FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 38517

FusionGeneSummary for TMEM185A_APRT

check button Fusion gene summary
Fusion gene informationFusion gene name: TMEM185A_APRT
Fusion gene ID: 38517
HgeneTgene
Gene symbol

TMEM185A

APRT

Gene ID

84548

353

Gene nametransmembrane protein 185Aadenine phosphoribosyltransferase
SynonymsCXorf13|FAM11A|FRAXF|ee3AMP|APRTD
Cytomap

Xq28

16q24.3

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane protein 185Afamily with sequence similarity 11, member Afragile site, folic acid type, rare, fra(X)(q28) Fadenine phosphoribosyltransferaseAMP diphosphorylaseAMP pyrophosphorylasetransphosphoribosidase
Modification date2018052320180523
UniProtAcc

Q8NFB2

P07741

Ensembl transtripts involved in fusion geneENST00000536359, ENST00000316916, 
ENST00000507237, 
ENST00000378364, 
ENST00000426324, ENST00000563655, 
Fusion gene scores* DoF score2 X 2 X 2=83 X 3 X 2=18
# samples 23
** MAII scorelog2(2/8*10)=1.32192809488736log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TMEM185A [Title/Abstract] AND APRT [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BQ222629TMEM185AchrX

148693035

+APRTchr16

88878314

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000536359ENST00000378364TMEM185AchrX

148693035

+APRTchr16

88878314

-
intron-5UTRENST00000536359ENST00000426324TMEM185AchrX

148693035

+APRTchr16

88878314

-
intron-5UTRENST00000536359ENST00000563655TMEM185AchrX

148693035

+APRTchr16

88878314

-
intron-5UTRENST00000316916ENST00000378364TMEM185AchrX

148693035

+APRTchr16

88878314

-
intron-5UTRENST00000316916ENST00000426324TMEM185AchrX

148693035

+APRTchr16

88878314

-
intron-5UTRENST00000316916ENST00000563655TMEM185AchrX

148693035

+APRTchr16

88878314

-
intron-5UTRENST00000507237ENST00000378364TMEM185AchrX

148693035

+APRTchr16

88878314

-
intron-5UTRENST00000507237ENST00000426324TMEM185AchrX

148693035

+APRTchr16

88878314

-
intron-5UTRENST00000507237ENST00000563655TMEM185AchrX

148693035

+APRTchr16

88878314

-

Top

FusionProtFeatures for TMEM185A_APRT


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TMEM185A

Q8NFB2

APRT

P07741

Catalyzes a salvage reaction resulting in the formationof AMP, that is energically less costly than de novo synthesis.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for TMEM185A_APRT


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for TMEM185A_APRT


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for TMEM185A_APRT


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneAPRTP07741DB04272Citric AcidAdenine phosphoribosyltransferasesmall moleculeapproved|nutraceutical|vet_approved

Top

RelatedDiseases for TMEM185A_APRT


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneAPRTC0011570Mental Depression5PSYGENET
TgeneAPRTC0011581Depressive disorder5PSYGENET
TgeneAPRTC0268120Adenine phosphoribosyltransferase deficiency5ORPHANET;UNIPROT
TgeneAPRTC0451641Urolithiasis2CTD_human
TgeneAPRTC0007134Renal Cell Carcinoma1CTD_human
TgeneAPRTC0041696Unipolar Depression1PSYGENET
TgeneAPRTC1269683Major Depressive Disorder1PSYGENET
TgeneAPRTC1458155Mammary Neoplasms1CTD_human