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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 38436

FusionGeneSummary for TMEM147_AKAP11

check button Fusion gene summary
Fusion gene informationFusion gene name: TMEM147_AKAP11
Fusion gene ID: 38436
HgeneTgene
Gene symbol

TMEM147

AKAP11

Gene ID

10430

11215

Gene nametransmembrane protein 147A-kinase anchoring protein 11
SynonymsNIFIE14AKAP-11|AKAP220|PPP1R44|PRKA11
Cytomap

19q13.12

13q14.11

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane protein 147protein NIFIE 14seven transmembrane domain proteinA-kinase anchor protein 11A kinase (PRKA) anchor protein 11A-kinase anchor protein 220 kDaA-kinase anchoring protein, 220kDaa kinase anchor protein 220 kDaprotein kinase A anchoring protein 11protein phosphatase 1, regulatory subunit 44
Modification date2018052320180523
UniProtAcc

Q9BVK8

Q9UKA4

Ensembl transtripts involved in fusion geneENST00000222284, ENST00000392204, 
ENST00000392205, 
ENST00000025301, 
Fusion gene scores* DoF score2 X 2 X 2=83 X 3 X 1=9
# samples 23
** MAII scorelog2(2/8*10)=1.32192809488736log2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TMEM147 [Title/Abstract] AND AKAP11 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BG655839TMEM147chr19

36038300

-AKAP11chr13

42876630

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000222284ENST00000025301TMEM147chr19

36038300

-AKAP11chr13

42876630

-
In-frameENST00000392204ENST00000025301TMEM147chr19

36038300

-AKAP11chr13

42876630

-
Frame-shiftENST00000392205ENST00000025301TMEM147chr19

36038300

-AKAP11chr13

42876630

-

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FusionProtFeatures for TMEM147_AKAP11


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TMEM147

Q9BVK8

AKAP11

Q9UKA4

Binds to type II regulatory subunits of protein kinase Aand anchors/targets them.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TMEM147_AKAP11


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_TMEM147_ENST00000222284_chr19_36038300_-_AKAP11_ENST00000025301_chr13_42876630_-_0aa

>In-frame_TMEM147_ENST00000392204_chr19_36038300_-_AKAP11_ENST00000025301_chr13_42876630_-_0aa


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_TMEM147_ENST00000222284_chr19_36038300_-_AKAP11_ENST00000025301_chr13_42876630_-_0nt

>In-frame_TMEM147_ENST00000392204_chr19_36038300_-_AKAP11_ENST00000025301_chr13_42876630_-_0nt


* Fusion transcript sequences (Full-length transcript).
>In-frame_TMEM147_ENST00000222284_chr19_36038300_-_AKAP11_ENST00000025301_chr13_42876630_-_0nt

>In-frame_TMEM147_ENST00000392204_chr19_36038300_-_AKAP11_ENST00000025301_chr13_42876630_-_0nt


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FusionGenePPI for TMEM147_AKAP11


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TMEM147_AKAP11


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TMEM147_AKAP11


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource