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Fusion gene ID: 38678 |
FusionGeneSummary for TMEM64_NECAB1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TMEM64_NECAB1 | Fusion gene ID: 38678 | Hgene | Tgene | Gene symbol | TMEM64 | NECAB1 | Gene ID | 169200 | 64168 |
| Gene name | transmembrane protein 64 | N-terminal EF-hand calcium binding protein 1 | |
| Synonyms | - | EFCBP1|STIP-1 | |
| Cytomap | 8q21.3 | 8q21.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | transmembrane protein 64 | N-terminal EF-hand calcium-binding protein 1EF-hand calcium-binding protein 1neuronal calcium binding proteinneuronal calcium-binding protein 1synaptotagmin interacting protein 1 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q6YI46 | Q8N987 | |
| Ensembl transtripts involved in fusion gene | ENST00000519519, ENST00000418210, ENST00000458549, ENST00000523902, | ENST00000417640, ENST00000521954, ENST00000522820, ENST00000521366, | |
| Fusion gene scores | * DoF score | 5 X 3 X 3=45 | 4 X 2 X 2=16 |
| # samples | 4 | 4 | |
| ** MAII score | log2(4/45*10)=-0.169925001442312 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/16*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: TMEM64 [Title/Abstract] AND NECAB1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-A2-A0CZ-01A | TMEM64 | chr8 | 91657339 | - | NECAB1 | chr8 | 91813919 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000519519 | ENST00000417640 | TMEM64 | chr8 | 91657339 | - | NECAB1 | chr8 | 91813919 | + |
| intron-3UTR | ENST00000519519 | ENST00000521954 | TMEM64 | chr8 | 91657339 | - | NECAB1 | chr8 | 91813919 | + |
| intron-intron | ENST00000519519 | ENST00000522820 | TMEM64 | chr8 | 91657339 | - | NECAB1 | chr8 | 91813919 | + |
| intron-intron | ENST00000519519 | ENST00000521366 | TMEM64 | chr8 | 91657339 | - | NECAB1 | chr8 | 91813919 | + |
| In-frame | ENST00000418210 | ENST00000417640 | TMEM64 | chr8 | 91657339 | - | NECAB1 | chr8 | 91813919 | + |
| 5CDS-3UTR | ENST00000418210 | ENST00000521954 | TMEM64 | chr8 | 91657339 | - | NECAB1 | chr8 | 91813919 | + |
| 5CDS-intron | ENST00000418210 | ENST00000522820 | TMEM64 | chr8 | 91657339 | - | NECAB1 | chr8 | 91813919 | + |
| 5CDS-intron | ENST00000418210 | ENST00000521366 | TMEM64 | chr8 | 91657339 | - | NECAB1 | chr8 | 91813919 | + |
| In-frame | ENST00000458549 | ENST00000417640 | TMEM64 | chr8 | 91657339 | - | NECAB1 | chr8 | 91813919 | + |
| 5CDS-3UTR | ENST00000458549 | ENST00000521954 | TMEM64 | chr8 | 91657339 | - | NECAB1 | chr8 | 91813919 | + |
| 5CDS-intron | ENST00000458549 | ENST00000522820 | TMEM64 | chr8 | 91657339 | - | NECAB1 | chr8 | 91813919 | + |
| 5CDS-intron | ENST00000458549 | ENST00000521366 | TMEM64 | chr8 | 91657339 | - | NECAB1 | chr8 | 91813919 | + |
| intron-3CDS | ENST00000523902 | ENST00000417640 | TMEM64 | chr8 | 91657339 | - | NECAB1 | chr8 | 91813919 | + |
| intron-3UTR | ENST00000523902 | ENST00000521954 | TMEM64 | chr8 | 91657339 | - | NECAB1 | chr8 | 91813919 | + |
| intron-intron | ENST00000523902 | ENST00000522820 | TMEM64 | chr8 | 91657339 | - | NECAB1 | chr8 | 91813919 | + |
| intron-intron | ENST00000523902 | ENST00000521366 | TMEM64 | chr8 | 91657339 | - | NECAB1 | chr8 | 91813919 | + |
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FusionProtFeatures for TMEM64_NECAB1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TMEM64 | NECAB1 |
| Positively regulates TNFSF11-induced osteoclastdifferentiation. Acts as a regulator of TNFSF11-mediated Ca(2+)signaling pathways via its interaction with SERCA2 which iscritical for the TNFSF11-induced CREB1 activation andmitochondrial ROS generation necessary for proper osteoclastgeneration. Association between TMEM64 and SERCA2 in the ER leadsto cytosolic Ca (2+) spiking for activation of NFATC1 andproduction of mitochondrial ROS, thereby triggering Ca (2+)signaling cascades that promote osteoclast differentiation andactivation. Negatively regulates osteoblast differentiation andpositively regulates adipocyte differentiation via modulation ofthe canonical Wnt signaling pathway. Mediates the switch inlineage commitment to osteogenesis rather than to adipogenesis inmesenchymal stem cells by negatively regulating the expression,activity and nuclear localization of CTNNB1.{ECO:0000250|UniProtKB:Q3U145}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TMEM64_NECAB1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_TMEM64_ENST00000418210_chr8_91657339_-_NECAB1_ENST00000417640_chr8_91813919_+_584aa MRSPGGILLQALPRLLQHAALPGLAELPARWALPRGAGGDGPADRLPRGGGASAAAAAAAASGALLGAYLERHGPPEASELPEPGGALAG GPGSGGGGVVVGVAEVRNWRCCCLGSTCWCRSLVLVCVLAALCFASLALVRRYLHHLLLWVESLDSLLGVLLFVVGFIVVSFPCGWGYIV LNVAAGYLYGFVLGMGLMMVGVLIGTFIAHVVCKRLLTAWVAARIQSSEKLSAVIRVVEGGSGLKVVALARLTPIPFGLQNAVFSILRRA DKNDDGKLSFEEFKAYFADGVLSGEELHELFHTIDTHNTNNLDTEELCEYFSQHLGEYENVLAALEDLNLSILKAMGKTKKDYQEASNLE QFVTRFLLKETLNQLQSLQNSLECAMETTEEQTRQERQGPAKPEVLSIQWPGKRSSRRVQRHNSFSPNSPQFNVSGPGLLEEDNQWMTQI NRLQKLIDRLEKKDLKLEPPEEEIIEGNTKSHIMLVQRQMSVIEEDLEEFQLALKHYVESASSQSGCLRISIQKLSNESRYMIYEFWENS >In-frame_TMEM64_ENST00000458549_chr8_91657339_-_NECAB1_ENST00000417640_chr8_91813919_+_584aa MRSPGGILLQALPRLLQHAALPGLAELPARWALPRGAGGDGPADRLPRGGGASAAAAAAAASGALLGAYLERHGPPEASELPEPGGALAG GPGSGGGGVVVGVAEVRNWRCCCLGSTCWCRSLVLVCVLAALCFASLALVRRYLHHLLLWVESLDSLLGVLLFVVGFIVVSFPCGWGYIV LNVAAGYLYGFVLGMGLMMVGVLIGTFIAHVVCKRLLTAWVAARIQSSEKLSAVIRVVEGGSGLKVVALARLTPIPFGLQNAVFSILRRA DKNDDGKLSFEEFKAYFADGVLSGEELHELFHTIDTHNTNNLDTEELCEYFSQHLGEYENVLAALEDLNLSILKAMGKTKKDYQEASNLE QFVTRFLLKETLNQLQSLQNSLECAMETTEEQTRQERQGPAKPEVLSIQWPGKRSSRRVQRHNSFSPNSPQFNVSGPGLLEEDNQWMTQI NRLQKLIDRLEKKDLKLEPPEEEIIEGNTKSHIMLVQRQMSVIEEDLEEFQLALKHYVESASSQSGCLRISIQKLSNESRYMIYEFWENS |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_TMEM64_ENST00000418210_chr8_91657339_-_NECAB1_ENST00000417640_chr8_91813919_+_1752nt ATGCGGAGCCCGGGCGGGATCCTGCTCCAGGCGCTGCCCCGGCTGCTGCAGCACGCCGCCCTCCCGGGCCTCGCCGAGCTGCCGGCCCGC TGGGCCCTGCCGCGGGGTGCGGGCGGGGACGGCCCGGCGGACCGCCTTCCCCGCGGGGGCGGGGCGAGCGCGGCGGCGGCAGCAGCGGCG GCCTCGGGCGCCCTGCTCGGCGCCTATCTGGAGCGCCACGGTCCGCCCGAGGCTTCGGAGCTGCCGGAGCCGGGCGGGGCCTTGGCGGGC GGCCCCGGGAGTGGCGGCGGCGGCGTGGTGGTCGGCGTGGCTGAGGTGAGAAACTGGCGCTGCTGCTGCCTCGGCAGCACCTGTTGGTGC CGGAGCCTCGTGCTGGTCTGCGTGTTGGCCGCCCTGTGCTTCGCTTCCCTGGCCCTGGTCCGCCGCTACCTTCACCACCTCCTGCTGTGG GTGGAGAGCCTTGACTCGCTGCTGGGGGTCCTGCTCTTCGTCGTGGGCTTCATCGTGGTCTCTTTCCCCTGCGGCTGGGGCTACATCGTG CTCAACGTGGCCGCTGGCTACCTGTACGGCTTCGTGCTGGGCATGGGTCTGATGATGGTGGGCGTCCTCATCGGCACCTTCATCGCCCAT GTGGTCTGCAAGCGGCTCCTCACCGCCTGGGTGGCCGCCAGGATCCAGAGCAGCGAGAAGCTGAGCGCGGTTATTCGCGTAGTGGAGGGA GGAAGCGGCCTGAAAGTGGTGGCGCTGGCCAGACTGACACCCATACCTTTTGGGCTTCAGAATGCAGTGTTTTCGATACTGAGGAGAGCA GACAAAAATGATGATGGAAAATTATCCTTTGAAGAATTCAAAGCATATTTTGCAGATGGTGTTCTCAGTGGAGAAGAATTACACGAGCTT TTCCATACCATTGATACACATAATACTAATAATCTTGACACAGAAGAGCTATGTGAATATTTTTCTCAGCACTTGGGCGAGTATGAGAAT GTACTAGCAGCACTTGAAGACCTGAATCTTTCCATCCTGAAGGCAATGGGCAAAACAAAGAAAGACTACCAAGAAGCCTCCAATTTGGAA CAATTCGTAACTAGATTTTTATTGAAGGAAACCCTGAATCAGCTGCAGTCTCTCCAGAATTCCCTGGAATGTGCCATGGAAACTACTGAG GAGCAAACCCGTCAAGAAAGGCAAGGGCCAGCCAAGCCAGAAGTCCTGTCGATTCAATGGCCTGGAAAACGATCAAGCCGCCGAGTCCAG AGACACAACAGCTTCTCCCCAAACAGCCCTCAGTTTAATGTCAGCGGTCCAGGCTTATTAGAAGAAGACAACCAGTGGATGACCCAGATA AATAGACTCCAGAAATTAATTGATAGACTGGAAAAGAAGGATCTCAAACTCGAACCACCAGAAGAAGAAATTATTGAAGGGAATACTAAA TCTCACATCATGCTTGTGCAGCGGCAGATGTCTGTGATAGAAGAGGACCTGGAAGAATTCCAGCTCGCTCTGAAACACTACGTGGAGAGT GCTTCCTCCCAAAGTGGATGCTTGCGTATTTCTATACAGAAGCTTTCAAATGAATCTCGCTACATGATCTATGAGTTCTGGGAGAATAGT AGTGTATGGAATAGCCACCTTCAGACAAATTATAGCAAGACATTCCAAAGAAGTAATGTGGATTTCTTGGAAACTCCAGAACTCACATCT >In-frame_TMEM64_ENST00000458549_chr8_91657339_-_NECAB1_ENST00000417640_chr8_91813919_+_1752nt ATGCGGAGCCCGGGCGGGATCCTGCTCCAGGCGCTGCCCCGGCTGCTGCAGCACGCCGCCCTCCCGGGCCTCGCCGAGCTGCCGGCCCGC TGGGCCCTGCCGCGGGGTGCGGGCGGGGACGGCCCGGCGGACCGCCTTCCCCGCGGGGGCGGGGCGAGCGCGGCGGCGGCAGCAGCGGCG GCCTCGGGCGCCCTGCTCGGCGCCTATCTGGAGCGCCACGGTCCGCCCGAGGCTTCGGAGCTGCCGGAGCCGGGCGGGGCCTTGGCGGGC GGCCCCGGGAGTGGCGGCGGCGGCGTGGTGGTCGGCGTGGCTGAGGTGAGAAACTGGCGCTGCTGCTGCCTCGGCAGCACCTGTTGGTGC CGGAGCCTCGTGCTGGTCTGCGTGTTGGCCGCCCTGTGCTTCGCTTCCCTGGCCCTGGTCCGCCGCTACCTTCACCACCTCCTGCTGTGG GTGGAGAGCCTTGACTCGCTGCTGGGGGTCCTGCTCTTCGTCGTGGGCTTCATCGTGGTCTCTTTCCCCTGCGGCTGGGGCTACATCGTG CTCAACGTGGCCGCTGGCTACCTGTACGGCTTCGTGCTGGGCATGGGTCTGATGATGGTGGGCGTCCTCATCGGCACCTTCATCGCCCAT GTGGTCTGCAAGCGGCTCCTCACCGCCTGGGTGGCCGCCAGGATCCAGAGCAGCGAGAAGCTGAGCGCGGTTATTCGCGTAGTGGAGGGA GGAAGCGGCCTGAAAGTGGTGGCGCTGGCCAGACTGACACCCATACCTTTTGGGCTTCAGAATGCAGTGTTTTCGATACTGAGGAGAGCA GACAAAAATGATGATGGAAAATTATCCTTTGAAGAATTCAAAGCATATTTTGCAGATGGTGTTCTCAGTGGAGAAGAATTACACGAGCTT TTCCATACCATTGATACACATAATACTAATAATCTTGACACAGAAGAGCTATGTGAATATTTTTCTCAGCACTTGGGCGAGTATGAGAAT GTACTAGCAGCACTTGAAGACCTGAATCTTTCCATCCTGAAGGCAATGGGCAAAACAAAGAAAGACTACCAAGAAGCCTCCAATTTGGAA CAATTCGTAACTAGATTTTTATTGAAGGAAACCCTGAATCAGCTGCAGTCTCTCCAGAATTCCCTGGAATGTGCCATGGAAACTACTGAG GAGCAAACCCGTCAAGAAAGGCAAGGGCCAGCCAAGCCAGAAGTCCTGTCGATTCAATGGCCTGGAAAACGATCAAGCCGCCGAGTCCAG AGACACAACAGCTTCTCCCCAAACAGCCCTCAGTTTAATGTCAGCGGTCCAGGCTTATTAGAAGAAGACAACCAGTGGATGACCCAGATA AATAGACTCCAGAAATTAATTGATAGACTGGAAAAGAAGGATCTCAAACTCGAACCACCAGAAGAAGAAATTATTGAAGGGAATACTAAA TCTCACATCATGCTTGTGCAGCGGCAGATGTCTGTGATAGAAGAGGACCTGGAAGAATTCCAGCTCGCTCTGAAACACTACGTGGAGAGT GCTTCCTCCCAAAGTGGATGCTTGCGTATTTCTATACAGAAGCTTTCAAATGAATCTCGCTACATGATCTATGAGTTCTGGGAGAATAGT AGTGTATGGAATAGCCACCTTCAGACAAATTATAGCAAGACATTCCAAAGAAGTAATGTGGATTTCTTGGAAACTCCAGAACTCACATCT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_TMEM64_ENST00000418210_chr8_91657339_-_NECAB1_ENST00000417640_chr8_91813919_+_5648nt ATGCGGAGCCCGGGCGGGATCCTGCTCCAGGCGCTGCCCCGGCTGCTGCAGCACGCCGCCCTCCCGGGCCTCGCCGAGCTGCCGGCCCGC TGGGCCCTGCCGCGGGGTGCGGGCGGGGACGGCCCGGCGGACCGCCTTCCCCGCGGGGGCGGGGCGAGCGCGGCGGCGGCAGCAGCGGCG GCCTCGGGCGCCCTGCTCGGCGCCTATCTGGAGCGCCACGGTCCGCCCGAGGCTTCGGAGCTGCCGGAGCCGGGCGGGGCCTTGGCGGGC GGCCCCGGGAGTGGCGGCGGCGGCGTGGTGGTCGGCGTGGCTGAGGTGAGAAACTGGCGCTGCTGCTGCCTCGGCAGCACCTGTTGGTGC CGGAGCCTCGTGCTGGTCTGCGTGTTGGCCGCCCTGTGCTTCGCTTCCCTGGCCCTGGTCCGCCGCTACCTTCACCACCTCCTGCTGTGG GTGGAGAGCCTTGACTCGCTGCTGGGGGTCCTGCTCTTCGTCGTGGGCTTCATCGTGGTCTCTTTCCCCTGCGGCTGGGGCTACATCGTG CTCAACGTGGCCGCTGGCTACCTGTACGGCTTCGTGCTGGGCATGGGTCTGATGATGGTGGGCGTCCTCATCGGCACCTTCATCGCCCAT GTGGTCTGCAAGCGGCTCCTCACCGCCTGGGTGGCCGCCAGGATCCAGAGCAGCGAGAAGCTGAGCGCGGTTATTCGCGTAGTGGAGGGA GGAAGCGGCCTGAAAGTGGTGGCGCTGGCCAGACTGACACCCATACCTTTTGGGCTTCAGAATGCAGTGTTTTCGATACTGAGGAGAGCA GACAAAAATGATGATGGAAAATTATCCTTTGAAGAATTCAAAGCATATTTTGCAGATGGTGTTCTCAGTGGAGAAGAATTACACGAGCTT TTCCATACCATTGATACACATAATACTAATAATCTTGACACAGAAGAGCTATGTGAATATTTTTCTCAGCACTTGGGCGAGTATGAGAAT GTACTAGCAGCACTTGAAGACCTGAATCTTTCCATCCTGAAGGCAATGGGCAAAACAAAGAAAGACTACCAAGAAGCCTCCAATTTGGAA CAATTCGTAACTAGATTTTTATTGAAGGAAACCCTGAATCAGCTGCAGTCTCTCCAGAATTCCCTGGAATGTGCCATGGAAACTACTGAG GAGCAAACCCGTCAAGAAAGGCAAGGGCCAGCCAAGCCAGAAGTCCTGTCGATTCAATGGCCTGGAAAACGATCAAGCCGCCGAGTCCAG AGACACAACAGCTTCTCCCCAAACAGCCCTCAGTTTAATGTCAGCGGTCCAGGCTTATTAGAAGAAGACAACCAGTGGATGACCCAGATA AATAGACTCCAGAAATTAATTGATAGACTGGAAAAGAAGGATCTCAAACTCGAACCACCAGAAGAAGAAATTATTGAAGGGAATACTAAA TCTCACATCATGCTTGTGCAGCGGCAGATGTCTGTGATAGAAGAGGACCTGGAAGAATTCCAGCTCGCTCTGAAACACTACGTGGAGAGT GCTTCCTCCCAAAGTGGATGCTTGCGTATTTCTATACAGAAGCTTTCAAATGAATCTCGCTACATGATCTATGAGTTCTGGGAGAATAGT AGTGTATGGAATAGCCACCTTCAGACAAATTATAGCAAGACATTCCAAAGAAGTAATGTGGATTTCTTGGAAACTCCAGAACTCACATCT ACAATGCTAGTTCCTGCTTCGTGGTGGATCCTGAACAACTAGATGTTCCTAGACATTTTCTTTATGGTTCCAAGTGCAAAACAGGTGTTC TTATCTAAAACGTCAATTAGAAAATTATCTGCGGTTGTTAATCTACTGTATATTTTTGTTTGGTATATTTACTAAGTGCACTCTTTCAAA ACTTATTCTATAACTTTATCAATTCATGTGAATTTTAGCTCAATTTTCAAAGTTCACTAATATTCTCAATATTTAATGCTAAATGCTTTG CTACATTGTAACTCACCTAAAACCTTTTAGTGACAAAATCCTAATATGTGGAAAAAAGCATATGCATAAAGGAATAATATTGTGAAAATG AATCTGTTATGATAAAGAAAAAATAAAGTGGAAACTTTTAGAGTATTACTTCATAGGGCAGATTTTGTAAACTGTCGTATACTGTAAAGG GTTAAATCAGCGTTTTGTGATTTTTAAGTAACTGTGAGTGAAGTTTATTCTTCAACAATGTCTACTCCATCCCCAACCCAACTCACAGCC CTATGACTACTATCTTTGCATTAGTTAAAAAGTTAGTATATAGGCATCAAACAACCTTGGCTGTAACCTATAGAATCTCTATCCACGTAT CAGGTTATAGACTGGTTTTTCAAAAGTGAACAATCCTGTGATAAGTTGGAGTACCATTTAGTAATACAGCAACATTGTGTCATTTATTAG CATCATAATTCTTTGTTATGTAAGTTAAATATATCAAGAAAGAAGAGACTGTTTGGAAAAATGTGGTTCAAGTTTTATGCTATATAGTTT TGGTATGCGATACAGACAGCTAACTTTTCTTATGAAAAATACATATTTGCATGTAAACAATGATTTCAAAATACTTGAAAAATAAAATTT TAACCCAAATGAATAACTAAGAAATATAAAACAAGCACAAAATCTTAGGGAAGTCATAAAATAGTAGTGAAAGTATTAGACAGAAGACAT CTGTTTTCGAATTTCAACACTAGAATGACTAAAACTATCTACCTATAGAACTATCTGTAGATAGTATACTATCTACACTCTGCTCAACAA GCTCAGAAATTAAATATTTTTAATAATAAAAATCTGTTCTGGTTATAAACCTTGCTAATGAAAATACAATACATATAAAAATGTATAGCC ATGTTATTTTCTAGTATAAATTCCTTTGAAACTATAAGTCTTTGAGGAAAATTATAAGGTAAAATTTTCCTGTTTTTCCCCCTTTGAAAA ACTCAGGAAAAAAGGAAGATTGAACTAATAAAATTTTATTTCTTAAATATAAATTTGACCTAAAATATTTTCTCAAACTAATTCATGAAA CAGCAACTTTTACCAATACCTTTGTATACTCTCAGTTCTCATTCAGTATAAATAAAATTTTAAAATCCTTTCATAGTTCTATTAGAAATA AGTAGTAAATTTTGATATATTGTACATACACACGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTATTTGTGTGCCTCTG GTCAACTCTAAGGATGACAGACACTGTGTAACAACACCTGGGTCAACTCTTTTAATTTATATACAAAGCAAAGAACAACATTAATGGAGA TGCACAATGATTATTCAAACAAGCTATATATATGTACAAAGGCAAACAGACACATAACAGTCTCTGCAGACTGATTGTATATAGTAAGAA AAGATCAAAAGACTTTAAAACCTAAATGACTTTTGACATACAAACTCTTCTTGAGAATGTTTGTTGTAAATGGTTTCAAAAATACAAATT ATAGCCAATCAAAACATTGCTTTGGTTGGTGCATTTAAGTATCCAACTCAAAAAGCATATCAAATATTTTGGGTACTAGGCAGTTTCCAA AGTAGCATGGTAGTATTACTTGTTAAAAGGGTTCTGTTTTCATTAACAGTACTAAGTGGAAGGGATCTGCAGATTCCAAACTGGAATAAG CTCTATCATATTCTGAAACAAGAATTAGAATGACTTGAGAACGGGCAAATAACAAAGCAAACCAATATAATTATATGGTCATTCTGACCC CAGCTCTTATACAAATTATACATGTATTTTTGTGTATGTTTGTGAGAGTTGTATGTATGTGAATGTGTGTGAGTGTGTATTCACATACAC ATATATACTGGAACCTATAGTAGAAAAGGAAACTAGTAGGGCCAAAAAAAAAAAGAAAAAGAAAAAGAAAAAAGAAAAAAAAAGAAAAAA CTGGGACCTAAGTATAAATATCTCATCCTAAAGTAAACAATAAGTTTATAGTTAACGAAGATTTTTTTCTATTTAAAACCCCATTTTCCT AAAGAACAAAGTAGTAAAATAAAAAAAAATTTAAAAAATTAAAAAATAAAAAAAAGAGGTCACTAAAAGACCAAGATGGGAAACGTAACA TGGAATACAAGCTTGAATCTGGGAAACAAGCTCAAAAAACAGTGAAAAAAAAAGTACTGGTTTAGGAGTTCAAAATTCAGTGAAACAAAC TTTTTGCCAATAGACCTAGGGATCTAAGAAATAGAATTAGGGAGAGTTTACACTTACTTACCTATATATCAGCAGATTTTTCTGGAAGAA ACCCTTTTTTTTTTTTTTTTTAAACAGTAACATCCAGAGTGACAAATTGCAGGAGATTTAATGTATAAAATTTCTAGGAATTAAAAGCTT AAACCCAAAAATTGTTCATCCATATATAAGAAATTATCGAATTAAAACTTAATGTATGTCAATTATTTTCAAATGTCTAAATTCCTTTGG AAATAAAAATATCAGTTTTACTTTGAAATTGCTCAACTTCTGCTATTCATATGGTCTGATTAGTGACATAAGTAGCAGCCGTTTTTCAAC TTCAGTTTCATTCACTACCATTGTTTCCAAATTATCAATCTCTGCTAGTAATTATGAATTTAAGACCATATTATTATCAAAAACCTAGAG ACCAATCATATATCTGAAAAGAAATACCCATTAAAAATTCTGCCTCCTGTTTATTGAGAACTATGCATTGAACATTCTGAATCATTCTAA GCCTCTGGAGAGACTGTAATGATCCATTCATGAGCTGGTATGAAATCAGTGGGAAGCAGAACAACAGAAGGAACTTTAAAAGCAACAAGC AATTATGTACCATATATACACTGTAGCAAATATTTTATATTTGAGAGTCTTTACAGCTTACATTTCCATTCCATTATTACAAGTGATGAA AAACAAAAAATTGCAAGTAGTATGCAAATTATAAATATACAGTCTTCCCACTTCACTAACCAAATTCCTACTTTCCAGTGTTACTTCCCA ATTTATGCAGGAAACCTCCTGCAAAGCTGAAACTGATTAGAAAATTCTTTATATTTTAAAATAGCTCTTTCTCATTTTTAGAGAAGTCAA ATAGCCAACCATCAAAATTAAGAATAAATTGAATTGTCACAGTCCATTACAGTTATTGTTGCTAGATCCACCTCATTTGCAGATGTCCAA ACTTAAATTCATCTGTTCTTAAAATGCTACTTAAAACTTTGGTTGTTTTCCTGTAATATAAAAGAAAAAGTTAATTTATCAATTGATTGA ATACAGTTTTTACTAATTAGTTTATCAAACCAAATACTGTGAACGTACCAGGTGTTTACAGATTTAAATGCATGTTACCATAGAAACTAT TAAAGTAACTAGAACTGTCAAATAACAAAACGGCTCATGTTTTTAAAATATATGTAACTCATTTTAAAATATATTAAATTGTATTCCAAA CCTGTTCTTCTGTTTCTGTGGCACCTAGGTTTAAAATATGTATTAATGTGTAAATCACAAGTAAAATGAATTCTAATGTACAAGTTTGTT >In-frame_TMEM64_ENST00000458549_chr8_91657339_-_NECAB1_ENST00000417640_chr8_91813919_+_5826nt ACTCCCCGCCTGGCCGTCGCTCCTCCGCTGACTCCGCGCCCTTCTACGGGCCGTCTCCCACCCTCTGAGCGGACGCAGGGAGTCGATGCC GGGCGAACCGGGCGCCATGAAGGGCAGCTGCCTAACGGGCGCCGCGGCGGAGGGGCTGGCCGGCTGAGGGCCCGCGCTGGGCCGAGGCAT GCGGAGCCCGGGCGGGATCCTGCTCCAGGCGCTGCCCCGGCTGCTGCAGCACGCCGCCCTCCCGGGCCTCGCCGAGCTGCCGGCCCGCTG GGCCCTGCCGCGGGGTGCGGGCGGGGACGGCCCGGCGGACCGCCTTCCCCGCGGGGGCGGGGCGAGCGCGGCGGCGGCAGCAGCGGCGGC CTCGGGCGCCCTGCTCGGCGCCTATCTGGAGCGCCACGGTCCGCCCGAGGCTTCGGAGCTGCCGGAGCCGGGCGGGGCCTTGGCGGGCGG CCCCGGGAGTGGCGGCGGCGGCGTGGTGGTCGGCGTGGCTGAGGTGAGAAACTGGCGCTGCTGCTGCCTCGGCAGCACCTGTTGGTGCCG GAGCCTCGTGCTGGTCTGCGTGTTGGCCGCCCTGTGCTTCGCTTCCCTGGCCCTGGTCCGCCGCTACCTTCACCACCTCCTGCTGTGGGT GGAGAGCCTTGACTCGCTGCTGGGGGTCCTGCTCTTCGTCGTGGGCTTCATCGTGGTCTCTTTCCCCTGCGGCTGGGGCTACATCGTGCT CAACGTGGCCGCTGGCTACCTGTACGGCTTCGTGCTGGGCATGGGTCTGATGATGGTGGGCGTCCTCATCGGCACCTTCATCGCCCATGT GGTCTGCAAGCGGCTCCTCACCGCCTGGGTGGCCGCCAGGATCCAGAGCAGCGAGAAGCTGAGCGCGGTTATTCGCGTAGTGGAGGGAGG AAGCGGCCTGAAAGTGGTGGCGCTGGCCAGACTGACACCCATACCTTTTGGGCTTCAGAATGCAGTGTTTTCGATACTGAGGAGAGCAGA CAAAAATGATGATGGAAAATTATCCTTTGAAGAATTCAAAGCATATTTTGCAGATGGTGTTCTCAGTGGAGAAGAATTACACGAGCTTTT CCATACCATTGATACACATAATACTAATAATCTTGACACAGAAGAGCTATGTGAATATTTTTCTCAGCACTTGGGCGAGTATGAGAATGT ACTAGCAGCACTTGAAGACCTGAATCTTTCCATCCTGAAGGCAATGGGCAAAACAAAGAAAGACTACCAAGAAGCCTCCAATTTGGAACA ATTCGTAACTAGATTTTTATTGAAGGAAACCCTGAATCAGCTGCAGTCTCTCCAGAATTCCCTGGAATGTGCCATGGAAACTACTGAGGA GCAAACCCGTCAAGAAAGGCAAGGGCCAGCCAAGCCAGAAGTCCTGTCGATTCAATGGCCTGGAAAACGATCAAGCCGCCGAGTCCAGAG ACACAACAGCTTCTCCCCAAACAGCCCTCAGTTTAATGTCAGCGGTCCAGGCTTATTAGAAGAAGACAACCAGTGGATGACCCAGATAAA TAGACTCCAGAAATTAATTGATAGACTGGAAAAGAAGGATCTCAAACTCGAACCACCAGAAGAAGAAATTATTGAAGGGAATACTAAATC TCACATCATGCTTGTGCAGCGGCAGATGTCTGTGATAGAAGAGGACCTGGAAGAATTCCAGCTCGCTCTGAAACACTACGTGGAGAGTGC TTCCTCCCAAAGTGGATGCTTGCGTATTTCTATACAGAAGCTTTCAAATGAATCTCGCTACATGATCTATGAGTTCTGGGAGAATAGTAG TGTATGGAATAGCCACCTTCAGACAAATTATAGCAAGACATTCCAAAGAAGTAATGTGGATTTCTTGGAAACTCCAGAACTCACATCTAC AATGCTAGTTCCTGCTTCGTGGTGGATCCTGAACAACTAGATGTTCCTAGACATTTTCTTTATGGTTCCAAGTGCAAAACAGGTGTTCTT ATCTAAAACGTCAATTAGAAAATTATCTGCGGTTGTTAATCTACTGTATATTTTTGTTTGGTATATTTACTAAGTGCACTCTTTCAAAAC TTATTCTATAACTTTATCAATTCATGTGAATTTTAGCTCAATTTTCAAAGTTCACTAATATTCTCAATATTTAATGCTAAATGCTTTGCT ACATTGTAACTCACCTAAAACCTTTTAGTGACAAAATCCTAATATGTGGAAAAAAGCATATGCATAAAGGAATAATATTGTGAAAATGAA TCTGTTATGATAAAGAAAAAATAAAGTGGAAACTTTTAGAGTATTACTTCATAGGGCAGATTTTGTAAACTGTCGTATACTGTAAAGGGT TAAATCAGCGTTTTGTGATTTTTAAGTAACTGTGAGTGAAGTTTATTCTTCAACAATGTCTACTCCATCCCCAACCCAACTCACAGCCCT ATGACTACTATCTTTGCATTAGTTAAAAAGTTAGTATATAGGCATCAAACAACCTTGGCTGTAACCTATAGAATCTCTATCCACGTATCA GGTTATAGACTGGTTTTTCAAAAGTGAACAATCCTGTGATAAGTTGGAGTACCATTTAGTAATACAGCAACATTGTGTCATTTATTAGCA TCATAATTCTTTGTTATGTAAGTTAAATATATCAAGAAAGAAGAGACTGTTTGGAAAAATGTGGTTCAAGTTTTATGCTATATAGTTTTG GTATGCGATACAGACAGCTAACTTTTCTTATGAAAAATACATATTTGCATGTAAACAATGATTTCAAAATACTTGAAAAATAAAATTTTA ACCCAAATGAATAACTAAGAAATATAAAACAAGCACAAAATCTTAGGGAAGTCATAAAATAGTAGTGAAAGTATTAGACAGAAGACATCT GTTTTCGAATTTCAACACTAGAATGACTAAAACTATCTACCTATAGAACTATCTGTAGATAGTATACTATCTACACTCTGCTCAACAAGC TCAGAAATTAAATATTTTTAATAATAAAAATCTGTTCTGGTTATAAACCTTGCTAATGAAAATACAATACATATAAAAATGTATAGCCAT GTTATTTTCTAGTATAAATTCCTTTGAAACTATAAGTCTTTGAGGAAAATTATAAGGTAAAATTTTCCTGTTTTTCCCCCTTTGAAAAAC TCAGGAAAAAAGGAAGATTGAACTAATAAAATTTTATTTCTTAAATATAAATTTGACCTAAAATATTTTCTCAAACTAATTCATGAAACA GCAACTTTTACCAATACCTTTGTATACTCTCAGTTCTCATTCAGTATAAATAAAATTTTAAAATCCTTTCATAGTTCTATTAGAAATAAG TAGTAAATTTTGATATATTGTACATACACACGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTATTTGTGTGCCTCTGGT CAACTCTAAGGATGACAGACACTGTGTAACAACACCTGGGTCAACTCTTTTAATTTATATACAAAGCAAAGAACAACATTAATGGAGATG CACAATGATTATTCAAACAAGCTATATATATGTACAAAGGCAAACAGACACATAACAGTCTCTGCAGACTGATTGTATATAGTAAGAAAA GATCAAAAGACTTTAAAACCTAAATGACTTTTGACATACAAACTCTTCTTGAGAATGTTTGTTGTAAATGGTTTCAAAAATACAAATTAT AGCCAATCAAAACATTGCTTTGGTTGGTGCATTTAAGTATCCAACTCAAAAAGCATATCAAATATTTTGGGTACTAGGCAGTTTCCAAAG TAGCATGGTAGTATTACTTGTTAAAAGGGTTCTGTTTTCATTAACAGTACTAAGTGGAAGGGATCTGCAGATTCCAAACTGGAATAAGCT CTATCATATTCTGAAACAAGAATTAGAATGACTTGAGAACGGGCAAATAACAAAGCAAACCAATATAATTATATGGTCATTCTGACCCCA GCTCTTATACAAATTATACATGTATTTTTGTGTATGTTTGTGAGAGTTGTATGTATGTGAATGTGTGTGAGTGTGTATTCACATACACAT ATATACTGGAACCTATAGTAGAAAAGGAAACTAGTAGGGCCAAAAAAAAAAAGAAAAAGAAAAAGAAAAAAGAAAAAAAAAGAAAAAACT GGGACCTAAGTATAAATATCTCATCCTAAAGTAAACAATAAGTTTATAGTTAACGAAGATTTTTTTCTATTTAAAACCCCATTTTCCTAA AGAACAAAGTAGTAAAATAAAAAAAAATTTAAAAAATTAAAAAATAAAAAAAAGAGGTCACTAAAAGACCAAGATGGGAAACGTAACATG GAATACAAGCTTGAATCTGGGAAACAAGCTCAAAAAACAGTGAAAAAAAAAGTACTGGTTTAGGAGTTCAAAATTCAGTGAAACAAACTT TTTGCCAATAGACCTAGGGATCTAAGAAATAGAATTAGGGAGAGTTTACACTTACTTACCTATATATCAGCAGATTTTTCTGGAAGAAAC CCTTTTTTTTTTTTTTTTTAAACAGTAACATCCAGAGTGACAAATTGCAGGAGATTTAATGTATAAAATTTCTAGGAATTAAAAGCTTAA ACCCAAAAATTGTTCATCCATATATAAGAAATTATCGAATTAAAACTTAATGTATGTCAATTATTTTCAAATGTCTAAATTCCTTTGGAA ATAAAAATATCAGTTTTACTTTGAAATTGCTCAACTTCTGCTATTCATATGGTCTGATTAGTGACATAAGTAGCAGCCGTTTTTCAACTT CAGTTTCATTCACTACCATTGTTTCCAAATTATCAATCTCTGCTAGTAATTATGAATTTAAGACCATATTATTATCAAAAACCTAGAGAC CAATCATATATCTGAAAAGAAATACCCATTAAAAATTCTGCCTCCTGTTTATTGAGAACTATGCATTGAACATTCTGAATCATTCTAAGC CTCTGGAGAGACTGTAATGATCCATTCATGAGCTGGTATGAAATCAGTGGGAAGCAGAACAACAGAAGGAACTTTAAAAGCAACAAGCAA TTATGTACCATATATACACTGTAGCAAATATTTTATATTTGAGAGTCTTTACAGCTTACATTTCCATTCCATTATTACAAGTGATGAAAA ACAAAAAATTGCAAGTAGTATGCAAATTATAAATATACAGTCTTCCCACTTCACTAACCAAATTCCTACTTTCCAGTGTTACTTCCCAAT TTATGCAGGAAACCTCCTGCAAAGCTGAAACTGATTAGAAAATTCTTTATATTTTAAAATAGCTCTTTCTCATTTTTAGAGAAGTCAAAT AGCCAACCATCAAAATTAAGAATAAATTGAATTGTCACAGTCCATTACAGTTATTGTTGCTAGATCCACCTCATTTGCAGATGTCCAAAC TTAAATTCATCTGTTCTTAAAATGCTACTTAAAACTTTGGTTGTTTTCCTGTAATATAAAAGAAAAAGTTAATTTATCAATTGATTGAAT ACAGTTTTTACTAATTAGTTTATCAAACCAAATACTGTGAACGTACCAGGTGTTTACAGATTTAAATGCATGTTACCATAGAAACTATTA AAGTAACTAGAACTGTCAAATAACAAAACGGCTCATGTTTTTAAAATATATGTAACTCATTTTAAAATATATTAAATTGTATTCCAAACC TGTTCTTCTGTTTCTGTGGCACCTAGGTTTAAAATATGTATTAATGTGTAAATCACAAGTAAAATGAATTCTAATGTACAAGTTTGTTTT |
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FusionGenePPI for TMEM64_NECAB1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TMEM64 | AGO2 | NECAB1 | APP, NECAB3, NECAB2, CIRH1A, IP6K3, KANSL2, MPRIP, RNF138, MCRS1, CCDC6, RAI14 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TMEM64_NECAB1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TMEM64_NECAB1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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