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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 38713

FusionGeneSummary for TMEM9B_NPIPB7

check button Fusion gene summary
Fusion gene informationFusion gene name: TMEM9B_NPIPB7
Fusion gene ID: 38713
HgeneTgene
Gene symbol

TMEM9B

NPIPB7

Gene ID

56674

440350

Gene nameTMEM9 domain family member Bnuclear pore complex interacting protein family member B7
SynonymsC11orf15A-575C2.4|A-761H5.5|NPIPL1
Cytomap

11p15.4

16p12.1

Type of geneprotein-codingpseudo
Descriptiontransmembrane protein 9Bnuclear pore complex-interacting protein-like 1
Modification date2018052220180329
UniProtAcc

Q9NQ34

O75200

Ensembl transtripts involved in fusion geneENST00000309134, ENST00000534025, 
ENST00000525069, ENST00000528117, 
ENST00000452313, 
Fusion gene scores* DoF score4 X 4 X 3=4816 X 18 X 1=288
# samples 519
** MAII scorelog2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(19/288*10)=-0.600069393111365
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TMEM9B [Title/Abstract] AND NPIPB7 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA115561TMEM9Bchr11

8969555

-NPIPB7chr16

28975467

+
ChiTaRS3.1AA150513TMEM9Bchr11

8969555

-NPIPB7chr16

28975467

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000309134ENST00000452313TMEM9Bchr11

8969555

-NPIPB7chr16

28975467

+
intron-intronENST00000534025ENST00000452313TMEM9Bchr11

8969555

-NPIPB7chr16

28975467

+
intron-intronENST00000525069ENST00000452313TMEM9Bchr11

8969555

-NPIPB7chr16

28975467

+
intron-intronENST00000528117ENST00000452313TMEM9Bchr11

8969555

-NPIPB7chr16

28975467

+

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FusionProtFeatures for TMEM9B_NPIPB7


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TMEM9B

Q9NQ34

NPIPB7

O75200

Enhances production of proinflammatory cytokines inducedby TNF, IL1B, and TLR ligands. Has a role in TNF activation ofboth the NF-kappaB and MAPK pathways.{ECO:0000269|PubMed:18541524}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TMEM9B_NPIPB7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TMEM9B_NPIPB7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TMEM9B_NPIPB7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TMEM9B_NPIPB7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource