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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 38471

FusionGeneSummary for TMEM167B_LYPLA1

check button Fusion gene summary
Fusion gene informationFusion gene name: TMEM167B_LYPLA1
Fusion gene ID: 38471
HgeneTgene
Gene symbol

TMEM167B

LYPLA1

Gene ID

56900

10434

Gene nametransmembrane protein 167Blysophospholipase I
SynonymsAD-020|C1orf119APT-1|APT1|LPL-I|LPL1|hAPT1
Cytomap

1p13.3

8q11.23

Type of geneprotein-codingprotein-coding
Descriptionprotein kish-Bprotein x 013acyl-protein thioesterase 1lysoPLA Ilysophospholipid-specific lysophospholipase
Modification date2018052320180523
UniProtAcc

Q9NRX6

O75608

Ensembl transtripts involved in fusion geneENST00000338272, ENST00000473828, 
ENST00000316963, ENST00000343231, 
ENST00000522007, ENST00000519926, 
Fusion gene scores* DoF score1 X 1 X 1=13 X 2 X 2=12
# samples 12
** MAII scorelog2(1/1*10)=3.32192809488736log2(2/12*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TMEM167B [Title/Abstract] AND LYPLA1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-3B-A9HS-01ATMEM167Bchr1

109635643

+LYPLA1chr8

54967693

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000338272ENST00000316963TMEM167Bchr1

109635643

+LYPLA1chr8

54967693

-
In-frameENST00000338272ENST00000343231TMEM167Bchr1

109635643

+LYPLA1chr8

54967693

-
5CDS-intronENST00000338272ENST00000522007TMEM167Bchr1

109635643

+LYPLA1chr8

54967693

-
5CDS-5UTRENST00000338272ENST00000519926TMEM167Bchr1

109635643

+LYPLA1chr8

54967693

-
3UTR-3CDSENST00000473828ENST00000316963TMEM167Bchr1

109635643

+LYPLA1chr8

54967693

-
3UTR-3CDSENST00000473828ENST00000343231TMEM167Bchr1

109635643

+LYPLA1chr8

54967693

-
3UTR-intronENST00000473828ENST00000522007TMEM167Bchr1

109635643

+LYPLA1chr8

54967693

-
3UTR-5UTRENST00000473828ENST00000519926TMEM167Bchr1

109635643

+LYPLA1chr8

54967693

-

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FusionProtFeatures for TMEM167B_LYPLA1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TMEM167B

Q9NRX6

LYPLA1

O75608

Involved in the early part of the secretory pathway.{ECO:0000269|PubMed:19942856}. Hydrolyzes fatty acids from S-acylated cysteine residuesin proteins such as trimeric G alpha proteins or HRAS. Hasdepalmitoylating activity toward KCNMA1. Has low lysophospholipaseactivity. {ECO:0000269|PubMed:20418879,ECO:0000269|PubMed:22399288}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTMEM167Bchr1:109635643chr8:54967693ENST00000338272+2323_524775Topological domainExtracellular
HgeneTMEM167Bchr1:109635643chr8:54967693ENST00000338272+2374_744775Topological domainCytoplasmic
HgeneTMEM167Bchr1:109635643chr8:54967693ENST00000338272+2353_734775TransmembraneHelical


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FusionGeneSequence for TMEM167B_LYPLA1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_TMEM167B_ENST00000338272_chr1_109635643_+_LYPLA1_ENST00000316963_chr8_54967693_-_183aa
MTNVYSLDGILVFGLLFVCTCAYFKKVPRLKTWLLSEKKGVWGVFYKVKALIDQEVKNGIPSNRIILGGFSQGGALSLYTALTTQQKLAG
VTALSCWLPLRASFPQGPIGGANRDISILQCHGDCDPLVPLMFGSLTVEKLKTLVNPANVTFKTYEGMMHSSCQQEMMDVKQFIDKLLPP

>In-frame_TMEM167B_ENST00000338272_chr1_109635643_+_LYPLA1_ENST00000343231_chr8_54967693_-_183aa
MTNVYSLDGILVFGLLFVCTCAYFKKVPRLKTWLLSEKKGVWGVFYKVKALIDQEVKNGIPSNRIILGGFSQGGALSLYTALTTQQKLAG
VTALSCWLPLRASFPQGPIGGANRDISILQCHGDCDPLVPLMFGSLTVEKLKTLVNPANVTFKTYEGMMHSSCQQEMMDVKQFIDKLLPP


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_TMEM167B_ENST00000338272_chr1_109635643_+_LYPLA1_ENST00000316963_chr8_54967693_-_549nt
ATGACGAACGTGTACTCCTTGGATGGGATTCTGGTGTTTGGTTTGCTCTTTGTTTGCACCTGTGCCTACTTCAAGAAAGTACCTCGTCTC
AAAACCTGGCTGCTATCAGAGAAGAAGGGTGTTTGGGGTGTGTTTTACAAAGTAAAAGCTTTGATTGATCAAGAAGTGAAGAATGGCATT
CCTTCTAACAGAATTATTTTGGGAGGGTTTTCTCAGGGAGGAGCTTTATCTTTATATACTGCCCTTACCACACAGCAGAAACTGGCAGGT
GTCACTGCACTCAGTTGCTGGCTTCCACTTCGGGCTTCCTTTCCACAGGGTCCTATCGGTGGTGCTAATAGAGATATTTCTATTCTCCAG
TGCCACGGGGATTGTGACCCTTTGGTTCCCCTGATGTTTGGTTCTCTTACGGTGGAAAAACTAAAAACATTGGTGAATCCAGCCAATGTG
ACCTTTAAAACCTATGAAGGTATGATGCACAGTTCGTGTCAACAGGAAATGATGGATGTCAAGCAATTCATTGATAAACTCCTACCTCCA

>In-frame_TMEM167B_ENST00000338272_chr1_109635643_+_LYPLA1_ENST00000343231_chr8_54967693_-_549nt
ATGACGAACGTGTACTCCTTGGATGGGATTCTGGTGTTTGGTTTGCTCTTTGTTTGCACCTGTGCCTACTTCAAGAAAGTACCTCGTCTC
AAAACCTGGCTGCTATCAGAGAAGAAGGGTGTTTGGGGTGTGTTTTACAAAGTAAAAGCTTTGATTGATCAAGAAGTGAAGAATGGCATT
CCTTCTAACAGAATTATTTTGGGAGGGTTTTCTCAGGGAGGAGCTTTATCTTTATATACTGCCCTTACCACACAGCAGAAACTGGCAGGT
GTCACTGCACTCAGTTGCTGGCTTCCACTTCGGGCTTCCTTTCCACAGGGTCCTATCGGTGGTGCTAATAGAGATATTTCTATTCTCCAG
TGCCACGGGGATTGTGACCCTTTGGTTCCCCTGATGTTTGGTTCTCTTACGGTGGAAAAACTAAAAACATTGGTGAATCCAGCCAATGTG
ACCTTTAAAACCTATGAAGGTATGATGCACAGTTCGTGTCAACAGGAAATGATGGATGTCAAGCAATTCATTGATAAACTCCTACCTCCA


* Fusion transcript sequences (Full-length transcript).
>In-frame_TMEM167B_ENST00000338272_chr1_109635643_+_LYPLA1_ENST00000316963_chr8_54967693_-_3306nt
CGACGACGTGGTGCTTTAGGATCTGAAAGATGCGACTTGGTTTTTGTTGTTGTTGTTGTTGTTGTTGTTGTTTTTGAGACGGAGTTTCCG
CTCTTGTTGCCCAGGCTGGAGTGCAATGGCGCGATCTCGGCTCACCGCAACCTCCGCCTCCCAGGTTCAAGCGATTCTCCTGCCTCGGCC
TCCCGAGTAGCTGGGATTACATTACAGGCATGAGCCACCATGCCCGGCTAATTTTGTATTTGTAGTAGAGACGGGGTTTCTCCATGTTGG
TCAGGCTGGTCTCGAACTACGATCTCAGGTGATCCGCCTGCCTCGGCCTCCTAAAGTGCTTAGATTACAGGCATGAGCCACCGCGCCCGG
CTAATTTTGTATGTTTAGTAGAGACGGGGTTTCTCCTTGTTGGTCAGGCTGGTCTCGAACTCCGACCTCAGGTGATCCGCCTGGCTCGGC
CTCCCAAAGTGCTGGGATTACAGGCGTGAACCACCGCGCCCGGCCGCGACTTGTTTTTGTTACAAGGTTCCTCATTTCATTTGCAACGTT
CAGACGCAGTCTGACTAGATTTCCATCCGGAGTAAGGAAGAGCAGCTCAAGGGCAGTCACGGAGGCCGCAGGTGCGGCTTCTTCACCCGC
GGTGCTGGAGTTCTCTCAAGTGGAAGCCCAGGACGATGAAAACCTCATAGGTAGGCTGCTGCTTACACACAGCAGCCGCCACGGCGCAAA
ATAAACTACAAAACTACAAGCCTTTACCTTTTCAAACACACTGACGCGGGCCAGCCCCAGCCCTACGCCCGCAGGGGCACGCAGAAAAGA
CTTAGTTACCACGGCCAAGTACGAAGCCTTCGAGATAGCGTTCTTCTTACCCTACGTAAACACGCAGTTTCCCGAGCTCGACAATCGGCT
AGCCACTCCTGATAGCGTTCGGCGCTCGCCTCTCGGCCCTTGCTCCTGCGTACTACGGCTTCTTCCAGTCACCTCGGCCCGGATCGGGAA
GTGTCAAGCGGGCGCTCCCCCATCTCCGCCGCTATTACCACTGAACCCGGACCCCCTACCCAGGTCCAGGGCCAGCCGCCATGACGAACG
TGTACTCCTTGGATGGGATTCTGGTGTTTGGTTTGCTCTTTGTTTGCACCTGTGCCTACTTCAAGAAAGTACCTCGTCTCAAAACCTGGC
TGCTATCAGAGAAGAAGGGTGTTTGGGGTGTGTTTTACAAAGTAAAAGCTTTGATTGATCAAGAAGTGAAGAATGGCATTCCTTCTAACA
GAATTATTTTGGGAGGGTTTTCTCAGGGAGGAGCTTTATCTTTATATACTGCCCTTACCACACAGCAGAAACTGGCAGGTGTCACTGCAC
TCAGTTGCTGGCTTCCACTTCGGGCTTCCTTTCCACAGGGTCCTATCGGTGGTGCTAATAGAGATATTTCTATTCTCCAGTGCCACGGGG
ATTGTGACCCTTTGGTTCCCCTGATGTTTGGTTCTCTTACGGTGGAAAAACTAAAAACATTGGTGAATCCAGCCAATGTGACCTTTAAAA
CCTATGAAGGTATGATGCACAGTTCGTGTCAACAGGAAATGATGGATGTCAAGCAATTCATTGATAAACTCCTACCTCCAATTGATTGAC
GTCACTAAGAGGCCTTGTGTAGAAGTACACCAGCATCATTGTAGTAGAGTGTAAACCTTTTCCCATGCCCAGTCTTCAAATTTCTAATGT
TTTGCAGTGTTAAAATGTTTTGCAAATACATGCCAATAACACAGATCAAATAATATCTCCTCATGAGAAATTTATGATCTTTTAAGTTTC
TATACATGTATTCTTATAAGACGACCCAGGATCTACTATATTAGAATAGATGAAGCAGGTAGCTTCTTTTTTCTCAAATGTAATTCAGCA
AAATAATACAGTACTGCCACCAGATTTTTTATTACATCATTTGAAAATTAGCAGTATGCTTAATGAAAATTTGTTCAGGTATAAATGAGC
AGTTAAGATATAAACAATTTATGCATGCTGTGACTTAGTCTATGGATTTATTCCAAAATTGCTTAGTCACCATGCAGTGTCTGTATTTTT
ATATATGTGTTCATATATACATAATGATTATAATACATAATAAGAATGAGGTGGTATTACATTATTCCTAATAATAGGGATAATGCTGTT
TATTGTCAAGAAAAAGTAAAATCGTTCTCTTCAATTAATGGCCCTTTTATTTTGGGACCAGGCTTTTATTTTCCCTGATATTATTTCTAT
TTAATACTCTTTTCTCTCAAGAAAAAAAAAAAAGTTTGTTTTTTCTTTATTGTCCTTCATAGCAGGCCAAGTATTGCCTCTCTGCAATAG
ACAGCTACTGTCAATACATGCTGTAATTTGACATTCTGGGTCACAGATATAAGGTATTTAAAATCTATTTATGCTTTATAGAGAAACCAG
ACATTAAAACTTCATGCACTACTTATTTCGAATTACTGTACCTTATCCAAATTTACACCTAGCTATTAGGATCTTCAACCCAGGTAACAG
GAATAATTCTGTGGTTTCATTTTTCTGTAAACAACTGAAAGAATAATTAGATCATATTCTAGTATGTTCTGAAATATCTTTAAGACTGAT
CTTAAAAACTAACTTCTAAGATGATTTCATCTTCTCATAGTATAGAGTTTACTTTGTACACGTTTGAAACCAACTACTGTAGAAGATGAG
GAATCTATTGTAATTTTTTGCTTTATTTTCATCTGCCAGTGGACTTATTTGAAATTTTCACTTTAGTCAAATTATTTTTTGTATTAGTTT
TTGATGCAGACATAAAAATAGCAATCATTTTAAATTGTCAAAATTTCCAGATTACTGGTAAAAATTATTTGAAAACAAACTTATGGGTAA
TAAAGGCTAGTCAGAACCCTATACCATAAAGTGTAGTTACCATACAGATTAATATGTAGCAAAAATGTATGCTTGATATTTCTCAACTGT
GTTAATTTTTCTGCTGTATTCCAGCTGACCAAAACAATATTAAGAATGCATCTTTATAAATGGGTGCTAATTGATAATGGAAATAATTTA
GTAATGGACTATACAGGATGTTAATAATGAAGCCATATGTTTATGTCTGGATTTAAAAATTTTAAACAATCATTTACTATGTCATTTTTC
TTTACCTTGAAGAACATAAACTGTTATTTCACTTCTACAAATCAGCAAGATATTATTTATGGCAAGAAATATTCCATTGAAATATTGTGC

>In-frame_TMEM167B_ENST00000338272_chr1_109635643_+_LYPLA1_ENST00000343231_chr8_54967693_-_2277nt
CGACGACGTGGTGCTTTAGGATCTGAAAGATGCGACTTGGTTTTTGTTGTTGTTGTTGTTGTTGTTGTTGTTTTTGAGACGGAGTTTCCG
CTCTTGTTGCCCAGGCTGGAGTGCAATGGCGCGATCTCGGCTCACCGCAACCTCCGCCTCCCAGGTTCAAGCGATTCTCCTGCCTCGGCC
TCCCGAGTAGCTGGGATTACATTACAGGCATGAGCCACCATGCCCGGCTAATTTTGTATTTGTAGTAGAGACGGGGTTTCTCCATGTTGG
TCAGGCTGGTCTCGAACTACGATCTCAGGTGATCCGCCTGCCTCGGCCTCCTAAAGTGCTTAGATTACAGGCATGAGCCACCGCGCCCGG
CTAATTTTGTATGTTTAGTAGAGACGGGGTTTCTCCTTGTTGGTCAGGCTGGTCTCGAACTCCGACCTCAGGTGATCCGCCTGGCTCGGC
CTCCCAAAGTGCTGGGATTACAGGCGTGAACCACCGCGCCCGGCCGCGACTTGTTTTTGTTACAAGGTTCCTCATTTCATTTGCAACGTT
CAGACGCAGTCTGACTAGATTTCCATCCGGAGTAAGGAAGAGCAGCTCAAGGGCAGTCACGGAGGCCGCAGGTGCGGCTTCTTCACCCGC
GGTGCTGGAGTTCTCTCAAGTGGAAGCCCAGGACGATGAAAACCTCATAGGTAGGCTGCTGCTTACACACAGCAGCCGCCACGGCGCAAA
ATAAACTACAAAACTACAAGCCTTTACCTTTTCAAACACACTGACGCGGGCCAGCCCCAGCCCTACGCCCGCAGGGGCACGCAGAAAAGA
CTTAGTTACCACGGCCAAGTACGAAGCCTTCGAGATAGCGTTCTTCTTACCCTACGTAAACACGCAGTTTCCCGAGCTCGACAATCGGCT
AGCCACTCCTGATAGCGTTCGGCGCTCGCCTCTCGGCCCTTGCTCCTGCGTACTACGGCTTCTTCCAGTCACCTCGGCCCGGATCGGGAA
GTGTCAAGCGGGCGCTCCCCCATCTCCGCCGCTATTACCACTGAACCCGGACCCCCTACCCAGGTCCAGGGCCAGCCGCCATGACGAACG
TGTACTCCTTGGATGGGATTCTGGTGTTTGGTTTGCTCTTTGTTTGCACCTGTGCCTACTTCAAGAAAGTACCTCGTCTCAAAACCTGGC
TGCTATCAGAGAAGAAGGGTGTTTGGGGTGTGTTTTACAAAGTAAAAGCTTTGATTGATCAAGAAGTGAAGAATGGCATTCCTTCTAACA
GAATTATTTTGGGAGGGTTTTCTCAGGGAGGAGCTTTATCTTTATATACTGCCCTTACCACACAGCAGAAACTGGCAGGTGTCACTGCAC
TCAGTTGCTGGCTTCCACTTCGGGCTTCCTTTCCACAGGGTCCTATCGGTGGTGCTAATAGAGATATTTCTATTCTCCAGTGCCACGGGG
ATTGTGACCCTTTGGTTCCCCTGATGTTTGGTTCTCTTACGGTGGAAAAACTAAAAACATTGGTGAATCCAGCCAATGTGACCTTTAAAA
CCTATGAAGGTATGATGCACAGTTCGTGTCAACAGGAAATGATGGATGTCAAGCAATTCATTGATAAACTCCTACCTCCAATTGATTGAC
GTCACTAAGAGGCCTTGTGTAGAAGTACACCAGCATCATTGTAGTAGAGTGTAAACCTTTTCCCATGCCCAGTCTTCAAATTTCTAATGT
TTTGCAGTGTTAAAATGTTTTGCAAATACATGCCAATAACACAGATCAAATAATATCTCCTCATGAGAAATTTATGATCTTTTAAGTTTC
TATACATGTATTCTTATAAGACGACCCAGGATCTACTATATTAGAATAGATGAAGCAGGTAGCTTCTTTTTTCTCAAATGTAATTCAGCA
AAATAATACAGTACTGCCACCAGATTTTTTATTACATCATTTGAAAATTAGCAGTATGCTTAATGAAAATTTGTTCAGGTATAAATGAGC
AGTTAAGATATAAACAATTTATGCATGCTGTGACTTAGTCTATGGATTTATTCCAAAATTGCTTAGTCACCATGCAGTGTCTGTATTTTT
ATATATGTGTTCATATATACATAATGATTATAATACATAATAAGAATGAGGTGGTATTACATTATTCCTAATAATAGGGATAATGCTGTT
TATTGTCAAGAAAAAGTAAAATCGTTCTCTTCAATTAATGGCCCTTTTATTTTGGGACCAGGCTTTTATTTTCCCTGATATTATTTCTAT


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FusionGenePPI for TMEM167B_LYPLA1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TMEM167BELAVL1LYPLA1LYPLA1, ELAVL1, VCAM1, FN1, ITGA4, GOLGA2, TEAD4, CTSO, APRT, ASNS, DPYSL2, ARFIP1, CDA, OXCT1, PARK7, PCCB, PRDX6, TTC38, TRIM11, USP47, GTF2E2, FCF1, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TMEM167B_LYPLA1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TMEM167B_LYPLA1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource