAATCAAAGTCGGAGAGAAGGAATATCTTTG CAGCAAGACCCAGGGGCGTTGTATGACTTTAATTTAGATGAGGAATTGGAAATTGATCTTGATGATGAGGCGATGGAAGCTATGTTTGGA CAAGACCTGACCAGTGACAATGATATTCTGGGAATGTGGATCCCAGAGGTACTGGATTGGCCTACCTGGCATGTTTGTGAGTCTGAAGAC AGGGAAGAAGTGGTGGTGTGTGAACTGTGTGAATGCAGCGTCGTCAGCTTCAATCAGCACATGAAGAGAAACCATCCAGGCTGTGGGCGC AGTGCAAACCGCCAGGGCTATCGCAGCAATGGTTCCTATGTGGATGGCTGGTTTGGCGGTGAATGTGGGAGTGGAAATCCGTACTACCTG TTATGTGGCACCTGCAGGGAGAAGTACTTAGCCATGAAGACCAAATCTAAGTCAACAAGTTCTGAAAGGTACAAGGGACAAGCTCCAGAT CTAATTGGCAAGCAAGACAGTGTGTATGAAGAAGACTGGGACATGTTGGATGTTGATGAAGATGAAAAGCTAACTGGTGAAGAAGAATTT GAATTACTTGCTGGACCGCTTGGTTTAAATGACCGGCGCATTGTACCAGAACCAGTTCAGTTCCCTGACAGCGATCCACTGGGAGCATCA GTAGCAATGGTCACAGCCACCAACAGTATGGAAGAGACTCTGATGCAAATAGGTTGCCATGGCTCCGTAGAAAAGAGCTCCTCTGGGAGA ATAACGTTAGGAGAGCAGGCAGCTGCCCTAGCAAACCCTCATGACCGTGTGGTGGCTTTAAGGAGAGTGACTGCTGCTGCTCAGGTTCTT CTGGCCAGAACCATGGTCATGAGAGCGCTGTCTCTTCTCTCAGTCAGTGGTTCCAGTTGTAGCCTGGCTGCTGGTCTTGAGTCTCTGGGG CTAACAGATATCCGAACGCTAGTTCGATTAATGTGCTTGGCAGCAGCAGGGAGAGCTGGCCTCTCCACCAGCCCTTCTGCCATGGCTAGC ACCTCAGAACGATCACGAGGTGGGCATAGCAAGGCTAACAAGCCTATCTCTTGCCTGGCCTATTTGAGCACAGCAGTGGGATGTCTGGCA TCAAATGCTCCTAGTGCTGCCAAACTGCTTGTACAGTTGTGTACACAGAACTTGATTTCTGCTGCAACAGGTGTAAATCTAACCACAGTT GATGACTCAATTCAGCGAAAGTTTCTACCCAGCTTTCTCCGAGGAATTGCTGAAGAGAACAAGCTTGTGACCTCCCCAAACTTTGTTGTA ACACAGGCCCTTGTGGCATTGCTAGCAGACAAAGGGGCCAAACTAAGACCTAACTATGATAAGTCAGAAGTTGAAAAGAAAGGCCCTCTG GAGTTGGCTAATGCCCTGGCAGCCTGCTGCCTCTCCTCCAGGCTGTCCTCACAGCATCGGCAATGGGCAGCTCAGCAACTCGTGCGCACT CTTGCTGCACACGACCGTGACAACCAAACTACTCTGCAGACACTTGCTGATATGGGAGGAGATCTTAGAAAATGCTCCTTTATCAAATTG GAGGCTCATCAGAACAGAGTAATGACATGTGTTTGGTGTAATAAAAAAGGTCTTTTGGCTACAAGTGGCAATGATGGCACCATCCGCGTA TGGAATGTTACCAAGAAGCAATATTCACTGCAACAGACCTGTGTGTTCAACAGATTGGAAGGGGATGCTGAGGAAAGCCTGGGATCACCC AGTGATCCAAGTTTCTCACCAGTTTCCTGGAGTATCAGTGGCAAATATCTAGCAGGCGCTTTGGAAAAGATGGTGAATATCTGGCAAGTT AATGGAGGAAAAGGATTAGTAGATATTCAGCCTCATTGGGTATCTGCCCTGGCTTGGCCAGAAGAGGGTCCGGCTACAGCCTGGTCAGGA GAGTCTCCAGAATTGTTGTTGGTGGGACGGATGGATGGATCTCTGGGACTGATTGAAGTTGTTGATGTGTCCACCATGCACCGTCGAGAA TTGGAGCATTGCTATCGAAAGGATGTGTCTGTTACTTGCATTGCATGGTTCAGTGAAGACAGACCATTTGCAGTGGGATATTTTGATGGA AAACTGTTACTGGGAACAAAGGAACCACTTGAGAAAGGAGGCATTGTTCTAATTGATGCACATAAGGATACTCTTATTAGCATGAAGTGG GACCCTACAGGTCATATTCTTATGACATGTGCCAAAGAAGACAGTGTGAAACTCTGGGGCTCTATTTCGGGATGCTGGTGCTGTCTACAT TCACTCTGCCATCCATCTATTGTAAATGGCATTGCTTGGTGCCGCCTTCCAGGGAAAGGATCCAAGTTGCAGTTACTGATGGCTACTGGC TGTCAGAGTGGCTTAGTATGTGTTTGGCGCATTCCTCAAGATACTACACAGACCAATGTGACTAGTGCAGAAGGATGGTGGGAGCAGGAA TCAAATTGCCAGGATGGATATAGGAAATCATCAGGAGCCAAGTGTGTTTATCAGCTGCGGGGACACATCACTCCTGTTCGGACTGTTGCC TTTAGTTCTGATGGGTTGGCCCTGGTGTCTGGTGGACTAGGTGGGCTCATGAACATTTGGTCTTTAAGGGATGGCTCTGTCTTGCAAACT GTTGTGATAGGCTCTGGAGCTATTCAGACCACAGTATGGATTCCAGAAGTTGGAGTAGCTGCTTGCTCAAATAGATCAAAGGATGTTTTG GTCGTGAATTGTACAGCAGAATGGGCAGCTGCCAATCATGTTTTGGCAACCTGTAGGACAGCATTGAAACAGCAGGGTGTTCTGGGATTG AACATGGCTCCCTGCATGAGAGCATTTTTGGAGCGGCTCCCCATGATGCTTCAGGAGCAGTATGCCTATGAAAAGCCTCATGTGGTTTGT GGTGACCAACTTGTTCATAGCCCCTATATGCAATGCTTGGCTTCCCTTGCTGTGGGACTTCATCTGGATCAGCTGTTGTGTAACCCTCCA GTGCCACCACACCACCAGAACTGTCTCCCTGACCCTGCATCCTGGAATCCAAATGAATGGGCCTGGTTAGAATGTTTCTCAACCACTATA AAAGCTGCCGAAGCCCTGACCAATGGAGCCCAGTTTCCAGAATCTTTTACCGTTCCAGATCTAGAACCTGTTCCAGAGGATGAACTTGTA TTTCTAATGGATAACAGTAAATGGATTAACGGCATGGATGAACAAATTATGTCTTGGGCAACTTCCAGACCTGAGGACTGGCACCTGGGA GGTAAATGTGATGTCTACTTATGGGGTGCTGGTAGGCATGGACAGCTGGCAGAAGCTGGAAGAAATGTAATGGTACCTGCAGCAGCTCCC TCATTCTCACAGGCCCAACAGGTCATTTGTGGTCAGAATTGTACCTTTGTCATCCAGGCCAATGGCACAGTGTTGGCTTGTGGGGAAGGA AGTTATGGCAGATTAGGACAAGGAAATTCAGATGACCTTCATGTGCTGACAGTTATTTCAGCCTTACAAGGCTTTGTGGTGACCCAGCTG GTGACTTCCTGTGGTTCTGATGGGCACTCTATGGCCCTAACTGAAAGTGGTGAGGTCTTTAGCTGGGGAGATGGTGACTATGGTAAACTT GGCCATGGGAACAGCGACAGGCAGCGGCGGCCCAGGCAGATCGAGGCCTTACAAGGAGAAGAAGTGGTGCAGATGTCTTGTGGCTTCAAG CACTCAGCAGTGGTCACTTCAGATGGCAAACTGTTCACCTTTGGGAATGGTGACTATGGTCGTCTGGGTCTTGGAAATACCTCTAACAAA AAACTTCCAGAGAGAGTGACTGCACTGGAGGGATATCAGATTGGACAGGTGGCCTGTGGATTAAACCACACTTTGGCAGTGTCAGCAGAT GGTTCCATGGTGTGGGCTTTTGGAGATGGAGACTATGGAAAACTAGGCTTAGGAAATTCCACTGCAAAATCTTCACCTCAGAAAATTGAC GTCCTTTGTGGAATTGGAATAAAAAAGGTTGCTTGTGGAACTCAGTTTTCTGTTGCTTTGACCAAAGATGGTCATGTGTATACCTTTGGT CAAGATCGCCTGATAGGCTTGCCAGAGGGGCGTGCTCGCAATCACAATCGACCGCAACAAATCCCTGTCCTGGCTGGAGTAATCATAGAA GATGTGGCAGTTGGAGCTGAACACACACTTGCTTTGGCATCAAATGGAGATGTGTATGCCTGGGGGAGCAATTCAGAAGGGCAGCTCGGC TTAGGCCATACCAACCATGTTCGAGAACCAACCCTGGTAACAGGTCTGCAAGGGAAAAATGTTCGGCAGATCTCGGCTGGCCGCTGCCAC AGTGCTGCATGGACAGCACCACCTGTCCCACCAAGAGCACCAGGTGTGTCAGTACCTCTGCAGCTGGGCCTGCCTGACACAGTGCCCCCC CAGTATGGGGCGCTGAGAGAAGTCAGCATTCACACGGTGCGGGCCAGGCTCCGGCTGCTCTACCACTTCTCTGACCTCATGTACTCATCC TGGAGACTGCTGAACCTTAGCCCCAACAACCAGAACAGCACATCCCATTATAATGCTGGAACTTGGGGCATTGTACAGGGACAACTTCGG CCTTTGTTAGCCCCAAGAGTCTACACTCTGCCAATGGTGCGCTCCATAGGAAAAACCATGGTTCAAGGCAAAAACTATGGACCTCAGATA ACTGTAAAGAGGATATCAACCAGAGGACGGAAGTGTAAGCCTATTTTTGTCCAAATAGCGAGACAAGTAGTTAAGCTGAATGCTTCAGAC CTCCGCCTGCCTTCCCGAGCGTGGAAGGTTAAGCTGGTTGGAGAAGGGGCTGATGATGCTGGAGGAGTGTTTGATGACACCATCACAGAG ATGTGCCAGGAACTTGAAACTGGTATTGTTGACCTTCTTATACCCTCTCCCAATGCCACCGCAGAAGTGGGTTACAATAGGGACAGGTTC CTTTTTAACCCTTCTGCCTGCCTCGATGAACACTTAATGCAGTTTAAGTTTTTAGGAATTTTAATGGGGGTTGCCATTCGCACAAAGAAG CCTCTGGACCTCCACTTGGCCCCTCTGGTGTGGAAGCAGCTGTGCTGTGTCCCACTCACCCTAGAGGACCTGGAGGAGGTGGATCTGCTC TACGTGCAGACTCTCAACAGCATTCTTCACATTGAAGACAGTGGGATTACCGAGGAGAGTTTCCATGAGATGATTCCTCTTGATTCTTTT GTTGGCCAGAGTGCTGATGGCAAAATGGTTCCTATAATCCCTGGTGGAAATAGTATCCCACTCACATTTTCCAACAGGAAGGAATATGTG GAGAGGGCCATTGAATATCGACTTCATGAGATGGACAGACAGGTGGCTGCAGTCCGAGAAGGGATGTCCTGGATTGTTCCTGTGCCGCTG CTGTCCCTCCTCACAGCAAAACAACTGGAGCAGATGGTGTGTGGGATGCCCGAGATCTCTGTGGAAGTCTTGAAGAAAGTGGTGCGGTAC CGTGAGGTGGATGAGCAGCATCAGCTGGTGCAGTGGTTCTGGCACACGCTGGAAGAGTTCTCCAATGAGGAGCGGGTGCTTTTCATGAGG TTTGTGTCAGGAAGATCTCGACTACCAGCCAACACTGCTGACATTTCTCAGAGATTTCAAATCATGAAGGTTGATAGGCCTTACGACAGT CTGCCTACCTCACAGACCTGCTTCTTCCAGCTGAGGCTGCCCCCGTACTCCAGCCAGCTGGTCATGGCCGAGCGCCTGCGCTATGCCATC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_TMTC2_ENST00000321196_chr12_83081448_+_HERC1_ENST00000443617_chr15_63956793_-_7284nt GTCACGCAGGCGCGGGGGGCCGCGTCGAGAACCCCACGCGGGAGCTTCTGGAGTCTCCAGCCACCGCTTCTCACTTCACTGGAGAAGGGA GCTGGGGCTGGGGCTGGGGCTGGGGCTGGGAGGGAGCTAATAAACATTGAATGTGCAGCAGCTGCCTTGGCGGCCGGAGTCCGCCCGAGC GACACCGGAGCAGTGCGCCCGGGAGGCGGCGAGGGGAGGCGGTTCGCCTTGTCCCTCCCACCCGCGCCTCTTTCTCTCTCTTCCTCCAGC TGGTCCCAGAGCCCGGCTTGGTCCGGTCCCTCTGCCCCCATCCCGCACCCTTCCACCTCCTCCGAGTCCCACTCCTCACCTAGGACGCCC CAAACTGCCATGGGTTAGGGTGGGGATCGCGACCCGCGCGAAAGACCAGCCCTGCGCTTCCGCCGGGGGACGCGGAGCCCAAACGCCGCT CACCGCTTGCGGGCGCCGGGCATGGGGAGTGTGGTGTGAGCCCGCACCCGGGGAGGACGCAGGAGCTGCGGAGACGGGCGCGAGGAGGAG GAGAGGAGTCGTGGATTGGAAGGACCCGAGGGAGGGAGGGTGGGGAAGCGAGGGAAAAGTGAAGCTGGGAGGAGAAGGCGGCGGAAGGTG GAGATTGATGCTTCTGTTTTTTGTTGCCGCTGCTGCCCTCGCGCTGGGAGCCGAGCCGGAGGGAAGGCGGTGGAGAGATGATTGCAGAGT TGGTGAGCAGCGCTCTGGGGCTCGCCTTGTATCTCAACACCCTGAGTGCGGATTTCTGCTATGATGACAGCCCTGATAATTTGGATCATA CAGAGAATGCAGCTTCTGGAAGTGGACCATCAGCTAGAGGTCGCTCAGCGGTAACAAGAAGACACAAGTTTGACTTAGCTGCTCGCACAC TGCTAGCAAGAGCAGCGGGATTATACCGCTCTGTGCAGGCCCACAGGAATCAAAGTCGGAGAGAAGGAATATCTTTGCAGCAAGACCCAG GGGCGTTGTATGACTTTAATTTAGATGAGGAATTGGAAATTGATCTTGATGATGAGGCGATGGAAGCTATGTTTGGACAAGACCTGACCA GTGACAATGATATTCTGGGAATGTGGATCCCAGAGGTACTGGATTGGCCTACCTGGCATGTTTGTGAGTCTGAAGACAGGGAAGAAGTGG TGGTGTGTGAACTGTGTGAATGCAGCGTCGTCAGCTTCAATCAGCACATGAAGAGAAACCATCCAGGCTGTGGGCGCAGTGCAAACCGCC AGGGCTATCGCAGCAATGGTTCCTATGTGGATGGCTGGTTTGGCGGTGAATGTGGGAGTGGAAATCCGTACTACCTGTTATGTGGCACCT GCAGGGAGAAGTACTTAGCCATGAAGACCAAATCTAAGTCAACAAGTTCTGAAAGGTACAAGGGACAAGCTCCAGATCTAATTGGCAAGC AAGACAGTGTGTATGAAGAAGACTGGGACATGTTGGATGTTGATGAAGATGAAAAGCTAACTGGTGAAGAAGAATTTGAATTACTTGCTG GACCGCTTGGTTTAAATGACCGGCGCATTGTACCAGAACCAGTTCAGTTCCCTGACAGCGATCCACTGGGAGCATCAGTAGCAATGGTCA CAGCCACCAACAGTATGGAAGAGACTCTGATGCAAATAGGTTGCCATGGCTCCGTAGAAAAGAGCTCCTCTGGGAGAATAACGTTAGGAG AGCAGGCAGCTGCCCTAGCAAACCCTCATGACCGTGTGGTGGCTTTAAGGAGAGTGACTGCTGCTGCTCAGGTTCTTCTGGCCAGAACCA TGGTCATGAGAGCGCTGTCTCTTCTCTCAGTCAGTGGTTCCAGTTGTAGCCTGGCTGCTGGTCTTGAGTCTCTGGGGCTAACAGATATCC GAACGCTAGTTCGATTAATGTGCTTGGCAGCAGCAGGGAGAGCTGGCCTCTCCACCAGCCCTTCTGCCATGGCTAGCACCTCAGAACGAT CACGAGGTGGGCATAGCAAGGCTAACAAGCCTATCTCTTGCCTGGCCTATTTGAGCACAGCAGTGGGATGTCTGGCATCAAATGCTCCTA GTGCTGCCAAACTGCTTGTACAGTTGTGTACACAGAACTTGATTTCTGCTGCAACAGGTGTAAATCTAACCACAGTTGATGACTCAATTC AGCGAAAGTTTCTACCCAGCTTTCTCCGAGGAATTGCTGAAGAGAACAAGCTTGTGACCTCCCCAAACTTTGTTGTAACACAGGCCCTTG TGGCATTGCTAGCAGACAAAGGGGCCAAACTAAGACCTAACTATGATAAGTCAGAAGTTGAAAAGAAAGGCCCTCTGGAGTTGGCTAATG CCCTGGCAGCCTGCTGCCTCTCCTCCAGGCTGTCCTCACAGCATCGGCAATGGGCAGCTCAGCAACTCGTGCGCACTCTTGCTGCACACG ACCGTGACAACCAAACTACTCTGCAGACACTTGCTGATATGGGAGGAGATCTTAGAAAATGCTCCTTTATCAAATTGGAGGCTCATCAGA ACAGAGTAATGACATGTGTTTGGTGTAATAAAAAAGGTCTTTTGGCTACAAGTGGCAATGATGGCACCATCCGCGTATGGAATGTTACCA AGAAGCAATATTCACTGCAACAGACCTGTGTGTTCAACAGATTGGAAGGGGATGCTGAGGAAAGCCTGGGATCACCCAGTGATCCAAGTT TCTCACCAGTTTCCTGGAGTATCAGTGGCAAATATCTAGCAGGCGCTTTGGAAAAGATGGTGAATATCTGGCAAGTTAATGGAGGAAAAG GATTAGTAGATATTCAGCCTCATTGGGTATCTGCCCTGGCTTGGCCAGAAGAGGGTCCGGCTACAGCCTGGTCAGGAGAGTCTCCAGAAT TGTTGTTGGTGGGACGGATGGATGGATCTCTGGGACTGATTGAAGTTGTTGATGTGTCCACCATGCACCGTCGAGAATTGGAGCATTGCT ATCGAAAGGATGTGTCTGTTACTTGCATTGCATGGTTCAGTGAAGACAGACCATTTGCAGTGGGATATTTTGATGGAAAACTGTTACTGG GAACAAAGGAACCACTTGAGAAAGGAGGCATTGTTCTAATTGATGCACATAAGGATACTCTTATTAGCATGAAGTGGGACCCTACAGGTC ATATTCTTATGACATGTGCCAAAGAAGACAGTGTGAAACTCTGGGGCTCTATTTCGGGATGCTGGTGCTGTCTACATTCACTCTGCCATC CATCTATTGTAAATGGCATTGCTTGGTGCCGCCTTCCAGGGAAAGGATCCAAGTTGCAGTTACTGATGGCTACTGGCTGTCAGAGTGGCT TAGTATGTGTTTGGCGCATTCCTCAAGATACTACACAGACCAATGTGACTAGTGCAGAAGGATGGTGGGAGCAGGAATCAAATTGCCAGG ATGGATATAGGAAATCATCAGGAGCCAAGTGTGTTTATCAGCTGCGGGGACACATCACTCCTGTTCGGACTGTTGCCTTTAGTTCTGATG GGTTGGCCCTGGTGTCTGGTGGACTAGGTGGGCTCATGAACATTTGGTCTTTAAGGGATGGCTCTGTCTTGCAAACTGTTGTGATAGGCT CTGGAGCTATTCAGACCACAGTATGGATTCCAGAAGTTGGAGTAGCTGCTTGCTCAAATAGATCAAAGGATGTTTTGGTCGTGAATTGTA CAGCAGAATGGGCAGCTGCCAATCATGTTTTGGCAACCTGTAGGACAGCATTGAAACAGCAGGGTGTTCTGGGATTGAACATGGCTCCCT GCATGAGAGCATTTTTGGAGCGGCTCCCCATGATGCTTCAGGAGCAGTATGCCTATGAAAAGCCTCATGTGGTTTGTGGTGACCAACTTG TTCATAGCCCCTATATGCAATGCTTGGCTTCCCTTGCTGTGGGACTTCATCTGGATCAGCTGTTGTGTAACCCTCCAGTGCCACCACACC ACCAGAACTGTCTCCCTGACCCTGCATCCTGGAATCCAAATGAATGGGCCTGGTTAGAATGTTTCTCAACCACTATAAAAGCTGCCGAAG CCCTGACCAATGGAGCCCAGTTTCCAGAATCTTTTACCGTTCCAGATCTAGAACCTGTTCCAGAGGATGAACTTGTATTTCTAATGGATA ACAGTAAATGGATTAACGGCATGGATGAACAAATTATGTCTTGGGCAACTTCCAGACCTGAGGACTGGCACCTGGGAGGTAAATGTGATG TCTACTTATGGGGTGCTGGTAGGCATGGACAGCTGGCAGAAGCTGGAAGAAATGTAATGGTACCTGCAGCAGCTCCCTCATTCTCACAGG CCCAACAGGTCATTTGTGGTCAGAATTGTACCTTTGTCATCCAGGCCAATGGCACAGTGTTGGCTTGTGGGGAAGGAAGTTATGGCAGAT TAGGACAAGGAAATTCAGATGACCTTCATGTGCTGACAGTTATTTCAGCCTTACAAGGCTTTGTGGTGACCCAGCTGGTGACTTCCTGTG GTTCTGATGGGCACTCTATGGCCCTAACTGAAAGTGGTGAGGTCTTTAGCTGGGGAGATGGTGACTATGGTAAACTTGGCCATGGGAACA GCGACAGGCAGCGGCGGCCCAGGCAGATCGAGGCCTTACAAGGAGAAGAAGTGGTGCAGATGTCTTGTGGCTTCAAGCACTCAGCAGTGG TCACTTCAGATGGCAAACTGTTCACCTTTGGGAATGGTGACTATGGTCGTCTGGGTCTTGGAAATACCTCTAACAAAAAACTTCCAGAGA GAGTGACTGCACTGGAGGGATATCAGATTGGACAGGTGGCCTGTGGATTAAACCACACTTTGGCAGTGTCAGCAGATGGTTCCATGGTGT GGGCTTTTGGAGATGGAGACTATGGAAAACTAGGCTTAGGAAATTCCACTGCAAAATCTTCACCTCAGAAAATTGACGTCCTTTGTGGAA TTGGAATAAAAAAGGTTGCTTGTGGAACTCAGTTTTCTGTTGCTTTGACCAAAGATGGTCATGTGTATACCTTTGGTCAAGATCGCCTGA TAGGCTTGCCAGAGGGGCGTGCTCGCAATCACAATCGACCGCAACAAATCCCTGTCCTGGCTGGAGTAATCATAGAAGATGTGGCAGTTG GAGCTGAACACACACTTGCTTTGGCATCAAATGGAGATGTGTATGCCTGGGGGAGCAATTCAGAAGGGCAGCTCGGCTTAGGCCATACCA ACCATGTTCGAGAACCAACCCTGGTAACAGGTCTGCAAGGGAAAAATGTTCGGCAGATCTCGGCTGGCCGCTGCCACAGTGCTGCATGGA CAGCACCACCTGTCCCACCAAGAGCACCAGGTGTGTCAGTACCTCTGCAGCTGGGCCTGCCTGACACAGTGCCCCCCCAGTATGGGGCGC TGAGAGAAGTCAGCATTCACACGGTGCGGGCCAGGCTCCGGCTGCTCTACCACTTCTCTGACCTCATGTACTCATCCTGGAGACTGCTGA ACCTTAGCCCCAACAACCAGAACAGCACATCCCATTATAATGCTGGAACTTGGGGCATTGTACAGGGACAACTTCGGCCTTTGTTAGCCC CAAGAGTCTACACTCTGCCAATGGTGCGCTCCATAGGAAAAACCATGGTTCAAGGCAAAAACTATGGACCTCAGATAACTGTAAAGAGGA TATCAACCAGAGGACGGAAGTGTAAGCCTATTTTTGTCCAAATAGCGAGACAAGTAGTTAAGCTGAATGCTTCAGACCTCCGCCTGCCTT CCCGAGCGTGGAAGGTTAAGCTGGTTGGAGAAGGGGCTGATGATGCTGGAGGAGTGTTTGATGACACCATCACAGAGATGTGCCAGGAAC TTGAAACTGGTATTGTTGACCTTCTTATACCCTCTCCCAATGCCACCGCAGAAGTGGGTTACAATAGGGACAGGTTCCTTTTTAACCCTT CTGCCTGCCTCGATGAACACTTAATGCAGTTTAAGTTTTTAGGAATTTTAATGGGGGTTGCCATTCGCACAAAGAAGCCTCTGGACCTCC ACTTGGCCCCTCTGGTGTGGAAGCAGCTGTGCTGTGTCCCACTCACCCTAGAGGACCTGGAGGAGGTGGATCTGCTCTACGTGCAGACTC TCAACAGCATTCTTCACATTGAAGACAGTGGGATTACCGAGGAGAGTTTCCATGAGATGATTCCTCTTGATTCTTTTGTTGGCCAGAGTG CTGATGGCAAAATGGTTCCTATAATCCCTGGTGGAAATAGTATCCCACTCACATTTTCCAACAGGAAGGAATATGTGGAGAGGGCCATTG AATATCGACTTCATGAGATGGACAGACAGGTGGCTGCAGTCCGAGAAGGGATGTCCTGGATTGTTCCTGTGCCGCTGCTGTCCCTCCTCA CAGCAAAACAACTGGAGCAGATGGTGTGTGGGATGCCCGAGATCTCTGTGGAAGTCTTGAAGAAAGTGGTGCGGTACCGTGAGGTGGATG AGCAGCATCAGCTGGTGCAGTGGTTCTGGCACACGCTGGAAGAGTTCTCCAATGAGGAGCGGGTGCTTTTCATGAGGTTTGTGTCAGGAA GATCTCGACTACCAGCCAACACTGCTGACATTTCTCAGAGATTTCAAATCATGAAGGTTGATAGGCCTTACGACAGTCTGCCTACCTCAC AGACCTGCTTCTTCCAGCTGAGGCTGCCCCCGTACTCCAGCCAGCTGGTCATGGCCGAGCGCCTGCGCTATGCCATCAACAACTGCCGCT CAATCGACATGGACAACTACATGCTCTCGAGAAACGTGGACAACGCCGAGGGCTCCGACACTGACTACTGACCGTGCGGGTGCTCTCACC CTCCCTTCTCTCCCTCAATAATGCTCACTTCTGATTTGATGTTGATATACTTTTATGGTAACTACATAGATGTTATAAGAACATAAACCA ACATTATAAACAATGGCCACATTTAGTTACTCTAAATGTAACAAAGAAATTAGATGTTTTTATTTTTCTGTGATTGTACAAAAACAACAA AAACGAAGTGCTCTCAGTCAGGTTTTTCCCTCCATATTTTTGGTCACTTTTGATAAGTTTGCATGAAACCATTTTGGTGCATTTTTAGTT GGGAATGGTACATTTTTGTAAATCCACCCAGTGAACATGAAATTGTACATTGTGTATAATTGTTCATTAGAAAGGACAGTTTTACATGAA >In-frame_TMTC2_ENST00000548305_chr12_83081448_+_HERC1_ENST00000443617_chr15_63956793_-_7163nt GGGAGCTAATAAACATTGAATGTGCAGCAGCTGCCTTGGCGGCCGGAGTCCGCCCGAGCGACACCGGAGCAGTGCGCCCGGGAGGCGGCG AGGGGAGGCGGTTCGCCTTGTCCCTCCCACCCGCGCCTCTTTCTCTCTCTTCCTCCAGCTGGTCCCAGAGCCCGGCTTGGTCCGGTCCCT CTGCCCCCATCCCGCACCCTTCCACCTCCTCCGAGTCCCACTCCTCACCTAGGACGCCCCAAACTGCCATGGGTTAGGGTGGGGATCGCG ACCCGCGCGAAAGACCAGCCCTGCGCTTCCGCCGGGGGACGCGGAGCCCAAACGCCGCTCACCGCTTGCGGGCGCCGGGCATGGGGAGTG TGGTGTGAGCCCGCACCCGGGGAGGACGCAGGAGCTGCGGAGACGGGCGCGAGGAGGAGGAGAGGAGTCGTGGATTGGAAGGACCCGAGG GAGGGAGGGTGGGGAAGCGAGGGAAAAGTGAAGCTGGGAGGAGAAGGCGGCGGAAGGTGGAGATTGATGCTTCTGTTTTTTGTTGCCGCT GCTGCCCTCGCGCTGGGAGCCGAGCCGGAGGGAAGGCGGTGGAGAGATGATTGCAGAGTTGGTGAGCAGCGCTCTGGGGCTCGCCTTGTA TCTCAACACCCTGAGTGCGGATTTCTGCTATGATGACAGCCCTGATAATTTGGATCATACAGAGAATGCAGCTTCTGGAAGTGGACCATC AGCTAGAGGTCGCTCAGCGGTAACAAGAAGACACAAGTTTGACTTAGCTGCTCGCACACTGCTAGCAAGAGCAGCGGGATTATACCGCTC TGTGCAGGCCCACAGGAATCAAAGTCGGAGAGAAGGAATATCTTTGCAGCAAGACCCAGGGGCGTTGTATGACTTTAATTTAGATGAGGA ATTGGAAATTGATCTTGATGATGAGGCGATGGAAGCTATGTTTGGACAAGACCTGACCAGTGACAATGATATTCTGGGAATGTGGATCCC AGAGGTACTGGATTGGCCTACCTGGCATGTTTGTGAGTCTGAAGACAGGGAAGAAGTGGTGGTGTGTGAACTGTGTGAATGCAGCGTCGT CAGCTTCAATCAGCACATGAAGAGAAACCATCCAGGCTGTGGGCGCAGTGCAAACCGCCAGGGCTATCGCAGCAATGGTTCCTATGTGGA TGGCTGGTTTGGCGGTGAATGTGGGAGTGGAAATCCGTACTACCTGTTATGTGGCACCTGCAGGGAGAAGTACTTAGCCATGAAGACCAA ATCTAAGTCAACAAGTTCTGAAAGGTACAAGGGACAAGCTCCAGATCTAATTGGCAAGCAAGACAGTGTGTATGAAGAAGACTGGGACAT GTTGGATGTTGATGAAGATGAAAAGCTAACTGGTGAAGAAGAATTTGAATTACTTGCTGGACCGCTTGGTTTAAATGACCGGCGCATTGT ACCAGAACCAGTTCAGTTCCCTGACAGCGATCCACTGGGAGCATCAGTAGCAATGGTCACAGCCACCAACAGTATGGAAGAGACTCTGAT GCAAATAGGTTGCCATGGCTCCGTAGAAAAGAGCTCCTCTGGGAGAATAACGTTAGGAGAGCAGGCAGCTGCCCTAGCAAACCCTCATGA CCGTGTGGTGGCTTTAAGGAGAGTGACTGCTGCTGCTCAGGTTCTTCTGGCCAGAACCATGGTCATGAGAGCGCTGTCTCTTCTCTCAGT CAGTGGTTCCAGTTGTAGCCTGGCTGCTGGTCTTGAGTCTCTGGGGCTAACAGATATCCGAACGCTAGTTCGATTAATGTGCTTGGCAGC AGCAGGGAGAGCTGGCCTCTCCACCAGCCCTTCTGCCATGGCTAGCACCTCAGAACGATCACGAGGTGGGCATAGCAAGGCTAACAAGCC TATCTCTTGCCTGGCCTATTTGAGCACAGCAGTGGGATGTCTGGCATCAAATGCTCCTAGTGCTGCCAAACTGCTTGTACAGTTGTGTAC ACAGAACTTGATTTCTGCTGCAACAGGTGTAAATCTAACCACAGTTGATGACTCAATTCAGCGAAAGTTTCTACCCAGCTTTCTCCGAGG AATTGCTGAAGAGAACAAGCTTGTGACCTCCCCAAACTTTGTTGTAACACAGGCCCTTGTGGCATTGCTAGCAGACAAAGGGGCCAAACT AAGACCTAACTATGATAAGTCAGAAGTTGAAAAGAAAGGCCCTCTGGAGTTGGCTAATGCCCTGGCAGCCTGCTGCCTCTCCTCCAGGCT GTCCTCACAGCATCGGCAATGGGCAGCTCAGCAACTCGTGCGCACTCTTGCTGCACACGACCGTGACAACCAAACTACTCTGCAGACACT TGCTGATATGGGAGGAGATCTTAGAAAATGCTCCTTTATCAAATTGGAGGCTCATCAGAACAGAGTAATGACATGTGTTTGGTGTAATAA AAAAGGTCTTTTGGCTACAAGTGGCAATGATGGCACCATCCGCGTATGGAATGTTACCAAGAAGCAATATTCACTGCAACAGACCTGTGT GTTCAACAGATTGGAAGGGGATGCTGAGGAAAGCCTGGGATCACCCAGTGATCCAAGTTTCTCACCAGTTTCCTGGAGTATCAGTGGCAA ATATCTAGCAGGCGCTTTGGAAAAGATGGTGAATATCTGGCAAGTTAATGGAGGAAAAGGATTAGTAGATATTCAGCCTCATTGGGTATC TGCCCTGGCTTGGCCAGAAGAGGGTCCGGCTACAGCCTGGTCAGGAGAGTCTCCAGAATTGTTGTTGGTGGGACGGATGGATGGATCTCT GGGACTGATTGAAGTTGTTGATGTGTCCACCATGCACCGTCGAGAATTGGAGCATTGCTATCGAAAGGATGTGTCTGTTACTTGCATTGC ATGGTTCAGTGAAGACAGACCATTTGCAGTGGGATATTTTGATGGAAAACTGTTACTGGGAACAAAGGAACCACTTGAGAAAGGAGGCAT TGTTCTAATTGATGCACATAAGGATACTCTTATTAGCATGAAGTGGGACCCTACAGGTCATATTCTTATGACATGTGCCAAAGAAGACAG TGTGAAACTCTGGGGCTCTATTTCGGGATGCTGGTGCTGTCTACATTCACTCTGCCATCCATCTATTGTAAATGGCATTGCTTGGTGCCG CCTTCCAGGGAAAGGATCCAAGTTGCAGTTACTGATGGCTACTGGCTGTCAGAGTGGCTTAGTATGTGTTTGGCGCATTCCTCAAGATAC TACACAGACCAATGTGACTAGTGCAGAAGGATGGTGGGAGCAGGAATCAAATTGCCAGGATGGATATAGGAAATCATCAGGAGCCAAGTG TGTTTATCAGCTGCGGGGACACATCACTCCTGTTCGGACTGTTGCCTTTAGTTCTGATGGGTTGGCCCTGGTGTCTGGTGGACTAGGTGG GCTCATGAACATTTGGTCTTTAAGGGATGGCTCTGTCTTGCAAACTGTTGTGATAGGCTCTGGAGCTATTCAGACCACAGTATGGATTCC AGAAGTTGGAGTAGCTGCTTGCTCAAATAGATCAAAGGATGTTTTGGTCGTGAATTGTACAGCAGAATGGGCAGCTGCCAATCATGTTTT GGCAACCTGTAGGACAGCATTGAAACAGCAGGGTGTTCTGGGATTGAACATGGCTCCCTGCATGAGAGCATTTTTGGAGCGGCTCCCCAT GATGCTTCAGGAGCAGTATGCCTATGAAAAGCCTCATGTGGTTTGTGGTGACCAACTTGTTCATAGCCCCTATATGCAATGCTTGGCTTC CCTTGCTGTGGGACTTCATCTGGATCAGCTGTTGTGTAACCCTCCAGTGCCACCACACCACCAGAACTGTCTCCCTGACCCTGCATCCTG GAATCCAAATGAATGGGCCTGGTTAGAATGTTTCTCAACCACTATAAAAGCTGCCGAAGCCCTGACCAATGGAGCCCAGTTTCCAGAATC TTTTACCGTTCCAGATCTAGAACCTGTTCCAGAGGATGAACTTGTATTTCTAATGGATAACAGTAAATGGATTAACGGCATGGATGAACA AATTATGTCTTGGGCAACTTCCAGACCTGAGGACTGGCACCTGGGAGGTAAATGTGATGTCTACTTATGGGGTGCTGGTAGGCATGGACA GCTGGCAGAAGCTGGAAGAAATGTAATGGTACCTGCAGCAGCTCCCTCATTCTCACAGGCCCAACAGGTCATTTGTGGTCAGAATTGTAC CTTTGTCATCCAGGCCAATGGCACAGTGTTGGCTTGTGGGGAAGGAAGTTATGGCAGATTAGGACAAGGAAATTCAGATGACCTTCATGT GCTGACAGTTATTTCAGCCTTACAAGGCTTTGTGGTGACCCAGCTGGTGACTTCCTGTGGTTCTGATGGGCACTCTATGGCCCTAACTGA AAGTGGTGAGGTCTTTAGCTGGGGAGATGGTGACTATGGTAAACTTGGCCATGGGAACAGCGACAGGCAGCGGCGGCCCAGGCAGATCGA GGCCTTACAAGGAGAAGAAGTGGTGCAGATGTCTTGTGGCTTCAAGCACTCAGCAGTGGTCACTTCAGATGGCAAACTGTTCACCTTTGG GAATGGTGACTATGGTCGTCTGGGTCTTGGAAATACCTCTAACAAAAAACTTCCAGAGAGAGTGACTGCACTGGAGGGATATCAGATTGG ACAGGTGGCCTGTGGATTAAACCACACTTTGGCAGTGTCAGCAGATGGTTCCATGGTGTGGGCTTTTGGAGATGGAGACTATGGAAAACT AGGCTTAGGAAATTCCACTGCAAAATCTTCACCTCAGAAAATTGACGTCCTTTGTGGAATTGGAATAAAAAAGGTTGCTTGTGGAACTCA GTTTTCTGTTGCTTTGACCAAAGATGGTCATGTGTATACCTTTGGTCAAGATCGCCTGATAGGCTTGCCAGAGGGGCGTGCTCGCAATCA CAATCGACCGCAACAAATCCCTGTCCTGGCTGGAGTAATCATAGAAGATGTGGCAGTTGGAGCTGAACACACACTTGCTTTGGCATCAAA TGGAGATGTGTATGCCTGGGGGAGCAATTCAGAAGGGCAGCTCGGCTTAGGCCATACCAACCATGTTCGAGAACCAACCCTGGTAACAGG TCTGCAAGGGAAAAATGTTCGGCAGATCTCGGCTGGCCGCTGCCACAGTGCTGCATGGACAGCACCACCTGTCCCACCAAGAGCACCAGG TGTGTCAGTACCTCTGCAGCTGGGCCTGCCTGACACAGTGCCCCCCCAGTATGGGGCGCTGAGAGAAGTCAGCATTCACACGGTGCGGGC CAGGCTCCGGCTGCTCTACCACTTCTCTGACCTCATGTACTCATCCTGGAGACTGCTGAACCTTAGCCCCAACAACCAGAACAGCACATC CCATTATAATGCTGGAACTTGGGGCATTGTACAGGGACAACTTCGGCCTTTGTTAGCCCCAAGAGTCTACACTCTGCCAATGGTGCGCTC CATAGGAAAAACCATGGTTCAAGGCAAAAACTATGGACCTCAGATAACTGTAAAGAGGATATCAACCAGAGGACGGAAGTGTAAGCCTAT TTTTGTCCAAATAGCGAGACAAGTAGTTAAGCTGAATGCTTCAGACCTCCGCCTGCCTTCCCGAGCGTGGAAGGTTAAGCTGGTTGGAGA AGGGGCTGATGATGCTGGAGGAGTGTTTGATGACACCATCACAGAGATGTGCCAGGAACTTGAAACTGGTATTGTTGACCTTCTTATACC CTCTCCCAATGCCACCGCAGAAGTGGGTTACAATAGGGACAGGTTCCTTTTTAACCCTTCTGCCTGCCTCGATGAACACTTAATGCAGTT TAAGTTTTTAGGAATTTTAATGGGGGTTGCCATTCGCACAAAGAAGCCTCTGGACCTCCACTTGGCCCCTCTGGTGTGGAAGCAGCTGTG CTGTGTCCCACTCACCCTAGAGGACCTGGAGGAGGTGGATCTGCTCTACGTGCAGACTCTCAACAGCATTCTTCACATTGAAGACAGTGG GATTACCGAGGAGAGTTTCCATGAGATGATTCCTCTTGATTCTTTTGTTGGCCAGAGTGCTGATGGCAAAATGGTTCCTATAATCCCTGG TGGAAATAGTATCCCACTCACATTTTCCAACAGGAAGGAATATGTGGAGAGGGCCATTGAATATCGACTTCATGAGATGGACAGACAGGT GGCTGCAGTCCGAGAAGGGATGTCCTGGATTGTTCCTGTGCCGCTGCTGTCCCTCCTCACAGCAAAACAACTGGAGCAGATGGTGTGTGG GATGCCCGAGATCTCTGTGGAAGTCTTGAAGAAAGTGGTGCGGTACCGTGAGGTGGATGAGCAGCATCAGCTGGTGCAGTGGTTCTGGCA CACGCTGGAAGAGTTCTCCAATGAGGAGCGGGTGCTTTTCATGAGGTTTGTGTCAGGAAGATCTCGACTACCAGCCAACACTGCTGACAT TTCTCAGAGATTTCAAATCATGAAGGTTGATAGGCCTTACGACAGTCTGCCTACCTCACAGACCTGCTTCTTCCAGCTGAGGCTGCCCCC GTACTCCAGCCAGCTGGTCATGGCCGAGCGCCTGCGCTATGCCATCAACAACTGCCGCTCAATCGACATGGACAACTACATGCTCTCGAG AAACGTGGACAACGCCGAGGGCTCCGACACTGACTACTGACCGTGCGGGTGCTCTCACCCTCCCTTCTCTCCCTCAATAATGCTCACTTC TGATTTGATGTTGATATACTTTTATGGTAACTACATAGATGTTATAAGAACATAAACCAACATTATAAACAATGGCCACATTTAGTTACT CTAAATGTAACAAAGAAATTAGATGTTTTTATTTTTCTGTGATTGTACAAAAACAACAAAAACGAAGTGCTCTCAGTCAGGTTTTTCCCT CCATATTTTTGGTCACTTTTGATAAGTTTGCATGAAACCATTTTGGTGCATTTTTAGTTGGGAATGGTACATTTTTGTAAATCCACCCAG TGAACATGAAATTGTACATTGTGTATAATTGTTCATTAGAAAGGACAGTTTTACATGAATATTCATATATTTATTTTGTTTTAATTTGAA |
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FusionGenePPI for TMTC2_HERC1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TMTC2 | CUL3, PCDHB11, PCDHGB1 | HERC1 | DFFA, PKM, EP300, ARF1, TSC2, CLTC, NOS2, SOX9, UBE2D3, BYSL, GRIPAP1, KCMF1, MYL12A, BAK1, BRCA1, MORC1, RSPH10B2, MLF1, ECHS1, RAPSN, DNM3, USP18, TFDP3, ARHGAP29, TTLL1, UNK, HERC2, HERC1, UBE2S, EGFR, SSH3, IFIT1B, WDFY3, TIGD6, CCDC65, GCNT3, TRPC4AP, CSNK1A1, NEUROG3, C1orf87, RAPGEF5, ZBBX, SMOX, TPTE2, ZNF610, FMO5, ZNF223, ZNF571, VPS36, ZNF555, RABGEF1, ZNF563, UBC |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TMTC2_HERC1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TMTC2_HERC1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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