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Fusion gene ID: 3866 |
FusionGeneSummary for BAZ2A_BIN2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: BAZ2A_BIN2 | Fusion gene ID: 3866 | Hgene | Tgene | Gene symbol | BAZ2A | BIN2 | Gene ID | 11176 | 51411 |
| Gene name | bromodomain adjacent to zinc finger domain 2A | bridging integrator 2 | |
| Synonyms | TIP5|WALp3 | BRAP-1 | |
| Cytomap | 12q13.3 | 12q13.13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | bromodomain adjacent to zinc finger domain protein 2ATTF-I interacting peptide 5TTF-I-interacting protein 5transcription termination factor I-interacting protein 5 | bridging integrator 2breast cancer associated protein BRAP1breast cancer-associated protein 1 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q9UIF9 | Q9UBW5 | |
| Ensembl transtripts involved in fusion gene | ENST00000379441, ENST00000179765, ENST00000551812, ENST00000549884, ENST00000553222, | ENST00000604560, ENST00000452142, ENST00000267012, ENST00000544402, ENST00000603260, | |
| Fusion gene scores | * DoF score | 10 X 11 X 6=660 | 4 X 4 X 2=32 |
| # samples | 12 | 4 | |
| ** MAII score | log2(12/660*10)=-2.4594316186373 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: BAZ2A [Title/Abstract] AND BIN2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | BIN2 | GO:0097320 | plasma membrane tubulation | 23285027 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUAD | TCGA-49-6745-01A | BAZ2A | chr12 | 57023909 | - | BIN2 | chr12 | 51686128 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000379441 | ENST00000604560 | BAZ2A | chr12 | 57023909 | - | BIN2 | chr12 | 51686128 | - |
| intron-3CDS | ENST00000379441 | ENST00000452142 | BAZ2A | chr12 | 57023909 | - | BIN2 | chr12 | 51686128 | - |
| intron-3CDS | ENST00000379441 | ENST00000267012 | BAZ2A | chr12 | 57023909 | - | BIN2 | chr12 | 51686128 | - |
| intron-3CDS | ENST00000379441 | ENST00000544402 | BAZ2A | chr12 | 57023909 | - | BIN2 | chr12 | 51686128 | - |
| intron-intron | ENST00000379441 | ENST00000603260 | BAZ2A | chr12 | 57023909 | - | BIN2 | chr12 | 51686128 | - |
| intron-3CDS | ENST00000179765 | ENST00000604560 | BAZ2A | chr12 | 57023909 | - | BIN2 | chr12 | 51686128 | - |
| intron-3CDS | ENST00000179765 | ENST00000452142 | BAZ2A | chr12 | 57023909 | - | BIN2 | chr12 | 51686128 | - |
| intron-3CDS | ENST00000179765 | ENST00000267012 | BAZ2A | chr12 | 57023909 | - | BIN2 | chr12 | 51686128 | - |
| intron-3CDS | ENST00000179765 | ENST00000544402 | BAZ2A | chr12 | 57023909 | - | BIN2 | chr12 | 51686128 | - |
| intron-intron | ENST00000179765 | ENST00000603260 | BAZ2A | chr12 | 57023909 | - | BIN2 | chr12 | 51686128 | - |
| intron-3CDS | ENST00000551812 | ENST00000604560 | BAZ2A | chr12 | 57023909 | - | BIN2 | chr12 | 51686128 | - |
| intron-3CDS | ENST00000551812 | ENST00000452142 | BAZ2A | chr12 | 57023909 | - | BIN2 | chr12 | 51686128 | - |
| intron-3CDS | ENST00000551812 | ENST00000267012 | BAZ2A | chr12 | 57023909 | - | BIN2 | chr12 | 51686128 | - |
| intron-3CDS | ENST00000551812 | ENST00000544402 | BAZ2A | chr12 | 57023909 | - | BIN2 | chr12 | 51686128 | - |
| intron-intron | ENST00000551812 | ENST00000603260 | BAZ2A | chr12 | 57023909 | - | BIN2 | chr12 | 51686128 | - |
| 5UTR-3CDS | ENST00000549884 | ENST00000604560 | BAZ2A | chr12 | 57023909 | - | BIN2 | chr12 | 51686128 | - |
| 5UTR-3CDS | ENST00000549884 | ENST00000452142 | BAZ2A | chr12 | 57023909 | - | BIN2 | chr12 | 51686128 | - |
| 5UTR-3CDS | ENST00000549884 | ENST00000267012 | BAZ2A | chr12 | 57023909 | - | BIN2 | chr12 | 51686128 | - |
| 5UTR-3CDS | ENST00000549884 | ENST00000544402 | BAZ2A | chr12 | 57023909 | - | BIN2 | chr12 | 51686128 | - |
| 5UTR-intron | ENST00000549884 | ENST00000603260 | BAZ2A | chr12 | 57023909 | - | BIN2 | chr12 | 51686128 | - |
| intron-3CDS | ENST00000553222 | ENST00000604560 | BAZ2A | chr12 | 57023909 | - | BIN2 | chr12 | 51686128 | - |
| intron-3CDS | ENST00000553222 | ENST00000452142 | BAZ2A | chr12 | 57023909 | - | BIN2 | chr12 | 51686128 | - |
| intron-3CDS | ENST00000553222 | ENST00000267012 | BAZ2A | chr12 | 57023909 | - | BIN2 | chr12 | 51686128 | - |
| intron-3CDS | ENST00000553222 | ENST00000544402 | BAZ2A | chr12 | 57023909 | - | BIN2 | chr12 | 51686128 | - |
| intron-intron | ENST00000553222 | ENST00000603260 | BAZ2A | chr12 | 57023909 | - | BIN2 | chr12 | 51686128 | - |
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FusionProtFeatures for BAZ2A_BIN2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| BAZ2A | BIN2 |
| Essential component of the NoRC (nucleolar remodelingcomplex) complex, a complex that mediates silencing of a fractionof rDNA by recruiting histone-modifying enzymes and DNAmethyltransferases, leading to heterochromatin formation andtranscriptional silencing. In the complex, it plays a central roleby being recruited to rDNA and by targeting chromatin modifyingenzymes such as HDAC1, leading to repress RNA polymerase Itranscription. Recruited to rDNA via its interaction with TTF1 andits ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12acbut not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAsthat are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNAsilencing (By similarity). {ECO:0000250}. | Promotes cell motility and migration, probably via itsinteraction with the cell membrane and with podosome proteins thatmediate interaction with the cytoskeleton. Modulates membranecurvature and mediates membrane tubulation. Plays a role inpodosome formation. Inhibits phagocytosis.{ECO:0000269|PubMed:23285027}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for BAZ2A_BIN2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for BAZ2A_BIN2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| BAZ2A | SMARCA5, TTF1, KAT8, HIST1H4A, HDAC1, DNMT1, DNMT3B, SIRT7, EED, IFI16, KIAA1107, C10orf12, RACGAP1, CBX8, BEND3, USP21 | BIN2 | TERF1, TINF2, POT1, BIN1, AMPH, KIF1B, EFEMP1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for BAZ2A_BIN2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for BAZ2A_BIN2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | BAZ2A | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
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