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Fusion gene ID: 38471 |
FusionGeneSummary for TMEM167B_LYPLA1 |
Fusion gene summary |
Fusion gene information | Fusion gene name: TMEM167B_LYPLA1 | Fusion gene ID: 38471 | Hgene | Tgene | Gene symbol | TMEM167B | LYPLA1 | Gene ID | 56900 | 10434 |
Gene name | transmembrane protein 167B | lysophospholipase I | |
Synonyms | AD-020|C1orf119 | APT-1|APT1|LPL-I|LPL1|hAPT1 | |
Cytomap | 1p13.3 | 8q11.23 | |
Type of gene | protein-coding | protein-coding | |
Description | protein kish-Bprotein x 013 | acyl-protein thioesterase 1lysoPLA Ilysophospholipid-specific lysophospholipase | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9NRX6 | O75608 | |
Ensembl transtripts involved in fusion gene | ENST00000338272, ENST00000473828, | ENST00000316963, ENST00000343231, ENST00000522007, ENST00000519926, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 3 X 2 X 2=12 |
# samples | 1 | 2 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(2/12*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: TMEM167B [Title/Abstract] AND LYPLA1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | SARC | TCGA-3B-A9HS-01A | TMEM167B | chr1 | 109635643 | + | LYPLA1 | chr8 | 54967693 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000338272 | ENST00000316963 | TMEM167B | chr1 | 109635643 | + | LYPLA1 | chr8 | 54967693 | - |
In-frame | ENST00000338272 | ENST00000343231 | TMEM167B | chr1 | 109635643 | + | LYPLA1 | chr8 | 54967693 | - |
5CDS-intron | ENST00000338272 | ENST00000522007 | TMEM167B | chr1 | 109635643 | + | LYPLA1 | chr8 | 54967693 | - |
5CDS-5UTR | ENST00000338272 | ENST00000519926 | TMEM167B | chr1 | 109635643 | + | LYPLA1 | chr8 | 54967693 | - |
3UTR-3CDS | ENST00000473828 | ENST00000316963 | TMEM167B | chr1 | 109635643 | + | LYPLA1 | chr8 | 54967693 | - |
3UTR-3CDS | ENST00000473828 | ENST00000343231 | TMEM167B | chr1 | 109635643 | + | LYPLA1 | chr8 | 54967693 | - |
3UTR-intron | ENST00000473828 | ENST00000522007 | TMEM167B | chr1 | 109635643 | + | LYPLA1 | chr8 | 54967693 | - |
3UTR-5UTR | ENST00000473828 | ENST00000519926 | TMEM167B | chr1 | 109635643 | + | LYPLA1 | chr8 | 54967693 | - |
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FusionProtFeatures for TMEM167B_LYPLA1 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
TMEM167B | LYPLA1 |
Involved in the early part of the secretory pathway.{ECO:0000269|PubMed:19942856}. | Hydrolyzes fatty acids from S-acylated cysteine residuesin proteins such as trimeric G alpha proteins or HRAS. Hasdepalmitoylating activity toward KCNMA1. Has low lysophospholipaseactivity. {ECO:0000269|PubMed:20418879,ECO:0000269|PubMed:22399288}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >TMEM167B | chr1:109635643 | chr8:54967693 | ENST00000338272 | + | 2 | 3 | 23_52 | 47 | 75 | Topological domain | Extracellular |
Hgene | >TMEM167B | chr1:109635643 | chr8:54967693 | ENST00000338272 | + | 2 | 3 | 74_74 | 47 | 75 | Topological domain | Cytoplasmic |
Hgene | >TMEM167B | chr1:109635643 | chr8:54967693 | ENST00000338272 | + | 2 | 3 | 53_73 | 47 | 75 | Transmembrane | Helical |
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FusionGeneSequence for TMEM167B_LYPLA1 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_TMEM167B_ENST00000338272_chr1_109635643_+_LYPLA1_ENST00000316963_chr8_54967693_-_183aa MTNVYSLDGILVFGLLFVCTCAYFKKVPRLKTWLLSEKKGVWGVFYKVKALIDQEVKNGIPSNRIILGGFSQGGALSLYTALTTQQKLAG VTALSCWLPLRASFPQGPIGGANRDISILQCHGDCDPLVPLMFGSLTVEKLKTLVNPANVTFKTYEGMMHSSCQQEMMDVKQFIDKLLPP >In-frame_TMEM167B_ENST00000338272_chr1_109635643_+_LYPLA1_ENST00000343231_chr8_54967693_-_183aa MTNVYSLDGILVFGLLFVCTCAYFKKVPRLKTWLLSEKKGVWGVFYKVKALIDQEVKNGIPSNRIILGGFSQGGALSLYTALTTQQKLAG VTALSCWLPLRASFPQGPIGGANRDISILQCHGDCDPLVPLMFGSLTVEKLKTLVNPANVTFKTYEGMMHSSCQQEMMDVKQFIDKLLPP |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_TMEM167B_ENST00000338272_chr1_109635643_+_LYPLA1_ENST00000316963_chr8_54967693_-_549nt ATGACGAACGTGTACTCCTTGGATGGGATTCTGGTGTTTGGTTTGCTCTTTGTTTGCACCTGTGCCTACTTCAAGAAAGTACCTCGTCTC AAAACCTGGCTGCTATCAGAGAAGAAGGGTGTTTGGGGTGTGTTTTACAAAGTAAAAGCTTTGATTGATCAAGAAGTGAAGAATGGCATT CCTTCTAACAGAATTATTTTGGGAGGGTTTTCTCAGGGAGGAGCTTTATCTTTATATACTGCCCTTACCACACAGCAGAAACTGGCAGGT GTCACTGCACTCAGTTGCTGGCTTCCACTTCGGGCTTCCTTTCCACAGGGTCCTATCGGTGGTGCTAATAGAGATATTTCTATTCTCCAG TGCCACGGGGATTGTGACCCTTTGGTTCCCCTGATGTTTGGTTCTCTTACGGTGGAAAAACTAAAAACATTGGTGAATCCAGCCAATGTG ACCTTTAAAACCTATGAAGGTATGATGCACAGTTCGTGTCAACAGGAAATGATGGATGTCAAGCAATTCATTGATAAACTCCTACCTCCA >In-frame_TMEM167B_ENST00000338272_chr1_109635643_+_LYPLA1_ENST00000343231_chr8_54967693_-_549nt ATGACGAACGTGTACTCCTTGGATGGGATTCTGGTGTTTGGTTTGCTCTTTGTTTGCACCTGTGCCTACTTCAAGAAAGTACCTCGTCTC AAAACCTGGCTGCTATCAGAGAAGAAGGGTGTTTGGGGTGTGTTTTACAAAGTAAAAGCTTTGATTGATCAAGAAGTGAAGAATGGCATT CCTTCTAACAGAATTATTTTGGGAGGGTTTTCTCAGGGAGGAGCTTTATCTTTATATACTGCCCTTACCACACAGCAGAAACTGGCAGGT GTCACTGCACTCAGTTGCTGGCTTCCACTTCGGGCTTCCTTTCCACAGGGTCCTATCGGTGGTGCTAATAGAGATATTTCTATTCTCCAG TGCCACGGGGATTGTGACCCTTTGGTTCCCCTGATGTTTGGTTCTCTTACGGTGGAAAAACTAAAAACATTGGTGAATCCAGCCAATGTG ACCTTTAAAACCTATGAAGGTATGATGCACAGTTCGTGTCAACAGGAAATGATGGATGTCAAGCAATTCATTGATAAACTCCTACCTCCA |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_TMEM167B_ENST00000338272_chr1_109635643_+_LYPLA1_ENST00000316963_chr8_54967693_-_3306nt CGACGACGTGGTGCTTTAGGATCTGAAAGATGCGACTTGGTTTTTGTTGTTGTTGTTGTTGTTGTTGTTGTTTTTGAGACGGAGTTTCCG CTCTTGTTGCCCAGGCTGGAGTGCAATGGCGCGATCTCGGCTCACCGCAACCTCCGCCTCCCAGGTTCAAGCGATTCTCCTGCCTCGGCC TCCCGAGTAGCTGGGATTACATTACAGGCATGAGCCACCATGCCCGGCTAATTTTGTATTTGTAGTAGAGACGGGGTTTCTCCATGTTGG TCAGGCTGGTCTCGAACTACGATCTCAGGTGATCCGCCTGCCTCGGCCTCCTAAAGTGCTTAGATTACAGGCATGAGCCACCGCGCCCGG CTAATTTTGTATGTTTAGTAGAGACGGGGTTTCTCCTTGTTGGTCAGGCTGGTCTCGAACTCCGACCTCAGGTGATCCGCCTGGCTCGGC CTCCCAAAGTGCTGGGATTACAGGCGTGAACCACCGCGCCCGGCCGCGACTTGTTTTTGTTACAAGGTTCCTCATTTCATTTGCAACGTT CAGACGCAGTCTGACTAGATTTCCATCCGGAGTAAGGAAGAGCAGCTCAAGGGCAGTCACGGAGGCCGCAGGTGCGGCTTCTTCACCCGC GGTGCTGGAGTTCTCTCAAGTGGAAGCCCAGGACGATGAAAACCTCATAGGTAGGCTGCTGCTTACACACAGCAGCCGCCACGGCGCAAA ATAAACTACAAAACTACAAGCCTTTACCTTTTCAAACACACTGACGCGGGCCAGCCCCAGCCCTACGCCCGCAGGGGCACGCAGAAAAGA CTTAGTTACCACGGCCAAGTACGAAGCCTTCGAGATAGCGTTCTTCTTACCCTACGTAAACACGCAGTTTCCCGAGCTCGACAATCGGCT AGCCACTCCTGATAGCGTTCGGCGCTCGCCTCTCGGCCCTTGCTCCTGCGTACTACGGCTTCTTCCAGTCACCTCGGCCCGGATCGGGAA GTGTCAAGCGGGCGCTCCCCCATCTCCGCCGCTATTACCACTGAACCCGGACCCCCTACCCAGGTCCAGGGCCAGCCGCCATGACGAACG TGTACTCCTTGGATGGGATTCTGGTGTTTGGTTTGCTCTTTGTTTGCACCTGTGCCTACTTCAAGAAAGTACCTCGTCTCAAAACCTGGC TGCTATCAGAGAAGAAGGGTGTTTGGGGTGTGTTTTACAAAGTAAAAGCTTTGATTGATCAAGAAGTGAAGAATGGCATTCCTTCTAACA GAATTATTTTGGGAGGGTTTTCTCAGGGAGGAGCTTTATCTTTATATACTGCCCTTACCACACAGCAGAAACTGGCAGGTGTCACTGCAC TCAGTTGCTGGCTTCCACTTCGGGCTTCCTTTCCACAGGGTCCTATCGGTGGTGCTAATAGAGATATTTCTATTCTCCAGTGCCACGGGG ATTGTGACCCTTTGGTTCCCCTGATGTTTGGTTCTCTTACGGTGGAAAAACTAAAAACATTGGTGAATCCAGCCAATGTGACCTTTAAAA CCTATGAAGGTATGATGCACAGTTCGTGTCAACAGGAAATGATGGATGTCAAGCAATTCATTGATAAACTCCTACCTCCAATTGATTGAC GTCACTAAGAGGCCTTGTGTAGAAGTACACCAGCATCATTGTAGTAGAGTGTAAACCTTTTCCCATGCCCAGTCTTCAAATTTCTAATGT TTTGCAGTGTTAAAATGTTTTGCAAATACATGCCAATAACACAGATCAAATAATATCTCCTCATGAGAAATTTATGATCTTTTAAGTTTC TATACATGTATTCTTATAAGACGACCCAGGATCTACTATATTAGAATAGATGAAGCAGGTAGCTTCTTTTTTCTCAAATGTAATTCAGCA AAATAATACAGTACTGCCACCAGATTTTTTATTACATCATTTGAAAATTAGCAGTATGCTTAATGAAAATTTGTTCAGGTATAAATGAGC AGTTAAGATATAAACAATTTATGCATGCTGTGACTTAGTCTATGGATTTATTCCAAAATTGCTTAGTCACCATGCAGTGTCTGTATTTTT ATATATGTGTTCATATATACATAATGATTATAATACATAATAAGAATGAGGTGGTATTACATTATTCCTAATAATAGGGATAATGCTGTT TATTGTCAAGAAAAAGTAAAATCGTTCTCTTCAATTAATGGCCCTTTTATTTTGGGACCAGGCTTTTATTTTCCCTGATATTATTTCTAT TTAATACTCTTTTCTCTCAAGAAAAAAAAAAAAGTTTGTTTTTTCTTTATTGTCCTTCATAGCAGGCCAAGTATTGCCTCTCTGCAATAG ACAGCTACTGTCAATACATGCTGTAATTTGACATTCTGGGTCACAGATATAAGGTATTTAAAATCTATTTATGCTTTATAGAGAAACCAG ACATTAAAACTTCATGCACTACTTATTTCGAATTACTGTACCTTATCCAAATTTACACCTAGCTATTAGGATCTTCAACCCAGGTAACAG GAATAATTCTGTGGTTTCATTTTTCTGTAAACAACTGAAAGAATAATTAGATCATATTCTAGTATGTTCTGAAATATCTTTAAGACTGAT CTTAAAAACTAACTTCTAAGATGATTTCATCTTCTCATAGTATAGAGTTTACTTTGTACACGTTTGAAACCAACTACTGTAGAAGATGAG GAATCTATTGTAATTTTTTGCTTTATTTTCATCTGCCAGTGGACTTATTTGAAATTTTCACTTTAGTCAAATTATTTTTTGTATTAGTTT TTGATGCAGACATAAAAATAGCAATCATTTTAAATTGTCAAAATTTCCAGATTACTGGTAAAAATTATTTGAAAACAAACTTATGGGTAA TAAAGGCTAGTCAGAACCCTATACCATAAAGTGTAGTTACCATACAGATTAATATGTAGCAAAAATGTATGCTTGATATTTCTCAACTGT GTTAATTTTTCTGCTGTATTCCAGCTGACCAAAACAATATTAAGAATGCATCTTTATAAATGGGTGCTAATTGATAATGGAAATAATTTA GTAATGGACTATACAGGATGTTAATAATGAAGCCATATGTTTATGTCTGGATTTAAAAATTTTAAACAATCATTTACTATGTCATTTTTC TTTACCTTGAAGAACATAAACTGTTATTTCACTTCTACAAATCAGCAAGATATTATTTATGGCAAGAAATATTCCATTGAAATATTGTGC >In-frame_TMEM167B_ENST00000338272_chr1_109635643_+_LYPLA1_ENST00000343231_chr8_54967693_-_2277nt CGACGACGTGGTGCTTTAGGATCTGAAAGATGCGACTTGGTTTTTGTTGTTGTTGTTGTTGTTGTTGTTGTTTTTGAGACGGAGTTTCCG CTCTTGTTGCCCAGGCTGGAGTGCAATGGCGCGATCTCGGCTCACCGCAACCTCCGCCTCCCAGGTTCAAGCGATTCTCCTGCCTCGGCC TCCCGAGTAGCTGGGATTACATTACAGGCATGAGCCACCATGCCCGGCTAATTTTGTATTTGTAGTAGAGACGGGGTTTCTCCATGTTGG TCAGGCTGGTCTCGAACTACGATCTCAGGTGATCCGCCTGCCTCGGCCTCCTAAAGTGCTTAGATTACAGGCATGAGCCACCGCGCCCGG CTAATTTTGTATGTTTAGTAGAGACGGGGTTTCTCCTTGTTGGTCAGGCTGGTCTCGAACTCCGACCTCAGGTGATCCGCCTGGCTCGGC CTCCCAAAGTGCTGGGATTACAGGCGTGAACCACCGCGCCCGGCCGCGACTTGTTTTTGTTACAAGGTTCCTCATTTCATTTGCAACGTT CAGACGCAGTCTGACTAGATTTCCATCCGGAGTAAGGAAGAGCAGCTCAAGGGCAGTCACGGAGGCCGCAGGTGCGGCTTCTTCACCCGC GGTGCTGGAGTTCTCTCAAGTGGAAGCCCAGGACGATGAAAACCTCATAGGTAGGCTGCTGCTTACACACAGCAGCCGCCACGGCGCAAA ATAAACTACAAAACTACAAGCCTTTACCTTTTCAAACACACTGACGCGGGCCAGCCCCAGCCCTACGCCCGCAGGGGCACGCAGAAAAGA CTTAGTTACCACGGCCAAGTACGAAGCCTTCGAGATAGCGTTCTTCTTACCCTACGTAAACACGCAGTTTCCCGAGCTCGACAATCGGCT AGCCACTCCTGATAGCGTTCGGCGCTCGCCTCTCGGCCCTTGCTCCTGCGTACTACGGCTTCTTCCAGTCACCTCGGCCCGGATCGGGAA GTGTCAAGCGGGCGCTCCCCCATCTCCGCCGCTATTACCACTGAACCCGGACCCCCTACCCAGGTCCAGGGCCAGCCGCCATGACGAACG TGTACTCCTTGGATGGGATTCTGGTGTTTGGTTTGCTCTTTGTTTGCACCTGTGCCTACTTCAAGAAAGTACCTCGTCTCAAAACCTGGC TGCTATCAGAGAAGAAGGGTGTTTGGGGTGTGTTTTACAAAGTAAAAGCTTTGATTGATCAAGAAGTGAAGAATGGCATTCCTTCTAACA GAATTATTTTGGGAGGGTTTTCTCAGGGAGGAGCTTTATCTTTATATACTGCCCTTACCACACAGCAGAAACTGGCAGGTGTCACTGCAC TCAGTTGCTGGCTTCCACTTCGGGCTTCCTTTCCACAGGGTCCTATCGGTGGTGCTAATAGAGATATTTCTATTCTCCAGTGCCACGGGG ATTGTGACCCTTTGGTTCCCCTGATGTTTGGTTCTCTTACGGTGGAAAAACTAAAAACATTGGTGAATCCAGCCAATGTGACCTTTAAAA CCTATGAAGGTATGATGCACAGTTCGTGTCAACAGGAAATGATGGATGTCAAGCAATTCATTGATAAACTCCTACCTCCAATTGATTGAC GTCACTAAGAGGCCTTGTGTAGAAGTACACCAGCATCATTGTAGTAGAGTGTAAACCTTTTCCCATGCCCAGTCTTCAAATTTCTAATGT TTTGCAGTGTTAAAATGTTTTGCAAATACATGCCAATAACACAGATCAAATAATATCTCCTCATGAGAAATTTATGATCTTTTAAGTTTC TATACATGTATTCTTATAAGACGACCCAGGATCTACTATATTAGAATAGATGAAGCAGGTAGCTTCTTTTTTCTCAAATGTAATTCAGCA AAATAATACAGTACTGCCACCAGATTTTTTATTACATCATTTGAAAATTAGCAGTATGCTTAATGAAAATTTGTTCAGGTATAAATGAGC AGTTAAGATATAAACAATTTATGCATGCTGTGACTTAGTCTATGGATTTATTCCAAAATTGCTTAGTCACCATGCAGTGTCTGTATTTTT ATATATGTGTTCATATATACATAATGATTATAATACATAATAAGAATGAGGTGGTATTACATTATTCCTAATAATAGGGATAATGCTGTT TATTGTCAAGAAAAAGTAAAATCGTTCTCTTCAATTAATGGCCCTTTTATTTTGGGACCAGGCTTTTATTTTCCCTGATATTATTTCTAT |
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FusionGenePPI for TMEM167B_LYPLA1 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
TMEM167B | ELAVL1 | LYPLA1 | LYPLA1, ELAVL1, VCAM1, FN1, ITGA4, GOLGA2, TEAD4, CTSO, APRT, ASNS, DPYSL2, ARFIP1, CDA, OXCT1, PARK7, PCCB, PRDX6, TTC38, TRIM11, USP47, GTF2E2, FCF1, TRIM25 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TMEM167B_LYPLA1 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TMEM167B_LYPLA1 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |