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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 38747

FusionGeneSummary for TMPRSS2_EML4

check button Fusion gene summary
Fusion gene informationFusion gene name: TMPRSS2_EML4
Fusion gene ID: 38747
HgeneTgene
Gene symbol

TMPRSS2

EML4

Gene ID

7113

27436

Gene nametransmembrane serine protease 2echinoderm microtubule associated protein like 4
SynonymsPP9284|PRSS10C2orf2|ELP120|EMAP-4|EMAPL4|ROPP120
Cytomap

21q22.3

2p21

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane protease serine 2epitheliasinserine protease 10transmembrane protease, serine 2echinoderm microtubule-associated protein-like 4restrictedly overexpressed proliferation-associated proteinropp 120
Modification date2018052320180523
UniProtAcc

O15393

Q9HC35

Ensembl transtripts involved in fusion geneENST00000332149, ENST00000398585, 
ENST00000458356, ENST00000497881, 
ENST00000318522, ENST00000402711, 
ENST00000482660, ENST00000401738, 
ENST00000453191, 
Fusion gene scores* DoF score29 X 21 X 6=36547 X 9 X 4=252
# samples 2289
** MAII scorelog2(228/3654*10)=-0.680442809575384
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(9/252*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TMPRSS2 [Title/Abstract] AND EML4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTMPRSS2

GO:0006508

proteolysis

21068237|24227843

HgeneTMPRSS2

GO:0046598

positive regulation of viral entry into host cell

21068237|24227843


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDPRADTCGA-XK-AAIV-01ATMPRSS2chr21

42859167

-EML4chr2

42558831

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000332149ENST00000318522TMPRSS2chr21

42859167

-EML4chr2

42558831

+
intron-intronENST00000332149ENST00000402711TMPRSS2chr21

42859167

-EML4chr2

42558831

+
intron-intronENST00000332149ENST00000482660TMPRSS2chr21

42859167

-EML4chr2

42558831

+
intron-intronENST00000332149ENST00000401738TMPRSS2chr21

42859167

-EML4chr2

42558831

+
intron-intronENST00000332149ENST00000453191TMPRSS2chr21

42859167

-EML4chr2

42558831

+
intron-3UTRENST00000398585ENST00000318522TMPRSS2chr21

42859167

-EML4chr2

42558831

+
intron-intronENST00000398585ENST00000402711TMPRSS2chr21

42859167

-EML4chr2

42558831

+
intron-intronENST00000398585ENST00000482660TMPRSS2chr21

42859167

-EML4chr2

42558831

+
intron-intronENST00000398585ENST00000401738TMPRSS2chr21

42859167

-EML4chr2

42558831

+
intron-intronENST00000398585ENST00000453191TMPRSS2chr21

42859167

-EML4chr2

42558831

+
intron-3UTRENST00000458356ENST00000318522TMPRSS2chr21

42859167

-EML4chr2

42558831

+
intron-intronENST00000458356ENST00000402711TMPRSS2chr21

42859167

-EML4chr2

42558831

+
intron-intronENST00000458356ENST00000482660TMPRSS2chr21

42859167

-EML4chr2

42558831

+
intron-intronENST00000458356ENST00000401738TMPRSS2chr21

42859167

-EML4chr2

42558831

+
intron-intronENST00000458356ENST00000453191TMPRSS2chr21

42859167

-EML4chr2

42558831

+
intron-3UTRENST00000497881ENST00000318522TMPRSS2chr21

42859167

-EML4chr2

42558831

+
intron-intronENST00000497881ENST00000402711TMPRSS2chr21

42859167

-EML4chr2

42558831

+
intron-intronENST00000497881ENST00000482660TMPRSS2chr21

42859167

-EML4chr2

42558831

+
intron-intronENST00000497881ENST00000401738TMPRSS2chr21

42859167

-EML4chr2

42558831

+
intron-intronENST00000497881ENST00000453191TMPRSS2chr21

42859167

-EML4chr2

42558831

+

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FusionProtFeatures for TMPRSS2_EML4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TMPRSS2

O15393

EML4

Q9HC35

Serine protease that proteolytically cleaves andactivates the viral spike glycoproteins which facilitate virus-cell membrane fusions; spike proteins are synthesized andmaintained in precursor intermediate folding states andproteolysis permits the refolding and energy release required tocreate stable virus-cell linkages and membrane coalescence.Facilitates human SARS coronavirus (SARS-CoV) infection via twoindependent mechanisms, proteolytic cleavage of ACE2, which mightpromote viral uptake, and cleavage of coronavirus spikeglycoprotein which activates the glycoprotein for cathepsin L-independent host cell entry. Proteolytically cleaves and activatesthe spike glycoproteins of human coronavirus 229E (HCoV-229E) andhuman coronavirus EMC (HCoV-EMC) and the fusion glycoproteins F0of Sendai virus (SeV), human metapneumovirus (HMPV), humanparainfluenza 1, 2, 3, 4a and 4b viruses (HPIV). Essential forspread and pathogenesis of influenza A virus (strains H1N1, H3N2and H7N9); involved in proteolytic cleavage and activation ofhemagglutinin (HA) protein which is essential for viralinfectivity. {ECO:0000269|PubMed:21068237,ECO:0000269|PubMed:21325420, ECO:0000269|PubMed:23536651,ECO:0000269|PubMed:23966399, ECO:0000269|PubMed:24027332,ECO:0000269|PubMed:24227843}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TMPRSS2_EML4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TMPRSS2_EML4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TMPRSS2CLK1EML4NEK6, ARL4D, ARIH2, ELAVL1, EML4, ILK, PRPS1, TUBB2A, TUBB2B, FBXW11, NTRK1, SPICE1, DCTN1, TFEB, NUDC, EML1, FBXO28, TUBB3, CTAGE5, TUBB, TKT, PHKG2, NEK7


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TMPRSS2_EML4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TMPRSS2_EML4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTMPRSS2C0033578Prostatic Neoplasms2CTD_human
TgeneEML4C0007131Non-Small Cell Lung Carcinoma6CTD_human
TgeneEML4C0027627Neoplasm Metastasis2CTD_human
TgeneEML4C0152013Adenocarcinoma of lung (disorder)2CTD_human
TgeneEML4C0006118Brain Neoplasms1CTD_human