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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 38697

FusionGeneSummary for TMEM87B_SLC1A3

check button Fusion gene summary
Fusion gene informationFusion gene name: TMEM87B_SLC1A3
Fusion gene ID: 38697
HgeneTgene
Gene symbol

TMEM87B

SLC1A3

Gene ID

84910

6507

Gene nametransmembrane protein 87Bsolute carrier family 1 member 3
Synonyms-EA6|EAAT1|GLAST|GLAST1
Cytomap

2q13

5p13.2

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane protein 87Bexcitatory amino acid transporter 1GLAST-1sodium-dependent glutamate/aspartate transporter 1solute carrier family 1 (glial high affinity glutamate transporter), member 3
Modification date2018051920180519
UniProtAcc

Q96K49

P43003

Ensembl transtripts involved in fusion geneENST00000283206, ENST00000463427, 
ENST00000265113, ENST00000506725, 
ENST00000381918, 
Fusion gene scores* DoF score4 X 7 X 9=25210 X 9 X 6=540
# samples 1212
** MAII scorelog2(12/252*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(12/540*10)=-2.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TMEM87B [Title/Abstract] AND SLC1A3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSLC1A3

GO:0015813

L-glutamate transmembrane transport

26690923

TgeneSLC1A3

GO:0051938

L-glutamate import

7521911

TgeneSLC1A3

GO:0070779

D-aspartate import across plasma membrane

7521911

TgeneSLC1A3

GO:0071805

potassium ion transmembrane transport

20477940

TgeneSLC1A3

GO:0098712

L-glutamate import across plasma membrane

26690923

TgeneSLC1A3

GO:0140009

L-aspartate import across plasma membrane

20477940

TgeneSLC1A3

GO:1902476

chloride transmembrane transport

20477940


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF368084TMEM87Bchr2

112854699

-SLC1A3chr5

36660079

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000283206ENST00000265113TMEM87Bchr2

112854699

-SLC1A3chr5

36660079

-
5CDS-intronENST00000283206ENST00000506725TMEM87Bchr2

112854699

-SLC1A3chr5

36660079

-
5CDS-intronENST00000283206ENST00000381918TMEM87Bchr2

112854699

-SLC1A3chr5

36660079

-
3UTR-intronENST00000463427ENST00000265113TMEM87Bchr2

112854699

-SLC1A3chr5

36660079

-
3UTR-intronENST00000463427ENST00000506725TMEM87Bchr2

112854699

-SLC1A3chr5

36660079

-
3UTR-intronENST00000463427ENST00000381918TMEM87Bchr2

112854699

-SLC1A3chr5

36660079

-

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FusionProtFeatures for TMEM87B_SLC1A3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TMEM87B

Q96K49

SLC1A3

P43003

May be involved in retrograde transport from endosomesto the trans-Golgi network (TGN). {ECO:0000269|PubMed:26157166}. Sodium-dependent, high-affinity amino acid transporterthat mediates the uptake of L-glutamate and also L-aspartate andD-aspartate (PubMed:7521911, PubMed:8123008, PubMed:20477940,PubMed:26690923, PubMed:28032905, PubMed:28424515). Functions as asymporter that transports one amino acid molecule together withtwo or three Na(+) ions and one proton, in parallel with thecounter-transport of one K(+) ion (PubMed:20477940). MediatesCl(-) flux that is not coupled to amino acid transport; thisavoids the accumulation of negative charges due to aspartate andNa(+) symport (PubMed:20477940). Plays a redundant role in therapid removal of released glutamate from the synaptic cleft, whichis essential for terminating the postsynaptic action of glutamate(By similarity). {ECO:0000250|UniProtKB:P56564,ECO:0000269|PubMed:20477940, ECO:0000269|PubMed:26690923,ECO:0000269|PubMed:28032905, ECO:0000269|PubMed:28424515,ECO:0000269|PubMed:7521911, ECO:0000269|PubMed:8123008}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TMEM87B_SLC1A3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TMEM87B_SLC1A3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TMEM87B_SLC1A3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneSLC1A3P43003DB00142Glutamic AcidExcitatory amino acid transporter 1 {ECO:0000303|PubMed:16042756, ECO:0000303|PubMed:8647279}small moleculeapproved|nutraceutical

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RelatedDiseases for TMEM87B_SLC1A3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSLC1A3C0036341Schizophrenia4PSYGENET
TgeneSLC1A3C0004352Autistic Disorder1CTD_human
TgeneSLC1A3C0005586Bipolar Disorder1PSYGENET
TgeneSLC1A3C0014544Epilepsy1CTD_human;HPO
TgeneSLC1A3C0178417Anhedonia1PSYGENET
TgeneSLC1A3C2675211EPISODIC ATAXIA, TYPE 6 (disorder)1CTD_human;ORPHANET;UNIPROT