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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 38563

FusionGeneSummary for TMEM241_TMED4

check button Fusion gene summary
Fusion gene informationFusion gene name: TMEM241_TMED4
Fusion gene ID: 38563
HgeneTgene
Gene symbol

TMEM241

TMED4

Gene ID

85019

222068

Gene nametransmembrane protein 241transmembrane p24 trafficking protein 4
SynonymsC18orf45|hVVTERS25|GMP25iso|HNLF|p24a3|p24alpha3
Cytomap

18q11.2

7p13

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane protein 241putative vertebrate vrg4-like nucleotide-sugar transporter truncated variant2putative vertebrate vrg4-like nucleotide-sugar transporter variant1transmembrane protein C18orf45transmembrane emp24 domain-containing protein 4endoplasmic reticulum stress-response protein 25 kDap24 family protein alpha-3putative NF-kappa-B-activating protein 156putative NFkB activating protein HNLFtransmembrane emp24 protein transport domain c
Modification date2018051920180523
UniProtAcc

Q24JQ0

Q7Z7H5

Ensembl transtripts involved in fusion geneENST00000450466, ENST00000383233, 
ENST00000542162, ENST00000399707, 
ENST00000475185, 
ENST00000457408, 
ENST00000289577, ENST00000481238, 
ENST00000444131, 
Fusion gene scores* DoF score5 X 5 X 6=1502 X 2 X 1=4
# samples 72
** MAII scorelog2(7/150*10)=-1.09953567355091
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/4*10)=2.32192809488736
Context

PubMed: TMEM241 [Title/Abstract] AND TMED4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CA432178TMEM241chr18

20876351

+TMED4chr7

44620519

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000450466ENST00000457408TMEM241chr18

20876351

+TMED4chr7

44620519

+
intron-intronENST00000450466ENST00000289577TMEM241chr18

20876351

+TMED4chr7

44620519

+
intron-3UTRENST00000450466ENST00000481238TMEM241chr18

20876351

+TMED4chr7

44620519

+
intron-intronENST00000450466ENST00000444131TMEM241chr18

20876351

+TMED4chr7

44620519

+
intron-intronENST00000383233ENST00000457408TMEM241chr18

20876351

+TMED4chr7

44620519

+
intron-intronENST00000383233ENST00000289577TMEM241chr18

20876351

+TMED4chr7

44620519

+
intron-3UTRENST00000383233ENST00000481238TMEM241chr18

20876351

+TMED4chr7

44620519

+
intron-intronENST00000383233ENST00000444131TMEM241chr18

20876351

+TMED4chr7

44620519

+
intron-intronENST00000542162ENST00000457408TMEM241chr18

20876351

+TMED4chr7

44620519

+
intron-intronENST00000542162ENST00000289577TMEM241chr18

20876351

+TMED4chr7

44620519

+
intron-3UTRENST00000542162ENST00000481238TMEM241chr18

20876351

+TMED4chr7

44620519

+
intron-intronENST00000542162ENST00000444131TMEM241chr18

20876351

+TMED4chr7

44620519

+
intron-intronENST00000399707ENST00000457408TMEM241chr18

20876351

+TMED4chr7

44620519

+
intron-intronENST00000399707ENST00000289577TMEM241chr18

20876351

+TMED4chr7

44620519

+
intron-3UTRENST00000399707ENST00000481238TMEM241chr18

20876351

+TMED4chr7

44620519

+
intron-intronENST00000399707ENST00000444131TMEM241chr18

20876351

+TMED4chr7

44620519

+
intron-intronENST00000475185ENST00000457408TMEM241chr18

20876351

+TMED4chr7

44620519

+
intron-intronENST00000475185ENST00000289577TMEM241chr18

20876351

+TMED4chr7

44620519

+
intron-3UTRENST00000475185ENST00000481238TMEM241chr18

20876351

+TMED4chr7

44620519

+
intron-intronENST00000475185ENST00000444131TMEM241chr18

20876351

+TMED4chr7

44620519

+

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FusionProtFeatures for TMEM241_TMED4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TMEM241

Q24JQ0

TMED4

Q7Z7H5

Involved in vesicular protein trafficking, mainly in theearly secretory pathway. targeting. Involved in the maintenance ofthe Golgi apparatus. Appears to play a role in the biosynthesis ofsecreted cargo including processing. Involved in endoplasmicreticulum stress response. May play a role in the regulation ofheat-shock response and apoptosis (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TMEM241_TMED4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TMEM241_TMED4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TMEM241MDFI, ELAVL1, KRT40, TRIM25TMED4ELAVL1, KIAA0368, CHCHD6, TMED2, SF1, PPIC, SLC25A3, SRPRB, IKBIP, MOV10, NXF1, TMED10, TMED3, CHST8, HTR3C, LMAN1, NAGLU, LIPG, SCN3B, CDK5RAP3, FGF3, GORASP2, IL13RA2, SPPL2B, RFX3, PDHA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TMEM241_TMED4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TMEM241_TMED4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource