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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 38749

FusionGeneSummary for TMPRSS2_ETV1

check button Fusion gene summary
Fusion gene informationFusion gene name: TMPRSS2_ETV1
Fusion gene ID: 38749
HgeneTgene
Gene symbol

TMPRSS2

ETV1

Gene ID

7113

2115

Gene nametransmembrane serine protease 2ETS variant 1
SynonymsPP9284|PRSS10ER81
Cytomap

21q22.3

7p21.2

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane protease serine 2epitheliasinserine protease 10transmembrane protease, serine 2ETS translocation variant 1ets variant gene 1ets-related protein 81
Modification date2018052320180523
UniProtAcc

O15393

P50549

Ensembl transtripts involved in fusion geneENST00000332149, ENST00000398585, 
ENST00000458356, ENST00000497881, 
ENST00000430479, ENST00000399357, 
ENST00000420159, ENST00000343495, 
ENST00000242066, ENST00000405192, 
ENST00000405358, ENST00000403527, 
ENST00000405218, ENST00000403685, 
ENST00000476720, 
Fusion gene scores* DoF score29 X 21 X 6=365411 X 14 X 3=462
# samples 22827
** MAII scorelog2(228/3654*10)=-0.680442809575384
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(27/462*10)=-0.774933444365227
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TMPRSS2 [Title/Abstract] AND ETV1 [Title/Abstract] AND fusion [Title/Abstract]

Molecular genetic analyses of the TMPRSS2-ERG and TMPRSS2-ETV1 gene fusions in 50 cases of prostate cancer. (pmid: 17390040)
Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTMPRSS2

GO:0006508

proteolysis

21068237|24227843

HgeneTMPRSS2

GO:0046598

positive regulation of viral entry into host cell

21068237|24227843

TgeneETV1

GO:0045944

positive regulation of transcription by RNA polymerase II

12750007


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-EJ-7788-01ATMPRSS2chr21

42870046

-ETV1chr7

13978871

-
TCGARVPRADTCGA-EJ-5501-01ATMPRSS2chr21

42879877

-ETV1chr7

13978871

-
TCGARVPRADTCGA-YL-A8SC-01ATMPRSS2chr21

42879877

-ETV1chr7

13978871

-
TCGARVPRADTCGA-HC-7818-01ATMPRSS2chr21

42866283

-ETV1chr7

13971374

-
ChiTaRS3.1DQ204770TMPRSS2chr21

42880008

-ETV1chr7

14017108

-
ChiTaRS3.1DQ204771TMPRSS2chr21

42870046

-ETV1chr7

14017105

-
ChiTaRS3.1EU090249TMPRSS2chr21

42866302

-ETV1chr7

13975469

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000332149ENST00000430479TMPRSS2chr21

42870046

-ETV1chr7

13978871

-
Frame-shitENST00000332149ENST00000399357TMPRSS2chr21

42870046

-ETV1chr7

13978871

-
Frame-shitENST00000332149ENST00000420159TMPRSS2chr21

42870046

-ETV1chr7

13978871

-
Frame-shitENST00000332149ENST00000343495TMPRSS2chr21

42870046

-ETV1chr7

13978871

-
Frame-shitENST00000332149ENST00000242066TMPRSS2chr21

42870046

-ETV1chr7

13978871

-
Frame-shitENST00000332149ENST00000405192TMPRSS2chr21

42870046

-ETV1chr7

13978871

-
Frame-shitENST00000332149ENST00000405358TMPRSS2chr21

42870046

-ETV1chr7

13978871

-
Frame-shitENST00000332149ENST00000403527TMPRSS2chr21

42870046

-ETV1chr7

13978871

-
Frame-shitENST00000332149ENST00000405218TMPRSS2chr21

42870046

-ETV1chr7

13978871

-
Frame-shitENST00000332149ENST00000403685TMPRSS2chr21

42870046

-ETV1chr7

13978871

-
5CDS-5UTRENST00000332149ENST00000476720TMPRSS2chr21

42870046

-ETV1chr7

13978871

-
Frame-shitENST00000398585ENST00000430479TMPRSS2chr21

42870046

-ETV1chr7

13978871

-
Frame-shitENST00000398585ENST00000399357TMPRSS2chr21

42870046

-ETV1chr7

13978871

-
Frame-shitENST00000398585ENST00000420159TMPRSS2chr21

42870046

-ETV1chr7

13978871

-
Frame-shitENST00000398585ENST00000343495TMPRSS2chr21

42870046

-ETV1chr7

13978871

-
Frame-shitENST00000398585ENST00000242066TMPRSS2chr21

42870046

-ETV1chr7

13978871

-
Frame-shitENST00000398585ENST00000405192TMPRSS2chr21

42870046

-ETV1chr7

13978871

-
Frame-shitENST00000398585ENST00000405358TMPRSS2chr21

42870046

-ETV1chr7

13978871

-
Frame-shitENST00000398585ENST00000403527TMPRSS2chr21

42870046

-ETV1chr7

13978871

-
Frame-shitENST00000398585ENST00000405218TMPRSS2chr21

42870046

-ETV1chr7

13978871

-
Frame-shitENST00000398585ENST00000403685TMPRSS2chr21

42870046

-ETV1chr7

13978871

-
5CDS-5UTRENST00000398585ENST00000476720TMPRSS2chr21

42870046

-ETV1chr7

13978871

-
Frame-shitENST00000458356ENST00000430479TMPRSS2chr21

42870046

-ETV1chr7

13978871

-
Frame-shitENST00000458356ENST00000399357TMPRSS2chr21

42870046

-ETV1chr7

13978871

-
Frame-shitENST00000458356ENST00000420159TMPRSS2chr21

42870046

-ETV1chr7

13978871

-
Frame-shitENST00000458356ENST00000343495TMPRSS2chr21

42870046

-ETV1chr7

13978871

-
Frame-shitENST00000458356ENST00000242066TMPRSS2chr21

42870046

-ETV1chr7

13978871

-
Frame-shitENST00000458356ENST00000405192TMPRSS2chr21

42870046

-ETV1chr7

13978871

-
Frame-shitENST00000458356ENST00000405358TMPRSS2chr21

42870046

-ETV1chr7

13978871

-
Frame-shitENST00000458356ENST00000403527TMPRSS2chr21

42870046

-ETV1chr7

13978871

-
Frame-shitENST00000458356ENST00000405218TMPRSS2chr21

42870046

-ETV1chr7

13978871

-
Frame-shitENST00000458356ENST00000403685TMPRSS2chr21

42870046

-ETV1chr7

13978871

-
5CDS-5UTRENST00000458356ENST00000476720TMPRSS2chr21

42870046

-ETV1chr7

13978871

-
5UTR-3CDSENST00000497881ENST00000430479TMPRSS2chr21

42870046

-ETV1chr7

13978871

-
5UTR-3CDSENST00000497881ENST00000399357TMPRSS2chr21

42870046

-ETV1chr7

13978871

-
5UTR-3CDSENST00000497881ENST00000420159TMPRSS2chr21

42870046

-ETV1chr7

13978871

-
5UTR-3CDSENST00000497881ENST00000343495TMPRSS2chr21

42870046

-ETV1chr7

13978871

-
5UTR-3CDSENST00000497881ENST00000242066TMPRSS2chr21

42870046

-ETV1chr7

13978871

-
5UTR-3CDSENST00000497881ENST00000405192TMPRSS2chr21

42870046

-ETV1chr7

13978871

-
5UTR-3CDSENST00000497881ENST00000405358TMPRSS2chr21

42870046

-ETV1chr7

13978871

-
5UTR-3CDSENST00000497881ENST00000403527TMPRSS2chr21

42870046

-ETV1chr7

13978871

-
5UTR-3CDSENST00000497881ENST00000405218TMPRSS2chr21

42870046

-ETV1chr7

13978871

-
5UTR-3CDSENST00000497881ENST00000403685TMPRSS2chr21

42870046

-ETV1chr7

13978871

-
5UTR-5UTRENST00000497881ENST00000476720TMPRSS2chr21

42870046

-ETV1chr7

13978871

-
intron-3CDSENST00000332149ENST00000430479TMPRSS2chr21

42879877

-ETV1chr7

13978871

-
intron-3CDSENST00000332149ENST00000399357TMPRSS2chr21

42879877

-ETV1chr7

13978871

-
intron-3CDSENST00000332149ENST00000420159TMPRSS2chr21

42879877

-ETV1chr7

13978871

-
intron-3CDSENST00000332149ENST00000343495TMPRSS2chr21

42879877

-ETV1chr7

13978871

-
intron-3CDSENST00000332149ENST00000242066TMPRSS2chr21

42879877

-ETV1chr7

13978871

-
intron-3CDSENST00000332149ENST00000405192TMPRSS2chr21

42879877

-ETV1chr7

13978871

-
intron-3CDSENST00000332149ENST00000405358TMPRSS2chr21

42879877

-ETV1chr7

13978871

-
intron-3CDSENST00000332149ENST00000403527TMPRSS2chr21

42879877

-ETV1chr7

13978871

-
intron-3CDSENST00000332149ENST00000405218TMPRSS2chr21

42879877

-ETV1chr7

13978871

-
intron-3CDSENST00000332149ENST00000403685TMPRSS2chr21

42879877

-ETV1chr7

13978871

-
intron-5UTRENST00000332149ENST00000476720TMPRSS2chr21

42879877

-ETV1chr7

13978871

-
Frame-shitENST00000398585ENST00000430479TMPRSS2chr21

42879877

-ETV1chr7

13978871

-
Frame-shitENST00000398585ENST00000399357TMPRSS2chr21

42879877

-ETV1chr7

13978871

-
Frame-shitENST00000398585ENST00000420159TMPRSS2chr21

42879877

-ETV1chr7

13978871

-
Frame-shitENST00000398585ENST00000343495TMPRSS2chr21

42879877

-ETV1chr7

13978871

-
Frame-shitENST00000398585ENST00000242066TMPRSS2chr21

42879877

-ETV1chr7

13978871

-
Frame-shitENST00000398585ENST00000405192TMPRSS2chr21

42879877

-ETV1chr7

13978871

-
Frame-shitENST00000398585ENST00000405358TMPRSS2chr21

42879877

-ETV1chr7

13978871

-
Frame-shitENST00000398585ENST00000403527TMPRSS2chr21

42879877

-ETV1chr7

13978871

-
Frame-shitENST00000398585ENST00000405218TMPRSS2chr21

42879877

-ETV1chr7

13978871

-
Frame-shitENST00000398585ENST00000403685TMPRSS2chr21

42879877

-ETV1chr7

13978871

-
5CDS-5UTRENST00000398585ENST00000476720TMPRSS2chr21

42879877

-ETV1chr7

13978871

-
5UTR-3CDSENST00000458356ENST00000430479TMPRSS2chr21

42879877

-ETV1chr7

13978871

-
5UTR-3CDSENST00000458356ENST00000399357TMPRSS2chr21

42879877

-ETV1chr7

13978871

-
5UTR-3CDSENST00000458356ENST00000420159TMPRSS2chr21

42879877

-ETV1chr7

13978871

-
5UTR-3CDSENST00000458356ENST00000343495TMPRSS2chr21

42879877

-ETV1chr7

13978871

-
5UTR-3CDSENST00000458356ENST00000242066TMPRSS2chr21

42879877

-ETV1chr7

13978871

-
5UTR-3CDSENST00000458356ENST00000405192TMPRSS2chr21

42879877

-ETV1chr7

13978871

-
5UTR-3CDSENST00000458356ENST00000405358TMPRSS2chr21

42879877

-ETV1chr7

13978871

-
5UTR-3CDSENST00000458356ENST00000403527TMPRSS2chr21

42879877

-ETV1chr7

13978871

-
5UTR-3CDSENST00000458356ENST00000405218TMPRSS2chr21

42879877

-ETV1chr7

13978871

-
5UTR-3CDSENST00000458356ENST00000403685TMPRSS2chr21

42879877

-ETV1chr7

13978871

-
5UTR-5UTRENST00000458356ENST00000476720TMPRSS2chr21

42879877

-ETV1chr7

13978871

-
intron-3CDSENST00000497881ENST00000430479TMPRSS2chr21

42879877

-ETV1chr7

13978871

-
intron-3CDSENST00000497881ENST00000399357TMPRSS2chr21

42879877

-ETV1chr7

13978871

-
intron-3CDSENST00000497881ENST00000420159TMPRSS2chr21

42879877

-ETV1chr7

13978871

-
intron-3CDSENST00000497881ENST00000343495TMPRSS2chr21

42879877

-ETV1chr7

13978871

-
intron-3CDSENST00000497881ENST00000242066TMPRSS2chr21

42879877

-ETV1chr7

13978871

-
intron-3CDSENST00000497881ENST00000405192TMPRSS2chr21

42879877

-ETV1chr7

13978871

-
intron-3CDSENST00000497881ENST00000405358TMPRSS2chr21

42879877

-ETV1chr7

13978871

-
intron-3CDSENST00000497881ENST00000403527TMPRSS2chr21

42879877

-ETV1chr7

13978871

-
intron-3CDSENST00000497881ENST00000405218TMPRSS2chr21

42879877

-ETV1chr7

13978871

-
intron-3CDSENST00000497881ENST00000403685TMPRSS2chr21

42879877

-ETV1chr7

13978871

-
intron-5UTRENST00000497881ENST00000476720TMPRSS2chr21

42879877

-ETV1chr7

13978871

-
Frame-shitENST00000332149ENST00000430479TMPRSS2chr21

42866283

-ETV1chr7

13971374

-
Frame-shitENST00000332149ENST00000399357TMPRSS2chr21

42866283

-ETV1chr7

13971374

-
Frame-shitENST00000332149ENST00000420159TMPRSS2chr21

42866283

-ETV1chr7

13971374

-
Frame-shitENST00000332149ENST00000343495TMPRSS2chr21

42866283

-ETV1chr7

13971374

-
Frame-shitENST00000332149ENST00000242066TMPRSS2chr21

42866283

-ETV1chr7

13971374

-
Frame-shitENST00000332149ENST00000405192TMPRSS2chr21

42866283

-ETV1chr7

13971374

-
Frame-shitENST00000332149ENST00000405358TMPRSS2chr21

42866283

-ETV1chr7

13971374

-
Frame-shitENST00000332149ENST00000403527TMPRSS2chr21

42866283

-ETV1chr7

13971374

-
Frame-shitENST00000332149ENST00000405218TMPRSS2chr21

42866283

-ETV1chr7

13971374

-
Frame-shitENST00000332149ENST00000403685TMPRSS2chr21

42866283

-ETV1chr7

13971374

-
5CDS-5UTRENST00000332149ENST00000476720TMPRSS2chr21

42866283

-ETV1chr7

13971374

-
Frame-shitENST00000398585ENST00000430479TMPRSS2chr21

42866283

-ETV1chr7

13971374

-
Frame-shitENST00000398585ENST00000399357TMPRSS2chr21

42866283

-ETV1chr7

13971374

-
Frame-shitENST00000398585ENST00000420159TMPRSS2chr21

42866283

-ETV1chr7

13971374

-
Frame-shitENST00000398585ENST00000343495TMPRSS2chr21

42866283

-ETV1chr7

13971374

-
Frame-shitENST00000398585ENST00000242066TMPRSS2chr21

42866283

-ETV1chr7

13971374

-
Frame-shitENST00000398585ENST00000405192TMPRSS2chr21

42866283

-ETV1chr7

13971374

-
Frame-shitENST00000398585ENST00000405358TMPRSS2chr21

42866283

-ETV1chr7

13971374

-
Frame-shitENST00000398585ENST00000403527TMPRSS2chr21

42866283

-ETV1chr7

13971374

-
Frame-shitENST00000398585ENST00000405218TMPRSS2chr21

42866283

-ETV1chr7

13971374

-
Frame-shitENST00000398585ENST00000403685TMPRSS2chr21

42866283

-ETV1chr7

13971374

-
5CDS-5UTRENST00000398585ENST00000476720TMPRSS2chr21

42866283

-ETV1chr7

13971374

-
Frame-shitENST00000458356ENST00000430479TMPRSS2chr21

42866283

-ETV1chr7

13971374

-
Frame-shitENST00000458356ENST00000399357TMPRSS2chr21

42866283

-ETV1chr7

13971374

-
Frame-shitENST00000458356ENST00000420159TMPRSS2chr21

42866283

-ETV1chr7

13971374

-
Frame-shitENST00000458356ENST00000343495TMPRSS2chr21

42866283

-ETV1chr7

13971374

-
Frame-shitENST00000458356ENST00000242066TMPRSS2chr21

42866283

-ETV1chr7

13971374

-
Frame-shitENST00000458356ENST00000405192TMPRSS2chr21

42866283

-ETV1chr7

13971374

-
Frame-shitENST00000458356ENST00000405358TMPRSS2chr21

42866283

-ETV1chr7

13971374

-
Frame-shitENST00000458356ENST00000403527TMPRSS2chr21

42866283

-ETV1chr7

13971374

-
Frame-shitENST00000458356ENST00000405218TMPRSS2chr21

42866283

-ETV1chr7

13971374

-
Frame-shitENST00000458356ENST00000403685TMPRSS2chr21

42866283

-ETV1chr7

13971374

-
5CDS-5UTRENST00000458356ENST00000476720TMPRSS2chr21

42866283

-ETV1chr7

13971374

-
intron-3CDSENST00000497881ENST00000430479TMPRSS2chr21

42866283

-ETV1chr7

13971374

-
intron-3CDSENST00000497881ENST00000399357TMPRSS2chr21

42866283

-ETV1chr7

13971374

-
intron-3CDSENST00000497881ENST00000420159TMPRSS2chr21

42866283

-ETV1chr7

13971374

-
intron-3CDSENST00000497881ENST00000343495TMPRSS2chr21

42866283

-ETV1chr7

13971374

-
intron-3CDSENST00000497881ENST00000242066TMPRSS2chr21

42866283

-ETV1chr7

13971374

-
intron-3CDSENST00000497881ENST00000405192TMPRSS2chr21

42866283

-ETV1chr7

13971374

-
intron-3CDSENST00000497881ENST00000405358TMPRSS2chr21

42866283

-ETV1chr7

13971374

-
intron-3CDSENST00000497881ENST00000403527TMPRSS2chr21

42866283

-ETV1chr7

13971374

-
intron-3CDSENST00000497881ENST00000405218TMPRSS2chr21

42866283

-ETV1chr7

13971374

-
intron-3CDSENST00000497881ENST00000403685TMPRSS2chr21

42866283

-ETV1chr7

13971374

-
intron-5UTRENST00000497881ENST00000476720TMPRSS2chr21

42866283

-ETV1chr7

13971374

-
5UTR-3CDSENST00000332149ENST00000430479TMPRSS2chr21

42880008

-ETV1chr7

14017108

-
5UTR-3CDSENST00000332149ENST00000399357TMPRSS2chr21

42880008

-ETV1chr7

14017108

-
5UTR-intronENST00000332149ENST00000420159TMPRSS2chr21

42880008

-ETV1chr7

14017108

-
5UTR-intronENST00000332149ENST00000343495TMPRSS2chr21

42880008

-ETV1chr7

14017108

-
5UTR-intronENST00000332149ENST00000242066TMPRSS2chr21

42880008

-ETV1chr7

14017108

-
5UTR-intronENST00000332149ENST00000405192TMPRSS2chr21

42880008

-ETV1chr7

14017108

-
5UTR-intronENST00000332149ENST00000405358TMPRSS2chr21

42880008

-ETV1chr7

14017108

-
5UTR-intronENST00000332149ENST00000403527TMPRSS2chr21

42880008

-ETV1chr7

14017108

-
5UTR-intronENST00000332149ENST00000405218TMPRSS2chr21

42880008

-ETV1chr7

14017108

-
5UTR-intronENST00000332149ENST00000403685TMPRSS2chr21

42880008

-ETV1chr7

14017108

-
5UTR-5UTRENST00000332149ENST00000476720TMPRSS2chr21

42880008

-ETV1chr7

14017108

-
intron-3CDSENST00000398585ENST00000430479TMPRSS2chr21

42880008

-ETV1chr7

14017108

-
intron-3CDSENST00000398585ENST00000399357TMPRSS2chr21

42880008

-ETV1chr7

14017108

-
intron-intronENST00000398585ENST00000420159TMPRSS2chr21

42880008

-ETV1chr7

14017108

-
intron-intronENST00000398585ENST00000343495TMPRSS2chr21

42880008

-ETV1chr7

14017108

-
intron-intronENST00000398585ENST00000242066TMPRSS2chr21

42880008

-ETV1chr7

14017108

-
intron-intronENST00000398585ENST00000405192TMPRSS2chr21

42880008

-ETV1chr7

14017108

-
intron-intronENST00000398585ENST00000405358TMPRSS2chr21

42880008

-ETV1chr7

14017108

-
intron-intronENST00000398585ENST00000403527TMPRSS2chr21

42880008

-ETV1chr7

14017108

-
intron-intronENST00000398585ENST00000405218TMPRSS2chr21

42880008

-ETV1chr7

14017108

-
intron-intronENST00000398585ENST00000403685TMPRSS2chr21

42880008

-ETV1chr7

14017108

-
intron-5UTRENST00000398585ENST00000476720TMPRSS2chr21

42880008

-ETV1chr7

14017108

-
intron-3CDSENST00000458356ENST00000430479TMPRSS2chr21

42880008

-ETV1chr7

14017108

-
intron-3CDSENST00000458356ENST00000399357TMPRSS2chr21

42880008

-ETV1chr7

14017108

-
intron-intronENST00000458356ENST00000420159TMPRSS2chr21

42880008

-ETV1chr7

14017108

-
intron-intronENST00000458356ENST00000343495TMPRSS2chr21

42880008

-ETV1chr7

14017108

-
intron-intronENST00000458356ENST00000242066TMPRSS2chr21

42880008

-ETV1chr7

14017108

-
intron-intronENST00000458356ENST00000405192TMPRSS2chr21

42880008

-ETV1chr7

14017108

-
intron-intronENST00000458356ENST00000405358TMPRSS2chr21

42880008

-ETV1chr7

14017108

-
intron-intronENST00000458356ENST00000403527TMPRSS2chr21

42880008

-ETV1chr7

14017108

-
intron-intronENST00000458356ENST00000405218TMPRSS2chr21

42880008

-ETV1chr7

14017108

-
intron-intronENST00000458356ENST00000403685TMPRSS2chr21

42880008

-ETV1chr7

14017108

-
intron-5UTRENST00000458356ENST00000476720TMPRSS2chr21

42880008

-ETV1chr7

14017108

-
5UTR-3CDSENST00000497881ENST00000430479TMPRSS2chr21

42880008

-ETV1chr7

14017108

-
5UTR-3CDSENST00000497881ENST00000399357TMPRSS2chr21

42880008

-ETV1chr7

14017108

-
5UTR-intronENST00000497881ENST00000420159TMPRSS2chr21

42880008

-ETV1chr7

14017108

-
5UTR-intronENST00000497881ENST00000343495TMPRSS2chr21

42880008

-ETV1chr7

14017108

-
5UTR-intronENST00000497881ENST00000242066TMPRSS2chr21

42880008

-ETV1chr7

14017108

-
5UTR-intronENST00000497881ENST00000405192TMPRSS2chr21

42880008

-ETV1chr7

14017108

-
5UTR-intronENST00000497881ENST00000405358TMPRSS2chr21

42880008

-ETV1chr7

14017108

-
5UTR-intronENST00000497881ENST00000403527TMPRSS2chr21

42880008

-ETV1chr7

14017108

-
5UTR-intronENST00000497881ENST00000405218TMPRSS2chr21

42880008

-ETV1chr7

14017108

-
5UTR-intronENST00000497881ENST00000403685TMPRSS2chr21

42880008

-ETV1chr7

14017108

-
5UTR-5UTRENST00000497881ENST00000476720TMPRSS2chr21

42880008

-ETV1chr7

14017108

-
Frame-shitENST00000332149ENST00000430479TMPRSS2chr21

42870046

-ETV1chr7

14017105

-
Frame-shitENST00000332149ENST00000399357TMPRSS2chr21

42870046

-ETV1chr7

14017105

-
5CDS-intronENST00000332149ENST00000420159TMPRSS2chr21

42870046

-ETV1chr7

14017105

-
5CDS-intronENST00000332149ENST00000343495TMPRSS2chr21

42870046

-ETV1chr7

14017105

-
5CDS-intronENST00000332149ENST00000242066TMPRSS2chr21

42870046

-ETV1chr7

14017105

-
5CDS-intronENST00000332149ENST00000405192TMPRSS2chr21

42870046

-ETV1chr7

14017105

-
5CDS-intronENST00000332149ENST00000405358TMPRSS2chr21

42870046

-ETV1chr7

14017105

-
5CDS-intronENST00000332149ENST00000403527TMPRSS2chr21

42870046

-ETV1chr7

14017105

-
5CDS-intronENST00000332149ENST00000405218TMPRSS2chr21

42870046

-ETV1chr7

14017105

-
5CDS-intronENST00000332149ENST00000403685TMPRSS2chr21

42870046

-ETV1chr7

14017105

-
5CDS-5UTRENST00000332149ENST00000476720TMPRSS2chr21

42870046

-ETV1chr7

14017105

-
Frame-shitENST00000398585ENST00000430479TMPRSS2chr21

42870046

-ETV1chr7

14017105

-
Frame-shitENST00000398585ENST00000399357TMPRSS2chr21

42870046

-ETV1chr7

14017105

-
5CDS-intronENST00000398585ENST00000420159TMPRSS2chr21

42870046

-ETV1chr7

14017105

-
5CDS-intronENST00000398585ENST00000343495TMPRSS2chr21

42870046

-ETV1chr7

14017105

-
5CDS-intronENST00000398585ENST00000242066TMPRSS2chr21

42870046

-ETV1chr7

14017105

-
5CDS-intronENST00000398585ENST00000405192TMPRSS2chr21

42870046

-ETV1chr7

14017105

-
5CDS-intronENST00000398585ENST00000405358TMPRSS2chr21

42870046

-ETV1chr7

14017105

-
5CDS-intronENST00000398585ENST00000403527TMPRSS2chr21

42870046

-ETV1chr7

14017105

-
5CDS-intronENST00000398585ENST00000405218TMPRSS2chr21

42870046

-ETV1chr7

14017105

-
5CDS-intronENST00000398585ENST00000403685TMPRSS2chr21

42870046

-ETV1chr7

14017105

-
5CDS-5UTRENST00000398585ENST00000476720TMPRSS2chr21

42870046

-ETV1chr7

14017105

-
Frame-shitENST00000458356ENST00000430479TMPRSS2chr21

42870046

-ETV1chr7

14017105

-
Frame-shitENST00000458356ENST00000399357TMPRSS2chr21

42870046

-ETV1chr7

14017105

-
5CDS-intronENST00000458356ENST00000420159TMPRSS2chr21

42870046

-ETV1chr7

14017105

-
5CDS-intronENST00000458356ENST00000343495TMPRSS2chr21

42870046

-ETV1chr7

14017105

-
5CDS-intronENST00000458356ENST00000242066TMPRSS2chr21

42870046

-ETV1chr7

14017105

-
5CDS-intronENST00000458356ENST00000405192TMPRSS2chr21

42870046

-ETV1chr7

14017105

-
5CDS-intronENST00000458356ENST00000405358TMPRSS2chr21

42870046

-ETV1chr7

14017105

-
5CDS-intronENST00000458356ENST00000403527TMPRSS2chr21

42870046

-ETV1chr7

14017105

-
5CDS-intronENST00000458356ENST00000405218TMPRSS2chr21

42870046

-ETV1chr7

14017105

-
5CDS-intronENST00000458356ENST00000403685TMPRSS2chr21

42870046

-ETV1chr7

14017105

-
5CDS-5UTRENST00000458356ENST00000476720TMPRSS2chr21

42870046

-ETV1chr7

14017105

-
5UTR-3CDSENST00000497881ENST00000430479TMPRSS2chr21

42870046

-ETV1chr7

14017105

-
5UTR-3CDSENST00000497881ENST00000399357TMPRSS2chr21

42870046

-ETV1chr7

14017105

-
5UTR-intronENST00000497881ENST00000420159TMPRSS2chr21

42870046

-ETV1chr7

14017105

-
5UTR-intronENST00000497881ENST00000343495TMPRSS2chr21

42870046

-ETV1chr7

14017105

-
5UTR-intronENST00000497881ENST00000242066TMPRSS2chr21

42870046

-ETV1chr7

14017105

-
5UTR-intronENST00000497881ENST00000405192TMPRSS2chr21

42870046

-ETV1chr7

14017105

-
5UTR-intronENST00000497881ENST00000405358TMPRSS2chr21

42870046

-ETV1chr7

14017105

-
5UTR-intronENST00000497881ENST00000403527TMPRSS2chr21

42870046

-ETV1chr7

14017105

-
5UTR-intronENST00000497881ENST00000405218TMPRSS2chr21

42870046

-ETV1chr7

14017105

-
5UTR-intronENST00000497881ENST00000403685TMPRSS2chr21

42870046

-ETV1chr7

14017105

-
5UTR-5UTRENST00000497881ENST00000476720TMPRSS2chr21

42870046

-ETV1chr7

14017105

-
intron-3CDSENST00000332149ENST00000430479TMPRSS2chr21

42866302

-ETV1chr7

13975469

-
intron-intronENST00000332149ENST00000399357TMPRSS2chr21

42866302

-ETV1chr7

13975469

-
intron-intronENST00000332149ENST00000420159TMPRSS2chr21

42866302

-ETV1chr7

13975469

-
intron-intronENST00000332149ENST00000343495TMPRSS2chr21

42866302

-ETV1chr7

13975469

-
intron-intronENST00000332149ENST00000242066TMPRSS2chr21

42866302

-ETV1chr7

13975469

-
intron-intronENST00000332149ENST00000405192TMPRSS2chr21

42866302

-ETV1chr7

13975469

-
intron-intronENST00000332149ENST00000405358TMPRSS2chr21

42866302

-ETV1chr7

13975469

-
intron-intronENST00000332149ENST00000403527TMPRSS2chr21

42866302

-ETV1chr7

13975469

-
intron-intronENST00000332149ENST00000405218TMPRSS2chr21

42866302

-ETV1chr7

13975469

-
intron-intronENST00000332149ENST00000403685TMPRSS2chr21

42866302

-ETV1chr7

13975469

-
intron-5UTRENST00000332149ENST00000476720TMPRSS2chr21

42866302

-ETV1chr7

13975469

-
intron-3CDSENST00000398585ENST00000430479TMPRSS2chr21

42866302

-ETV1chr7

13975469

-
intron-intronENST00000398585ENST00000399357TMPRSS2chr21

42866302

-ETV1chr7

13975469

-
intron-intronENST00000398585ENST00000420159TMPRSS2chr21

42866302

-ETV1chr7

13975469

-
intron-intronENST00000398585ENST00000343495TMPRSS2chr21

42866302

-ETV1chr7

13975469

-
intron-intronENST00000398585ENST00000242066TMPRSS2chr21

42866302

-ETV1chr7

13975469

-
intron-intronENST00000398585ENST00000405192TMPRSS2chr21

42866302

-ETV1chr7

13975469

-
intron-intronENST00000398585ENST00000405358TMPRSS2chr21

42866302

-ETV1chr7

13975469

-
intron-intronENST00000398585ENST00000403527TMPRSS2chr21

42866302

-ETV1chr7

13975469

-
intron-intronENST00000398585ENST00000405218TMPRSS2chr21

42866302

-ETV1chr7

13975469

-
intron-intronENST00000398585ENST00000403685TMPRSS2chr21

42866302

-ETV1chr7

13975469

-
intron-5UTRENST00000398585ENST00000476720TMPRSS2chr21

42866302

-ETV1chr7

13975469

-
intron-3CDSENST00000458356ENST00000430479TMPRSS2chr21

42866302

-ETV1chr7

13975469

-
intron-intronENST00000458356ENST00000399357TMPRSS2chr21

42866302

-ETV1chr7

13975469

-
intron-intronENST00000458356ENST00000420159TMPRSS2chr21

42866302

-ETV1chr7

13975469

-
intron-intronENST00000458356ENST00000343495TMPRSS2chr21

42866302

-ETV1chr7

13975469

-
intron-intronENST00000458356ENST00000242066TMPRSS2chr21

42866302

-ETV1chr7

13975469

-
intron-intronENST00000458356ENST00000405192TMPRSS2chr21

42866302

-ETV1chr7

13975469

-
intron-intronENST00000458356ENST00000405358TMPRSS2chr21

42866302

-ETV1chr7

13975469

-
intron-intronENST00000458356ENST00000403527TMPRSS2chr21

42866302

-ETV1chr7

13975469

-
intron-intronENST00000458356ENST00000405218TMPRSS2chr21

42866302

-ETV1chr7

13975469

-
intron-intronENST00000458356ENST00000403685TMPRSS2chr21

42866302

-ETV1chr7

13975469

-
intron-5UTRENST00000458356ENST00000476720TMPRSS2chr21

42866302

-ETV1chr7

13975469

-
intron-3CDSENST00000497881ENST00000430479TMPRSS2chr21

42866302

-ETV1chr7

13975469

-
intron-intronENST00000497881ENST00000399357TMPRSS2chr21

42866302

-ETV1chr7

13975469

-
intron-intronENST00000497881ENST00000420159TMPRSS2chr21

42866302

-ETV1chr7

13975469

-
intron-intronENST00000497881ENST00000343495TMPRSS2chr21

42866302

-ETV1chr7

13975469

-
intron-intronENST00000497881ENST00000242066TMPRSS2chr21

42866302

-ETV1chr7

13975469

-
intron-intronENST00000497881ENST00000405192TMPRSS2chr21

42866302

-ETV1chr7

13975469

-
intron-intronENST00000497881ENST00000405358TMPRSS2chr21

42866302

-ETV1chr7

13975469

-
intron-intronENST00000497881ENST00000403527TMPRSS2chr21

42866302

-ETV1chr7

13975469

-
intron-intronENST00000497881ENST00000405218TMPRSS2chr21

42866302

-ETV1chr7

13975469

-
intron-intronENST00000497881ENST00000403685TMPRSS2chr21

42866302

-ETV1chr7

13975469

-
intron-5UTRENST00000497881ENST00000476720TMPRSS2chr21

42866302

-ETV1chr7

13975469

-

Top

FusionProtFeatures for TMPRSS2_ETV1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TMPRSS2

O15393

ETV1

P50549

Serine protease that proteolytically cleaves andactivates the viral spike glycoproteins which facilitate virus-cell membrane fusions; spike proteins are synthesized andmaintained in precursor intermediate folding states andproteolysis permits the refolding and energy release required tocreate stable virus-cell linkages and membrane coalescence.Facilitates human SARS coronavirus (SARS-CoV) infection via twoindependent mechanisms, proteolytic cleavage of ACE2, which mightpromote viral uptake, and cleavage of coronavirus spikeglycoprotein which activates the glycoprotein for cathepsin L-independent host cell entry. Proteolytically cleaves and activatesthe spike glycoproteins of human coronavirus 229E (HCoV-229E) andhuman coronavirus EMC (HCoV-EMC) and the fusion glycoproteins F0of Sendai virus (SeV), human metapneumovirus (HMPV), humanparainfluenza 1, 2, 3, 4a and 4b viruses (HPIV). Essential forspread and pathogenesis of influenza A virus (strains H1N1, H3N2and H7N9); involved in proteolytic cleavage and activation ofhemagglutinin (HA) protein which is essential for viralinfectivity. {ECO:0000269|PubMed:21068237,ECO:0000269|PubMed:21325420, ECO:0000269|PubMed:23536651,ECO:0000269|PubMed:23966399, ECO:0000269|PubMed:24027332,ECO:0000269|PubMed:24227843}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for TMPRSS2_ETV1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for TMPRSS2_ETV1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TMPRSS2CLK1ETV1SPI1, MAPK8, MAPK3, MAPK14, MAPKAPK2, EP300, KAT2B, RFWD2, RPS6KA5, NSMCE2, CCND3, NCOA3, NCOA2, JUN, UBE2I, STK40, DET1, TP53, TERT, ATR


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for TMPRSS2_ETV1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for TMPRSS2_ETV1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTMPRSS2C0033578Prostatic Neoplasms2CTD_human
TgeneETV1C0033578Prostatic Neoplasms2CTD_human