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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 38533

FusionGeneSummary for TMEM203_TMEM87A

check button Fusion gene summary
Fusion gene informationFusion gene name: TMEM203_TMEM87A
Fusion gene ID: 38533
HgeneTgene
Gene symbol

TMEM203

TMEM87A

Gene ID

94107

25963

Gene nametransmembrane protein 203transmembrane protein 87A
SynonymsHBEBP1-
Cytomap

9q34.3

15q15.1

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane protein 203HBeAg-binding protein 1transmembrane protein 87A
Modification date2018052320180519
UniProtAcc

Q969S6

Q8NBN3

Ensembl transtripts involved in fusion geneENST00000343666, ENST00000537254, 
ENST00000389834, ENST00000448392, 
ENST00000307216, ENST00000568432, 
Fusion gene scores* DoF score1 X 1 X 1=15 X 5 X 3=75
# samples 15
** MAII scorelog2(1/1*10)=3.32192809488736log2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TMEM203 [Title/Abstract] AND TMEM87A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTMEM203

GO:0006874

cellular calcium ion homeostasis

25996873


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-AO-A03V-01ATMEM203chr9

140098556

-TMEM87Achr15

42503947

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000343666ENST00000389834TMEM203chr9

140098556

-TMEM87Achr15

42503947

-
intron-3CDSENST00000343666ENST00000448392TMEM203chr9

140098556

-TMEM87Achr15

42503947

-
intron-intronENST00000343666ENST00000307216TMEM203chr9

140098556

-TMEM87Achr15

42503947

-
intron-intronENST00000343666ENST00000568432TMEM203chr9

140098556

-TMEM87Achr15

42503947

-
intron-3CDSENST00000537254ENST00000389834TMEM203chr9

140098556

-TMEM87Achr15

42503947

-
intron-3CDSENST00000537254ENST00000448392TMEM203chr9

140098556

-TMEM87Achr15

42503947

-
intron-intronENST00000537254ENST00000307216TMEM203chr9

140098556

-TMEM87Achr15

42503947

-
intron-intronENST00000537254ENST00000568432TMEM203chr9

140098556

-TMEM87Achr15

42503947

-

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FusionProtFeatures for TMEM203_TMEM87A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TMEM203

Q969S6

TMEM87A

Q8NBN3

Involved in the regulation of cellular calciumhomeotasis (PubMed:25996873). Required for spermatogenesis(PubMed:25996873). {ECO:0000269|PubMed:25996873}. May be involved in retrograde transport from endosomesto the trans-Golgi network (TGN). {ECO:0000269|PubMed:26157166}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TMEM203_TMEM87A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TMEM203_TMEM87A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TMEM203EIF3H, CREB3, LMNATMEM87ATSPAN5, BTNL8, ERGIC3, LPAR1, GLRA2, HTR3C, USP7, AGPS, SPCS2, TMEM17, TMEM216, CDH1, SNX1, ERAP1, SCN3B, IPPK, SLC22A9, SYP, UPK1A, SLC9A6


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TMEM203_TMEM87A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TMEM203_TMEM87A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource