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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 3874

FusionGeneSummary for BAZ2B_DMTF1

check button Fusion gene summary
Fusion gene informationFusion gene name: BAZ2B_DMTF1
Fusion gene ID: 3874
HgeneTgene
Gene symbol

BAZ2B

DMTF1

Gene ID

29994

9988

Gene namebromodomain adjacent to zinc finger domain 2Bcyclin D binding myb like transcription factor 1
SynonymsWALp4DMP1|DMTF|MRUL|hDMP1
Cytomap

2q24.2

7q21.12

Type of geneprotein-codingprotein-coding
Descriptionbromodomain adjacent to zinc finger domain protein 2Bcyclin-D-binding Myb-like transcription factor 1cyclin D-binding Myb-like proteincyclin-D-interacting Myb-like protein 1hDMTF1
Modification date2018051920180523
UniProtAcc

Q9UIF8

Q9Y222

Ensembl transtripts involved in fusion geneENST00000355831, ENST00000343439, 
ENST00000392782, ENST00000392783, 
ENST00000483316, 
ENST00000394702, 
ENST00000331242, ENST00000413276, 
ENST00000411766, ENST00000432937, 
ENST00000394703, ENST00000580710, 
ENST00000414194, 
Fusion gene scores* DoF score10 X 10 X 7=7004 X 4 X 3=48
# samples 114
** MAII scorelog2(11/700*10)=-2.66985139830767
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BAZ2B [Title/Abstract] AND DMTF1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DB236588BAZ2Bchr2

160335086

-DMTF1chr7

86792810

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000355831ENST00000394702BAZ2Bchr2

160335086

-DMTF1chr7

86792810

+
5CDS-5UTRENST00000355831ENST00000331242BAZ2Bchr2

160335086

-DMTF1chr7

86792810

+
5CDS-5UTRENST00000355831ENST00000413276BAZ2Bchr2

160335086

-DMTF1chr7

86792810

+
5CDS-5UTRENST00000355831ENST00000411766BAZ2Bchr2

160335086

-DMTF1chr7

86792810

+
5CDS-5UTRENST00000355831ENST00000432937BAZ2Bchr2

160335086

-DMTF1chr7

86792810

+
5CDS-5UTRENST00000355831ENST00000394703BAZ2Bchr2

160335086

-DMTF1chr7

86792810

+
5CDS-3UTRENST00000355831ENST00000580710BAZ2Bchr2

160335086

-DMTF1chr7

86792810

+
5CDS-5UTRENST00000355831ENST00000414194BAZ2Bchr2

160335086

-DMTF1chr7

86792810

+
5CDS-5UTRENST00000343439ENST00000394702BAZ2Bchr2

160335086

-DMTF1chr7

86792810

+
5CDS-5UTRENST00000343439ENST00000331242BAZ2Bchr2

160335086

-DMTF1chr7

86792810

+
5CDS-5UTRENST00000343439ENST00000413276BAZ2Bchr2

160335086

-DMTF1chr7

86792810

+
5CDS-5UTRENST00000343439ENST00000411766BAZ2Bchr2

160335086

-DMTF1chr7

86792810

+
5CDS-5UTRENST00000343439ENST00000432937BAZ2Bchr2

160335086

-DMTF1chr7

86792810

+
5CDS-5UTRENST00000343439ENST00000394703BAZ2Bchr2

160335086

-DMTF1chr7

86792810

+
5CDS-3UTRENST00000343439ENST00000580710BAZ2Bchr2

160335086

-DMTF1chr7

86792810

+
5CDS-5UTRENST00000343439ENST00000414194BAZ2Bchr2

160335086

-DMTF1chr7

86792810

+
5CDS-5UTRENST00000392782ENST00000394702BAZ2Bchr2

160335086

-DMTF1chr7

86792810

+
5CDS-5UTRENST00000392782ENST00000331242BAZ2Bchr2

160335086

-DMTF1chr7

86792810

+
5CDS-5UTRENST00000392782ENST00000413276BAZ2Bchr2

160335086

-DMTF1chr7

86792810

+
5CDS-5UTRENST00000392782ENST00000411766BAZ2Bchr2

160335086

-DMTF1chr7

86792810

+
5CDS-5UTRENST00000392782ENST00000432937BAZ2Bchr2

160335086

-DMTF1chr7

86792810

+
5CDS-5UTRENST00000392782ENST00000394703BAZ2Bchr2

160335086

-DMTF1chr7

86792810

+
5CDS-3UTRENST00000392782ENST00000580710BAZ2Bchr2

160335086

-DMTF1chr7

86792810

+
5CDS-5UTRENST00000392782ENST00000414194BAZ2Bchr2

160335086

-DMTF1chr7

86792810

+
5CDS-5UTRENST00000392783ENST00000394702BAZ2Bchr2

160335086

-DMTF1chr7

86792810

+
5CDS-5UTRENST00000392783ENST00000331242BAZ2Bchr2

160335086

-DMTF1chr7

86792810

+
5CDS-5UTRENST00000392783ENST00000413276BAZ2Bchr2

160335086

-DMTF1chr7

86792810

+
5CDS-5UTRENST00000392783ENST00000411766BAZ2Bchr2

160335086

-DMTF1chr7

86792810

+
5CDS-5UTRENST00000392783ENST00000432937BAZ2Bchr2

160335086

-DMTF1chr7

86792810

+
5CDS-5UTRENST00000392783ENST00000394703BAZ2Bchr2

160335086

-DMTF1chr7

86792810

+
5CDS-3UTRENST00000392783ENST00000580710BAZ2Bchr2

160335086

-DMTF1chr7

86792810

+
5CDS-5UTRENST00000392783ENST00000414194BAZ2Bchr2

160335086

-DMTF1chr7

86792810

+
5UTR-5UTRENST00000483316ENST00000394702BAZ2Bchr2

160335086

-DMTF1chr7

86792810

+
5UTR-5UTRENST00000483316ENST00000331242BAZ2Bchr2

160335086

-DMTF1chr7

86792810

+
5UTR-5UTRENST00000483316ENST00000413276BAZ2Bchr2

160335086

-DMTF1chr7

86792810

+
5UTR-5UTRENST00000483316ENST00000411766BAZ2Bchr2

160335086

-DMTF1chr7

86792810

+
5UTR-5UTRENST00000483316ENST00000432937BAZ2Bchr2

160335086

-DMTF1chr7

86792810

+
5UTR-5UTRENST00000483316ENST00000394703BAZ2Bchr2

160335086

-DMTF1chr7

86792810

+
5UTR-3UTRENST00000483316ENST00000580710BAZ2Bchr2

160335086

-DMTF1chr7

86792810

+
5UTR-5UTRENST00000483316ENST00000414194BAZ2Bchr2

160335086

-DMTF1chr7

86792810

+

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FusionProtFeatures for BAZ2B_DMTF1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BAZ2B

Q9UIF8

DMTF1

Q9Y222

May play a role in transcriptional regulationinteracting with ISWI.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for BAZ2B_DMTF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for BAZ2B_DMTF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
BAZ2BCTBP2, ELAVL1, PRNP, SOX2, ZBTB14, FXR2, STAC3, ZBTB8A, TRIM23, HDGFRP3, INADMTF1TP53, SRA1, DNMT3L, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for BAZ2B_DMTF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for BAZ2B_DMTF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource