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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 38511

FusionGeneSummary for TMEM184B_CSNK1E

check button Fusion gene summary
Fusion gene informationFusion gene name: TMEM184B_CSNK1E
Fusion gene ID: 38511
HgeneTgene
Gene symbol

TMEM184B

CSNK1E

Gene ID

25829

1454

Gene nametransmembrane protein 184Bcasein kinase 1 epsilon
SynonymsC22orf5|FM08|HS5O6A|HSPC256CKIe|CKIepsilon|HCKIE
Cytomap

22q13.1

22q13.1

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane protein 184Bputative MAPK-activating protein FM08casein kinase I isoform epsilon
Modification date2018052320180523
UniProtAcc

Q9Y519

P49674

Ensembl transtripts involved in fusion geneENST00000361906, ENST00000361684, 
ENST00000504337, 
ENST00000359867, 
ENST00000396832, ENST00000400206, 
ENST00000403904, ENST00000413574, 
ENST00000405675, ENST00000498529, 
Fusion gene scores* DoF score6 X 4 X 5=1208 X 6 X 4=192
# samples 68
** MAII scorelog2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/192*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TMEM184B [Title/Abstract] AND CSNK1E [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCSNK1E

GO:0006468

protein phosphorylation

15917222|17244647

TgeneCSNK1E

GO:0018105

peptidyl-serine phosphorylation

25500533

TgeneCSNK1E

GO:0032091

negative regulation of protein binding

23109420

TgeneCSNK1E

GO:0060070

canonical Wnt signaling pathway

14722104

TgeneCSNK1E

GO:1903827

regulation of cellular protein localization

17244647


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVREADTCGA-AF-5654-01ATMEM184Bchr22

38620792

-CSNK1Echr22

38699253

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000361906ENST00000359867TMEM184Bchr22

38620792

-CSNK1Echr22

38699253

-
In-frameENST00000361906ENST00000396832TMEM184Bchr22

38620792

-CSNK1Echr22

38699253

-
In-frameENST00000361906ENST00000400206TMEM184Bchr22

38620792

-CSNK1Echr22

38699253

-
In-frameENST00000361906ENST00000403904TMEM184Bchr22

38620792

-CSNK1Echr22

38699253

-
In-frameENST00000361906ENST00000413574TMEM184Bchr22

38620792

-CSNK1Echr22

38699253

-
In-frameENST00000361906ENST00000405675TMEM184Bchr22

38620792

-CSNK1Echr22

38699253

-
5CDS-intronENST00000361906ENST00000498529TMEM184Bchr22

38620792

-CSNK1Echr22

38699253

-
Frame-shiftENST00000361684ENST00000359867TMEM184Bchr22

38620792

-CSNK1Echr22

38699253

-
Frame-shiftENST00000361684ENST00000396832TMEM184Bchr22

38620792

-CSNK1Echr22

38699253

-
Frame-shiftENST00000361684ENST00000400206TMEM184Bchr22

38620792

-CSNK1Echr22

38699253

-
Frame-shiftENST00000361684ENST00000403904TMEM184Bchr22

38620792

-CSNK1Echr22

38699253

-
Frame-shiftENST00000361684ENST00000413574TMEM184Bchr22

38620792

-CSNK1Echr22

38699253

-
Frame-shiftENST00000361684ENST00000405675TMEM184Bchr22

38620792

-CSNK1Echr22

38699253

-
5CDS-intronENST00000361684ENST00000498529TMEM184Bchr22

38620792

-CSNK1Echr22

38699253

-
intron-3CDSENST00000504337ENST00000359867TMEM184Bchr22

38620792

-CSNK1Echr22

38699253

-
intron-3CDSENST00000504337ENST00000396832TMEM184Bchr22

38620792

-CSNK1Echr22

38699253

-
intron-3CDSENST00000504337ENST00000400206TMEM184Bchr22

38620792

-CSNK1Echr22

38699253

-
intron-3CDSENST00000504337ENST00000403904TMEM184Bchr22

38620792

-CSNK1Echr22

38699253

-
intron-3CDSENST00000504337ENST00000413574TMEM184Bchr22

38620792

-CSNK1Echr22

38699253

-
intron-3CDSENST00000504337ENST00000405675TMEM184Bchr22

38620792

-CSNK1Echr22

38699253

-
intron-intronENST00000504337ENST00000498529TMEM184Bchr22

38620792

-CSNK1Echr22

38699253

-

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FusionProtFeatures for TMEM184B_CSNK1E


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TMEM184B

Q9Y519

CSNK1E

P49674

May activate the MAP kinase signaling pathway.{ECO:0000269|PubMed:12761501}. Casein kinases are operationally defined by theirpreferential utilization of acidic proteins such as caseins assubstrates. Can phosphorylate a large number of proteins.Participates in Wnt signaling. Phosphorylates DVL1 and DVL2.Central component of the circadian clock. In balance with PP1,determines the circadian period length, through the regulation ofthe speed and rhythmicity of PER1 and PER2 phosphorylation.Controls PER1 and PER2 nuclear transport and degradation. Inhibitscytokine-induced granuloytic differentiation.{ECO:0000269|PubMed:12556519, ECO:0000269|PubMed:15070676,ECO:0000269|PubMed:15917222, ECO:0000269|PubMed:16790549,ECO:0000269|PubMed:23413191}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTMEM184Bchr22:38620792chr22:38699253ENST00000361684-89121_141327408TransmembraneHelical
HgeneTMEM184Bchr22:38620792chr22:38699253ENST00000361684-89178_198327408TransmembraneHelical
HgeneTMEM184Bchr22:38620792chr22:38699253ENST00000361684-89214_234327408TransmembraneHelical
HgeneTMEM184Bchr22:38620792chr22:38699253ENST00000361684-89249_269327408TransmembraneHelical
HgeneTMEM184Bchr22:38620792chr22:38699253ENST00000361684-89290_310327408TransmembraneHelical
HgeneTMEM184Bchr22:38620792chr22:38699253ENST00000361684-8940_60327408TransmembraneHelical
HgeneTMEM184Bchr22:38620792chr22:38699253ENST00000361684-8984_104327408TransmembraneHelical
HgeneTMEM184Bchr22:38620792chr22:38699253ENST00000361906-89121_141327408TransmembraneHelical
HgeneTMEM184Bchr22:38620792chr22:38699253ENST00000361906-89178_198327408TransmembraneHelical
HgeneTMEM184Bchr22:38620792chr22:38699253ENST00000361906-89214_234327408TransmembraneHelical
HgeneTMEM184Bchr22:38620792chr22:38699253ENST00000361906-89249_269327408TransmembraneHelical
HgeneTMEM184Bchr22:38620792chr22:38699253ENST00000361906-89290_310327408TransmembraneHelical
HgeneTMEM184Bchr22:38620792chr22:38699253ENST00000361906-8940_60327408TransmembraneHelical
HgeneTMEM184Bchr22:38620792chr22:38699253ENST00000361906-8984_104327408TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCSNK1Echr22:38620792chr22:38699253ENST00000359867-1119_27725792DomainProtein kinase
TgeneCSNK1Echr22:38620792chr22:38699253ENST00000396832-1119_27725742DomainProtein kinase
TgeneCSNK1Echr22:38620792chr22:38699253ENST00000400206-5159_27725583DomainProtein kinase
TgeneCSNK1Echr22:38620792chr22:38699253ENST00000403904-1109_27725417DomainProtein kinase
TgeneCSNK1Echr22:38620792chr22:38699253ENST00000359867-11115_2325792Nucleotide bindingATP
TgeneCSNK1Echr22:38620792chr22:38699253ENST00000396832-11115_2325742Nucleotide bindingATP
TgeneCSNK1Echr22:38620792chr22:38699253ENST00000400206-51515_2325583Nucleotide bindingATP
TgeneCSNK1Echr22:38620792chr22:38699253ENST00000403904-11015_2325417Nucleotide bindingATP


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FusionGeneSequence for TMEM184B_CSNK1E


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TMEM184B_CSNK1E


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TMEM184BLPAR6, ERGIC3, SNIP1, REN, CLASRP, CCDC9, ACIN1, INPPL1, TIMM23, FPR2, GPR21, C17orf85, SLC22A9, CLEC2D, YTHDF1, ZFYVE27, PDCD1, ABCG8, BBS4CSNK1EDVL2, RAD54B, MCC, PER3, PER1, ARNTL, AXIN1, DVL1, ANKRD6, NCOA3, CADM4, HES1, GTF3C1, RBX1, KAT7, TAOK1, BBS10, ZNF227, PNO1, C2orf44, FAM110A, FBP1, ARHGEF1, FAM83D, ZMYND8, ELAVL1, MYC, MYCN, TAZ, CTNND1, DBNDD2, APP, BYSL, PPP1R14A, PPP1CA, SDCCAG3, TENC1, FAM110C, SAV1, REST, CSNK1A1, ZSWIM8, USP9Y, PRMT5, SEC16A, AHCYL1, HMMR, MTA2, FARP2, CSNK1D, SEC13, WDR5, ACACA, PRDX4, STK3, CUL2, TCEB2, CRY1, PPP6R3, FAM83B, FAM199X, FAM83H, VPS13B, FAM110B, USP9X, AHCYL2, SNX22, KLHDC3, UNC45A, ADAM22, STOX2, RASAL2, SNX24, TIAM1, DVL3, OCLN, CSNK1E, DEC1, BHLHE41, PER2, PPP1CC, PPP2R5E, RORC, CSNK2B, FBXW11, NR1D2, CLOCK, PPP2R5D, RORA, UBE2S, DRICH1, CACNG2, TRA2A, TEX264, MRPL4, CACNG4, RP2, SGOL2, MAPK9, MICU2, LTBR, PCMT1, SMARCD1, LDLRAD4, NTRK1, ALYREF, DHX16, DTD1, NLRP1, NSUN2, USP39, NOB1, PPM1B, CEP290, CEP162, PCM1, CEP128, XPO1, CRY2, CLTC, JAK3, KIF2A, BAIAP2, GTSE1, CAMKK1, PRKAR2A, OFD1, KIAA0753, TRIM3, CEP131, GAPVD1, CEP72, MIER1, FOPNL, SPICE1, WDR90, CCDC61, APC, BID, TP53, UBXN7, TRAF3, MAVS, ATOH1, LPIN1, ZNF618, PDE4DIP, ANKRD49, SSMEM1, NXF2, RPS4Y2, FKBPL, UQCC1, POTEF, ARHGAP22, HSPA8, KLHL42, CACNG5, RNF43, TNFRSF1A, BTBD1, C7orf60, PRKAR2B, MTMR4, FOXP2, WWC1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TMEM184B_CSNK1E


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TMEM184B_CSNK1E


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTMEM184BC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneCSNK1EC0005586Bipolar Disorder5PSYGENET
TgeneCSNK1EC0036341Schizophrenia2PSYGENET
TgeneCSNK1EC0033975Psychotic Disorders1PSYGENET
TgeneCSNK1EC0349204Nonorganic psychosis1PSYGENET