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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 38528

FusionGeneSummary for TMEM200A_FYN

check button Fusion gene summary
Fusion gene informationFusion gene name: TMEM200A_FYN
Fusion gene ID: 38528
HgeneTgene
Gene symbol

TMEM200A

FYN

Gene ID

114801

2534

Gene nametransmembrane protein 200AFYN proto-oncogene, Src family tyrosine kinase
SynonymsKIAA1913|TTMA|TTMCSLK|SYN|p59-FYN
Cytomap

6q23.1

6q21

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane protein 200Atwo transmembrane Ctyrosine-protein kinase FynFYN oncogene related to SRC, FGR, YESOKT3-induced calcium influx regulatorc-syn protooncogeneproto-oncogene Synproto-oncogene c-Fynsrc-like kinasesrc/yes-related noveltyrosine kinase p59fyn(T)
Modification date2018051920180523
UniProtAcc

Q86VY9

P06241

Ensembl transtripts involved in fusion geneENST00000296978, ENST00000545622, 
ENST00000392429, 		ENST00000368682, 
ENST00000354650, ENST00000229471, 
ENST00000368667, ENST00000368678, 
ENST00000229470, ENST00000356013, 
ENST00000538466, ENST00000476769, 
Fusion gene scores* DoF score1 X 1 X 1=110 X 9 X 10=900
# samples 114
** MAII scorelog2(1/1*10)=3.32192809488736log2(14/900*10)=-2.68449817427207
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TMEM200A [Title/Abstract] AND FYN [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneFYN

GO:0050852

T cell receptor signaling pathway

7722293


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVUVMTCGA-VD-A8KJ-01ATMEM200Achr6

130687669

+FYNchr6

112101838

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-5UTRENST00000296978ENST00000368682TMEM200Achr6

130687669

+FYNchr6

112101838

-
5UTR-5UTRENST00000296978ENST00000354650TMEM200Achr6

130687669

+FYNchr6

112101838

-
5UTR-intronENST00000296978ENST00000229471TMEM200Achr6

130687669

+FYNchr6

112101838

-
5UTR-5UTRENST00000296978ENST00000368667TMEM200Achr6

130687669

+FYNchr6

112101838

-
5UTR-intronENST00000296978ENST00000368678TMEM200Achr6

130687669

+FYNchr6

112101838

-
5UTR-5UTRENST00000296978ENST00000229470TMEM200Achr6

130687669

+FYNchr6

112101838

-
5UTR-5UTRENST00000296978ENST00000356013TMEM200Achr6

130687669

+FYNchr6

112101838

-
5UTR-intronENST00000296978ENST00000538466TMEM200Achr6

130687669

+FYNchr6

112101838

-
5UTR-intronENST00000296978ENST00000476769TMEM200Achr6

130687669

+FYNchr6

112101838

-
intron-5UTRENST00000545622ENST00000368682TMEM200Achr6

130687669

+FYNchr6

112101838

-
intron-5UTRENST00000545622ENST00000354650TMEM200Achr6

130687669

+FYNchr6

112101838

-
intron-intronENST00000545622ENST00000229471TMEM200Achr6

130687669

+FYNchr6

112101838

-
intron-5UTRENST00000545622ENST00000368667TMEM200Achr6

130687669

+FYNchr6

112101838

-
intron-intronENST00000545622ENST00000368678TMEM200Achr6

130687669

+FYNchr6

112101838

-
intron-5UTRENST00000545622ENST00000229470TMEM200Achr6

130687669

+FYNchr6

112101838

-
intron-5UTRENST00000545622ENST00000356013TMEM200Achr6

130687669

+FYNchr6

112101838

-
intron-intronENST00000545622ENST00000538466TMEM200Achr6

130687669

+FYNchr6

112101838

-
intron-intronENST00000545622ENST00000476769TMEM200Achr6

130687669

+FYNchr6

112101838

-
intron-5UTRENST00000392429ENST00000368682TMEM200Achr6

130687669

+FYNchr6

112101838

-
intron-5UTRENST00000392429ENST00000354650TMEM200Achr6

130687669

+FYNchr6

112101838

-
intron-intronENST00000392429ENST00000229471TMEM200Achr6

130687669

+FYNchr6

112101838

-
intron-5UTRENST00000392429ENST00000368667TMEM200Achr6

130687669

+FYNchr6

112101838

-
intron-intronENST00000392429ENST00000368678TMEM200Achr6

130687669

+FYNchr6

112101838

-
intron-5UTRENST00000392429ENST00000229470TMEM200Achr6

130687669

+FYNchr6

112101838

-
intron-5UTRENST00000392429ENST00000356013TMEM200Achr6

130687669

+FYNchr6

112101838

-
intron-intronENST00000392429ENST00000538466TMEM200Achr6

130687669

+FYNchr6

112101838

-
intron-intronENST00000392429ENST00000476769TMEM200Achr6

130687669

+FYNchr6

112101838

-

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FusionProtFeatures for TMEM200A_FYN


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TMEM200A

Q86VY9

FYN

P06241

Non-receptor tyrosine-protein kinase that plays a rolein many biological processes including regulation of cell growthand survival, cell adhesion, integrin-mediated signaling,cytoskeletal remodeling, cell motility, immune response and axonguidance. Inactive FYN is phosphorylated on its C-terminal tailwithin the catalytic domain. Following activation by PKA, theprotein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1phosphorylation, activation and targeting to focal adhesions.Involved in the regulation of cell adhesion and motility throughphosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin). Regulates cytoskeletal remodeling by phosphorylatingseveral proteins including the actin regulator WAS and themicrotubule-associated proteins MAP2 and MAPT. Promotes cellsurvival by phosphorylating AGAP2/PIKE-A and preventing itsapoptotic cleavage. Participates in signal transduction pathwaysthat regulate the integrity of the glomerular slit diaphragm (anessential part of the glomerular filter of the kidney) byphosphorylating several slit diaphragm components including NPHS1,KIRREL1 and TRPC6. Plays a role in neural processes byphosphorylating DPYSL2, a multifunctional adapter protein withinthe central nervous system, ARHGAP32, a regulator for Rho familyGTPases implicated in various neural functions, and SNCA, a smallpre-synaptic protein. Participates in the downstream signalingpathways that lead to T-cell differentiation and proliferationfollowing T-cell receptor (TCR) stimulation. PhosphorylatesPTK2B/PYK2 in response to T-cell receptor activation. Alsoparticipates in negative feedback regulation of TCR signalingthrough phosphorylation of PAG1, thereby promoting interactionbetween PAG1 and CSK and recruitment of CSK to lipid rafts. CSKmaintains LCK and FYN in an inactive form. Promotes CD28-inducedphosphorylation of VAV1. {ECO:0000269|PubMed:11005864,ECO:0000269|PubMed:11162638, ECO:0000269|PubMed:11536198,ECO:0000269|PubMed:12788081, ECO:0000269|PubMed:14707117,ECO:0000269|PubMed:14761972, ECO:0000269|PubMed:15536091,ECO:0000269|PubMed:15557120, ECO:0000269|PubMed:16387660,ECO:0000269|PubMed:16841086, ECO:0000269|PubMed:17194753,ECO:0000269|PubMed:18056706, ECO:0000269|PubMed:18258597,ECO:0000269|PubMed:19179337, ECO:0000269|PubMed:19652227,ECO:0000269|PubMed:20028775, ECO:0000269|PubMed:20100835,ECO:0000269|PubMed:22080863, ECO:0000269|PubMed:7568038,ECO:0000269|PubMed:7822789}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TMEM200A_FYN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TMEM200A_FYN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TMEM200ATP53, PPP3CC, FHOD1, PPP3CB, PPP3R1, MYADM, STX6, STX10, PPP3CA, GOSR1, STX7FYNPIK3R1, TRPC6, UNC119, GRIN2A, NPHS1, CTNND1, ARHGAP32, CTNNB1, CDH1, YES1, WAS, CHRNA7, JAK2, DLG4, KHDRBS1, PTK2B, BCAR1, GRB10, SH3BP2, SOCS1, PRKCQ, CBLC, ZAP70, PIK3R2, SRC, CD36, PLCG2, CSK, SH2D1A, GAB3, SKAP2, CDK1, DAG1, ADD2, FYB, RAF1, SKAP1, BTK, TUBA3C, MAPT, VAV1, NTRK2, MCAM, SLAMF1, PECAM1, MS4A1, PAG1, TRAT1, NEDD9, CBL, NMT1, MAP2, CSF1R, GNB2L1, CD2, SNCA, EPHB3, ITK, IL7R, PTK2, ADAM15, PTPN11, RPL10, CD44, FASLG, TOM1L1, BCL3, CTLA4, SDC3, FAS, PXN, FYN, PTPRA, GRIN2B, PTPN5, TRPV4, EPHA4, GP6, TYK2, SYK, EPHA8, SIT1, THY1, MAG, TNK2, SOS1, CD226, EPHA3, ITCH, TNFRSF1A, NDFIP2, NEDD4, UHRF2, C7orf25, TNNT1, C8orf33, HSP90AA1, NR3C1, CD3G, TRAF6, SH3KBP1, FRK, FGFR2, EFS, CD5, CAV1, VAV2, KCNA2, KCNA4, KCNA5, ATXN1, LAT, ENO1, CD244, CLTC, PDE4D, MED28, GRIN1, STAT3, TNF, IL1B, TCAP, CMA1, KDM1A, PRMT6, SUV39H1, IKBKG, IFITM3, WBP11, CCDC8, ABCE1, SLC25A41, HOXB5, SLC25A11, ANKRD12, TMEM185A, CCNL2, CBLB, NOS1AP, PIK3R3, GNB1, GNG2, LIMK1, MYH9, PMS2, TSNAX, MAPRE1, ANLN, TMEM132A, ZNFX1, MYO18A, PRKCD, RPS6KA1, HSP90AB3P, HSP90AA4P, RPS6KA3, RPS6KA2, PRUNE2, HSP90AB4P, PRKCI, MED21, LRRIQ1, PCDHGC3, PTPRD, HSP90AB1, ACBD7, GJB7, MTUS2, TNFRSF10B, CDC37, SLC4A8, GRM1, GRASP


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TMEM200A_FYN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneFYNP06241DB01254DasatinibTyrosine-protein kinase Fynsmall moleculeapproved|investigational

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RelatedDiseases for TMEM200A_FYN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneFYNC0005586Bipolar Disorder2PSYGENET
TgeneFYNC0036341Schizophrenia2PSYGENET
TgeneFYNC0001969Alcoholic Intoxication1PSYGENET
TgeneFYNC0001973Alcoholic Intoxication, Chronic1PSYGENET
TgeneFYNC0007370Catalepsy1CTD_human
TgeneFYNC0023493Adult T-Cell Lymphoma/Leukemia1CTD_human
TgeneFYNC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneFYNC0038356Stomach Neoplasms1CTD_human
TgeneFYNC0079774Peripheral T-Cell Lymphoma1CTD_human
TgeneFYNC0085762Alcohol abuse1PSYGENET