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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 38772

FusionGeneSummary for TMPRSS4_TMEM25

check button Fusion gene summary
Fusion gene informationFusion gene name: TMPRSS4_TMEM25
Fusion gene ID: 38772
HgeneTgene
Gene symbol

TMPRSS4

TMEM25

Gene ID

56649

84866

Gene nametransmembrane serine protease 4transmembrane protein 25
SynonymsCAPH2|MT-SP2|TMPRSS3-
Cytomap

11q23.3

11q23.3

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane protease serine 4channel-activating protease 2membrane-type serine protease 2transmembrane protease, serine 4transmembrane serine protease 3type II membrane serine proteasetransmembrane protein 250610039J01Rik
Modification date2018051920180519
UniProtAcc

Q9NRS4

Q86YD3

Ensembl transtripts involved in fusion geneENST00000534111, ENST00000522307, 
ENST00000523251, ENST00000437212, 
ENST00000522824, ENST00000518413, 
ENST00000411589, ENST00000359862, 
ENST00000442938, ENST00000544878, 
ENST00000354284, ENST00000529001, 
ENST00000354064, ENST00000533102, 
ENST00000313236, ENST00000524725, 
Fusion gene scores* DoF score1 X 1 X 1=12 X 2 X 2=8
# samples 12
** MAII scorelog2(1/1*10)=3.32192809488736log2(2/8*10)=1.32192809488736
Context

PubMed: TMPRSS4 [Title/Abstract] AND TMEM25 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSTADTCGA-D7-8579-01ATMPRSS4chr11

117975535

+TMEM25chr11

118404572

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000534111ENST00000411589TMPRSS4chr11

117975535

+TMEM25chr11

118404572

+
Frame-shiftENST00000534111ENST00000359862TMPRSS4chr11

117975535

+TMEM25chr11

118404572

+
Frame-shiftENST00000534111ENST00000442938TMPRSS4chr11

117975535

+TMEM25chr11

118404572

+
Frame-shiftENST00000534111ENST00000544878TMPRSS4chr11

117975535

+TMEM25chr11

118404572

+
Frame-shiftENST00000534111ENST00000354284TMPRSS4chr11

117975535

+TMEM25chr11

118404572

+
5CDS-intronENST00000534111ENST00000529001TMPRSS4chr11

117975535

+TMEM25chr11

118404572

+
5CDS-intronENST00000534111ENST00000354064TMPRSS4chr11

117975535

+TMEM25chr11

118404572

+
5CDS-intronENST00000534111ENST00000533102TMPRSS4chr11

117975535

+TMEM25chr11

118404572

+
5CDS-intronENST00000534111ENST00000313236TMPRSS4chr11

117975535

+TMEM25chr11

118404572

+
5CDS-intronENST00000534111ENST00000524725TMPRSS4chr11

117975535

+TMEM25chr11

118404572

+
Frame-shiftENST00000522307ENST00000411589TMPRSS4chr11

117975535

+TMEM25chr11

118404572

+
Frame-shiftENST00000522307ENST00000359862TMPRSS4chr11

117975535

+TMEM25chr11

118404572

+
Frame-shiftENST00000522307ENST00000442938TMPRSS4chr11

117975535

+TMEM25chr11

118404572

+
Frame-shiftENST00000522307ENST00000544878TMPRSS4chr11

117975535

+TMEM25chr11

118404572

+
Frame-shiftENST00000522307ENST00000354284TMPRSS4chr11

117975535

+TMEM25chr11

118404572

+
5CDS-intronENST00000522307ENST00000529001TMPRSS4chr11

117975535

+TMEM25chr11

118404572

+
5CDS-intronENST00000522307ENST00000354064TMPRSS4chr11

117975535

+TMEM25chr11

118404572

+
5CDS-intronENST00000522307ENST00000533102TMPRSS4chr11

117975535

+TMEM25chr11

118404572

+
5CDS-intronENST00000522307ENST00000313236TMPRSS4chr11

117975535

+TMEM25chr11

118404572

+
5CDS-intronENST00000522307ENST00000524725TMPRSS4chr11

117975535

+TMEM25chr11

118404572

+
Frame-shiftENST00000523251ENST00000411589TMPRSS4chr11

117975535

+TMEM25chr11

118404572

+
Frame-shiftENST00000523251ENST00000359862TMPRSS4chr11

117975535

+TMEM25chr11

118404572

+
Frame-shiftENST00000523251ENST00000442938TMPRSS4chr11

117975535

+TMEM25chr11

118404572

+
Frame-shiftENST00000523251ENST00000544878TMPRSS4chr11

117975535

+TMEM25chr11

118404572

+
Frame-shiftENST00000523251ENST00000354284TMPRSS4chr11

117975535

+TMEM25chr11

118404572

+
5CDS-intronENST00000523251ENST00000529001TMPRSS4chr11

117975535

+TMEM25chr11

118404572

+
5CDS-intronENST00000523251ENST00000354064TMPRSS4chr11

117975535

+TMEM25chr11

118404572

+
5CDS-intronENST00000523251ENST00000533102TMPRSS4chr11

117975535

+TMEM25chr11

118404572

+
5CDS-intronENST00000523251ENST00000313236TMPRSS4chr11

117975535

+TMEM25chr11

118404572

+
5CDS-intronENST00000523251ENST00000524725TMPRSS4chr11

117975535

+TMEM25chr11

118404572

+
Frame-shiftENST00000437212ENST00000411589TMPRSS4chr11

117975535

+TMEM25chr11

118404572

+
Frame-shiftENST00000437212ENST00000359862TMPRSS4chr11

117975535

+TMEM25chr11

118404572

+
Frame-shiftENST00000437212ENST00000442938TMPRSS4chr11

117975535

+TMEM25chr11

118404572

+
Frame-shiftENST00000437212ENST00000544878TMPRSS4chr11

117975535

+TMEM25chr11

118404572

+
Frame-shiftENST00000437212ENST00000354284TMPRSS4chr11

117975535

+TMEM25chr11

118404572

+
5CDS-intronENST00000437212ENST00000529001TMPRSS4chr11

117975535

+TMEM25chr11

118404572

+
5CDS-intronENST00000437212ENST00000354064TMPRSS4chr11

117975535

+TMEM25chr11

118404572

+
5CDS-intronENST00000437212ENST00000533102TMPRSS4chr11

117975535

+TMEM25chr11

118404572

+
5CDS-intronENST00000437212ENST00000313236TMPRSS4chr11

117975535

+TMEM25chr11

118404572

+
5CDS-intronENST00000437212ENST00000524725TMPRSS4chr11

117975535

+TMEM25chr11

118404572

+
Frame-shiftENST00000522824ENST00000411589TMPRSS4chr11

117975535

+TMEM25chr11

118404572

+
Frame-shiftENST00000522824ENST00000359862TMPRSS4chr11

117975535

+TMEM25chr11

118404572

+
Frame-shiftENST00000522824ENST00000442938TMPRSS4chr11

117975535

+TMEM25chr11

118404572

+
Frame-shiftENST00000522824ENST00000544878TMPRSS4chr11

117975535

+TMEM25chr11

118404572

+
Frame-shiftENST00000522824ENST00000354284TMPRSS4chr11

117975535

+TMEM25chr11

118404572

+
5CDS-intronENST00000522824ENST00000529001TMPRSS4chr11

117975535

+TMEM25chr11

118404572

+
5CDS-intronENST00000522824ENST00000354064TMPRSS4chr11

117975535

+TMEM25chr11

118404572

+
5CDS-intronENST00000522824ENST00000533102TMPRSS4chr11

117975535

+TMEM25chr11

118404572

+
5CDS-intronENST00000522824ENST00000313236TMPRSS4chr11

117975535

+TMEM25chr11

118404572

+
5CDS-intronENST00000522824ENST00000524725TMPRSS4chr11

117975535

+TMEM25chr11

118404572

+
intron-3CDSENST00000518413ENST00000411589TMPRSS4chr11

117975535

+TMEM25chr11

118404572

+
intron-3CDSENST00000518413ENST00000359862TMPRSS4chr11

117975535

+TMEM25chr11

118404572

+
intron-3CDSENST00000518413ENST00000442938TMPRSS4chr11

117975535

+TMEM25chr11

118404572

+
intron-3CDSENST00000518413ENST00000544878TMPRSS4chr11

117975535

+TMEM25chr11

118404572

+
intron-3CDSENST00000518413ENST00000354284TMPRSS4chr11

117975535

+TMEM25chr11

118404572

+
intron-intronENST00000518413ENST00000529001TMPRSS4chr11

117975535

+TMEM25chr11

118404572

+
intron-intronENST00000518413ENST00000354064TMPRSS4chr11

117975535

+TMEM25chr11

118404572

+
intron-intronENST00000518413ENST00000533102TMPRSS4chr11

117975535

+TMEM25chr11

118404572

+
intron-intronENST00000518413ENST00000313236TMPRSS4chr11

117975535

+TMEM25chr11

118404572

+
intron-intronENST00000518413ENST00000524725TMPRSS4chr11

117975535

+TMEM25chr11

118404572

+

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FusionProtFeatures for TMPRSS4_TMEM25


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TMPRSS4

Q9NRS4

TMEM25

Q86YD3

Probable protease. Seems to be capable of activatingENaC (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TMPRSS4_TMEM25


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TMPRSS4_TMEM25


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TMPRSS4CLEC7A, TMEM79, CCDC155, SYNE4, LMNATMEM25ATXN1L, RABGGTB, GLRX3, TUBB8, HSPA5, GYLTL1B, CACNA2D2, CES3, WDR60, ALDH1L2, EHD1, TMEM132A, PCSK6, NOMO3, LPCAT4, ENTPD6, TAZ, LARGE, ARSA, COL14A1, IARS2, LAMB1, NAMPT, TUBA4A, TUBA1A, PAM, RPL23, COCH, FAM132B, NGLY1, NID2, ADAM9, PLXNA1, LPCAT2, EGFR, MOXD1, GUSB, EEF1A2, TCTN1, SGSH, LOXL2, HTRA3, SPATA5L1, CHID1, FUT11, CNTNAP3B, WDR34, PLAT, BSCL2, LAMB2, HTRA1, COL4A2, MGAT5, GDF11, LMLN, CERCAM, ARSK, SERPINF1, COL18A1, DHFRL1, PEX6, SEMA4F, BANP, B3GALTL, GNPTG, BTD, POGLUT1, GALNT12, GALNT18, PDF, LEPREL2, LAMA5, MAN2A2, SP3, FUZ, TPRKB, ZNF302, FIGNL1, ITGA8, ITGAV, SIRT3, NME4, CHST10, TUBB3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TMPRSS4_TMEM25


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for TMPRSS4_TMEM25


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTMEM25C1458155Mammary Neoplasms1CTD_human