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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 38687

FusionGeneSummary for TMEM68_ZNF821

check button Fusion gene summary
Fusion gene informationFusion gene name: TMEM68_ZNF821
Fusion gene ID: 38687
HgeneTgene
Gene symbol

TMEM68

ZNF821

Gene ID

137695

55565

Gene nametransmembrane protein 68zinc finger protein 821
Synonyms--
Cytomap

8q12.1

16q22.2

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane protein 68zinc finger protein 821
Modification date2018052320180523
UniProtAcc

Q96MH6

O75541

Ensembl transtripts involved in fusion geneENST00000434581, ENST00000334667, 
ENST00000519784, ENST00000523073, 
ENST00000521229, ENST00000522576, 
ENST00000446827, ENST00000425432, 
ENST00000313565, ENST00000564134, 
ENST00000565601, ENST00000564943, 
Fusion gene scores* DoF score4 X 4 X 2=322 X 2 X 1=4
# samples 42
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(2/4*10)=2.32192809488736
Context

PubMed: TMEM68 [Title/Abstract] AND ZNF821 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-KK-A8IM-01ATMEM68chr8

56685828

-ZNF821chr16

71913926

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-5UTRENST00000434581ENST00000446827TMEM68chr8

56685828

-ZNF821chr16

71913926

-
5UTR-5UTRENST00000434581ENST00000425432TMEM68chr8

56685828

-ZNF821chr16

71913926

-
5UTR-5UTRENST00000434581ENST00000313565TMEM68chr8

56685828

-ZNF821chr16

71913926

-
5UTR-5UTRENST00000434581ENST00000564134TMEM68chr8

56685828

-ZNF821chr16

71913926

-
5UTR-5UTRENST00000434581ENST00000565601TMEM68chr8

56685828

-ZNF821chr16

71913926

-
5UTR-5UTRENST00000434581ENST00000564943TMEM68chr8

56685828

-ZNF821chr16

71913926

-
5UTR-5UTRENST00000334667ENST00000446827TMEM68chr8

56685828

-ZNF821chr16

71913926

-
5UTR-5UTRENST00000334667ENST00000425432TMEM68chr8

56685828

-ZNF821chr16

71913926

-
5UTR-5UTRENST00000334667ENST00000313565TMEM68chr8

56685828

-ZNF821chr16

71913926

-
5UTR-5UTRENST00000334667ENST00000564134TMEM68chr8

56685828

-ZNF821chr16

71913926

-
5UTR-5UTRENST00000334667ENST00000565601TMEM68chr8

56685828

-ZNF821chr16

71913926

-
5UTR-5UTRENST00000334667ENST00000564943TMEM68chr8

56685828

-ZNF821chr16

71913926

-
5UTR-5UTRENST00000519784ENST00000446827TMEM68chr8

56685828

-ZNF821chr16

71913926

-
5UTR-5UTRENST00000519784ENST00000425432TMEM68chr8

56685828

-ZNF821chr16

71913926

-
5UTR-5UTRENST00000519784ENST00000313565TMEM68chr8

56685828

-ZNF821chr16

71913926

-
5UTR-5UTRENST00000519784ENST00000564134TMEM68chr8

56685828

-ZNF821chr16

71913926

-
5UTR-5UTRENST00000519784ENST00000565601TMEM68chr8

56685828

-ZNF821chr16

71913926

-
5UTR-5UTRENST00000519784ENST00000564943TMEM68chr8

56685828

-ZNF821chr16

71913926

-
5UTR-5UTRENST00000523073ENST00000446827TMEM68chr8

56685828

-ZNF821chr16

71913926

-
5UTR-5UTRENST00000523073ENST00000425432TMEM68chr8

56685828

-ZNF821chr16

71913926

-
5UTR-5UTRENST00000523073ENST00000313565TMEM68chr8

56685828

-ZNF821chr16

71913926

-
5UTR-5UTRENST00000523073ENST00000564134TMEM68chr8

56685828

-ZNF821chr16

71913926

-
5UTR-5UTRENST00000523073ENST00000565601TMEM68chr8

56685828

-ZNF821chr16

71913926

-
5UTR-5UTRENST00000523073ENST00000564943TMEM68chr8

56685828

-ZNF821chr16

71913926

-
5UTR-5UTRENST00000521229ENST00000446827TMEM68chr8

56685828

-ZNF821chr16

71913926

-
5UTR-5UTRENST00000521229ENST00000425432TMEM68chr8

56685828

-ZNF821chr16

71913926

-
5UTR-5UTRENST00000521229ENST00000313565TMEM68chr8

56685828

-ZNF821chr16

71913926

-
5UTR-5UTRENST00000521229ENST00000564134TMEM68chr8

56685828

-ZNF821chr16

71913926

-
5UTR-5UTRENST00000521229ENST00000565601TMEM68chr8

56685828

-ZNF821chr16

71913926

-
5UTR-5UTRENST00000521229ENST00000564943TMEM68chr8

56685828

-ZNF821chr16

71913926

-
intron-5UTRENST00000522576ENST00000446827TMEM68chr8

56685828

-ZNF821chr16

71913926

-
intron-5UTRENST00000522576ENST00000425432TMEM68chr8

56685828

-ZNF821chr16

71913926

-
intron-5UTRENST00000522576ENST00000313565TMEM68chr8

56685828

-ZNF821chr16

71913926

-
intron-5UTRENST00000522576ENST00000564134TMEM68chr8

56685828

-ZNF821chr16

71913926

-
intron-5UTRENST00000522576ENST00000565601TMEM68chr8

56685828

-ZNF821chr16

71913926

-
intron-5UTRENST00000522576ENST00000564943TMEM68chr8

56685828

-ZNF821chr16

71913926

-

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FusionProtFeatures for TMEM68_ZNF821


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TMEM68

Q96MH6

ZNF821

O75541

May be involved in transcriptional regulation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TMEM68_ZNF821


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TMEM68_ZNF821


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TMEM68ELAVL1, LYPD6, REEP5, GPR114, C3AR1, ZNRF4, RTN4, TMEM206, CLEC2DZNF821CCDC85B, LURAP1, PIM2, CDCA7L, ATM


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TMEM68_ZNF821


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TMEM68_ZNF821


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource