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Fusion gene ID: 38407 |
FusionGeneSummary for TMEM131_SPATA16 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TMEM131_SPATA16 | Fusion gene ID: 38407 | Hgene | Tgene | Gene symbol | TMEM131 | SPATA16 | Gene ID | 23505 | 83893 |
| Gene name | transmembrane protein 131 | spermatogenesis associated 16 | |
| Synonyms | CC28|PRO1048|RW1|YR-23 | NYD-SP12|SPGF6 | |
| Cytomap | 2q11.2 | 3q26.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | transmembrane protein 1312610524E03Rik | spermatogenesis-associated protein 16testicular tissue protein Li 185testis development protein NYD-SP12testis-specific Golgi protein | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q92545 | Q9BXB7 | |
| Ensembl transtripts involved in fusion gene | ENST00000186436, ENST00000425805, | ENST00000351008, | |
| Fusion gene scores | * DoF score | 6 X 5 X 6=180 | 8 X 6 X 6=288 |
| # samples | 7 | 8 | |
| ** MAII score | log2(7/180*10)=-1.36257007938471 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/288*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TMEM131 [Title/Abstract] AND SPATA16 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUAD | TCGA-05-4417-01A | TMEM131 | chr2 | 98543889 | - | SPATA16 | chr3 | 172766884 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000186436 | ENST00000351008 | TMEM131 | chr2 | 98543889 | - | SPATA16 | chr3 | 172766884 | - |
| Frame-shift | ENST00000425805 | ENST00000351008 | TMEM131 | chr2 | 98543889 | - | SPATA16 | chr3 | 172766884 | - |
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FusionProtFeatures for TMEM131_SPATA16 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TMEM131 | SPATA16 |
| May play a role in the immune response to viralinfection. {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >TMEM131 | chr2:98543889 | chr3:172766884 | ENST00000186436 | - | 2 | 41 | 1297_1332 | 83 | 1884 | Compositional bias | Note=Pro-rich |
| Hgene | >TMEM131 | chr2:98543889 | chr3:172766884 | ENST00000186436 | - | 2 | 41 | 1379_1474 | 83 | 1884 | Compositional bias | Note=Lys-rich |
| Hgene | >TMEM131 | chr2:98543889 | chr3:172766884 | ENST00000186436 | - | 2 | 41 | 1626_1630 | 83 | 1884 | Compositional bias | Note=Poly-Ser |
| Hgene | >TMEM131 | chr2:98543889 | chr3:172766884 | ENST00000186436 | - | 2 | 41 | 1679_1815 | 83 | 1884 | Compositional bias | Note=Ser-rich |
| Hgene | >TMEM131 | chr2:98543889 | chr3:172766884 | ENST00000186436 | - | 2 | 41 | 1091_1111 | 83 | 1884 | Transmembrane | Helical |
| Hgene | >TMEM131 | chr2:98543889 | chr3:172766884 | ENST00000186436 | - | 2 | 41 | 1118_1138 | 83 | 1884 | Transmembrane | Helical |
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FusionGeneSequence for TMEM131_SPATA16 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_TMEM131_ENST00000186436_chr2_98543889_-_SPATA16_ENST00000351008_chr3_172766884_-_449aa MGKRAGGGATGATTAAVSTSAGAGLEPAAARSGGPRSAAAGLLGALHLVMTLVVAAARAEKEAFVQSESIIEVLRFDDGGLLQLCSKGAV LGEPFDAPAEDIASVASFIETKLVTCYLRMRKPDLALNHAHRSIVLNPAYFRNHLRQATVFRCLERYSEAARSAMIADYMFWLGGGREES ISKLIKLYWQAMIEEAITRAESFSVMYTPFATKIRADKIEKVKDAFTKTHPAYAEYMYTDLQALHMLPQTVDWSSFPPQQYLLTLGFKNK DDGKFLEKISSRKLPIFTEHKTPFGLTREDTVRQMETMGKRILPILDFIRSTQLNGSFPASSGVMEKLQYASLLSQLQRVKEQSQVINQA |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_TMEM131_ENST00000186436_chr2_98543889_-_SPATA16_ENST00000351008_chr3_172766884_-_1347nt ATGGGGAAGCGGGCGGGAGGAGGAGCAACCGGAGCCACCACCGCCGCCGTCTCCACGTCCGCCGGGGCCGGGCTGGAACCTGCGGCCGCC CGTAGCGGGGGCCCGCGGAGCGCGGCCGCCGGCCTCCTAGGCGCGCTGCACCTGGTGATGACCCTCGTAGTGGCTGCGGCGCGGGCCGAG AAGGAAGCATTCGTTCAGTCAGAGAGCATAATAGAAGTACTGCGTTTTGATGATGGAGGGCTACTACAGCTTTGCAGCAAAGGAGCAGTT CTGGGAGAACCATTTGATGCACCTGCTGAAGATATAGCAAGCGTGGCAAGTTTCATTGAGACAAAGCTTGTTACCTGTTATCTACGGATG AGGAAACCAGATCTTGCCCTGAATCATGCACACAGGAGCATTGTTTTAAACCCAGCCTATTTCCGGAATCATCTTCGTCAAGCAACAGTG TTTAGATGTCTGGAGAGGTATTCAGAGGCTGCCCGGAGTGCCATGATTGCTGACTACATGTTCTGGCTTGGTGGAGGAAGGGAAGAGAGC ATAAGCAAGCTCATCAAACTGTATTGGCAGGCCATGATTGAGGAAGCCATCACCAGAGCTGAATCTTTCTCGGTTATGTACACACCATTT GCGACAAAAATAAGAGCTGATAAAATAGAAAAAGTAAAAGATGCTTTCACAAAAACTCATCCTGCATATGCAGAGTATATGTACACAGAT CTTCAAGCACTCCACATGTTGCCTCAGACAGTTGACTGGTCATCTTTTCCTCCCCAACAATATCTCTTGACTCTTGGGTTCAAAAACAAA GATGATGGAAAATTTTTGGAAAAAATATCAAGCAGGAAGCTGCCGATATTCACAGAGCATAAAACACCTTTCGGTCTGACCAGAGAAGAT ACAGTGAGGCAAATGGAGACAATGGGGAAGCGAATCTTGCCAATATTGGATTTTATTAGAAGCACCCAATTGAATGGGAGTTTTCCTGCA TCCTCAGGTGTGATGGAGAAGTTGCAATATGCCAGCCTCCTCAGCCAGCTGCAGAGAGTAAAGGAGCAGTCCCAGGTGATTAATCAAGCA ATGGCAGAGCTAGCAACCATTCCCTACCTACAGGACATCAGTCAACAGGAGGCAGAATTGCTGCAGTCACTAATGGCAGATGCTATGGAC ACCCTTGAAGGAAGAAGAAACAATAATGAACGTGTGTGGAATATGATCCAAAAGGTTGGACAAATTGAAGATTTTCTATACCAATTAGAG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_TMEM131_ENST00000186436_chr2_98543889_-_SPATA16_ENST00000351008_chr3_172766884_-_1788nt CTCCGCTCCGACTGCTTGTAGGCGATGCCCAGGCAAAGACCGTGACTGACACTCTCGCTCACACGCACGCACGGACCCAGGCCCACGCTC GGAGATCGAGCCCCGGGCTCGCAACCGTTGTCGCTCCCGGCGCCGCGGCCAGAGCCCGGACCACGGCTTCCGCGCCGCCGCCGCCTCGCC GAGAAGGGCCGCGCCGGACCTCGAGCGCGGCGGCCCCCGGCCGGCAGGGATGGGGAAGCGGGCGGGAGGAGGAGCAACCGGAGCCACCAC CGCCGCCGTCTCCACGTCCGCCGGGGCCGGGCTGGAACCTGCGGCCGCCCGTAGCGGGGGCCCGCGGAGCGCGGCCGCCGGCCTCCTAGG CGCGCTGCACCTGGTGATGACCCTCGTAGTGGCTGCGGCGCGGGCCGAGAAGGAAGCATTCGTTCAGTCAGAGAGCATAATAGAAGTACT GCGTTTTGATGATGGAGGGCTACTACAGCTTTGCAGCAAAGGAGCAGTTCTGGGAGAACCATTTGATGCACCTGCTGAAGATATAGCAAG CGTGGCAAGTTTCATTGAGACAAAGCTTGTTACCTGTTATCTACGGATGAGGAAACCAGATCTTGCCCTGAATCATGCACACAGGAGCAT TGTTTTAAACCCAGCCTATTTCCGGAATCATCTTCGTCAAGCAACAGTGTTTAGATGTCTGGAGAGGTATTCAGAGGCTGCCCGGAGTGC CATGATTGCTGACTACATGTTCTGGCTTGGTGGAGGAAGGGAAGAGAGCATAAGCAAGCTCATCAAACTGTATTGGCAGGCCATGATTGA GGAAGCCATCACCAGAGCTGAATCTTTCTCGGTTATGTACACACCATTTGCGACAAAAATAAGAGCTGATAAAATAGAAAAAGTAAAAGA TGCTTTCACAAAAACTCATCCTGCATATGCAGAGTATATGTACACAGATCTTCAAGCACTCCACATGTTGCCTCAGACAGTTGACTGGTC ATCTTTTCCTCCCCAACAATATCTCTTGACTCTTGGGTTCAAAAACAAAGATGATGGAAAATTTTTGGAAAAAATATCAAGCAGGAAGCT GCCGATATTCACAGAGCATAAAACACCTTTCGGTCTGACCAGAGAAGATACAGTGAGGCAAATGGAGACAATGGGGAAGCGAATCTTGCC AATATTGGATTTTATTAGAAGCACCCAATTGAATGGGAGTTTTCCTGCATCCTCAGGTGTGATGGAGAAGTTGCAATATGCCAGCCTCCT CAGCCAGCTGCAGAGAGTAAAGGAGCAGTCCCAGGTGATTAATCAAGCAATGGCAGAGCTAGCAACCATTCCCTACCTACAGGACATCAG TCAACAGGAGGCAGAATTGCTGCAGTCACTAATGGCAGATGCTATGGACACCCTTGAAGGAAGAAGAAACAATAATGAACGTGTGTGGAA TATGATCCAAAAGGTTGGACAAATTGAAGATTTTCTATACCAATTAGAGGACAGTTTCTTAAAAACTAAAAAACTGAGAACTGCTCGAAG GCAAAAAACAAAAATGAAGCGACTTCAAACTGTTCAGCAAAGGTAGTCATTAGGGAGCAGGCACTACCACTAAGATATCCCAGAAGAAGA GGCAAGGGCATCCACTCCAATGCCCACCTAGTACTGTGAAGCTGGATAACAAAAGCTTGTCACCAAAAGAAAGAGGTGGTATTCCCCTCA |
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FusionGenePPI for TMEM131_SPATA16 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TMEM131 | FBXO6, TAZ, MCOLN3, TNFSF13B, HLA-E, PTCH1, SIAE, NTRK1, CTR9, THOC2, PIGS, PTAR1, GABRA3, GRAMD1B, OS9, LYZL1, LRRTM1, DEFA1, GABRD, P2RX5, PLXDC2 | SPATA16 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TMEM131_SPATA16 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TMEM131_SPATA16 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | SPATA16 | C0403825 | Globozoospermia | 1 | CTD_human;UNIPROT |
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