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Fusion gene ID: 38477 |
FusionGeneSummary for TMEM170A_USP22 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TMEM170A_USP22 | Fusion gene ID: 38477 | Hgene | Tgene | Gene symbol | TMEM170A | USP22 | Gene ID | 124491 | 23326 |
| Gene name | transmembrane protein 170A | ubiquitin specific peptidase 22 | |
| Synonyms | TMEM170 | USP3L | |
| Cytomap | 16q23.1 | 17p11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | transmembrane protein 170Atransmembrane protein 170 | ubiquitin carboxyl-terminal hydrolase 22deubiquitinating enzyme 22ubiquitin specific protease 22ubiquitin thioesterase 22ubiquitin thiolesterase 22ubiquitin-specific processing protease 22 | |
| Modification date | 20180329 | 20180519 | |
| UniProtAcc | Q8WVE7 | Q9UPT9 | |
| Ensembl transtripts involved in fusion gene | ENST00000357613, ENST00000569540, ENST00000561878, ENST00000567796, ENST00000566980, ENST00000569276, | ENST00000261497, ENST00000537526, ENST00000455117, | |
| Fusion gene scores | * DoF score | 6 X 6 X 5=180 | 10 X 9 X 3=270 |
| # samples | 7 | 10 | |
| ** MAII score | log2(7/180*10)=-1.36257007938471 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/270*10)=-1.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TMEM170A [Title/Abstract] AND USP22 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | USP22 | GO:0016574 | histone ubiquitination | 18469533 |
| Tgene | USP22 | GO:0016578 | histone deubiquitination | 18206972|18206973 |
| Tgene | USP22 | GO:0016579 | protein deubiquitination | 16378762 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | PRAD | TCGA-CH-5790-01A | TMEM170A | chr16 | 75485636 | - | USP22 | chr17 | 20931987 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000357613 | ENST00000261497 | TMEM170A | chr16 | 75485636 | - | USP22 | chr17 | 20931987 | - |
| Frame-shift | ENST00000357613 | ENST00000537526 | TMEM170A | chr16 | 75485636 | - | USP22 | chr17 | 20931987 | - |
| 5CDS-5UTR | ENST00000357613 | ENST00000455117 | TMEM170A | chr16 | 75485636 | - | USP22 | chr17 | 20931987 | - |
| intron-3CDS | ENST00000569540 | ENST00000261497 | TMEM170A | chr16 | 75485636 | - | USP22 | chr17 | 20931987 | - |
| intron-3CDS | ENST00000569540 | ENST00000537526 | TMEM170A | chr16 | 75485636 | - | USP22 | chr17 | 20931987 | - |
| intron-5UTR | ENST00000569540 | ENST00000455117 | TMEM170A | chr16 | 75485636 | - | USP22 | chr17 | 20931987 | - |
| intron-3CDS | ENST00000561878 | ENST00000261497 | TMEM170A | chr16 | 75485636 | - | USP22 | chr17 | 20931987 | - |
| intron-3CDS | ENST00000561878 | ENST00000537526 | TMEM170A | chr16 | 75485636 | - | USP22 | chr17 | 20931987 | - |
| intron-5UTR | ENST00000561878 | ENST00000455117 | TMEM170A | chr16 | 75485636 | - | USP22 | chr17 | 20931987 | - |
| intron-3CDS | ENST00000567796 | ENST00000261497 | TMEM170A | chr16 | 75485636 | - | USP22 | chr17 | 20931987 | - |
| intron-3CDS | ENST00000567796 | ENST00000537526 | TMEM170A | chr16 | 75485636 | - | USP22 | chr17 | 20931987 | - |
| intron-5UTR | ENST00000567796 | ENST00000455117 | TMEM170A | chr16 | 75485636 | - | USP22 | chr17 | 20931987 | - |
| In-frame | ENST00000566980 | ENST00000261497 | TMEM170A | chr16 | 75485636 | - | USP22 | chr17 | 20931987 | - |
| In-frame | ENST00000566980 | ENST00000537526 | TMEM170A | chr16 | 75485636 | - | USP22 | chr17 | 20931987 | - |
| 5CDS-5UTR | ENST00000566980 | ENST00000455117 | TMEM170A | chr16 | 75485636 | - | USP22 | chr17 | 20931987 | - |
| intron-3CDS | ENST00000569276 | ENST00000261497 | TMEM170A | chr16 | 75485636 | - | USP22 | chr17 | 20931987 | - |
| intron-3CDS | ENST00000569276 | ENST00000537526 | TMEM170A | chr16 | 75485636 | - | USP22 | chr17 | 20931987 | - |
| intron-5UTR | ENST00000569276 | ENST00000455117 | TMEM170A | chr16 | 75485636 | - | USP22 | chr17 | 20931987 | - |
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FusionProtFeatures for TMEM170A_USP22 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TMEM170A | USP22 |
| Acts as a regulator of endoplasmic reticulum (ER) andnuclear envelope (NE) morphogenesis. Affects the ratio betweentubular ER and ER sheets by promoting sheet formation at theexpense of tubules. Influences NE expansion, nuclear pore complexformation and proper localization of inner nuclear membraneproteins (PubMed:26906412). {ECO:0000269|PubMed:26906412}. | Histone deubiquitinating component of the transcriptionregulatory histone acetylation (HAT) complex SAGA. Catalyzes thedeubiquitination of both histones H2A and H2B, thereby acting as acoactivator. Recruited to specific gene promoters by activatorssuch as MYC, where it is required for transcription. Required fornuclear receptor-mediated transactivation and cell cycleprogression. {ECO:0000269|PubMed:18206972,ECO:0000269|PubMed:18206973, ECO:0000269|PubMed:18469533}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TMEM170A_USP22 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_TMEM170A_ENST00000566980_chr16_75485636_-_USP22_ENST00000261497_chr17_20931987_-_502aa MWYGVFLWALVSSLFFHVPAGLLALFTLRHHKYGQVLYLPCLWRPPQQAAFLPLLCLLRLFHKEAYSRACEGEAAQPGHXSDVRRHLLFS VPGLHLXQRHGNNRQGGAAKSLENARRWREVFNLGTNQTGAXTAEAQPEKEKDHLELHHRSAWADQPWEHMLHELHRAGPDPHATSAGLL PVXQAPLXDAEPQLLSGLXDVLTVSGVLLWTPVPSHPVXVAAPGVDPREAPSRLRAAGRPRVPHRGPGRAPPTLQRXXQWEEGQQPQPLQ LHHRPDLHRRVAVRRHLPSLPWSLHHHRPLLGHQLGSPRLFHPILAPEPRERGQRGKRGKPRVGNHHAHGLPATIHQTRALGQQRQDQVQ RLPXLPGVHKAAHYEETAHRSLFSSQTIXTLSQAAAEDHHVCVLPPGAGHDPFHGLQQREQDEWTVPAAHGQSQQXQQVFPVCCCXPSRD >In-frame_TMEM170A_ENST00000566980_chr16_75485636_-_USP22_ENST00000537526_chr17_20931987_-_502aa MWYGVFLWALVSSLFFHVPAGLLALFTLRHHKYGQVLYLPCLWRPPQQAAFLPLLCLLRLFHKEAYSRACEGEAAQPGHXSDVRRHLLFS VPGLHLXQRHGNNRQGGAAKSLENARRWREVFNLGTNQTGAXTAEAQPEKEKDHLELHHRSAWADQPWEHMLHELHRAGPDPHATSAGLL PVXQAPLXDAEPQLLSGLXDVLTVSGVLLWTPVPSHPVXVAAPGVDPREAPSRLRAAGRPRVPHRGPGRAPPTLQRXXQWEEGQQPQPLQ LHHRPDLHRRVAVRRHLPSLPWSLHHHRPLLGHQLGSPRLFHPILAPEPRERGQRGKRGKPRVGNHHAHGLPATIHQTRALGQQRQDQVQ RLPXLPGVHKAAHYEETAHRSLFSSQTIXTLSQAAAEDHHVCVLPPGAGHDPFHGLQQREQDEWTVPAAHGQSQQXQQVFPVCCCXPSRD |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_TMEM170A_ENST00000566980_chr16_75485636_-_USP22_ENST00000261497_chr17_20931987_-_1507nt ATGTGGTATGGTGTATTCCTGTGGGCACTGGTGTCTTCTCTCTTCTTTCATGTCCCTGCTGGATTACTGGCCCTCTTCACCCTCAGACAT CACAAATATGGCCAAGTCCTGTATCTGCCATGTCTGTGGCGTCCACCTCAACAGGCTGCATTCCTGCCTCTACTGTGTCTTCTTCGGCTG TTTCACAAAGAAGCATATTCACGAGCATGCGAAGGCGAAGCGGCACAACCTGGCCATTGATCTGATGTACGGAGGCATCTACTGTTTTCT GTGCCAGGACTACATCTATGACAAAGACATGGAAATAATCGCCAAGGAGGAGCAGCGAAAAGCTTGGAAAATGCAAGGCGTTGGAGAGAA GTTTTCAACTTGGGAACCAACCAAACGGGAGCTTGAACTGCTGAAGCACAACCCGAAAAGGAGAAAGATCACCTCGAACTGCACCATAGG TCTGCGTGGGCTGATCAACCTTGGGAACACATGCTTCATGAACTGCATCGTGCAGGCCCTGACCCACACGCCACTTCTGCGGGACTTCTT CCTGTCTGACAGGCACCGCTGTGAGATGCAGAGCCCCAGCTCCTGTCTGGTCTGTGAGATGTCCTCACTGTTTCAGGAGTTTTACTCTGG ACACCGGTCCCCTCACATCCCGTATAAGTTGCTGCACCTGGTGTGGACCCACGCGAGGCACCTAGCAGGCTACGAGCAGCAGGACGCCCA CGAGTTCCTCATCGCGGCCCTGGACGTGCTCCACCGACACTGCAAAGGTGATGACAATGGGAAGAAGGCCAACAACCCCAACCACTGCAA CTGCATCATAGACCAGATCTTCACAGGCGGGTTGCAGTCAGACGTCACCTGCCAAGTCTGCCATGGAGTCTCCACCACCATCGACCCCTT CTGGGACATCAGCTTGGATCTCCCCGGCTCTTCCACCCCATTCTGGCCCCTGAGCCCAGGGAGCGAGGGCAACGTGGTAAACGGGGAAAG CCACGTGTCGGGAACCACCACGCTCACGGACTGCCTGCGACGATTCACCAGACCAGAGCACTTGGGCAGCAGCGCCAAGATCAAGTGCAG CGGTTGCCATAGCTACCAGGAGTCCACAAAGCAGCTCACTATGAAGAAACTGCCCATCGTAGCCTGTTTTCATCTCAAACGATTTGAACA CTCAGCCAAGCTGCGGCGGAAGATCACCACGTATGTGTCCTTCCCCCTGGAGCTGGACATGACCCCTTTCATGGCCTCCAGCAAAGAGAG CAGGATGAATGGACAGTACCAGCAGCCCACGGACAGTCTCAACAATGACAACAAGTATTCCCTGTTTGCTGTTGTTAACCATCAAGGGAC CTTGGAGAGTGGCCACTACACCAGCTTTATCCGGCAGCACAAAGACCAGTGGTTCAAGTGTGACGATGCCATCATCACCAAGGCCAGCAT >In-frame_TMEM170A_ENST00000566980_chr16_75485636_-_USP22_ENST00000537526_chr17_20931987_-_1507nt ATGTGGTATGGTGTATTCCTGTGGGCACTGGTGTCTTCTCTCTTCTTTCATGTCCCTGCTGGATTACTGGCCCTCTTCACCCTCAGACAT CACAAATATGGCCAAGTCCTGTATCTGCCATGTCTGTGGCGTCCACCTCAACAGGCTGCATTCCTGCCTCTACTGTGTCTTCTTCGGCTG TTTCACAAAGAAGCATATTCACGAGCATGCGAAGGCGAAGCGGCACAACCTGGCCATTGATCTGATGTACGGAGGCATCTACTGTTTTCT GTGCCAGGACTACATCTATGACAAAGACATGGAAATAATCGCCAAGGAGGAGCAGCGAAAAGCTTGGAAAATGCAAGGCGTTGGAGAGAA GTTTTCAACTTGGGAACCAACCAAACGGGAGCTTGAACTGCTGAAGCACAACCCGAAAAGGAGAAAGATCACCTCGAACTGCACCATAGG TCTGCGTGGGCTGATCAACCTTGGGAACACATGCTTCATGAACTGCATCGTGCAGGCCCTGACCCACACGCCACTTCTGCGGGACTTCTT CCTGTCTGACAGGCACCGCTGTGAGATGCAGAGCCCCAGCTCCTGTCTGGTCTGTGAGATGTCCTCACTGTTTCAGGAGTTTTACTCTGG ACACCGGTCCCCTCACATCCCGTATAAGTTGCTGCACCTGGTGTGGACCCACGCGAGGCACCTAGCAGGCTACGAGCAGCAGGACGCCCA CGAGTTCCTCATCGCGGCCCTGGACGTGCTCCACCGACACTGCAAAGGTGATGACAATGGGAAGAAGGCCAACAACCCCAACCACTGCAA CTGCATCATAGACCAGATCTTCACAGGCGGGTTGCAGTCAGACGTCACCTGCCAAGTCTGCCATGGAGTCTCCACCACCATCGACCCCTT CTGGGACATCAGCTTGGATCTCCCCGGCTCTTCCACCCCATTCTGGCCCCTGAGCCCAGGGAGCGAGGGCAACGTGGTAAACGGGGAAAG CCACGTGTCGGGAACCACCACGCTCACGGACTGCCTGCGACGATTCACCAGACCAGAGCACTTGGGCAGCAGCGCCAAGATCAAGTGCAG CGGTTGCCATAGCTACCAGGAGTCCACAAAGCAGCTCACTATGAAGAAACTGCCCATCGTAGCCTGTTTTCATCTCAAACGATTTGAACA CTCAGCCAAGCTGCGGCGGAAGATCACCACGTATGTGTCCTTCCCCCTGGAGCTGGACATGACCCCTTTCATGGCCTCCAGCAAAGAGAG CAGGATGAATGGACAGTACCAGCAGCCCACGGACAGTCTCAACAATGACAACAAGTATTCCCTGTTTGCTGTTGTTAACCATCAAGGGAC CTTGGAGAGTGGCCACTACACCAGCTTTATCCGGCAGCACAAAGACCAGTGGTTCAAGTGTGACGATGCCATCATCACCAAGGCCAGCAT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_TMEM170A_ENST00000566980_chr16_75485636_-_USP22_ENST00000261497_chr17_20931987_-_5009nt ACTTGGCAGCGCCGTTGGGATTGGGGGAAGAGGACCCCGGCTGGAGGTGACGCTGAGGCGGCGAGGAGATGTGGTATGGTGTATTCCTGT GGGCACTGGTGTCTTCTCTCTTCTTTCATGTCCCTGCTGGATTACTGGCCCTCTTCACCCTCAGACATCACAAATATGGCCAAGTCCTGT ATCTGCCATGTCTGTGGCGTCCACCTCAACAGGCTGCATTCCTGCCTCTACTGTGTCTTCTTCGGCTGTTTCACAAAGAAGCATATTCAC GAGCATGCGAAGGCGAAGCGGCACAACCTGGCCATTGATCTGATGTACGGAGGCATCTACTGTTTTCTGTGCCAGGACTACATCTATGAC AAAGACATGGAAATAATCGCCAAGGAGGAGCAGCGAAAAGCTTGGAAAATGCAAGGCGTTGGAGAGAAGTTTTCAACTTGGGAACCAACC AAACGGGAGCTTGAACTGCTGAAGCACAACCCGAAAAGGAGAAAGATCACCTCGAACTGCACCATAGGTCTGCGTGGGCTGATCAACCTT GGGAACACATGCTTCATGAACTGCATCGTGCAGGCCCTGACCCACACGCCACTTCTGCGGGACTTCTTCCTGTCTGACAGGCACCGCTGT GAGATGCAGAGCCCCAGCTCCTGTCTGGTCTGTGAGATGTCCTCACTGTTTCAGGAGTTTTACTCTGGACACCGGTCCCCTCACATCCCG TATAAGTTGCTGCACCTGGTGTGGACCCACGCGAGGCACCTAGCAGGCTACGAGCAGCAGGACGCCCACGAGTTCCTCATCGCGGCCCTG GACGTGCTCCACCGACACTGCAAAGGTGATGACAATGGGAAGAAGGCCAACAACCCCAACCACTGCAACTGCATCATAGACCAGATCTTC ACAGGCGGGTTGCAGTCAGACGTCACCTGCCAAGTCTGCCATGGAGTCTCCACCACCATCGACCCCTTCTGGGACATCAGCTTGGATCTC CCCGGCTCTTCCACCCCATTCTGGCCCCTGAGCCCAGGGAGCGAGGGCAACGTGGTAAACGGGGAAAGCCACGTGTCGGGAACCACCACG CTCACGGACTGCCTGCGACGATTCACCAGACCAGAGCACTTGGGCAGCAGCGCCAAGATCAAGTGCAGCGGTTGCCATAGCTACCAGGAG TCCACAAAGCAGCTCACTATGAAGAAACTGCCCATCGTAGCCTGTTTTCATCTCAAACGATTTGAACACTCAGCCAAGCTGCGGCGGAAG ATCACCACGTATGTGTCCTTCCCCCTGGAGCTGGACATGACCCCTTTCATGGCCTCCAGCAAAGAGAGCAGGATGAATGGACAGTACCAG CAGCCCACGGACAGTCTCAACAATGACAACAAGTATTCCCTGTTTGCTGTTGTTAACCATCAAGGGACCTTGGAGAGTGGCCACTACACC AGCTTTATCCGGCAGCACAAAGACCAGTGGTTCAAGTGTGACGATGCCATCATCACCAAGGCCAGCATCAAGGACGTCCTGGACAGCGAA GGGTACTTGCTGTTCTATCACAAACAGTTCCTGGAATACGAGTAGCCTTATCTGCAGCTGGTCAGAAAAACAAAGGCAATGCATTGGCAA GCCTCACAAAGTGATCCTCCCTGGCCCCCCCCTCCCCCAAGTCTCCCGCCGCCTCCCCGGCCTGGTGACACCACCTCCCATGCAGATGTG GCCCCTCTGCACCTGGGACCCATCGGGTCGGGATGGACCACACGGACGGGGAGGCTCCTGGAGCTGCTTTGAAGATGGATGAGATGAGGG GTGTGCTCTGGGTGGGAGGAGCAGCGTACACCCGTCACCAGAACATCTCTTGTGTCATGACATGGGGGTGCAACGGGGGCCTCACAGCAC AGAGTGACCGCTGCCTGGCGTTCCCCAGCACTCGGTGTGGAAAGGCCCCTACCTGCTGTAAGATTATGGGTCCATGAAAGCAGTAAGCTG GACACAGAGGTGTAGTGTGCGGGACAGAGGGCCTTGCAGATGCCTTTCTGTTGGTGTTTTAGTGTTAAAATACGGAGAGTATGGAACTCT TCACCTCCATTTTCTCAGCGGCTGTGAAGCAGCCTCCTAGCTTCGGAAGTACGGACACTACGTCGCGTTTTCAAGCGTGTCTGTTCTGCA GGTAACAGCATCAAGCTGCACGTGGAAGCATCTCGCGGTTTTCTAGAAACAGGCATTTTCTTATCCCTCTCCCGCTCCTTTTTCCACAAA GGTGAATTTCATAAATGTAATACTAGTAAAGTGAATGAATTACTGAGTTTATACAGAAATTTAGGTAACTTCTCCTTTAGTCTCAAGAGC GAGTCTTGCTTTTTAATGGGTGCCGTTTATGTTGCTGCCCGCCCTGTGTGCCTGGCTCCTCTGGGTGCCTTGGTGTCTGCTGGTGGCTGG CAGTGGGCGCAGCGGAGGAGAGTTGTGCTGCAGCTCATACGGTGTGTCTGTCATCTCAGTCTGGAGTAAATGCAGTGTCTGCCGGTGTCT GATGGGTTCTGTCCCTCGTATTTTCTTTGCCTTCTATCCCATTGCCTGGCTACCGCTGCCTGGCAGCCAAGGGTGTTGGTCGCGAAGCTG GAGTGGCCTCTGGTGGAGCCTGCATCTTGTCTCGTCTGCCTCTGCTTTACATTTGGTGTACTTTCGGGCGTGGTGGCAGTAAAATGACAC CGTGATTGAGCTTGTCAGCAGAGCTGAAAGAGAAAGTAGAAGGATGTGCATTGTTTCTTGTAAGATATCTTGCATGTATCTGTGTATTCA AATTCAAACAGAGATGGTTTGTCCATTTGTCCACTGAGAAATTAGAAACTAGGGACAAGGGGGAGGAAAAGTACTGAAATACAGTTTATG AAGCAAGTGTGTCTCGGGCTGTGCTTGTCCCAGGAGCCCCAGCAGCATCTGAACTGAGGCTTCTTCAGTCCTGCAGGAACAGGATCATCT GTCTCAGCGGTGGGCAGATGTTTTCATAGACAGCCAGGGAGTAAACACTGTTGGCTCTGTGGGCTGTATGGTCTCTGCCATAAATAGTAC AGAGATGTGGCTGTGTCTAGTACAACTTTTAGACACAGAAATCTGAATGACATATATTGTTCTGTGTCAAGAAACTTAGATTTTTTTTTT AACTATTTAAAAACGTGAAACCTATTCTTAGCTCACAGGCCATGGAGAAGCTGGTGGGGACCAGACCCAGCTCCTTAGCTGGCTGGGCTG GGGAGGGGGTAGTGACAGTGGCAGCTGCTACTCACTGCTCAGTGTGGAAAACACAGGACTTGGCAATCACAGCCCGCAGAACCATCATGT GTGGCAGAAGCCTGAGGGATGCGGTTTCTTGCCCACGTGCTCTGTTCATTTTCTGTTGTTTTTCTGCACTTAAAGAATTCACATGGAAGC ATGTTTTATAAAATGAATTACCAGAGAAACAGAGATGGGCCGAGATTTTCAGAAATGGTCCCATGTGACCAAGTTCTGCTGTTTGGGTGA CAGTGCTTTGAAGATCTCCTTTGAGGATGTGCAGTCTTTTTTTTTTTTTTTTTGAGATGGAGTTTGTTGCCCAGGCTGGAGTGAGTGGCA CAGTCTCGGCTCACTGCAACCTCCACCTCCTGGGTTCAAGCAGTTCTCGTGCCGCAGCCTCCCAAGTAGCTGGGACTACAGGCATGCACC ACCACGCCAGGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTCTCAAACTCCTGACCTCAGGCGATCCACCCACCTCAGC GTCCCAAAGTGCTGGGATTATAGGCGTGAGCCACCGCACCTGGCCTATGAGTGGTCTTTTAATTAGGAACAAATCTAATGGAAAGGAGAG TTGACTGAAGTTGGCCCACAGGATTGTGAGCTGGGCAGTGCCTTCATGAAGGCTTGCCACCTTGGGACGCCCCAGTTTACTGGGGTGTCT TGCGGAGTGCAGAAGGCTTTCTGGCAGCTGCCTGGGTTTGGCCAGACCCTGCCTCCCCTCCCGCCGGCCAACCCCTAGTCCCCTTCCTGT CTCCACTTGCATTCAGGGGTGGCTGCTGTTCTGAGAACATTAGAACTGGGAAGAGAGATGGAGTCACATGGATTTTTGGTGGGCATTATT CTAAACTTTCGTATCCAAGTTAGTCCCCCTTATTCCACTGTGGCATTGCCGTTCTAAGCAGTTACCTGATGCCTGCTGCTGAAGAGCTGC TCACAGGAGGCGGCGGCGGCCCTGGCACTGCCCCTTGCATTAGGTCTTGTGTTTGATGTGTTCTTGTGAATTTACTTTGTCAGAACAAAA TATTTACGCGTTGGGTTCAGGAATTTCTTTTAGCTCCCCATCTGGCTGTGAAATTCAGGAAACCTCCCGTTGCCTAGTAATCACCCCATG TAGGTGTACATTGTGACAAAGTGCATCTGACCACTAAGGGGCCCCCTTGGTGACCCCAGCACATTCACAGCAGTGTTAAAATGGCCTGCA TTTTGGAGATGCTGGCTGGCCTTTCAGTGCCTCCCAGGAAGACACATGGCCTTTCCCTCTTCAGATGCCTGAAGGGAGTGCTTTGAGGCA GGTGATGTGCTGGGAGTGTGGGCGGCCTCCCTCTGGCCCCGGGGCCCTCTGTGGACCTTGGCTCCCTCCGTGGACCTGGGCTTCGTGGTG AGCACTGCAGCCTCCCTGGGCATTCCCTCCAGCGCCAGCACCACTGCAACATATAGACCTGAGTGCTATTGTATTTTGGCTTGGTGTGTA TGCTCTTCATTGTGTAAAATTGCTGTTCTTTTGACAATTTAAGTGATTGTTTTGTTTACTGTAAGTTTGAAAATAAAAATGAAGAAAAAA ATTCCAATGACTGTGCTGTGGTTGGAGACTTTATTTACCAAGATGTTTACTCTTCCTTTCCCCTTCCATTTTGAGGAGCTGTGTCACTCC >In-frame_TMEM170A_ENST00000566980_chr16_75485636_-_USP22_ENST00000537526_chr17_20931987_-_5009nt ACTTGGCAGCGCCGTTGGGATTGGGGGAAGAGGACCCCGGCTGGAGGTGACGCTGAGGCGGCGAGGAGATGTGGTATGGTGTATTCCTGT GGGCACTGGTGTCTTCTCTCTTCTTTCATGTCCCTGCTGGATTACTGGCCCTCTTCACCCTCAGACATCACAAATATGGCCAAGTCCTGT ATCTGCCATGTCTGTGGCGTCCACCTCAACAGGCTGCATTCCTGCCTCTACTGTGTCTTCTTCGGCTGTTTCACAAAGAAGCATATTCAC GAGCATGCGAAGGCGAAGCGGCACAACCTGGCCATTGATCTGATGTACGGAGGCATCTACTGTTTTCTGTGCCAGGACTACATCTATGAC AAAGACATGGAAATAATCGCCAAGGAGGAGCAGCGAAAAGCTTGGAAAATGCAAGGCGTTGGAGAGAAGTTTTCAACTTGGGAACCAACC AAACGGGAGCTTGAACTGCTGAAGCACAACCCGAAAAGGAGAAAGATCACCTCGAACTGCACCATAGGTCTGCGTGGGCTGATCAACCTT GGGAACACATGCTTCATGAACTGCATCGTGCAGGCCCTGACCCACACGCCACTTCTGCGGGACTTCTTCCTGTCTGACAGGCACCGCTGT GAGATGCAGAGCCCCAGCTCCTGTCTGGTCTGTGAGATGTCCTCACTGTTTCAGGAGTTTTACTCTGGACACCGGTCCCCTCACATCCCG TATAAGTTGCTGCACCTGGTGTGGACCCACGCGAGGCACCTAGCAGGCTACGAGCAGCAGGACGCCCACGAGTTCCTCATCGCGGCCCTG GACGTGCTCCACCGACACTGCAAAGGTGATGACAATGGGAAGAAGGCCAACAACCCCAACCACTGCAACTGCATCATAGACCAGATCTTC ACAGGCGGGTTGCAGTCAGACGTCACCTGCCAAGTCTGCCATGGAGTCTCCACCACCATCGACCCCTTCTGGGACATCAGCTTGGATCTC CCCGGCTCTTCCACCCCATTCTGGCCCCTGAGCCCAGGGAGCGAGGGCAACGTGGTAAACGGGGAAAGCCACGTGTCGGGAACCACCACG CTCACGGACTGCCTGCGACGATTCACCAGACCAGAGCACTTGGGCAGCAGCGCCAAGATCAAGTGCAGCGGTTGCCATAGCTACCAGGAG TCCACAAAGCAGCTCACTATGAAGAAACTGCCCATCGTAGCCTGTTTTCATCTCAAACGATTTGAACACTCAGCCAAGCTGCGGCGGAAG ATCACCACGTATGTGTCCTTCCCCCTGGAGCTGGACATGACCCCTTTCATGGCCTCCAGCAAAGAGAGCAGGATGAATGGACAGTACCAG CAGCCCACGGACAGTCTCAACAATGACAACAAGTATTCCCTGTTTGCTGTTGTTAACCATCAAGGGACCTTGGAGAGTGGCCACTACACC AGCTTTATCCGGCAGCACAAAGACCAGTGGTTCAAGTGTGACGATGCCATCATCACCAAGGCCAGCATCAAGGACGTCCTGGACAGCGAA GGGTACTTGCTGTTCTATCACAAACAGTTCCTGGAATACGAGTAGCCTTATCTGCAGCTGGTCAGAAAAACAAAGGCAATGCATTGGCAA GCCTCACAAAGTGATCCTCCCTGGCCCCCCCCTCCCCCAAGTCTCCCGCCGCCTCCCCGGCCTGGTGACACCACCTCCCATGCAGATGTG GCCCCTCTGCACCTGGGACCCATCGGGTCGGGATGGACCACACGGACGGGGAGGCTCCTGGAGCTGCTTTGAAGATGGATGAGATGAGGG GTGTGCTCTGGGTGGGAGGAGCAGCGTACACCCGTCACCAGAACATCTCTTGTGTCATGACATGGGGGTGCAACGGGGGCCTCACAGCAC AGAGTGACCGCTGCCTGGCGTTCCCCAGCACTCGGTGTGGAAAGGCCCCTACCTGCTGTAAGATTATGGGTCCATGAAAGCAGTAAGCTG GACACAGAGGTGTAGTGTGCGGGACAGAGGGCCTTGCAGATGCCTTTCTGTTGGTGTTTTAGTGTTAAAATACGGAGAGTATGGAACTCT TCACCTCCATTTTCTCAGCGGCTGTGAAGCAGCCTCCTAGCTTCGGAAGTACGGACACTACGTCGCGTTTTCAAGCGTGTCTGTTCTGCA GGTAACAGCATCAAGCTGCACGTGGAAGCATCTCGCGGTTTTCTAGAAACAGGCATTTTCTTATCCCTCTCCCGCTCCTTTTTCCACAAA GGTGAATTTCATAAATGTAATACTAGTAAAGTGAATGAATTACTGAGTTTATACAGAAATTTAGGTAACTTCTCCTTTAGTCTCAAGAGC GAGTCTTGCTTTTTAATGGGTGCCGTTTATGTTGCTGCCCGCCCTGTGTGCCTGGCTCCTCTGGGTGCCTTGGTGTCTGCTGGTGGCTGG CAGTGGGCGCAGCGGAGGAGAGTTGTGCTGCAGCTCATACGGTGTGTCTGTCATCTCAGTCTGGAGTAAATGCAGTGTCTGCCGGTGTCT GATGGGTTCTGTCCCTCGTATTTTCTTTGCCTTCTATCCCATTGCCTGGCTACCGCTGCCTGGCAGCCAAGGGTGTTGGTCGCGAAGCTG GAGTGGCCTCTGGTGGAGCCTGCATCTTGTCTCGTCTGCCTCTGCTTTACATTTGGTGTACTTTCGGGCGTGGTGGCAGTAAAATGACAC CGTGATTGAGCTTGTCAGCAGAGCTGAAAGAGAAAGTAGAAGGATGTGCATTGTTTCTTGTAAGATATCTTGCATGTATCTGTGTATTCA AATTCAAACAGAGATGGTTTGTCCATTTGTCCACTGAGAAATTAGAAACTAGGGACAAGGGGGAGGAAAAGTACTGAAATACAGTTTATG AAGCAAGTGTGTCTCGGGCTGTGCTTGTCCCAGGAGCCCCAGCAGCATCTGAACTGAGGCTTCTTCAGTCCTGCAGGAACAGGATCATCT GTCTCAGCGGTGGGCAGATGTTTTCATAGACAGCCAGGGAGTAAACACTGTTGGCTCTGTGGGCTGTATGGTCTCTGCCATAAATAGTAC AGAGATGTGGCTGTGTCTAGTACAACTTTTAGACACAGAAATCTGAATGACATATATTGTTCTGTGTCAAGAAACTTAGATTTTTTTTTT AACTATTTAAAAACGTGAAACCTATTCTTAGCTCACAGGCCATGGAGAAGCTGGTGGGGACCAGACCCAGCTCCTTAGCTGGCTGGGCTG GGGAGGGGGTAGTGACAGTGGCAGCTGCTACTCACTGCTCAGTGTGGAAAACACAGGACTTGGCAATCACAGCCCGCAGAACCATCATGT GTGGCAGAAGCCTGAGGGATGCGGTTTCTTGCCCACGTGCTCTGTTCATTTTCTGTTGTTTTTCTGCACTTAAAGAATTCACATGGAAGC ATGTTTTATAAAATGAATTACCAGAGAAACAGAGATGGGCCGAGATTTTCAGAAATGGTCCCATGTGACCAAGTTCTGCTGTTTGGGTGA CAGTGCTTTGAAGATCTCCTTTGAGGATGTGCAGTCTTTTTTTTTTTTTTTTTGAGATGGAGTTTGTTGCCCAGGCTGGAGTGAGTGGCA CAGTCTCGGCTCACTGCAACCTCCACCTCCTGGGTTCAAGCAGTTCTCGTGCCGCAGCCTCCCAAGTAGCTGGGACTACAGGCATGCACC ACCACGCCAGGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTCTCAAACTCCTGACCTCAGGCGATCCACCCACCTCAGC GTCCCAAAGTGCTGGGATTATAGGCGTGAGCCACCGCACCTGGCCTATGAGTGGTCTTTTAATTAGGAACAAATCTAATGGAAAGGAGAG TTGACTGAAGTTGGCCCACAGGATTGTGAGCTGGGCAGTGCCTTCATGAAGGCTTGCCACCTTGGGACGCCCCAGTTTACTGGGGTGTCT TGCGGAGTGCAGAAGGCTTTCTGGCAGCTGCCTGGGTTTGGCCAGACCCTGCCTCCCCTCCCGCCGGCCAACCCCTAGTCCCCTTCCTGT CTCCACTTGCATTCAGGGGTGGCTGCTGTTCTGAGAACATTAGAACTGGGAAGAGAGATGGAGTCACATGGATTTTTGGTGGGCATTATT CTAAACTTTCGTATCCAAGTTAGTCCCCCTTATTCCACTGTGGCATTGCCGTTCTAAGCAGTTACCTGATGCCTGCTGCTGAAGAGCTGC TCACAGGAGGCGGCGGCGGCCCTGGCACTGCCCCTTGCATTAGGTCTTGTGTTTGATGTGTTCTTGTGAATTTACTTTGTCAGAACAAAA TATTTACGCGTTGGGTTCAGGAATTTCTTTTAGCTCCCCATCTGGCTGTGAAATTCAGGAAACCTCCCGTTGCCTAGTAATCACCCCATG TAGGTGTACATTGTGACAAAGTGCATCTGACCACTAAGGGGCCCCCTTGGTGACCCCAGCACATTCACAGCAGTGTTAAAATGGCCTGCA TTTTGGAGATGCTGGCTGGCCTTTCAGTGCCTCCCAGGAAGACACATGGCCTTTCCCTCTTCAGATGCCTGAAGGGAGTGCTTTGAGGCA GGTGATGTGCTGGGAGTGTGGGCGGCCTCCCTCTGGCCCCGGGGCCCTCTGTGGACCTTGGCTCCCTCCGTGGACCTGGGCTTCGTGGTG AGCACTGCAGCCTCCCTGGGCATTCCCTCCAGCGCCAGCACCACTGCAACATATAGACCTGAGTGCTATTGTATTTTGGCTTGGTGTGTA TGCTCTTCATTGTGTAAAATTGCTGTTCTTTTGACAATTTAAGTGATTGTTTTGTTTACTGTAAGTTTGAAAATAAAAATGAAGAAAAAA ATTCCAATGACTGTGCTGTGGTTGGAGACTTTATTTACCAAGATGTTTACTCTTCCTTTCCCCTTCCATTTTGAGGAGCTGTGTCACTCC |
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FusionGenePPI for TMEM170A_USP22 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TMEM170A | USP22 | HEXA, MRPL10, PSME1, SCFD1, ATXN7L3, TRRAP, ATXN7, KAT2A, SUPT3H, TAF10, ENY2, TAF9, DEDD, PREPL, SUPT7L, TADA3, TAF6L, CNOT1, POFUT2, USP8, SIRT1, CNOT10, SND1, TAF5L, SUPT20H, AASDHPPT, TADA2B, CCDC101, TADA1, ATXN7L2, KLHL23, KIF7, USP27X, ATXN7L3B, MRPL44, HIST2H2AC, HIST2H2BE, FUBP1, NFATC2, TADA2A, TAF9B, MYC, STAT3, MOV10, NXF1, RIC3, CD1B, CD274, NT5E, LYPD3, FAM63B, RCAN1, PTGS2, MDM4, OFD1, NPHP1, CCNB1, CDK1, CDC20, CDC23, USP22, TMEM173, TMED2, ZBED1, RNF19B, CD70, TMEM206, ENPP6, LRRN2, LDLRAD4, UNC5CL, FASN, C3AR1, CREB3L1, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TMEM170A_USP22 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TMEM170A_USP22 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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