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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 38413

FusionGeneSummary for TMEM132D_RALGAPA2

check button Fusion gene summary
Fusion gene informationFusion gene name: TMEM132D_RALGAPA2
Fusion gene ID: 38413
HgeneTgene
Gene symbol

TMEM132D

RALGAPA2

Gene ID

121256

57186

Gene nametransmembrane protein 132DRal GTPase activating protein catalytic alpha subunit 2
SynonymsMOLT|PPP1R153AS250|C20orf74|bA287B20.1|dJ1049G11|dJ1049G11.4|p220
Cytomap

12q24.33

20p11.23

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane protein 132Dmature OL transmembrane proteinmature oligodendrocytes transmembrane proteinprotein phosphatase 1, regulatory subunit 153ral GTPase-activating protein subunit alpha-2250 kDa substrate of AktRal GTPase activating protein, alpha subunit 2 (catalytic)RapGAPalpha2akt substrate AS250ral GTPase-activating protein alpha subunit 2
Modification date2018051920180523
UniProtAcc

Q14C87

Q2PPJ7

Ensembl transtripts involved in fusion geneENST00000422113, ENST00000389441, 
ENST00000202677, ENST00000495793, 
Fusion gene scores* DoF score4 X 3 X 3=368 X 8 X 6=384
# samples 49
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(9/384*10)=-2.09310940439148
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TMEM132D [Title/Abstract] AND RALGAPA2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTMEM132D

GO:0010923

negative regulation of phosphatase activity

19389623


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-55-8620-01ATMEM132Dchr12

130015604

-RALGAPA2chr20

20392792

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000422113ENST00000202677TMEM132Dchr12

130015604

-RALGAPA2chr20

20392792

-
5CDS-intronENST00000422113ENST00000495793TMEM132Dchr12

130015604

-RALGAPA2chr20

20392792

-
intron-3CDSENST00000389441ENST00000202677TMEM132Dchr12

130015604

-RALGAPA2chr20

20392792

-
intron-intronENST00000389441ENST00000495793TMEM132Dchr12

130015604

-RALGAPA2chr20

20392792

-

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FusionProtFeatures for TMEM132D_RALGAPA2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TMEM132D

Q14C87

RALGAPA2

Q2PPJ7

May serve as a cell-surface marker for oligodendrocytedifferentiation. {ECO:0000269|PubMed:12966072}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTMEM132Dchr12:130015604chr20:20392792ENST00000389441-1431_915-414638Topological domainExtracellular
HgeneTMEM132Dchr12:130015604chr20:20392792ENST00000389441-14937_1099-414638Topological domainCytoplasmic
HgeneTMEM132Dchr12:130015604chr20:20392792ENST00000422113-3931_9153711100Topological domainExtracellular
HgeneTMEM132Dchr12:130015604chr20:20392792ENST00000422113-39937_10993711100Topological domainCytoplasmic
HgeneTMEM132Dchr12:130015604chr20:20392792ENST00000389441-14916_936-414638TransmembraneHelical
HgeneTMEM132Dchr12:130015604chr20:20392792ENST00000422113-39916_9363711100TransmembraneHelical
TgeneRALGAPA2chr12:130015604chr20:20392792ENST00000202677-3640757_76018311974Compositional biasNote=Poly-Gln
TgeneRALGAPA2chr12:130015604chr20:20392792ENST00000202677-3640790_79318311974Compositional biasNote=Poly-Ser
TgeneRALGAPA2chr12:130015604chr20:20392792ENST00000202677-36401635_184318311974DomainRap-GAP


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FusionGeneSequence for TMEM132D_RALGAPA2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_TMEM132D_ENST00000422113_chr12_130015604_-_RALGAPA2_ENST00000202677_chr20_20392792_-_414aa
MCPSEMGTLWHHWSPVLISLAALFSKVTEGRGILESIQRFSLLPTYLPVTYHINNADVSFFLKEANQDIMRNSSLQSRVESFLIYKSRRL
PVLNASYGPFSIEQVVPQDLMLPSNPFGFTNKFSLNWKLKAHILRDKVYLSRPKVQVLFHIMGRDWDDRSAGEKLPCLRVFAFRETREVR
GSCRLQGDLGLCVAELELLSSWFSPPTVVAGRRKSVDQPEGTPVELYYTVHPGGERGDCVREDARRSNGIRTGHSDIDESGPPLQRIGSI
FLYQTHRKPSLRELRLDNSVAIHYIPKTVRKGDVLTFPVSISRNSTEDRFTLRAKVKKGVNIIGVRASSPSIWDVKERTDYTGKYAPAVI


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_TMEM132D_ENST00000422113_chr12_130015604_-_RALGAPA2_ENST00000202677_chr20_20392792_-_1242nt
ATGTGCCCGTCTGAGATGGGGACGCTGTGGCACCACTGGTCGCCGGTACTCATCAGCCTGGCCGCCCTGTTTTCCAAAGTGACGGAAGGT
CGAGGGATCCTTGAGAGCATCCAGAGGTTTTCCTTGCTGCCCACCTACCTCCCCGTGACCTACCACATCAACAACGCGGACGTCTCCTTC
TTCCTGAAGGAGGCCAACCAGGATATCATGAGGAACTCCAGCCTGCAGTCCCGGGTGGAGTCATTTCTGATTTACAAATCCAGGAGGCTG
CCTGTCCTCAATGCCAGCTACGGGCCTTTCTCCATCGAGCAAGTGGTGCCCCAGGATTTAATGCTACCTTCCAACCCATTTGGATTCACC
AACAAATTTTCTCTTAACTGGAAACTAAAAGCCCACATCCTGCGGGACAAAGTCTACCTGAGCCGGCCCAAAGTGCAGGTTCTGTTCCAC
ATCATGGGCAGAGACTGGGACGACCGCAGCGCCGGGGAGAAGCTGCCGTGCCTGAGGGTCTTTGCTTTCCGAGAGACCCGAGAGGTGCGG
GGCAGCTGCCGGCTGCAGGGGGACCTGGGGCTGTGCGTGGCCGAGCTGGAGCTCCTGTCCAGCTGGTTCAGCCCCCCCACGGTGGTTGCC
GGGAGGAGGAAGTCCGTGGACCAGCCGGAGGGGACCCCCGTGGAGCTCTACTACACCGTGCACCCAGGGGGTGAGAGAGGGGACTGCGTC
AGGGAAGACGCGAGGAGAAGCAATGGGATCCGGACAGGCCACAGTGACATCGATGAGTCCGGGCCCCCCTTGCAGAGGATCGGGAGCATC
TTCCTTTATCAGACACACAGGAAACCCTCCCTGAGAGAACTGCGTCTGGACAACAGCGTGGCCATCCACTATATACCAAAGACCGTGAGG
AAAGGAGACGTGCTGACTTTTCCTGTTTCCATCTCCAGAAATTCCACTGAAGATCGCTTCACGTTGAGGGCAAAGGTGAAGAAAGGCGTG
AACATCATCGGCGTGCGAGCCAGCAGCCCTTCCATTTGGGATGTCAAGGAGCGCACGGATTATACTGGAAAGTATGCACCAGCTGTCATC
GTTTGTCAGAAGAAAGCAGCTGGCTCAGAAAACAGCTATGAAGAGCGAGCTCTGTATCTCGAAGCAATAATTCAGAACCACCGCGAAGTA


* Fusion transcript sequences (Full-length transcript).
>In-frame_TMEM132D_ENST00000422113_chr12_130015604_-_RALGAPA2_ENST00000202677_chr20_20392792_-_2091nt
CCACTCTTCGCTCGGGTAAACAGGAAAGGAAATACCCCCTGTGGATTAAAATTTAAAAAAAATTCTGTTGGGGTCGAAGGAGGGAGGTGG
GGTTTGCCTGCGCGCGTGTTGGACTCCGGAGAGCAACTCAGGAGCCCGCGCGGTCGTCGCCTCCCGGCCTGGCCATGGACTGGCGGGAAG
AGGGAGCAGGGCGCCCGGGCTGCTCGGGCCCCTAGCCGGGCGCTCCCTCGCCACCGGCCCCGCTGCGGGCCTCTAGGGGACTGAGACGGT
CTCTTGTTCGCCTGGACGGCGCCGGGGAGCGGAGGATCTGCGCTCCGGGTCTCCAGGATGTGCCCGTCTGAGATGGGGACGCTGTGGCAC
CACTGGTCGCCGGTACTCATCAGCCTGGCCGCCCTGTTTTCCAAAGTGACGGAAGGTCGAGGGATCCTTGAGAGCATCCAGAGGTTTTCC
TTGCTGCCCACCTACCTCCCCGTGACCTACCACATCAACAACGCGGACGTCTCCTTCTTCCTGAAGGAGGCCAACCAGGATATCATGAGG
AACTCCAGCCTGCAGTCCCGGGTGGAGTCATTTCTGATTTACAAATCCAGGAGGCTGCCTGTCCTCAATGCCAGCTACGGGCCTTTCTCC
ATCGAGCAAGTGGTGCCCCAGGATTTAATGCTACCTTCCAACCCATTTGGATTCACCAACAAATTTTCTCTTAACTGGAAACTAAAAGCC
CACATCCTGCGGGACAAAGTCTACCTGAGCCGGCCCAAAGTGCAGGTTCTGTTCCACATCATGGGCAGAGACTGGGACGACCGCAGCGCC
GGGGAGAAGCTGCCGTGCCTGAGGGTCTTTGCTTTCCGAGAGACCCGAGAGGTGCGGGGCAGCTGCCGGCTGCAGGGGGACCTGGGGCTG
TGCGTGGCCGAGCTGGAGCTCCTGTCCAGCTGGTTCAGCCCCCCCACGGTGGTTGCCGGGAGGAGGAAGTCCGTGGACCAGCCGGAGGGG
ACCCCCGTGGAGCTCTACTACACCGTGCACCCAGGGGGTGAGAGAGGGGACTGCGTCAGGGAAGACGCGAGGAGAAGCAATGGGATCCGG
ACAGGCCACAGTGACATCGATGAGTCCGGGCCCCCCTTGCAGAGGATCGGGAGCATCTTCCTTTATCAGACACACAGGAAACCCTCCCTG
AGAGAACTGCGTCTGGACAACAGCGTGGCCATCCACTATATACCAAAGACCGTGAGGAAAGGAGACGTGCTGACTTTTCCTGTTTCCATC
TCCAGAAATTCCACTGAAGATCGCTTCACGTTGAGGGCAAAGGTGAAGAAAGGCGTGAACATCATCGGCGTGCGAGCCAGCAGCCCTTCC
ATTTGGGATGTCAAGGAGCGCACGGATTATACTGGAAAGTATGCACCAGCTGTCATCGTTTGTCAGAAGAAAGCAGCTGGCTCAGAAAAC
AGCTATGAAGAGCGAGCTCTGTATCTCGAAGCAATAATTCAGAACCACCGCGAAGTAATGACATTCGAGGATTTCGCAGCCCAAGTCTTT
TCTCCCTCTCCCAGCTACTCCCTCAGCGGAACGGATTAAAACACGTAAAGGTCTCATTTCAATATTTGAGCAAGGGGCCCTGGCCTCCAG
TCTGAGTGCTGACCTCGAAGAGCCCCTGAGTGAGGAGGAGACAGAACACCCTCTCCTGCCTCTGCCCCGAGCCACTAAACCCAGAATCTC
CAGGAAATTTCGTTGCTGTACTAGTGCCCTCAGCAGGTCTTCCCATTAGTGGACTTCTGAAGCCCATGGTGAATCCCACTACCGTGTCTC
AGATGGGACTCAAACTAGGCTGTATCATCTTGTCCTGAAACCTCACAAACCTTGGACTTCCAAAGAAGAAAAGAAAAAGTCACCAAAAAC
CAGAGATGAACCCACTGACACGTGGGCACTGGTGTGGCTGCTCTGGGCAGATGACAGCAGGAAAAGATTCTGCGCTTTCAGGGAGGGGGC
AGAGGGCAGCTTGCTTCTGCACCCCAAGTTGTTTCTTCTCATTTATGAACCCAAGCATGATTCACAAAGGGGCTGGCAAAACAATTGTCT


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FusionGenePPI for TMEM132D_RALGAPA2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TMEM132DRALGAPA2GFOD1, SPRTN, NKIRAS2, DPH7, MTMR7


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TMEM132D_RALGAPA2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TMEM132D_RALGAPA2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTMEM132DC0023903Liver neoplasms1CTD_human
HgeneTMEM132DC0032927Precancerous Conditions1CTD_human
HgeneTMEM132DC0149925Small cell carcinoma of lung1CTD_human