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Fusion gene ID: 38410 |
FusionGeneSummary for TMEM132C_CDH1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TMEM132C_CDH1 | Fusion gene ID: 38410 | Hgene | Tgene | Gene symbol | TMEM132C | CDH1 | Gene ID | 92293 | 51343 |
| Gene name | transmembrane protein 132C | fizzy and cell division cycle 20 related 1 | |
| Synonyms | PPP1R152 | CDC20C|CDH1|FZR|FZR2|HCDH|HCDH1 | |
| Cytomap | 12q24.32-q24.33 | 19p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | transmembrane protein 132Cprotein phosphatase 1, regulatory subunit 152 | fizzy-related protein homologCDC20 homolog 1CDC20-like 1bCDC20-like protein 1cdh1/Hct1 homologfizzy/cell division cycle 20 related 1 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q8N3T6 | P12830 | |
| Ensembl transtripts involved in fusion gene | ENST00000435159, ENST00000315208, ENST00000537538, | ENST00000261769, ENST00000422392, ENST00000562836, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 9 X 10 X 3=270 |
| # samples | 2 | 12 | |
| ** MAII score | log2(2/1*10)=4.32192809488736 | log2(12/270*10)=-1.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TMEM132C [Title/Abstract] AND CDH1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | CDH1 | GO:0031145 | anaphase-promoting complex-dependent catabolic process | 18662541|21596315 |
| Tgene | CDH1 | GO:0072425 | signal transduction involved in G2 DNA damage checkpoint | 18662541 |
| Tgene | CDH1 | GO:1904668 | positive regulation of ubiquitin protein ligase activity | 11459826 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BE816621 | TMEM132C | chr12 | 128928593 | + | CDH1 | chr16 | 68846084 | + | ||
| ChiTaRS3.1 | BE816637 | TMEM132C | chr12 | 128928593 | + | CDH1 | chr16 | 68846084 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000435159 | ENST00000261769 | TMEM132C | chr12 | 128928593 | + | CDH1 | chr16 | 68846084 | + |
| intron-3CDS | ENST00000435159 | ENST00000422392 | TMEM132C | chr12 | 128928593 | + | CDH1 | chr16 | 68846084 | + |
| intron-3UTR | ENST00000435159 | ENST00000562836 | TMEM132C | chr12 | 128928593 | + | CDH1 | chr16 | 68846084 | + |
| intron-3CDS | ENST00000315208 | ENST00000261769 | TMEM132C | chr12 | 128928593 | + | CDH1 | chr16 | 68846084 | + |
| intron-3CDS | ENST00000315208 | ENST00000422392 | TMEM132C | chr12 | 128928593 | + | CDH1 | chr16 | 68846084 | + |
| intron-3UTR | ENST00000315208 | ENST00000562836 | TMEM132C | chr12 | 128928593 | + | CDH1 | chr16 | 68846084 | + |
| intron-3CDS | ENST00000537538 | ENST00000261769 | TMEM132C | chr12 | 128928593 | + | CDH1 | chr16 | 68846084 | + |
| intron-3CDS | ENST00000537538 | ENST00000422392 | TMEM132C | chr12 | 128928593 | + | CDH1 | chr16 | 68846084 | + |
| intron-3UTR | ENST00000537538 | ENST00000562836 | TMEM132C | chr12 | 128928593 | + | CDH1 | chr16 | 68846084 | + |
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FusionProtFeatures for TMEM132C_CDH1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TMEM132C | CDH1 |
| Cadherins are calcium-dependent cell adhesion proteins(PubMed:11976333). They preferentially interact with themselves ina homophilic manner in connecting cells; cadherins may thuscontribute to the sorting of heterogeneous cell types. CDH1 isinvolved in mechanisms regulating cell-cell adhesions, mobilityand proliferation of epithelial cells (PubMed:11976333). Has apotent invasive suppressor role. It is a ligand for integrinalpha-E/beta-7. {ECO:0000269|PubMed:11976333,ECO:0000269|PubMed:16417575}. E-Cad/CTF2 promotes non-amyloidogenic degradation ofAbeta precursors. Has a strong inhibitory effect on APP C99 andC83 production. {ECO:0000269|PubMed:16417575}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TMEM132C_CDH1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TMEM132C_CDH1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TMEM132C_CDH1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TMEM132C_CDH1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | CDH1 | C0038356 | Stomach Neoplasms | 6 | CTD_human |
| Tgene | CDH1 | C1458155 | Mammary Neoplasms | 4 | CTD_human |
| Tgene | CDH1 | C0005695 | Bladder Neoplasm | 2 | CTD_human |
| Tgene | CDH1 | C0009404 | Colorectal Neoplasms | 2 | CTD_human |
| Tgene | CDH1 | C0023904 | Liver Neoplasms, Experimental | 2 | CTD_human |
| Tgene | CDH1 | C0027626 | Neoplasm Invasiveness | 2 | CTD_human |
| Tgene | CDH1 | C0027627 | Neoplasm Metastasis | 2 | CTD_human |
| Tgene | CDH1 | C0033578 | Prostatic Neoplasms | 2 | CTD_human |
| Tgene | CDH1 | C0206692 | Carcinoma, Lobular | 2 | CTD_human |
| Tgene | CDH1 | C1134719 | Invasive Ductal Breast Carcinoma | 2 | CTD_human |
| Tgene | CDH1 | C1708349 | Hereditary Diffuse Gastric Cancer | 2 | ORPHANET;UNIPROT |
| Tgene | CDH1 | C2931456 | Prostate cancer, familial | 2 | CTD_human |
| Tgene | CDH1 | C0007137 | Squamous cell carcinoma | 1 | CTD_human |
| Tgene | CDH1 | C0007621 | Neoplastic Cell Transformation | 1 | CTD_human |
| Tgene | CDH1 | C0009324 | Ulcerative Colitis | 1 | CTD_human |
| Tgene | CDH1 | C0010606 | Adenoid Cystic Carcinoma | 1 | CTD_human |
| Tgene | CDH1 | C0014170 | Endometrial Neoplasms | 1 | CTD_human |
| Tgene | CDH1 | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
| Tgene | CDH1 | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
| Tgene | CDH1 | C0025500 | Mesothelioma | 1 | CTD_human |
| Tgene | CDH1 | C0026936 | Mycoplasma Infections | 1 | CTD_human |
| Tgene | CDH1 | C0027746 | Nerve Degeneration | 1 | CTD_human |
| Tgene | CDH1 | C0030297 | Pancreatic Neoplasm | 1 | CTD_human |
| Tgene | CDH1 | C0032927 | Precancerous Conditions | 1 | CTD_human |
| Tgene | CDH1 | C0036095 | Salivary Gland Neoplasms | 1 | CTD_human |
| Tgene | CDH1 | C0079487 | Helicobacter Infections | 1 | CTD_human |
| Tgene | CDH1 | C0282612 | Prostatic Intraepithelial Neoplasias | 1 | CTD_human |
| Tgene | CDH1 | C0919267 | ovarian neoplasm | 1 | CTD_human |
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