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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 3869

FusionGeneSummary for BAZ2A_ERGIC3

check button Fusion gene summary
Fusion gene informationFusion gene name: BAZ2A_ERGIC3
Fusion gene ID: 3869
HgeneTgene
Gene symbol

BAZ2A

ERGIC3

Gene ID

11176

51614

Gene namebromodomain adjacent to zinc finger domain 2AERGIC and golgi 3
SynonymsTIP5|WALp3C20orf47|C2orf47|CGI-54|Erv46|NY-BR-84|PRO0989|SDBCAG84|dJ477O4.2
Cytomap

12q13.3

20q11.22

Type of geneprotein-codingprotein-coding
Descriptionbromodomain adjacent to zinc finger domain protein 2ATTF-I interacting peptide 5TTF-I-interacting protein 5transcription termination factor I-interacting protein 5endoplasmic reticulum-Golgi intermediate compartment protein 3endoplasmic reticulum-localized protein ERp43serologically defined breast cancer antigen 84serologically defined breast cancer antigen NY-BR-84
Modification date2018051920180523
UniProtAcc

Q9UIF9

Q9Y282

Ensembl transtripts involved in fusion geneENST00000379441, ENST00000179765, 
ENST00000551812, ENST00000549884, 
ENST00000553222, 
ENST00000348547, 
ENST00000357394, ENST00000279052, 
ENST00000447986, ENST00000482338, 
Fusion gene scores* DoF score10 X 11 X 6=6606 X 6 X 3=108
# samples 128
** MAII scorelog2(12/660*10)=-2.4594316186373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/108*10)=-0.432959407276106
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BAZ2A [Title/Abstract] AND ERGIC3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW380796BAZ2Achr12

56993542

+ERGIC3chr20

34130484

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000379441ENST00000348547BAZ2Achr12

56993542

+ERGIC3chr20

34130484

-
intron-intronENST00000379441ENST00000357394BAZ2Achr12

56993542

+ERGIC3chr20

34130484

-
intron-intronENST00000379441ENST00000279052BAZ2Achr12

56993542

+ERGIC3chr20

34130484

-
intron-intronENST00000379441ENST00000447986BAZ2Achr12

56993542

+ERGIC3chr20

34130484

-
intron-intronENST00000379441ENST00000482338BAZ2Achr12

56993542

+ERGIC3chr20

34130484

-
intron-intronENST00000179765ENST00000348547BAZ2Achr12

56993542

+ERGIC3chr20

34130484

-
intron-intronENST00000179765ENST00000357394BAZ2Achr12

56993542

+ERGIC3chr20

34130484

-
intron-intronENST00000179765ENST00000279052BAZ2Achr12

56993542

+ERGIC3chr20

34130484

-
intron-intronENST00000179765ENST00000447986BAZ2Achr12

56993542

+ERGIC3chr20

34130484

-
intron-intronENST00000179765ENST00000482338BAZ2Achr12

56993542

+ERGIC3chr20

34130484

-
intron-intronENST00000551812ENST00000348547BAZ2Achr12

56993542

+ERGIC3chr20

34130484

-
intron-intronENST00000551812ENST00000357394BAZ2Achr12

56993542

+ERGIC3chr20

34130484

-
intron-intronENST00000551812ENST00000279052BAZ2Achr12

56993542

+ERGIC3chr20

34130484

-
intron-intronENST00000551812ENST00000447986BAZ2Achr12

56993542

+ERGIC3chr20

34130484

-
intron-intronENST00000551812ENST00000482338BAZ2Achr12

56993542

+ERGIC3chr20

34130484

-
intron-intronENST00000549884ENST00000348547BAZ2Achr12

56993542

+ERGIC3chr20

34130484

-
intron-intronENST00000549884ENST00000357394BAZ2Achr12

56993542

+ERGIC3chr20

34130484

-
intron-intronENST00000549884ENST00000279052BAZ2Achr12

56993542

+ERGIC3chr20

34130484

-
intron-intronENST00000549884ENST00000447986BAZ2Achr12

56993542

+ERGIC3chr20

34130484

-
intron-intronENST00000549884ENST00000482338BAZ2Achr12

56993542

+ERGIC3chr20

34130484

-
intron-intronENST00000553222ENST00000348547BAZ2Achr12

56993542

+ERGIC3chr20

34130484

-
intron-intronENST00000553222ENST00000357394BAZ2Achr12

56993542

+ERGIC3chr20

34130484

-
intron-intronENST00000553222ENST00000279052BAZ2Achr12

56993542

+ERGIC3chr20

34130484

-
intron-intronENST00000553222ENST00000447986BAZ2Achr12

56993542

+ERGIC3chr20

34130484

-
intron-intronENST00000553222ENST00000482338BAZ2Achr12

56993542

+ERGIC3chr20

34130484

-

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FusionProtFeatures for BAZ2A_ERGIC3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BAZ2A

Q9UIF9

ERGIC3

Q9Y282

Essential component of the NoRC (nucleolar remodelingcomplex) complex, a complex that mediates silencing of a fractionof rDNA by recruiting histone-modifying enzymes and DNAmethyltransferases, leading to heterochromatin formation andtranscriptional silencing. In the complex, it plays a central roleby being recruited to rDNA and by targeting chromatin modifyingenzymes such as HDAC1, leading to repress RNA polymerase Itranscription. Recruited to rDNA via its interaction with TTF1 andits ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12acbut not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAsthat are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNAsilencing (By similarity). {ECO:0000250}. Possible role in transport between endoplasmic reticulumand Golgi. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for BAZ2A_ERGIC3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for BAZ2A_ERGIC3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for BAZ2A_ERGIC3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for BAZ2A_ERGIC3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneBAZ2AC0033578Prostatic Neoplasms1CTD_human