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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 38767

FusionGeneSummary for TMPRSS2_SETD4

check button Fusion gene summary
Fusion gene informationFusion gene name: TMPRSS2_SETD4
Fusion gene ID: 38767
HgeneTgene
Gene symbol

TMPRSS2

SETD4

Gene ID

7113

54093

Gene nametransmembrane serine protease 2SET domain containing 4
SynonymsPP9284|PRSS10C21orf18|C21orf27
Cytomap

21q22.3

21q22.12

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane protease serine 2epitheliasinserine protease 10transmembrane protease, serine 2SET domain-containing protein 4
Modification date2018052320180523
UniProtAcc

O15393

Q9NVD3

Ensembl transtripts involved in fusion geneENST00000332149, ENST00000398585, 
ENST00000458356, ENST00000497881, 
ENST00000399215, ENST00000481477, 
ENST00000399212, ENST00000332131, 
ENST00000399205, ENST00000399208, 
ENST00000399201, ENST00000399207, 
Fusion gene scores* DoF score29 X 21 X 6=36544 X 4 X 3=48
# samples 2284
** MAII scorelog2(228/3654*10)=-0.680442809575384
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TMPRSS2 [Title/Abstract] AND SETD4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTMPRSS2

GO:0006508

proteolysis

21068237|24227843

HgeneTMPRSS2

GO:0046598

positive regulation of viral entry into host cell

21068237|24227843


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSTADTCGA-VQ-A8DZ-01ATMPRSS2chr21

42860321

-SETD4chr21

37429502

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000332149ENST00000399215TMPRSS2chr21

42860321

-SETD4chr21

37429502

-
5CDS-5UTRENST00000332149ENST00000481477TMPRSS2chr21

42860321

-SETD4chr21

37429502

-
5CDS-5UTRENST00000332149ENST00000399212TMPRSS2chr21

42860321

-SETD4chr21

37429502

-
5CDS-5UTRENST00000332149ENST00000332131TMPRSS2chr21

42860321

-SETD4chr21

37429502

-
5CDS-5UTRENST00000332149ENST00000399205TMPRSS2chr21

42860321

-SETD4chr21

37429502

-
5CDS-5UTRENST00000332149ENST00000399208TMPRSS2chr21

42860321

-SETD4chr21

37429502

-
5CDS-5UTRENST00000332149ENST00000399201TMPRSS2chr21

42860321

-SETD4chr21

37429502

-
5CDS-5UTRENST00000332149ENST00000399207TMPRSS2chr21

42860321

-SETD4chr21

37429502

-
In-frameENST00000398585ENST00000399215TMPRSS2chr21

42860321

-SETD4chr21

37429502

-
5CDS-5UTRENST00000398585ENST00000481477TMPRSS2chr21

42860321

-SETD4chr21

37429502

-
5CDS-5UTRENST00000398585ENST00000399212TMPRSS2chr21

42860321

-SETD4chr21

37429502

-
5CDS-5UTRENST00000398585ENST00000332131TMPRSS2chr21

42860321

-SETD4chr21

37429502

-
5CDS-5UTRENST00000398585ENST00000399205TMPRSS2chr21

42860321

-SETD4chr21

37429502

-
5CDS-5UTRENST00000398585ENST00000399208TMPRSS2chr21

42860321

-SETD4chr21

37429502

-
5CDS-5UTRENST00000398585ENST00000399201TMPRSS2chr21

42860321

-SETD4chr21

37429502

-
5CDS-5UTRENST00000398585ENST00000399207TMPRSS2chr21

42860321

-SETD4chr21

37429502

-
Frame-shitENST00000458356ENST00000399215TMPRSS2chr21

42860321

-SETD4chr21

37429502

-
5CDS-5UTRENST00000458356ENST00000481477TMPRSS2chr21

42860321

-SETD4chr21

37429502

-
5CDS-5UTRENST00000458356ENST00000399212TMPRSS2chr21

42860321

-SETD4chr21

37429502

-
5CDS-5UTRENST00000458356ENST00000332131TMPRSS2chr21

42860321

-SETD4chr21

37429502

-
5CDS-5UTRENST00000458356ENST00000399205TMPRSS2chr21

42860321

-SETD4chr21

37429502

-
5CDS-5UTRENST00000458356ENST00000399208TMPRSS2chr21

42860321

-SETD4chr21

37429502

-
5CDS-5UTRENST00000458356ENST00000399201TMPRSS2chr21

42860321

-SETD4chr21

37429502

-
5CDS-5UTRENST00000458356ENST00000399207TMPRSS2chr21

42860321

-SETD4chr21

37429502

-
intron-3CDSENST00000497881ENST00000399215TMPRSS2chr21

42860321

-SETD4chr21

37429502

-
intron-5UTRENST00000497881ENST00000481477TMPRSS2chr21

42860321

-SETD4chr21

37429502

-
intron-5UTRENST00000497881ENST00000399212TMPRSS2chr21

42860321

-SETD4chr21

37429502

-
intron-5UTRENST00000497881ENST00000332131TMPRSS2chr21

42860321

-SETD4chr21

37429502

-
intron-5UTRENST00000497881ENST00000399205TMPRSS2chr21

42860321

-SETD4chr21

37429502

-
intron-5UTRENST00000497881ENST00000399208TMPRSS2chr21

42860321

-SETD4chr21

37429502

-
intron-5UTRENST00000497881ENST00000399201TMPRSS2chr21

42860321

-SETD4chr21

37429502

-
intron-5UTRENST00000497881ENST00000399207TMPRSS2chr21

42860321

-SETD4chr21

37429502

-

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FusionProtFeatures for TMPRSS2_SETD4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TMPRSS2

O15393

SETD4

Q9NVD3

Serine protease that proteolytically cleaves andactivates the viral spike glycoproteins which facilitate virus-cell membrane fusions; spike proteins are synthesized andmaintained in precursor intermediate folding states andproteolysis permits the refolding and energy release required tocreate stable virus-cell linkages and membrane coalescence.Facilitates human SARS coronavirus (SARS-CoV) infection via twoindependent mechanisms, proteolytic cleavage of ACE2, which mightpromote viral uptake, and cleavage of coronavirus spikeglycoprotein which activates the glycoprotein for cathepsin L-independent host cell entry. Proteolytically cleaves and activatesthe spike glycoproteins of human coronavirus 229E (HCoV-229E) andhuman coronavirus EMC (HCoV-EMC) and the fusion glycoproteins F0of Sendai virus (SeV), human metapneumovirus (HMPV), humanparainfluenza 1, 2, 3, 4a and 4b viruses (HPIV). Essential forspread and pathogenesis of influenza A virus (strains H1N1, H3N2and H7N9); involved in proteolytic cleavage and activation ofhemagglutinin (HA) protein which is essential for viralinfectivity. {ECO:0000269|PubMed:21068237,ECO:0000269|PubMed:21325420, ECO:0000269|PubMed:23536651,ECO:0000269|PubMed:23966399, ECO:0000269|PubMed:24027332,ECO:0000269|PubMed:24227843}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTMPRSS2chr21:42860321chr21:37429502ENST00000332149-514112_149148493DomainLDL-receptor class A
HgeneTMPRSS2chr21:42860321chr21:37429502ENST00000398585-514112_149185530DomainLDL-receptor class A
HgeneTMPRSS2chr21:42860321chr21:37429502ENST00000458356-514112_149148493DomainLDL-receptor class A
HgeneTMPRSS2chr21:42860321chr21:37429502ENST00000332149-5141_84148493Topological domainCytoplasmic
HgeneTMPRSS2chr21:42860321chr21:37429502ENST00000398585-5141_84185530Topological domainCytoplasmic
HgeneTMPRSS2chr21:42860321chr21:37429502ENST00000458356-5141_84148493Topological domainCytoplasmic
HgeneTMPRSS2chr21:42860321chr21:37429502ENST00000332149-51485_105148493TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS2chr21:42860321chr21:37429502ENST00000398585-51485_105185530TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS2chr21:42860321chr21:37429502ENST00000458356-51485_105148493TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneSETD4chr21:42860321chr21:37429502ENST00000332131-11248_27324865DomainSET
TgeneSETD4chr21:42860321chr21:37429502ENST00000399207-1748_27324308DomainSET
TgeneSETD4chr21:42860321chr21:37429502ENST00000399208-1748_27324308DomainSET
TgeneSETD4chr21:42860321chr21:37429502ENST00000399212-21248_2730417DomainSET
TgeneSETD4chr21:42860321chr21:37429502ENST00000399215-01048_27324441DomainSET

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTMPRSS2chr21:42860321chr21:37429502ENST00000332149-514150_242148493DomainSRCR
HgeneTMPRSS2chr21:42860321chr21:37429502ENST00000332149-514256_489148493DomainPeptidase S1
HgeneTMPRSS2chr21:42860321chr21:37429502ENST00000398585-514150_242185530DomainSRCR
HgeneTMPRSS2chr21:42860321chr21:37429502ENST00000398585-514256_489185530DomainPeptidase S1
HgeneTMPRSS2chr21:42860321chr21:37429502ENST00000458356-514150_242148493DomainSRCR
HgeneTMPRSS2chr21:42860321chr21:37429502ENST00000458356-514256_489148493DomainPeptidase S1
HgeneTMPRSS2chr21:42860321chr21:37429502ENST00000332149-514106_492148493Topological domainExtracellular
HgeneTMPRSS2chr21:42860321chr21:37429502ENST00000398585-514106_492185530Topological domainExtracellular
HgeneTMPRSS2chr21:42860321chr21:37429502ENST00000458356-514106_492148493Topological domainExtracellular


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FusionGeneSequence for TMPRSS2_SETD4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_TMPRSS2_ENST00000332149_chr21_42860321_-_SETD4_ENST00000399215_chr21_37429502_-_565aa
MALNSGSPPAIGPYTENHGYQPENPTPAQPTVVPTVYEVHPAQYYPSPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTSKTKKALCITLT
LGTFLVGAALAAGLLWKFMGSKCSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRCVNESHKSEFIELRKWLKARKFQDSNLAPACFP
GTGRGLMSQTSLQEGQMIISLPESCLLTTDTVIRSYLGAYITKWKPPPSPLLALCTFLVSEKHAGHRSLWKPYLEILPKATTCPVCLEPE
VVNLLPKSLKAKAEEQRAHVQEFFASSRDFFSSLQPLFAEAVDSIFSYSALLWAWCTVNTRAVYLRPRQRECLSAEPDTCALAPYLDLLN
HSPHVQVKAAFNEETHSYEIRTTSRWRKHEEVFICYGPHDNQRLFLEYGFVSVHNPHACVTVSREILVKTLPSTDKQMDKKISILKDHGT
IENLTFGWDGPSWRLLTALKLLCLEAEKFTCWKKVLLGEVISDTNEKTSLDIAQKICTTFIEETNAVLQKVSHMKDEKEALINQLTLVES

>In-frame_TMPRSS2_ENST00000398585_chr21_42860321_-_SETD4_ENST00000399215_chr21_37429502_-_602aa
MPPAPPGGESGCEERGAAGHIEHSRYLSLLDAVDNSKMALNSGSPPAIGPYTENHGYQPENPTPAQPTVVPTVYEVHPAQYYPSPVPQYA
PRVLTQASNPVVCTQPKSPSGTVCTSKTKKALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGIECDSSGTCINPSNWCDGVSHCPGGE
DENRCVNESHKSEFIELRKWLKARKFQDSNLAPACFPGTGRGLMSQTSLQEGQMIISLPESCLLTTDTVIRSYLGAYITKWKPPPSPLLA
LCTFLVSEKHAGHRSLWKPYLEILPKATTCPVCLEPEVVNLLPKSLKAKAEEQRAHVQEFFASSRDFFSSLQPLFAEAVDSIFSYSALLW
AWCTVNTRAVYLRPRQRECLSAEPDTCALAPYLDLLNHSPHVQVKAAFNEETHSYEIRTTSRWRKHEEVFICYGPHDNQRLFLEYGFVSV
HNPHACVTVSREILVKTLPSTDKQMDKKISILKDHGTIENLTFGWDGPSWRLLTALKLLCLEAEKFTCWKKVLLGEVISDTNEKTSLDIA


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_TMPRSS2_ENST00000332149_chr21_42860321_-_SETD4_ENST00000399215_chr21_37429502_-_1695nt
ATGGCTTTGAACTCAGGGTCACCACCAGCTATTGGACCTTACTATGAAAACCATGGATACCAACCGGAAAACCCCTATCCCGCACAGCCC
ACTGTGGTCCCCACTGTCTACGAGGTGCATCCGGCTCAGTACTACCCGTCCCCCGTGCCCCAGTACGCCCCGAGGGTCCTGACGCAGGCT
TCCAACCCCGTCGTCTGCACGCAGCCCAAATCCCCATCCGGGACAGTGTGCACCTCAAAGACTAAGAAAGCACTGTGCATCACCTTGACC
CTGGGGACCTTCCTCGTGGGAGCTGCGCTGGCCGCTGGCCTACTCTGGAAGTTCATGGGCAGCAAGTGCTCCAACTCTGGGATAGAGTGC
GACTCCTCAGGTACCTGCATCAACCCCTCTAACTGGTGTGATGGCGTGTCACACTGCCCCGGCGGGGAGGACGAGAATCGGTGTGTGAAT
GAGAGCCACAAGTCTGAATTTATAGAGCTGAGGAAGTGGCTGAAAGCTAGGAAGTTTCAAGATTCAAACTTAGCGCCTGCTTGTTTTCCA
GGTACAGGAAGAGGGCTGATGAGTCAAACATCCCTGCAGGAGGGACAGATGATTATTTCGTTGCCTGAGAGTTGCCTGCTCACCACGGAC
ACAGTGATTCGAAGCTACTTAGGGGCATACATTACTAAGTGGAAGCCTCCTCCATCTCCTCTGCTGGCGCTGTGCACCTTTTTAGTTTCA
GAAAAGCATGCTGGGCACCGATCTCTTTGGAAGCCTTACCTGGAGATTTTACCCAAGGCGTATACCTGCCCTGTTTGTTTGGAGCCGGAA
GTGGTGAACCTTCTTCCCAAATCTTTAAAAGCAAAGGCTGAAGAGCAGAGAGCCCACGTGCAGGAGTTCTTTGCTTCCTCCAGAGACTTT
TTCTCTTCTCTGCAGCCTCTGTTTGCGGAGGCTGTTGACAGCATCTTCAGCTACAGTGCCCTGCTGTGGGCTTGGTGCACCGTCAACACC
AGAGCCGTGTACCTGAGGCCCAGGCAGCGGGAATGCCTTTCTGCAGAGCCGGACACCTGTGCACTCGCTCCGTACCTGGACCTGCTGAAT
CATAGCCCACATGTCCAGGTAAAAGCAGCGTTTAATGAAGAAACTCATTCTTACGAAATTAGAACGACTTCACGTTGGAGAAAGCATGAA
GAGGTATTCATCTGTTACGGCCCTCACGATAATCAACGGCTGTTCCTGGAATACGGATTTGTTTCTGTCCATAATCCTCATGCTTGTGTT
TATGTCTCAAGAGAAATACTTGTTAAATATCTTCCATCAACAGATAAACAGATGGACAAAAAGATTTCTATTTTAAAGGATCATGGCTAT
ATAGAAAATTTGACATTTGGATGGGATGGACCATCTTGGAGGCTACTCACAGCCCTTAAGTTGTTATGTCTGGAAGCTGAGAAATTTACA
TGCTGGAAAAAAGTACTTCTTGGGGAGGTAATTTCAGATACGAATGAGAAGACAAGTTTGGACATAGCCCAGAAAATATGCTATTATTTC
ATAGAAGAGACTAATGCTGTGCTTCAAAAGGTGTCTCATATGAAGGATGAAAAAGAGGCCCTGATAAACCAACTAACTTTGGTGGAATCC

>In-frame_TMPRSS2_ENST00000398585_chr21_42860321_-_SETD4_ENST00000399215_chr21_37429502_-_1806nt
ATGCCCCCTGCCCCGCCCGGAGGTGAAAGCGGGTGTGAGGAGCGCGGCGCGGCAGGTCATATTGAACATTCCAGATACCTATCATTACTC
GATGCTGTTGATAACAGCAAGATGGCTTTGAACTCAGGGTCACCACCAGCTATTGGACCTTACTATGAAAACCATGGATACCAACCGGAA
AACCCCTATCCCGCACAGCCCACTGTGGTCCCCACTGTCTACGAGGTGCATCCGGCTCAGTACTACCCGTCCCCCGTGCCCCAGTACGCC
CCGAGGGTCCTGACGCAGGCTTCCAACCCCGTCGTCTGCACGCAGCCCAAATCCCCATCCGGGACAGTGTGCACCTCAAAGACTAAGAAA
GCACTGTGCATCACCTTGACCCTGGGGACCTTCCTCGTGGGAGCTGCGCTGGCCGCTGGCCTACTCTGGAAGTTCATGGGCAGCAAGTGC
TCCAACTCTGGGATAGAGTGCGACTCCTCAGGTACCTGCATCAACCCCTCTAACTGGTGTGATGGCGTGTCACACTGCCCCGGCGGGGAG
GACGAGAATCGGTGTGTGAATGAGAGCCACAAGTCTGAATTTATAGAGCTGAGGAAGTGGCTGAAAGCTAGGAAGTTTCAAGATTCAAAC
TTAGCGCCTGCTTGTTTTCCAGGTACAGGAAGAGGGCTGATGAGTCAAACATCCCTGCAGGAGGGACAGATGATTATTTCGTTGCCTGAG
AGTTGCCTGCTCACCACGGACACAGTGATTCGAAGCTACTTAGGGGCATACATTACTAAGTGGAAGCCTCCTCCATCTCCTCTGCTGGCG
CTGTGCACCTTTTTAGTTTCAGAAAAGCATGCTGGGCACCGATCTCTTTGGAAGCCTTACCTGGAGATTTTACCCAAGGCGTATACCTGC
CCTGTTTGTTTGGAGCCGGAAGTGGTGAACCTTCTTCCCAAATCTTTAAAAGCAAAGGCTGAAGAGCAGAGAGCCCACGTGCAGGAGTTC
TTTGCTTCCTCCAGAGACTTTTTCTCTTCTCTGCAGCCTCTGTTTGCGGAGGCTGTTGACAGCATCTTCAGCTACAGTGCCCTGCTGTGG
GCTTGGTGCACCGTCAACACCAGAGCCGTGTACCTGAGGCCCAGGCAGCGGGAATGCCTTTCTGCAGAGCCGGACACCTGTGCACTCGCT
CCGTACCTGGACCTGCTGAATCATAGCCCACATGTCCAGGTAAAAGCAGCGTTTAATGAAGAAACTCATTCTTACGAAATTAGAACGACT
TCACGTTGGAGAAAGCATGAAGAGGTATTCATCTGTTACGGCCCTCACGATAATCAACGGCTGTTCCTGGAATACGGATTTGTTTCTGTC
CATAATCCTCATGCTTGTGTTTATGTCTCAAGAGAAATACTTGTTAAATATCTTCCATCAACAGATAAACAGATGGACAAAAAGATTTCT
ATTTTAAAGGATCATGGCTATATAGAAAATTTGACATTTGGATGGGATGGACCATCTTGGAGGCTACTCACAGCCCTTAAGTTGTTATGT
CTGGAAGCTGAGAAATTTACATGCTGGAAAAAAGTACTTCTTGGGGAGGTAATTTCAGATACGAATGAGAAGACAAGTTTGGACATAGCC
CAGAAAATATGCTATTATTTCATAGAAGAGACTAATGCTGTGCTTCAAAAGGTGTCTCATATGAAGGATGAAAAAGAGGCCCTGATAAAC
CAACTAACTTTGGTGGAATCCTTGTGGACGGAAGAGCTAAAGATTCTCAGGGCATCTGCCGAGACCCTGCACAGTTTGCAAACAGCTTTT


* Fusion transcript sequences (Full-length transcript).
>In-frame_TMPRSS2_ENST00000332149_chr21_42860321_-_SETD4_ENST00000399215_chr21_37429502_-_3406nt
CGAGTAGGCGCGAGCTAAGCAGGAGGCGGAGGCGGAGGCGGAGGGCGAGGGGCGGGGAGCGCCGCCTGGAGCGCGGCAGGTCATATTGAA
CATTCCAGATACCTATCATTACTCGATGCTGTTGATAACAGCAAGATGGCTTTGAACTCAGGGTCACCACCAGCTATTGGACCTTACTAT
GAAAACCATGGATACCAACCGGAAAACCCCTATCCCGCACAGCCCACTGTGGTCCCCACTGTCTACGAGGTGCATCCGGCTCAGTACTAC
CCGTCCCCCGTGCCCCAGTACGCCCCGAGGGTCCTGACGCAGGCTTCCAACCCCGTCGTCTGCACGCAGCCCAAATCCCCATCCGGGACA
GTGTGCACCTCAAAGACTAAGAAAGCACTGTGCATCACCTTGACCCTGGGGACCTTCCTCGTGGGAGCTGCGCTGGCCGCTGGCCTACTC
TGGAAGTTCATGGGCAGCAAGTGCTCCAACTCTGGGATAGAGTGCGACTCCTCAGGTACCTGCATCAACCCCTCTAACTGGTGTGATGGC
GTGTCACACTGCCCCGGCGGGGAGGACGAGAATCGGTGTGTGAATGAGAGCCACAAGTCTGAATTTATAGAGCTGAGGAAGTGGCTGAAA
GCTAGGAAGTTTCAAGATTCAAACTTAGCGCCTGCTTGTTTTCCAGGTACAGGAAGAGGGCTGATGAGTCAAACATCCCTGCAGGAGGGA
CAGATGATTATTTCGTTGCCTGAGAGTTGCCTGCTCACCACGGACACAGTGATTCGAAGCTACTTAGGGGCATACATTACTAAGTGGAAG
CCTCCTCCATCTCCTCTGCTGGCGCTGTGCACCTTTTTAGTTTCAGAAAAGCATGCTGGGCACCGATCTCTTTGGAAGCCTTACCTGGAG
ATTTTACCCAAGGCGTATACCTGCCCTGTTTGTTTGGAGCCGGAAGTGGTGAACCTTCTTCCCAAATCTTTAAAAGCAAAGGCTGAAGAG
CAGAGAGCCCACGTGCAGGAGTTCTTTGCTTCCTCCAGAGACTTTTTCTCTTCTCTGCAGCCTCTGTTTGCGGAGGCTGTTGACAGCATC
TTCAGCTACAGTGCCCTGCTGTGGGCTTGGTGCACCGTCAACACCAGAGCCGTGTACCTGAGGCCCAGGCAGCGGGAATGCCTTTCTGCA
GAGCCGGACACCTGTGCACTCGCTCCGTACCTGGACCTGCTGAATCATAGCCCACATGTCCAGGTAAAAGCAGCGTTTAATGAAGAAACT
CATTCTTACGAAATTAGAACGACTTCACGTTGGAGAAAGCATGAAGAGGTATTCATCTGTTACGGCCCTCACGATAATCAACGGCTGTTC
CTGGAATACGGATTTGTTTCTGTCCATAATCCTCATGCTTGTGTTTATGTCTCAAGAGAAATACTTGTTAAATATCTTCCATCAACAGAT
AAACAGATGGACAAAAAGATTTCTATTTTAAAGGATCATGGCTATATAGAAAATTTGACATTTGGATGGGATGGACCATCTTGGAGGCTA
CTCACAGCCCTTAAGTTGTTATGTCTGGAAGCTGAGAAATTTACATGCTGGAAAAAAGTACTTCTTGGGGAGGTAATTTCAGATACGAAT
GAGAAGACAAGTTTGGACATAGCCCAGAAAATATGCTATTATTTCATAGAAGAGACTAATGCTGTGCTTCAAAAGGTGTCTCATATGAAG
GATGAAAAAGAGGCCCTGATAAACCAACTAACTTTGGTGGAATCCTTGTGGACGGAAGAGCTAAAGATTCTCAGGGCATCTGCCGAGACC
CTGCACAGTTTGCAAACAGCTTTTACCTGATTTCACCGAAGCGCATTTGGTCACCTCCTCTGGTGGGTGTTAGTCACACATTTTAGACTA
AGGTTTGATGGACTAAATTTATATAGTTTAGAGTCGATGAGTTGTGTCTACTCAACAATTAGGAACTTAATCCTTTTCCTTTTGCTTTTC
CTACAGAAACAAAAGTTAATTTTGAAGAGCATCATCATGGGCTGGGGTGGTGGCTGCCCCCAGGACATGCAGGATTTCTGCAGGGGGCAG
CACAGGTTCTGGGATTGTGAGGCTGTGAGTGAAGGTGGACAAGCTGTCTGGATGGCAGGTCTAATGCTCTTCCGAATAAAGTGCTGAACT
GTGAGGAGAGAGGCGGACTGTGAGGCAGCCAGGAGCCAGCTGCGTCCGTGTGTGGTCTGTCACCACGGGGCCTGCTTCTTATCTGACACA
GCAGCTATCAGAGTCTAGTGGTTGTGCTTTTAAGATGCTCTGATACCATTGGGTTAAGGGGCAGATTGGCGGTGGGTGTGGGGCAGTGTG
AGGTAGTCCTGGATCCCCGCCAGGGTGGCCCAGACGCCAGCCCTTCCCTGTGTGGCTGCACTGAGGTGGGTGTTGAAGAGCCCCCTAGGG
GACACACAGCTTCCAGGAGGAGGGAATGTCCTCTAAGCATGCTCCTGGCCTCTCAAGGTGGCGCTTGTCTAATTATTCACTTGGGAAGAA
TGACTAGCTCAGCCAGCGGCTCTTTCTGCTTTGTTCTGGCGACTTTCCTGGGCAGGCCTTTCCACCTGGGGAGCTGGCTCATCCTGCACA
GCTGGGCCGTGGTGGGCCTGTCTGCTTGATTCTGGGGTTCAGTGTAGGTCAGCTGATGGCGAACCATGGTGGTGGTTTGGCTTCTGTTCT
TATTCTTGAGTTTTGATACCACGCAGACCTTGGGTGGGGAGAGCTTCCTGCACAGCTCTCAGCGGCCTGTGGCCTTGGAACTGCCTGCGT
AAGTAACGGAGGGGCTGCTGGTCCTGTTCAGGCCCGTGCTGGGGACGCCGCTTAGACAATGTTGCCCAGAGTCCTGTTTACCCTCCCAGG
GTTCATTCTTCCCAAGAACTCAAATTCCTTTCTCATTGGAGCCTAGTGAAACCAAATGAACGGGACCTGCTGGCCTCAGGAGGCAGGCAG
AGTTTAAAATAAAACTTTCTCATGATTTCTTGAACATCTTTCCCTGTTTGTATATACACTTTGTGTTTATTTTTCAGTAGCTGCAGTATA
TTTTTTTTCAATATTCAGTATAATGCAGTGTATTTCATCATATGCTGTATGGAGAGTGGGCAGACTTCTGTGGAGGGCCCGATAGTAACC
ATTTGAAGCTTTCTGGACCTGTGGTCTTAGTCCCAGCGATTCTGCAGAGCGGCCATCGGCAGCATGTCAACCATTTGCATGGCTGGGCTC
CAGGGAAACTACTGACAACGACAGGTGGTGGGCCATAGTTTCCTGACCCCTGTGCTATGCCAGAATTTCTTTTTCCTCTTCCCTATGAGT

>In-frame_TMPRSS2_ENST00000398585_chr21_42860321_-_SETD4_ENST00000399215_chr21_37429502_-_3443nt
ACCAGGGTCCCGGCTCGGGGTCCGGGCTGGGGAGGGGAACCTGGGCGCCTGGGACCCGCCGATGCCCCCTGCCCCGCCCGGAGGTGAAAG
CGGGTGTGAGGAGCGCGGCGCGGCAGGTCATATTGAACATTCCAGATACCTATCATTACTCGATGCTGTTGATAACAGCAAGATGGCTTT
GAACTCAGGGTCACCACCAGCTATTGGACCTTACTATGAAAACCATGGATACCAACCGGAAAACCCCTATCCCGCACAGCCCACTGTGGT
CCCCACTGTCTACGAGGTGCATCCGGCTCAGTACTACCCGTCCCCCGTGCCCCAGTACGCCCCGAGGGTCCTGACGCAGGCTTCCAACCC
CGTCGTCTGCACGCAGCCCAAATCCCCATCCGGGACAGTGTGCACCTCAAAGACTAAGAAAGCACTGTGCATCACCTTGACCCTGGGGAC
CTTCCTCGTGGGAGCTGCGCTGGCCGCTGGCCTACTCTGGAAGTTCATGGGCAGCAAGTGCTCCAACTCTGGGATAGAGTGCGACTCCTC
AGGTACCTGCATCAACCCCTCTAACTGGTGTGATGGCGTGTCACACTGCCCCGGCGGGGAGGACGAGAATCGGTGTGTGAATGAGAGCCA
CAAGTCTGAATTTATAGAGCTGAGGAAGTGGCTGAAAGCTAGGAAGTTTCAAGATTCAAACTTAGCGCCTGCTTGTTTTCCAGGTACAGG
AAGAGGGCTGATGAGTCAAACATCCCTGCAGGAGGGACAGATGATTATTTCGTTGCCTGAGAGTTGCCTGCTCACCACGGACACAGTGAT
TCGAAGCTACTTAGGGGCATACATTACTAAGTGGAAGCCTCCTCCATCTCCTCTGCTGGCGCTGTGCACCTTTTTAGTTTCAGAAAAGCA
TGCTGGGCACCGATCTCTTTGGAAGCCTTACCTGGAGATTTTACCCAAGGCGTATACCTGCCCTGTTTGTTTGGAGCCGGAAGTGGTGAA
CCTTCTTCCCAAATCTTTAAAAGCAAAGGCTGAAGAGCAGAGAGCCCACGTGCAGGAGTTCTTTGCTTCCTCCAGAGACTTTTTCTCTTC
TCTGCAGCCTCTGTTTGCGGAGGCTGTTGACAGCATCTTCAGCTACAGTGCCCTGCTGTGGGCTTGGTGCACCGTCAACACCAGAGCCGT
GTACCTGAGGCCCAGGCAGCGGGAATGCCTTTCTGCAGAGCCGGACACCTGTGCACTCGCTCCGTACCTGGACCTGCTGAATCATAGCCC
ACATGTCCAGGTAAAAGCAGCGTTTAATGAAGAAACTCATTCTTACGAAATTAGAACGACTTCACGTTGGAGAAAGCATGAAGAGGTATT
CATCTGTTACGGCCCTCACGATAATCAACGGCTGTTCCTGGAATACGGATTTGTTTCTGTCCATAATCCTCATGCTTGTGTTTATGTCTC
AAGAGAAATACTTGTTAAATATCTTCCATCAACAGATAAACAGATGGACAAAAAGATTTCTATTTTAAAGGATCATGGCTATATAGAAAA
TTTGACATTTGGATGGGATGGACCATCTTGGAGGCTACTCACAGCCCTTAAGTTGTTATGTCTGGAAGCTGAGAAATTTACATGCTGGAA
AAAAGTACTTCTTGGGGAGGTAATTTCAGATACGAATGAGAAGACAAGTTTGGACATAGCCCAGAAAATATGCTATTATTTCATAGAAGA
GACTAATGCTGTGCTTCAAAAGGTGTCTCATATGAAGGATGAAAAAGAGGCCCTGATAAACCAACTAACTTTGGTGGAATCCTTGTGGAC
GGAAGAGCTAAAGATTCTCAGGGCATCTGCCGAGACCCTGCACAGTTTGCAAACAGCTTTTACCTGATTTCACCGAAGCGCATTTGGTCA
CCTCCTCTGGTGGGTGTTAGTCACACATTTTAGACTAAGGTTTGATGGACTAAATTTATATAGTTTAGAGTCGATGAGTTGTGTCTACTC
AACAATTAGGAACTTAATCCTTTTCCTTTTGCTTTTCCTACAGAAACAAAAGTTAATTTTGAAGAGCATCATCATGGGCTGGGGTGGTGG
CTGCCCCCAGGACATGCAGGATTTCTGCAGGGGGCAGCACAGGTTCTGGGATTGTGAGGCTGTGAGTGAAGGTGGACAAGCTGTCTGGAT
GGCAGGTCTAATGCTCTTCCGAATAAAGTGCTGAACTGTGAGGAGAGAGGCGGACTGTGAGGCAGCCAGGAGCCAGCTGCGTCCGTGTGT
GGTCTGTCACCACGGGGCCTGCTTCTTATCTGACACAGCAGCTATCAGAGTCTAGTGGTTGTGCTTTTAAGATGCTCTGATACCATTGGG
TTAAGGGGCAGATTGGCGGTGGGTGTGGGGCAGTGTGAGGTAGTCCTGGATCCCCGCCAGGGTGGCCCAGACGCCAGCCCTTCCCTGTGT
GGCTGCACTGAGGTGGGTGTTGAAGAGCCCCCTAGGGGACACACAGCTTCCAGGAGGAGGGAATGTCCTCTAAGCATGCTCCTGGCCTCT
CAAGGTGGCGCTTGTCTAATTATTCACTTGGGAAGAATGACTAGCTCAGCCAGCGGCTCTTTCTGCTTTGTTCTGGCGACTTTCCTGGGC
AGGCCTTTCCACCTGGGGAGCTGGCTCATCCTGCACAGCTGGGCCGTGGTGGGCCTGTCTGCTTGATTCTGGGGTTCAGTGTAGGTCAGC
TGATGGCGAACCATGGTGGTGGTTTGGCTTCTGTTCTTATTCTTGAGTTTTGATACCACGCAGACCTTGGGTGGGGAGAGCTTCCTGCAC
AGCTCTCAGCGGCCTGTGGCCTTGGAACTGCCTGCGTAAGTAACGGAGGGGCTGCTGGTCCTGTTCAGGCCCGTGCTGGGGACGCCGCTT
AGACAATGTTGCCCAGAGTCCTGTTTACCCTCCCAGGGTTCATTCTTCCCAAGAACTCAAATTCCTTTCTCATTGGAGCCTAGTGAAACC
AAATGAACGGGACCTGCTGGCCTCAGGAGGCAGGCAGAGTTTAAAATAAAACTTTCTCATGATTTCTTGAACATCTTTCCCTGTTTGTAT
ATACACTTTGTGTTTATTTTTCAGTAGCTGCAGTATATTTTTTTTCAATATTCAGTATAATGCAGTGTATTTCATCATATGCTGTATGGA
GAGTGGGCAGACTTCTGTGGAGGGCCCGATAGTAACCATTTGAAGCTTTCTGGACCTGTGGTCTTAGTCCCAGCGATTCTGCAGAGCGGC
CATCGGCAGCATGTCAACCATTTGCATGGCTGGGCTCCAGGGAAACTACTGACAACGACAGGTGGTGGGCCATAGTTTCCTGACCCCTGT
GCTATGCCAGAATTTCTTTTTCCTCTTCCCTATGAGTGGACCTAAATATGTTAATTCCTTTTCACCTTTCAAAACGGACAGCCCCTTGAA


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FusionGenePPI for TMPRSS2_SETD4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TMPRSS2CLK1SETD4NXF1, DDX55, MRPL1, ZMIZ1, GBE1, GDF15, TADA3, WWP1, LRRC59, CORO7


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TMPRSS2_SETD4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TMPRSS2_SETD4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTMPRSS2C0033578Prostatic Neoplasms2CTD_human