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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 38447

FusionGeneSummary for TMEM150C_TYW1

check button Fusion gene summary
Fusion gene informationFusion gene name: TMEM150C_TYW1
Fusion gene ID: 38447
HgeneTgene
Gene symbol

TMEM150C

TYW1

Gene ID

441027

55253

Gene nametransmembrane protein 150CtRNA-yW synthesizing protein 1 homolog
SynonymsTTN3RSAFD1|TYW1A|YPL207W
Cytomap

4q21.22

7q11.21

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane protein 150Ctentonin 3S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthaseradical S-adenosyl methionine and flavodoxin domain-containing protein 1radical S-adenosyl methionine and flavodoxin domains 1tRNA wybutosine-synthesizing protein 1 homologtRNA-yW synthe
Modification date2018052320180519
UniProtAcc

B9EJG8

Q9NV66

Ensembl transtripts involved in fusion geneENST00000515780, ENST00000449862, 
ENST00000508701, 
ENST00000359626, 
ENST00000491969, 
Fusion gene scores* DoF score2 X 1 X 2=43 X 2 X 2=12
# samples 23
** MAII scorelog2(2/4*10)=2.32192809488736log2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TMEM150C [Title/Abstract] AND TYW1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSARCTCGA-DX-A1KY-01ATMEM150Cchr4

83483059

-TYW1chr7

66548417

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000515780ENST00000359626TMEM150Cchr4

83483059

-TYW1chr7

66548417

+
intron-intronENST00000515780ENST00000491969TMEM150Cchr4

83483059

-TYW1chr7

66548417

+
5UTR-3CDSENST00000449862ENST00000359626TMEM150Cchr4

83483059

-TYW1chr7

66548417

+
5UTR-intronENST00000449862ENST00000491969TMEM150Cchr4

83483059

-TYW1chr7

66548417

+
5UTR-3CDSENST00000508701ENST00000359626TMEM150Cchr4

83483059

-TYW1chr7

66548417

+
5UTR-intronENST00000508701ENST00000491969TMEM150Cchr4

83483059

-TYW1chr7

66548417

+

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FusionProtFeatures for TMEM150C_TYW1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TMEM150C

B9EJG8

TYW1

Q9NV66

Component of a mechanosensitive cation channel. Confersmechanically activated (MA) currents with slow inactivationkinetics. May contribute to proprioception.{ECO:0000250|UniProtKB:Q8C8S3}. Probable component of the wybutosine biosynthesispathway. Wybutosine is a hyper modified guanosine with a tricyclicbase found at the 3'-position adjacent to the anticodon ofeukaryotic phenylalanine tRNA. Catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form thetricyclic 4-demethylwyosine, an intermediate in wybutosinebiosynthesis (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TMEM150C_TYW1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TMEM150C_TYW1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TMEM150CTYW1ELAVL1, MMS19, LYN, FAM96B, CIAO1, SPINT2, TMEM59, TSPAN17, BTN2A1, FAM189A2, EVA1C, LRRTM2, ZNRF4, GDPD5, LRRTM1, KLHL40, DLK2, RGS20, KCNS3, KCNC4, PCDHA3, NMUR2, PCDHGB4, IL17RC, RNF170, PDGFRB, IL17RB, GPR156, TMPRSS3, CHRND, ADAM33, PCDHGA5, PMEL, PCDHAC1, ATP6V0A2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TMEM150C_TYW1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TMEM150C_TYW1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource