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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 38440

FusionGeneSummary for TMEM14B_CAPRIN1

check button Fusion gene summary
Fusion gene informationFusion gene name: TMEM14B_CAPRIN1
Fusion gene ID: 38440
HgeneTgene
Gene symbol

TMEM14B

CAPRIN1

Gene ID

81853

4076

Gene nametransmembrane protein 14Bcell cycle associated protein 1
Synonyms-GPIAP1|GPIP137|GRIP137|M11S1|RNG105|p137GPI
Cytomap

6p24.2

11p13

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane protein 14Bcaprin-1GPI-anchored membrane protein 1GPI-anchored protein p137GPI-p137RNA granule protein 105activation/proliferation-associated protein 1caprin 1cytoplasmic activation- and proliferation-associated protein 1cytoplasmic activation/proliferation-
Modification date2018051920180519
UniProtAcc

Q9NUH8

Q14444

Ensembl transtripts involved in fusion geneENST00000379542, ENST00000491103, 
ENST00000461342, ENST00000475942, 
ENST00000379530, ENST00000473276, 
ENST00000481240, ENST00000467317, 
ENST00000341394, ENST00000389645, 
ENST00000532820, ENST00000530820, 
ENST00000529307, ENST00000533657, 
Fusion gene scores* DoF score4 X 4 X 2=326 X 5 X 4=120
# samples 48
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(8/120*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TMEM14B [Title/Abstract] AND CAPRIN1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTMEM14B

GO:0061351

neural precursor cell proliferation

29033352

HgeneTMEM14B

GO:2000045

regulation of G1/S transition of mitotic cell cycle

29033352


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BM153330TMEM14Bchr6

10748501

+CAPRIN1chr11

34197541

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000379542ENST00000341394TMEM14Bchr6

10748501

+CAPRIN1chr11

34197541

-
intron-intronENST00000379542ENST00000389645TMEM14Bchr6

10748501

+CAPRIN1chr11

34197541

-
intron-intronENST00000379542ENST00000532820TMEM14Bchr6

10748501

+CAPRIN1chr11

34197541

-
intron-intronENST00000379542ENST00000530820TMEM14Bchr6

10748501

+CAPRIN1chr11

34197541

-
intron-intronENST00000379542ENST00000529307TMEM14Bchr6

10748501

+CAPRIN1chr11

34197541

-
intron-intronENST00000379542ENST00000533657TMEM14Bchr6

10748501

+CAPRIN1chr11

34197541

-
intron-intronENST00000491103ENST00000341394TMEM14Bchr6

10748501

+CAPRIN1chr11

34197541

-
intron-intronENST00000491103ENST00000389645TMEM14Bchr6

10748501

+CAPRIN1chr11

34197541

-
intron-intronENST00000491103ENST00000532820TMEM14Bchr6

10748501

+CAPRIN1chr11

34197541

-
intron-intronENST00000491103ENST00000530820TMEM14Bchr6

10748501

+CAPRIN1chr11

34197541

-
intron-intronENST00000491103ENST00000529307TMEM14Bchr6

10748501

+CAPRIN1chr11

34197541

-
intron-intronENST00000491103ENST00000533657TMEM14Bchr6

10748501

+CAPRIN1chr11

34197541

-
intron-intronENST00000461342ENST00000341394TMEM14Bchr6

10748501

+CAPRIN1chr11

34197541

-
intron-intronENST00000461342ENST00000389645TMEM14Bchr6

10748501

+CAPRIN1chr11

34197541

-
intron-intronENST00000461342ENST00000532820TMEM14Bchr6

10748501

+CAPRIN1chr11

34197541

-
intron-intronENST00000461342ENST00000530820TMEM14Bchr6

10748501

+CAPRIN1chr11

34197541

-
intron-intronENST00000461342ENST00000529307TMEM14Bchr6

10748501

+CAPRIN1chr11

34197541

-
intron-intronENST00000461342ENST00000533657TMEM14Bchr6

10748501

+CAPRIN1chr11

34197541

-
intron-intronENST00000475942ENST00000341394TMEM14Bchr6

10748501

+CAPRIN1chr11

34197541

-
intron-intronENST00000475942ENST00000389645TMEM14Bchr6

10748501

+CAPRIN1chr11

34197541

-
intron-intronENST00000475942ENST00000532820TMEM14Bchr6

10748501

+CAPRIN1chr11

34197541

-
intron-intronENST00000475942ENST00000530820TMEM14Bchr6

10748501

+CAPRIN1chr11

34197541

-
intron-intronENST00000475942ENST00000529307TMEM14Bchr6

10748501

+CAPRIN1chr11

34197541

-
intron-intronENST00000475942ENST00000533657TMEM14Bchr6

10748501

+CAPRIN1chr11

34197541

-
intron-intronENST00000379530ENST00000341394TMEM14Bchr6

10748501

+CAPRIN1chr11

34197541

-
intron-intronENST00000379530ENST00000389645TMEM14Bchr6

10748501

+CAPRIN1chr11

34197541

-
intron-intronENST00000379530ENST00000532820TMEM14Bchr6

10748501

+CAPRIN1chr11

34197541

-
intron-intronENST00000379530ENST00000530820TMEM14Bchr6

10748501

+CAPRIN1chr11

34197541

-
intron-intronENST00000379530ENST00000529307TMEM14Bchr6

10748501

+CAPRIN1chr11

34197541

-
intron-intronENST00000379530ENST00000533657TMEM14Bchr6

10748501

+CAPRIN1chr11

34197541

-
intron-intronENST00000473276ENST00000341394TMEM14Bchr6

10748501

+CAPRIN1chr11

34197541

-
intron-intronENST00000473276ENST00000389645TMEM14Bchr6

10748501

+CAPRIN1chr11

34197541

-
intron-intronENST00000473276ENST00000532820TMEM14Bchr6

10748501

+CAPRIN1chr11

34197541

-
intron-intronENST00000473276ENST00000530820TMEM14Bchr6

10748501

+CAPRIN1chr11

34197541

-
intron-intronENST00000473276ENST00000529307TMEM14Bchr6

10748501

+CAPRIN1chr11

34197541

-
intron-intronENST00000473276ENST00000533657TMEM14Bchr6

10748501

+CAPRIN1chr11

34197541

-
intron-intronENST00000481240ENST00000341394TMEM14Bchr6

10748501

+CAPRIN1chr11

34197541

-
intron-intronENST00000481240ENST00000389645TMEM14Bchr6

10748501

+CAPRIN1chr11

34197541

-
intron-intronENST00000481240ENST00000532820TMEM14Bchr6

10748501

+CAPRIN1chr11

34197541

-
intron-intronENST00000481240ENST00000530820TMEM14Bchr6

10748501

+CAPRIN1chr11

34197541

-
intron-intronENST00000481240ENST00000529307TMEM14Bchr6

10748501

+CAPRIN1chr11

34197541

-
intron-intronENST00000481240ENST00000533657TMEM14Bchr6

10748501

+CAPRIN1chr11

34197541

-
intron-intronENST00000467317ENST00000341394TMEM14Bchr6

10748501

+CAPRIN1chr11

34197541

-
intron-intronENST00000467317ENST00000389645TMEM14Bchr6

10748501

+CAPRIN1chr11

34197541

-
intron-intronENST00000467317ENST00000532820TMEM14Bchr6

10748501

+CAPRIN1chr11

34197541

-
intron-intronENST00000467317ENST00000530820TMEM14Bchr6

10748501

+CAPRIN1chr11

34197541

-
intron-intronENST00000467317ENST00000529307TMEM14Bchr6

10748501

+CAPRIN1chr11

34197541

-
intron-intronENST00000467317ENST00000533657TMEM14Bchr6

10748501

+CAPRIN1chr11

34197541

-

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FusionProtFeatures for TMEM14B_CAPRIN1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TMEM14B

Q9NUH8

CAPRIN1

Q14444

Primate-specific protein involved in cortical expansionand folding in the developing neocortex. May drive neuralprogenitor proliferation through nuclear translocation of IQGAP1,which in turn promotes G1/S cell cycle transitions.{ECO:0000269|PubMed:29033352}. May regulate the transport and translation of mRNAs ofproteins involved in synaptic plasticity in neurons and cellproliferation and migration in multiple cell types. Binds directlyand selectively to MYC and CCND2 RNAs. In neuronal cells, directlybinds to several mRNAs associated with RNA granules, includingBDNF, CAMK2A, CREB1, MAP2, NTRK2 mRNAs, as well as to GRIN1 andKPNB1 mRNAs, but not to rRNAs. {ECO:0000269|PubMed:17210633}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TMEM14B_CAPRIN1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TMEM14B_CAPRIN1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TMEM14B_CAPRIN1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TMEM14B_CAPRIN1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource