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Fusion gene ID: 38331 |
FusionGeneSummary for TMED4_ENG |
Fusion gene summary |
Fusion gene information | Fusion gene name: TMED4_ENG | Fusion gene ID: 38331 | Hgene | Tgene | Gene symbol | TMED4 | ENG | Gene ID | 222068 | 2022 |
Gene name | transmembrane p24 trafficking protein 4 | endoglin | |
Synonyms | ERS25|GMP25iso|HNLF|p24a3|p24alpha3 | END|HHT1|ORW1 | |
Cytomap | 7p13 | 9q34.11 | |
Type of gene | protein-coding | protein-coding | |
Description | transmembrane emp24 domain-containing protein 4endoplasmic reticulum stress-response protein 25 kDap24 family protein alpha-3putative NF-kappa-B-activating protein 156putative NFkB activating protein HNLFtransmembrane emp24 protein transport domain c | endoglinCD105 antigen | |
Modification date | 20180523 | 20180527 | |
UniProtAcc | Q7Z7H5 | P17813 | |
Ensembl transtripts involved in fusion gene | ENST00000457408, ENST00000289577, ENST00000481238, ENST00000444131, | ENST00000373203, ENST00000344849, ENST00000480266, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 6 X 6 X 3=108 |
# samples | 1 | 7 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(7/108*10)=-0.625604485218502 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: TMED4 [Title/Abstract] AND ENG [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | ENG | GO:0001934 | positive regulation of protein phosphorylation | 12015308 |
Tgene | ENG | GO:0010862 | positive regulation of pathway-restricted SMAD protein phosphorylation | 12015308 |
Tgene | ENG | GO:0017015 | regulation of transforming growth factor beta receptor signaling pathway | 15702480 |
Tgene | ENG | GO:0030336 | negative regulation of cell migration | 19736306 |
Tgene | ENG | GO:0030513 | positive regulation of BMP signaling pathway | 17068149 |
Tgene | ENG | GO:0031953 | negative regulation of protein autophosphorylation | 12015308 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AK123738 | TMED4 | chr7 | 44620692 | - | ENG | chr9 | 130581112 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000457408 | ENST00000373203 | TMED4 | chr7 | 44620692 | - | ENG | chr9 | 130581112 | - |
In-frame | ENST00000457408 | ENST00000344849 | TMED4 | chr7 | 44620692 | - | ENG | chr9 | 130581112 | - |
5CDS-intron | ENST00000457408 | ENST00000480266 | TMED4 | chr7 | 44620692 | - | ENG | chr9 | 130581112 | - |
intron-3CDS | ENST00000289577 | ENST00000373203 | TMED4 | chr7 | 44620692 | - | ENG | chr9 | 130581112 | - |
intron-3CDS | ENST00000289577 | ENST00000344849 | TMED4 | chr7 | 44620692 | - | ENG | chr9 | 130581112 | - |
intron-intron | ENST00000289577 | ENST00000480266 | TMED4 | chr7 | 44620692 | - | ENG | chr9 | 130581112 | - |
intron-3CDS | ENST00000481238 | ENST00000373203 | TMED4 | chr7 | 44620692 | - | ENG | chr9 | 130581112 | - |
intron-3CDS | ENST00000481238 | ENST00000344849 | TMED4 | chr7 | 44620692 | - | ENG | chr9 | 130581112 | - |
intron-intron | ENST00000481238 | ENST00000480266 | TMED4 | chr7 | 44620692 | - | ENG | chr9 | 130581112 | - |
Frame-shift | ENST00000444131 | ENST00000373203 | TMED4 | chr7 | 44620692 | - | ENG | chr9 | 130581112 | - |
Frame-shift | ENST00000444131 | ENST00000344849 | TMED4 | chr7 | 44620692 | - | ENG | chr9 | 130581112 | - |
5CDS-intron | ENST00000444131 | ENST00000480266 | TMED4 | chr7 | 44620692 | - | ENG | chr9 | 130581112 | - |
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FusionProtFeatures for TMED4_ENG |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
TMED4 | ENG |
Involved in vesicular protein trafficking, mainly in theearly secretory pathway. targeting. Involved in the maintenance ofthe Golgi apparatus. Appears to play a role in the biosynthesis ofsecreted cargo including processing. Involved in endoplasmicreticulum stress response. May play a role in the regulation ofheat-shock response and apoptosis (By similarity). {ECO:0000250}. | Vascular endothelium glycoprotein that plays animportant role in the regulation of angiogenesis (PubMed:21737454,PubMed:23300529). Required for normal structure and integrity ofadult vasculature (PubMed:7894484). Regulates the migration ofvascular endothelial cells (PubMed:17540773). Required for normalextraembryonic angiogenesis and for embryonic heart development(By similarity). May regulate endothelial cell shape changes inresponse to blood flow, which drive vascular remodeling andestablishment of normal vascular morphology during angiogenesis(By similarity). May play a critical role in the binding ofendothelial cells to integrins and/or other RGD receptors(PubMed:1692830). Acts as TGF-beta coreceptor and is involved inthe TGF-beta/BMP signaling cascade that ultimately leads to theactivation of SMAD transcription factors (PubMed:8370410,PubMed:21737454, PubMed:22347366, PubMed:23300529). Required forGDF2/BMP9 signaling through SMAD1 in endothelial cells andmodulates TGFB1 signaling through SMAD3 (PubMed:21737454,PubMed:22347366, PubMed:23300529). {ECO:0000250|UniProtKB:Q63961,ECO:0000269|PubMed:17540773, ECO:0000269|PubMed:21737454,ECO:0000269|PubMed:23300529, ECO:0000269|PubMed:7894484,ECO:0000269|PubMed:8370410, ECO:0000305|PubMed:1692830}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | TMED4 | chr7:44620692 | chr9:130581112 | ENST00000457408 | - | 4 | 5 | 147_176 | 178 | 228 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TMED4 | chr7:44620692 | chr9:130581112 | ENST00000457408 | - | 4 | 5 | 39_137 | 178 | 228 | Domain | GOLD |
Tgene | >ENG | chr7:44620692 | chr9:130581112 | ENST00000344849 | - | 9 | 14 | 612_658 | 437 | 626 | Topological domain | Cytoplasmic |
Tgene | >ENG | chr7:44620692 | chr9:130581112 | ENST00000373203 | - | 9 | 15 | 612_658 | 437 | 659 | Topological domain | Cytoplasmic |
Tgene | >ENG | chr7:44620692 | chr9:130581112 | ENST00000344849 | - | 9 | 14 | 587_611 | 437 | 626 | Transmembrane | Helical |
Tgene | >ENG | chr7:44620692 | chr9:130581112 | ENST00000373203 | - | 9 | 15 | 587_611 | 437 | 659 | Transmembrane | Helical |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >TMED4 | chr7:44620692 | chr9:130581112 | ENST00000481238 | - | 1 | 4 | 147_176 | -9 | 187 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | >TMED4 | chr7:44620692 | chr9:130581112 | ENST00000481238 | - | 1 | 4 | 39_137 | -9 | 187 | Domain | GOLD |
Hgene | >TMED4 | chr7:44620692 | chr9:130581112 | ENST00000457408 | - | 4 | 5 | 220_221 | 178 | 228 | Motif | COPII vesicle coat-binding |
Hgene | >TMED4 | chr7:44620692 | chr9:130581112 | ENST00000457408 | - | 4 | 5 | 220_227 | 178 | 228 | Motif | COPI vesicle coat-binding |
Hgene | >TMED4 | chr7:44620692 | chr9:130581112 | ENST00000481238 | - | 1 | 4 | 220_221 | -9 | 187 | Motif | COPII vesicle coat-binding |
Hgene | >TMED4 | chr7:44620692 | chr9:130581112 | ENST00000481238 | - | 1 | 4 | 220_227 | -9 | 187 | Motif | COPI vesicle coat-binding |
Hgene | >TMED4 | chr7:44620692 | chr9:130581112 | ENST00000457408 | - | 4 | 5 | 213_227 | 178 | 228 | Topological domain | Cytoplasmic |
Hgene | >TMED4 | chr7:44620692 | chr9:130581112 | ENST00000457408 | - | 4 | 5 | 30_194 | 178 | 228 | Topological domain | Lumenal |
Hgene | >TMED4 | chr7:44620692 | chr9:130581112 | ENST00000481238 | - | 1 | 4 | 213_227 | -9 | 187 | Topological domain | Cytoplasmic |
Hgene | >TMED4 | chr7:44620692 | chr9:130581112 | ENST00000481238 | - | 1 | 4 | 30_194 | -9 | 187 | Topological domain | Lumenal |
Hgene | >TMED4 | chr7:44620692 | chr9:130581112 | ENST00000457408 | - | 4 | 5 | 195_212 | 178 | 228 | Transmembrane | Helical |
Hgene | >TMED4 | chr7:44620692 | chr9:130581112 | ENST00000481238 | - | 1 | 4 | 195_212 | -9 | 187 | Transmembrane | Helical |
Tgene | ENG | chr7:44620692 | chr9:130581112 | ENST00000344849 | - | 9 | 14 | 336_576 | 437 | 626 | Compositional bias | Note=Ser/Thr-rich |
Tgene | ENG | chr7:44620692 | chr9:130581112 | ENST00000373203 | - | 9 | 15 | 336_576 | 437 | 659 | Compositional bias | Note=Ser/Thr-rich |
Tgene | ENG | chr7:44620692 | chr9:130581112 | ENST00000344849 | - | 9 | 14 | 363_533 | 437 | 626 | Domain | ZP |
Tgene | ENG | chr7:44620692 | chr9:130581112 | ENST00000373203 | - | 9 | 15 | 363_533 | 437 | 659 | Domain | ZP |
Tgene | ENG | chr7:44620692 | chr9:130581112 | ENST00000344849 | - | 9 | 14 | 399_401 | 437 | 626 | Motif | Cell attachment site |
Tgene | ENG | chr7:44620692 | chr9:130581112 | ENST00000373203 | - | 9 | 15 | 399_401 | 437 | 659 | Motif | Cell attachment site |
Tgene | ENG | chr7:44620692 | chr9:130581112 | ENST00000344849 | - | 9 | 14 | 200_330 | 437 | 626 | Region | OR1%2C C-terminal part |
Tgene | ENG | chr7:44620692 | chr9:130581112 | ENST00000344849 | - | 9 | 14 | 26_46 | 437 | 626 | Region | OR1%2C N-terminal part |
Tgene | ENG | chr7:44620692 | chr9:130581112 | ENST00000344849 | - | 9 | 14 | 47_199 | 437 | 626 | Region | OR2 |
Tgene | ENG | chr7:44620692 | chr9:130581112 | ENST00000373203 | - | 9 | 15 | 200_330 | 437 | 659 | Region | OR1%2C C-terminal part |
Tgene | ENG | chr7:44620692 | chr9:130581112 | ENST00000373203 | - | 9 | 15 | 26_46 | 437 | 659 | Region | OR1%2C N-terminal part |
Tgene | ENG | chr7:44620692 | chr9:130581112 | ENST00000373203 | - | 9 | 15 | 47_199 | 437 | 659 | Region | OR2 |
Tgene | ENG | chr7:44620692 | chr9:130581112 | ENST00000344849 | - | 9 | 14 | 26_586 | 437 | 626 | Topological domain | Extracellular |
Tgene | ENG | chr7:44620692 | chr9:130581112 | ENST00000373203 | - | 9 | 15 | 26_586 | 437 | 659 | Topological domain | Extracellular |
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FusionGeneSequence for TMED4_ENG |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_TMED4_ENST00000457408_chr7_44620692_-_ENG_ENST00000373203_chr9_130581112_-_222aa KKVHCLNMDSLSFQLGLYLSPHFLQASNTIEPGQQSFVQVRVSPSVSEFLLQLDSCHLDLGPEGGTVELIQGRAAKGNCVSLLSPSPEGD PRFSFLLHFYTVPIPKTGTLSCTVALRPKTGSQDQEVHRTVFMRLNIISPDLSGCTSKGLVLPAVLGITFGAFLIGALLTAALWYIYSHT >In-frame_TMED4_ENST00000457408_chr7_44620692_-_ENG_ENST00000344849_chr9_130581112_-_189aa KKVHCLNMDSLSFQLGLYLSPHFLQASNTIEPGQQSFVQVRVSPSVSEFLLQLDSCHLDLGPEGGTVELIQGRAAKGNCVSLLSPSPEGD PRFSFLLHFYTVPIPKTGTLSCTVALRPKTGSQDQEVHRTVFMRLNIISPDLSGCTSKGLVLPAVLGITFGAFLIGALLTAALWYIYSHT |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_TMED4_ENST00000457408_chr7_44620692_-_ENG_ENST00000373203_chr9_130581112_-_666nt AAAAAGGTGCACTGCCTCAACATGGACAGCCTCTCTTTCCAGCTGGGCCTCTACCTCAGCCCACACTTCCTCCAGGCCTCCAACACCATC GAGCCGGGGCAGCAGAGCTTTGTGCAGGTCAGAGTGTCCCCATCCGTCTCCGAGTTCCTGCTCCAGTTAGACAGCTGCCACCTGGACTTG GGGCCTGAGGGAGGCACCGTGGAACTCATCCAGGGCCGGGCGGCCAAGGGCAACTGTGTGAGCCTGCTGTCCCCAAGCCCCGAGGGTGAC CCGCGCTTCAGCTTCCTCCTCCACTTCTACACAGTACCCATACCCAAAACCGGCACCCTCAGCTGCACGGTAGCCCTGCGTCCCAAGACC GGGTCTCAAGACCAGGAAGTCCATAGGACTGTCTTCATGCGCTTGAACATCATCAGCCCTGACCTGTCTGGTTGCACAAGCAAAGGCCTC GTCCTGCCCGCCGTGCTGGGCATCACCTTTGGTGCCTTCCTCATCGGGGCCCTGCTCACTGCTGCACTCTGGTACATCTACTCGCACACG CGTTCCCCCAGCAAGCGGGAGCCCGTGGTGGCGGTGGCTGCCCCGGCCTCCTCGGAGAGCAGCAGCACCAACCACAGCATCGGGAGCACC >In-frame_TMED4_ENST00000457408_chr7_44620692_-_ENG_ENST00000344849_chr9_130581112_-_567nt AAAAAGGTGCACTGCCTCAACATGGACAGCCTCTCTTTCCAGCTGGGCCTCTACCTCAGCCCACACTTCCTCCAGGCCTCCAACACCATC GAGCCGGGGCAGCAGAGCTTTGTGCAGGTCAGAGTGTCCCCATCCGTCTCCGAGTTCCTGCTCCAGTTAGACAGCTGCCACCTGGACTTG GGGCCTGAGGGAGGCACCGTGGAACTCATCCAGGGCCGGGCGGCCAAGGGCAACTGTGTGAGCCTGCTGTCCCCAAGCCCCGAGGGTGAC CCGCGCTTCAGCTTCCTCCTCCACTTCTACACAGTACCCATACCCAAAACCGGCACCCTCAGCTGCACGGTAGCCCTGCGTCCCAAGACC GGGTCTCAAGACCAGGAAGTCCATAGGACTGTCTTCATGCGCTTGAACATCATCAGCCCTGACCTGTCTGGTTGCACAAGCAAAGGCCTC GTCCTGCCCGCCGTGCTGGGCATCACCTTTGGTGCCTTCCTCATCGGGGCCCTGCTCACTGCTGCACTCTGGTACATCTACTCGCACACG |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_TMED4_ENST00000457408_chr7_44620692_-_ENG_ENST00000373203_chr9_130581112_-_1923nt GCAGGCGCAGAGCGATGCGCAAATGTGCGCAGGCGCTTAGGGGCTGAGGCGCGATGGCAGGTGTCGGGGCTGGGCCTCTGCGGGCGATGG GGCGGCAGGCCCTGCTGCTTCTCGCGCTGTGCGCCACAGGCGCCCAGGGGCTCTACTTCCACATCGGCGAGACCGAGAAGCGCTGTTTCA TCGAGGAAATCCCCGACGAGACCATGGTCATCGGCAACTATCGTACCCAGATGTGGGATAAGCAGAAGGAGGTCTTCCTGCCCTCGACCC CTGGCCTGGGCATGCACGTGGAAGTGAAGGACCCCGACGGCAAGGTGGTGCTGTCCCGGCAGTACGGCTCGGAGGGCCGCTTCACGTTCA CCTCCCACACGCCCGGTGACCATCAAATCTGTCTGCACTCCAATTCTACCAGGATGGCTCTCTTCGCTGGTGGCAAACTGCGGGTGCATC TCGACATCCAGGTTGGGGAGCATGCCAACAACTACCCTGAGATTGCTGCAAAAGATAAGCTGACGGAGCTACAGCTCCGCGCCCGCCAGT TGCTTGATCAGGTGGAACAGATTCAGAAGGAGCAGGATTACCAAAGGAAAAAGGTGCACTGCCTCAACATGGACAGCCTCTCTTTCCAGC TGGGCCTCTACCTCAGCCCACACTTCCTCCAGGCCTCCAACACCATCGAGCCGGGGCAGCAGAGCTTTGTGCAGGTCAGAGTGTCCCCAT CCGTCTCCGAGTTCCTGCTCCAGTTAGACAGCTGCCACCTGGACTTGGGGCCTGAGGGAGGCACCGTGGAACTCATCCAGGGCCGGGCGG CCAAGGGCAACTGTGTGAGCCTGCTGTCCCCAAGCCCCGAGGGTGACCCGCGCTTCAGCTTCCTCCTCCACTTCTACACAGTACCCATAC CCAAAACCGGCACCCTCAGCTGCACGGTAGCCCTGCGTCCCAAGACCGGGTCTCAAGACCAGGAAGTCCATAGGACTGTCTTCATGCGCT TGAACATCATCAGCCCTGACCTGTCTGGTTGCACAAGCAAAGGCCTCGTCCTGCCCGCCGTGCTGGGCATCACCTTTGGTGCCTTCCTCA TCGGGGCCCTGCTCACTGCTGCACTCTGGTACATCTACTCGCACACGCGTTCCCCCAGCAAGCGGGAGCCCGTGGTGGCGGTGGCTGCCC CGGCCTCCTCGGAGAGCAGCAGCACCAACCACAGCATCGGGAGCACCCAGAGCACCCCCTGCTCCACCAGCAGCATGGCATAGCCCCGGC CCCCCGCGCTCGCCCAGCAGGAGAGACTGAGCAGCCGCCAGCTGGGAGCACTGGTGTGAACTCACCCTGGGAGCCAGTCCTCCACTCGAC CCAGAATGGAGCCTGCTCTCCGCGCCTACCCTTCCCGCCTCCCTCTCAGAGGCCTGCTGCCAGTGCAGCCACTGGCTTGGAACACCTTGG GGTCCCTCCACCCCACAGAACCTTCAACCCAGTGGGTCTGGGATATGGCTGCCCAGGAGACAGACCACTTGCCACGCTGTTGTAAAAACC CAAGTCCCTGTCATTTGAACCTGGATCCAGCACTGGTGAACTGAGCTGGGCAGGAAGGGAGAACTTGAAACAGATTCAGGCCAGCCCAGC CAGGCCAACAGCACCTCCCCGCTGGGAAGAGAAGAGGGCCCAGCCCAGAGCCACCTGGATCTATCCCTGCGGCCTCCACACCTGAACTTG CCTAACTAACTGGCAGGGGAGACAGGAGCCTAGCGGAGCCCAGCCTGGGAGCCCAGAGGGTGGCAAGAACAGTGGGCGTTGGGAGCCTAG CTCCTGCCACATGGAGCCCCCTCTGCCGGTCGGGCAGCCAGCAGAGGGGGAGTAGCCAAGCTGCTTGTCCTGGGCCTGCCCCTGTGTATT >In-frame_TMED4_ENST00000457408_chr7_44620692_-_ENG_ENST00000344849_chr9_130581112_-_2054nt GCAGGCGCAGAGCGATGCGCAAATGTGCGCAGGCGCTTAGGGGCTGAGGCGCGATGGCAGGTGTCGGGGCTGGGCCTCTGCGGGCGATGG GGCGGCAGGCCCTGCTGCTTCTCGCGCTGTGCGCCACAGGCGCCCAGGGGCTCTACTTCCACATCGGCGAGACCGAGAAGCGCTGTTTCA TCGAGGAAATCCCCGACGAGACCATGGTCATCGGCAACTATCGTACCCAGATGTGGGATAAGCAGAAGGAGGTCTTCCTGCCCTCGACCC CTGGCCTGGGCATGCACGTGGAAGTGAAGGACCCCGACGGCAAGGTGGTGCTGTCCCGGCAGTACGGCTCGGAGGGCCGCTTCACGTTCA CCTCCCACACGCCCGGTGACCATCAAATCTGTCTGCACTCCAATTCTACCAGGATGGCTCTCTTCGCTGGTGGCAAACTGCGGGTGCATC TCGACATCCAGGTTGGGGAGCATGCCAACAACTACCCTGAGATTGCTGCAAAAGATAAGCTGACGGAGCTACAGCTCCGCGCCCGCCAGT TGCTTGATCAGGTGGAACAGATTCAGAAGGAGCAGGATTACCAAAGGAAAAAGGTGCACTGCCTCAACATGGACAGCCTCTCTTTCCAGC TGGGCCTCTACCTCAGCCCACACTTCCTCCAGGCCTCCAACACCATCGAGCCGGGGCAGCAGAGCTTTGTGCAGGTCAGAGTGTCCCCAT CCGTCTCCGAGTTCCTGCTCCAGTTAGACAGCTGCCACCTGGACTTGGGGCCTGAGGGAGGCACCGTGGAACTCATCCAGGGCCGGGCGG CCAAGGGCAACTGTGTGAGCCTGCTGTCCCCAAGCCCCGAGGGTGACCCGCGCTTCAGCTTCCTCCTCCACTTCTACACAGTACCCATAC CCAAAACCGGCACCCTCAGCTGCACGGTAGCCCTGCGTCCCAAGACCGGGTCTCAAGACCAGGAAGTCCATAGGACTGTCTTCATGCGCT TGAACATCATCAGCCCTGACCTGTCTGGTTGCACAAGCAAAGGCCTCGTCCTGCCCGCCGTGCTGGGCATCACCTTTGGTGCCTTCCTCA TCGGGGCCCTGCTCACTGCTGCACTCTGGTACATCTACTCGCACACGCGTGAGTACCCCAGGCCCCCACAGTGAGCATGCCGGGCCCCTC CATCCACCCGGGGGAGCCCAGTGAAGCCTCTGAGGGATTGAGGGGCCCTGGCCAGGACCCTGACCTCCGCCCCTGCCCCCGCTCCCGCTC CCAGGTTCCCCCAGCAAGCGGGAGCCCGTGGTGGCGGTGGCTGCCCCGGCCTCCTCGGAGAGCAGCAGCACCAACCACAGCATCGGGAGC ACCCAGAGCACCCCCTGCTCCACCAGCAGCATGGCATAGCCCCGGCCCCCCGCGCTCGCCCAGCAGGAGAGACTGAGCAGCCGCCAGCTG GGAGCACTGGTGTGAACTCACCCTGGGAGCCAGTCCTCCACTCGACCCAGAATGGAGCCTGCTCTCCGCGCCTACCCTTCCCGCCTCCCT CTCAGAGGCCTGCTGCCAGTGCAGCCACTGGCTTGGAACACCTTGGGGTCCCTCCACCCCACAGAACCTTCAACCCAGTGGGTCTGGGAT ATGGCTGCCCAGGAGACAGACCACTTGCCACGCTGTTGTAAAAACCCAAGTCCCTGTCATTTGAACCTGGATCCAGCACTGGTGAACTGA GCTGGGCAGGAAGGGAGAACTTGAAACAGATTCAGGCCAGCCCAGCCAGGCCAACAGCACCTCCCCGCTGGGAAGAGAAGAGGGCCCAGC CCAGAGCCACCTGGATCTATCCCTGCGGCCTCCACACCTGAACTTGCCTAACTAACTGGCAGGGGAGACAGGAGCCTAGCGGAGCCCAGC CTGGGAGCCCAGAGGGTGGCAAGAACAGTGGGCGTTGGGAGCCTAGCTCCTGCCACATGGAGCCCCCTCTGCCGGTCGGGCAGCCAGCAG |
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FusionGenePPI for TMED4_ENG |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
TMED4 | ELAVL1, KIAA0368, CHCHD6, TMED2, SF1, PPIC, SLC25A3, SRPRB, IKBIP, MOV10, NXF1, TMED10, TMED3, CHST8, HTR3C, LMAN1, NAGLU, LIPG, SCN3B, CDK5RAP3, FGF3, GORASP2, IL13RA2, SPPL2B, RFX3, PDHA1 | ENG | TGFBR2, TGFBR1, ACVR1, ACVR2B, BMP7, BMP2, ACVR2A, TUFM, ACVRL1, TGFB3, TGFB1, ENG |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TMED4_ENG |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TMED4_ENG |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | ENG | C0039445 | Hereditary hemorrhagic telangiectasia | 12 | CTD_human;ORPHANET;UNIPROT |