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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 38341

FusionGeneSummary for TMEFF2_TMPRSS2

check button Fusion gene summary
Fusion gene informationFusion gene name: TMEFF2_TMPRSS2
Fusion gene ID: 38341
HgeneTgene
Gene symbol

TMEFF2

TMPRSS2

Gene ID

23671

7113

Gene nametransmembrane protein with EGF like and two follistatin like domains 2transmembrane serine protease 2
SynonymsCT120.2|HPP1|TENB2|TPEF|TR|TR-2PP9284|PRSS10
Cytomap

2q32.3

21q22.3

Type of geneprotein-codingprotein-coding
Descriptiontomoregulin-2cancer/testis antigen family 120, member 2hyperplastic polyposis protein 1transmembrane protein TENB2transmembrane protein with EGF-like and two follistatin-like domainstransmembrane protease serine 2epitheliasinserine protease 10transmembrane protease, serine 2
Modification date2018051920180523
UniProtAcc

Q9UIK5

O15393

Ensembl transtripts involved in fusion geneENST00000392314, ENST00000272771, 
ENST00000487771, ENST00000409056, 
ENST00000332149, ENST00000398585, 
ENST00000458356, ENST00000497881, 
Fusion gene scores* DoF score7 X 4 X 2=5616 X 12 X 3=576
# samples 820
** MAII scorelog2(8/56*10)=0.514573172829758
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(20/576*10)=-1.52606881166759
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TMEFF2 [Title/Abstract] AND TMPRSS2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Tumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
Tissue-specifically expressed gene involved fusion gene, inframe and retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTMEFF2

GO:0030336

negative regulation of cell migration

24632071

HgeneTMEFF2

GO:0044319

wound healing, spreading of cells

24632071

HgeneTMEFF2

GO:0051497

negative regulation of stress fiber assembly

24632071

TgeneTMPRSS2

GO:0006508

proteolysis

21068237|24227843

TgeneTMPRSS2

GO:0046598

positive regulation of viral entry into host cell

21068237|24227843


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDPRADTCGA-KK-A59Y-01ATMEFF2chr2

193049080

-TMPRSS2chr21

42851209

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000392314ENST00000332149TMEFF2chr2

193049080

-TMPRSS2chr21

42851209

-
Frame-shitENST00000392314ENST00000398585TMEFF2chr2

193049080

-TMPRSS2chr21

42851209

-
Frame-shitENST00000392314ENST00000458356TMEFF2chr2

193049080

-TMPRSS2chr21

42851209

-
5CDS-intronENST00000392314ENST00000497881TMEFF2chr2

193049080

-TMPRSS2chr21

42851209

-
Frame-shitENST00000272771ENST00000332149TMEFF2chr2

193049080

-TMPRSS2chr21

42851209

-
Frame-shitENST00000272771ENST00000398585TMEFF2chr2

193049080

-TMPRSS2chr21

42851209

-
Frame-shitENST00000272771ENST00000458356TMEFF2chr2

193049080

-TMPRSS2chr21

42851209

-
5CDS-intronENST00000272771ENST00000497881TMEFF2chr2

193049080

-TMPRSS2chr21

42851209

-
intron-3CDSENST00000487771ENST00000332149TMEFF2chr2

193049080

-TMPRSS2chr21

42851209

-
intron-3CDSENST00000487771ENST00000398585TMEFF2chr2

193049080

-TMPRSS2chr21

42851209

-
intron-3CDSENST00000487771ENST00000458356TMEFF2chr2

193049080

-TMPRSS2chr21

42851209

-
intron-intronENST00000487771ENST00000497881TMEFF2chr2

193049080

-TMPRSS2chr21

42851209

-
Frame-shitENST00000409056ENST00000332149TMEFF2chr2

193049080

-TMPRSS2chr21

42851209

-
Frame-shitENST00000409056ENST00000398585TMEFF2chr2

193049080

-TMPRSS2chr21

42851209

-
Frame-shitENST00000409056ENST00000458356TMEFF2chr2

193049080

-TMPRSS2chr21

42851209

-
5CDS-intronENST00000409056ENST00000497881TMEFF2chr2

193049080

-TMPRSS2chr21

42851209

-

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FusionProtFeatures for TMEFF2_TMPRSS2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TMEFF2

Q9UIK5

TMPRSS2

O15393

Serine protease that proteolytically cleaves andactivates the viral spike glycoproteins which facilitate virus-cell membrane fusions; spike proteins are synthesized andmaintained in precursor intermediate folding states andproteolysis permits the refolding and energy release required tocreate stable virus-cell linkages and membrane coalescence.Facilitates human SARS coronavirus (SARS-CoV) infection via twoindependent mechanisms, proteolytic cleavage of ACE2, which mightpromote viral uptake, and cleavage of coronavirus spikeglycoprotein which activates the glycoprotein for cathepsin L-independent host cell entry. Proteolytically cleaves and activatesthe spike glycoproteins of human coronavirus 229E (HCoV-229E) andhuman coronavirus EMC (HCoV-EMC) and the fusion glycoproteins F0of Sendai virus (SeV), human metapneumovirus (HMPV), humanparainfluenza 1, 2, 3, 4a and 4b viruses (HPIV). Essential forspread and pathogenesis of influenza A virus (strains H1N1, H3N2and H7N9); involved in proteolytic cleavage and activation ofhemagglutinin (HA) protein which is essential for viralinfectivity. {ECO:0000269|PubMed:21068237,ECO:0000269|PubMed:21325420, ECO:0000269|PubMed:23536651,ECO:0000269|PubMed:23966399, ECO:0000269|PubMed:24027332,ECO:0000269|PubMed:24227843}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TMEFF2_TMPRSS2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TMEFF2_TMPRSS2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TMEFF2AGO2TMPRSS2CLK1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TMEFF2_TMPRSS2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TMEFF2_TMPRSS2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTMEFF2C0032460Polycystic Ovary Syndrome1CTD_human
HgeneTMEFF2C0033578Prostatic Neoplasms1CTD_human
TgeneTMPRSS2C0033578Prostatic Neoplasms2CTD_human