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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 38631

FusionGeneSummary for TMEM50A_TMEM50A

check button Fusion gene summary
Fusion gene informationFusion gene name: TMEM50A_TMEM50A
Fusion gene ID: 38631
HgeneTgene
Gene symbol

TMEM50A

TMEM50A

Gene ID

23585

23585

Gene nametransmembrane protein 50Atransmembrane protein 50A
SynonymsIFNRC|SMP1IFNRC|SMP1
Cytomap

1p36.11

1p36.11

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane protein 50Acervical cancer oncogene 9small membrane protein 1transmembrane protein 50Acervical cancer oncogene 9small membrane protein 1
Modification date2018052320180523
UniProtAcc

O95807

O95807

Ensembl transtripts involved in fusion geneENST00000374358, ENST00000480937, 
ENST00000374358, ENST00000480937, 
Fusion gene scores* DoF score2 X 6 X 1=123 X 7 X 2=42
# samples 99
** MAII scorelog2(9/12*10)=2.90689059560852
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(9/42*10)=1.09953567355091
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TMEM50A [Title/Abstract] AND TMEM50A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1C75391TMEM50Achr1

25688758

-TMEM50Achr1

25688785

+
ChiTaRS3.1C75640TMEM50Achr1

25688758

-TMEM50Achr1

25688785

+
ChiTaRS3.1D82127TMEM50Achr1

25688785

-TMEM50Achr1

25688758

+
ChiTaRS3.1C75568TMEM50Achr1

25688758

-TMEM50Achr1

25688785

+
ChiTaRS3.1BU675389TMEM50Achr1

25688630

-TMEM50Achr1

25688275

+
ChiTaRS3.1AW663344TMEM50Achr1

25687923

-TMEM50Achr1

25688267

+
ChiTaRS3.1BF352913TMEM50Achr1

25679404

+TMEM50Achr1

25669508

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000374358ENST00000374358TMEM50Achr1

25688758

-TMEM50Achr1

25688785

+
3UTR-intronENST00000374358ENST00000480937TMEM50Achr1

25688758

-TMEM50Achr1

25688785

+
intron-3UTRENST00000480937ENST00000374358TMEM50Achr1

25688758

-TMEM50Achr1

25688785

+
intron-intronENST00000480937ENST00000480937TMEM50Achr1

25688758

-TMEM50Achr1

25688785

+
3UTR-3UTRENST00000374358ENST00000374358TMEM50Achr1

25688785

-TMEM50Achr1

25688758

+
3UTR-intronENST00000374358ENST00000480937TMEM50Achr1

25688785

-TMEM50Achr1

25688758

+
intron-3UTRENST00000480937ENST00000374358TMEM50Achr1

25688785

-TMEM50Achr1

25688758

+
intron-intronENST00000480937ENST00000480937TMEM50Achr1

25688785

-TMEM50Achr1

25688758

+
3UTR-3UTRENST00000374358ENST00000374358TMEM50Achr1

25688630

-TMEM50Achr1

25688275

+
3UTR-intronENST00000374358ENST00000480937TMEM50Achr1

25688630

-TMEM50Achr1

25688275

+
intron-3UTRENST00000480937ENST00000374358TMEM50Achr1

25688630

-TMEM50Achr1

25688275

+
intron-intronENST00000480937ENST00000480937TMEM50Achr1

25688630

-TMEM50Achr1

25688275

+
3UTR-3UTRENST00000374358ENST00000374358TMEM50Achr1

25687923

-TMEM50Achr1

25688267

+
3UTR-intronENST00000374358ENST00000480937TMEM50Achr1

25687923

-TMEM50Achr1

25688267

+
intron-3UTRENST00000480937ENST00000374358TMEM50Achr1

25687923

-TMEM50Achr1

25688267

+
intron-intronENST00000480937ENST00000480937TMEM50Achr1

25687923

-TMEM50Achr1

25688267

+
Frame-shiftENST00000374358ENST00000374358TMEM50Achr1

25679404

+TMEM50Achr1

25669508

-
5CDS-3UTRENST00000374358ENST00000480937TMEM50Achr1

25679404

+TMEM50Achr1

25669508

-
intron-3CDSENST00000480937ENST00000374358TMEM50Achr1

25679404

+TMEM50Achr1

25669508

-
intron-3UTRENST00000480937ENST00000480937TMEM50Achr1

25679404

+TMEM50Achr1

25669508

-

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FusionProtFeatures for TMEM50A_TMEM50A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TMEM50A

O95807

TMEM50A

O95807


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TMEM50A_TMEM50A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TMEM50A_TMEM50A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TMEM50A_TMEM50A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TMEM50A_TMEM50A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource