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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 38331

FusionGeneSummary for TMED4_ENG

check button Fusion gene summary
Fusion gene informationFusion gene name: TMED4_ENG
Fusion gene ID: 38331
HgeneTgene
Gene symbol

TMED4

ENG

Gene ID

222068

2022

Gene nametransmembrane p24 trafficking protein 4endoglin
SynonymsERS25|GMP25iso|HNLF|p24a3|p24alpha3END|HHT1|ORW1
Cytomap

7p13

9q34.11

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane emp24 domain-containing protein 4endoplasmic reticulum stress-response protein 25 kDap24 family protein alpha-3putative NF-kappa-B-activating protein 156putative NFkB activating protein HNLFtransmembrane emp24 protein transport domain cendoglinCD105 antigen
Modification date2018052320180527
UniProtAcc

Q7Z7H5

P17813

Ensembl transtripts involved in fusion geneENST00000457408, ENST00000289577, 
ENST00000481238, ENST00000444131, 
ENST00000373203, ENST00000344849, 
ENST00000480266, 
Fusion gene scores* DoF score1 X 1 X 1=16 X 6 X 3=108
# samples 17
** MAII scorelog2(1/1*10)=3.32192809488736log2(7/108*10)=-0.625604485218502
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TMED4 [Title/Abstract] AND ENG [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneENG

GO:0001934

positive regulation of protein phosphorylation

12015308

TgeneENG

GO:0010862

positive regulation of pathway-restricted SMAD protein phosphorylation

12015308

TgeneENG

GO:0017015

regulation of transforming growth factor beta receptor signaling pathway

15702480

TgeneENG

GO:0030336

negative regulation of cell migration

19736306

TgeneENG

GO:0030513

positive regulation of BMP signaling pathway

17068149

TgeneENG

GO:0031953

negative regulation of protein autophosphorylation

12015308


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AK123738TMED4chr7

44620692

-ENGchr9

130581112

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000457408ENST00000373203TMED4chr7

44620692

-ENGchr9

130581112

-
In-frameENST00000457408ENST00000344849TMED4chr7

44620692

-ENGchr9

130581112

-
5CDS-intronENST00000457408ENST00000480266TMED4chr7

44620692

-ENGchr9

130581112

-
intron-3CDSENST00000289577ENST00000373203TMED4chr7

44620692

-ENGchr9

130581112

-
intron-3CDSENST00000289577ENST00000344849TMED4chr7

44620692

-ENGchr9

130581112

-
intron-intronENST00000289577ENST00000480266TMED4chr7

44620692

-ENGchr9

130581112

-
intron-3CDSENST00000481238ENST00000373203TMED4chr7

44620692

-ENGchr9

130581112

-
intron-3CDSENST00000481238ENST00000344849TMED4chr7

44620692

-ENGchr9

130581112

-
intron-intronENST00000481238ENST00000480266TMED4chr7

44620692

-ENGchr9

130581112

-
Frame-shiftENST00000444131ENST00000373203TMED4chr7

44620692

-ENGchr9

130581112

-
Frame-shiftENST00000444131ENST00000344849TMED4chr7

44620692

-ENGchr9

130581112

-
5CDS-intronENST00000444131ENST00000480266TMED4chr7

44620692

-ENGchr9

130581112

-

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FusionProtFeatures for TMED4_ENG


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TMED4

Q7Z7H5

ENG

P17813

Involved in vesicular protein trafficking, mainly in theearly secretory pathway. targeting. Involved in the maintenance ofthe Golgi apparatus. Appears to play a role in the biosynthesis ofsecreted cargo including processing. Involved in endoplasmicreticulum stress response. May play a role in the regulation ofheat-shock response and apoptosis (By similarity). {ECO:0000250}. Vascular endothelium glycoprotein that plays animportant role in the regulation of angiogenesis (PubMed:21737454,PubMed:23300529). Required for normal structure and integrity ofadult vasculature (PubMed:7894484). Regulates the migration ofvascular endothelial cells (PubMed:17540773). Required for normalextraembryonic angiogenesis and for embryonic heart development(By similarity). May regulate endothelial cell shape changes inresponse to blood flow, which drive vascular remodeling andestablishment of normal vascular morphology during angiogenesis(By similarity). May play a critical role in the binding ofendothelial cells to integrins and/or other RGD receptors(PubMed:1692830). Acts as TGF-beta coreceptor and is involved inthe TGF-beta/BMP signaling cascade that ultimately leads to theactivation of SMAD transcription factors (PubMed:8370410,PubMed:21737454, PubMed:22347366, PubMed:23300529). Required forGDF2/BMP9 signaling through SMAD1 in endothelial cells andmodulates TGFB1 signaling through SMAD3 (PubMed:21737454,PubMed:22347366, PubMed:23300529). {ECO:0000250|UniProtKB:Q63961,ECO:0000269|PubMed:17540773, ECO:0000269|PubMed:21737454,ECO:0000269|PubMed:23300529, ECO:0000269|PubMed:7894484,ECO:0000269|PubMed:8370410, ECO:0000305|PubMed:1692830}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTMED4chr7:44620692chr9:130581112ENST00000457408-45147_176178228Coiled coilOntology_term=ECO:0000255
HgeneTMED4chr7:44620692chr9:130581112ENST00000457408-4539_137178228DomainGOLD
TgeneENGchr7:44620692chr9:130581112ENST00000344849-914612_658437626Topological domainCytoplasmic
TgeneENGchr7:44620692chr9:130581112ENST00000373203-915612_658437659Topological domainCytoplasmic
TgeneENGchr7:44620692chr9:130581112ENST00000344849-914587_611437626TransmembraneHelical
TgeneENGchr7:44620692chr9:130581112ENST00000373203-915587_611437659TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTMED4chr7:44620692chr9:130581112ENST00000481238-14147_176-9187Coiled coilOntology_term=ECO:0000255
HgeneTMED4chr7:44620692chr9:130581112ENST00000481238-1439_137-9187DomainGOLD
HgeneTMED4chr7:44620692chr9:130581112ENST00000457408-45220_221178228MotifCOPII vesicle coat-binding
HgeneTMED4chr7:44620692chr9:130581112ENST00000457408-45220_227178228MotifCOPI vesicle coat-binding
HgeneTMED4chr7:44620692chr9:130581112ENST00000481238-14220_221-9187MotifCOPII vesicle coat-binding
HgeneTMED4chr7:44620692chr9:130581112ENST00000481238-14220_227-9187MotifCOPI vesicle coat-binding
HgeneTMED4chr7:44620692chr9:130581112ENST00000457408-45213_227178228Topological domainCytoplasmic
HgeneTMED4chr7:44620692chr9:130581112ENST00000457408-4530_194178228Topological domainLumenal
HgeneTMED4chr7:44620692chr9:130581112ENST00000481238-14213_227-9187Topological domainCytoplasmic
HgeneTMED4chr7:44620692chr9:130581112ENST00000481238-1430_194-9187Topological domainLumenal
HgeneTMED4chr7:44620692chr9:130581112ENST00000457408-45195_212178228TransmembraneHelical
HgeneTMED4chr7:44620692chr9:130581112ENST00000481238-14195_212-9187TransmembraneHelical
TgeneENGchr7:44620692chr9:130581112ENST00000344849-914336_576437626Compositional biasNote=Ser/Thr-rich
TgeneENGchr7:44620692chr9:130581112ENST00000373203-915336_576437659Compositional biasNote=Ser/Thr-rich
TgeneENGchr7:44620692chr9:130581112ENST00000344849-914363_533437626DomainZP
TgeneENGchr7:44620692chr9:130581112ENST00000373203-915363_533437659DomainZP
TgeneENGchr7:44620692chr9:130581112ENST00000344849-914399_401437626MotifCell attachment site
TgeneENGchr7:44620692chr9:130581112ENST00000373203-915399_401437659MotifCell attachment site
TgeneENGchr7:44620692chr9:130581112ENST00000344849-914200_330437626RegionOR1%2C C-terminal part
TgeneENGchr7:44620692chr9:130581112ENST00000344849-91426_46437626RegionOR1%2C N-terminal part
TgeneENGchr7:44620692chr9:130581112ENST00000344849-91447_199437626RegionOR2
TgeneENGchr7:44620692chr9:130581112ENST00000373203-915200_330437659RegionOR1%2C C-terminal part
TgeneENGchr7:44620692chr9:130581112ENST00000373203-91526_46437659RegionOR1%2C N-terminal part
TgeneENGchr7:44620692chr9:130581112ENST00000373203-91547_199437659RegionOR2
TgeneENGchr7:44620692chr9:130581112ENST00000344849-91426_586437626Topological domainExtracellular
TgeneENGchr7:44620692chr9:130581112ENST00000373203-91526_586437659Topological domainExtracellular


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FusionGeneSequence for TMED4_ENG


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_TMED4_ENST00000457408_chr7_44620692_-_ENG_ENST00000373203_chr9_130581112_-_222aa
KKVHCLNMDSLSFQLGLYLSPHFLQASNTIEPGQQSFVQVRVSPSVSEFLLQLDSCHLDLGPEGGTVELIQGRAAKGNCVSLLSPSPEGD
PRFSFLLHFYTVPIPKTGTLSCTVALRPKTGSQDQEVHRTVFMRLNIISPDLSGCTSKGLVLPAVLGITFGAFLIGALLTAALWYIYSHT

>In-frame_TMED4_ENST00000457408_chr7_44620692_-_ENG_ENST00000344849_chr9_130581112_-_189aa
KKVHCLNMDSLSFQLGLYLSPHFLQASNTIEPGQQSFVQVRVSPSVSEFLLQLDSCHLDLGPEGGTVELIQGRAAKGNCVSLLSPSPEGD
PRFSFLLHFYTVPIPKTGTLSCTVALRPKTGSQDQEVHRTVFMRLNIISPDLSGCTSKGLVLPAVLGITFGAFLIGALLTAALWYIYSHT


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_TMED4_ENST00000457408_chr7_44620692_-_ENG_ENST00000373203_chr9_130581112_-_666nt
AAAAAGGTGCACTGCCTCAACATGGACAGCCTCTCTTTCCAGCTGGGCCTCTACCTCAGCCCACACTTCCTCCAGGCCTCCAACACCATC
GAGCCGGGGCAGCAGAGCTTTGTGCAGGTCAGAGTGTCCCCATCCGTCTCCGAGTTCCTGCTCCAGTTAGACAGCTGCCACCTGGACTTG
GGGCCTGAGGGAGGCACCGTGGAACTCATCCAGGGCCGGGCGGCCAAGGGCAACTGTGTGAGCCTGCTGTCCCCAAGCCCCGAGGGTGAC
CCGCGCTTCAGCTTCCTCCTCCACTTCTACACAGTACCCATACCCAAAACCGGCACCCTCAGCTGCACGGTAGCCCTGCGTCCCAAGACC
GGGTCTCAAGACCAGGAAGTCCATAGGACTGTCTTCATGCGCTTGAACATCATCAGCCCTGACCTGTCTGGTTGCACAAGCAAAGGCCTC
GTCCTGCCCGCCGTGCTGGGCATCACCTTTGGTGCCTTCCTCATCGGGGCCCTGCTCACTGCTGCACTCTGGTACATCTACTCGCACACG
CGTTCCCCCAGCAAGCGGGAGCCCGTGGTGGCGGTGGCTGCCCCGGCCTCCTCGGAGAGCAGCAGCACCAACCACAGCATCGGGAGCACC

>In-frame_TMED4_ENST00000457408_chr7_44620692_-_ENG_ENST00000344849_chr9_130581112_-_567nt
AAAAAGGTGCACTGCCTCAACATGGACAGCCTCTCTTTCCAGCTGGGCCTCTACCTCAGCCCACACTTCCTCCAGGCCTCCAACACCATC
GAGCCGGGGCAGCAGAGCTTTGTGCAGGTCAGAGTGTCCCCATCCGTCTCCGAGTTCCTGCTCCAGTTAGACAGCTGCCACCTGGACTTG
GGGCCTGAGGGAGGCACCGTGGAACTCATCCAGGGCCGGGCGGCCAAGGGCAACTGTGTGAGCCTGCTGTCCCCAAGCCCCGAGGGTGAC
CCGCGCTTCAGCTTCCTCCTCCACTTCTACACAGTACCCATACCCAAAACCGGCACCCTCAGCTGCACGGTAGCCCTGCGTCCCAAGACC
GGGTCTCAAGACCAGGAAGTCCATAGGACTGTCTTCATGCGCTTGAACATCATCAGCCCTGACCTGTCTGGTTGCACAAGCAAAGGCCTC
GTCCTGCCCGCCGTGCTGGGCATCACCTTTGGTGCCTTCCTCATCGGGGCCCTGCTCACTGCTGCACTCTGGTACATCTACTCGCACACG


* Fusion transcript sequences (Full-length transcript).
>In-frame_TMED4_ENST00000457408_chr7_44620692_-_ENG_ENST00000373203_chr9_130581112_-_1923nt
GCAGGCGCAGAGCGATGCGCAAATGTGCGCAGGCGCTTAGGGGCTGAGGCGCGATGGCAGGTGTCGGGGCTGGGCCTCTGCGGGCGATGG
GGCGGCAGGCCCTGCTGCTTCTCGCGCTGTGCGCCACAGGCGCCCAGGGGCTCTACTTCCACATCGGCGAGACCGAGAAGCGCTGTTTCA
TCGAGGAAATCCCCGACGAGACCATGGTCATCGGCAACTATCGTACCCAGATGTGGGATAAGCAGAAGGAGGTCTTCCTGCCCTCGACCC
CTGGCCTGGGCATGCACGTGGAAGTGAAGGACCCCGACGGCAAGGTGGTGCTGTCCCGGCAGTACGGCTCGGAGGGCCGCTTCACGTTCA
CCTCCCACACGCCCGGTGACCATCAAATCTGTCTGCACTCCAATTCTACCAGGATGGCTCTCTTCGCTGGTGGCAAACTGCGGGTGCATC
TCGACATCCAGGTTGGGGAGCATGCCAACAACTACCCTGAGATTGCTGCAAAAGATAAGCTGACGGAGCTACAGCTCCGCGCCCGCCAGT
TGCTTGATCAGGTGGAACAGATTCAGAAGGAGCAGGATTACCAAAGGAAAAAGGTGCACTGCCTCAACATGGACAGCCTCTCTTTCCAGC
TGGGCCTCTACCTCAGCCCACACTTCCTCCAGGCCTCCAACACCATCGAGCCGGGGCAGCAGAGCTTTGTGCAGGTCAGAGTGTCCCCAT
CCGTCTCCGAGTTCCTGCTCCAGTTAGACAGCTGCCACCTGGACTTGGGGCCTGAGGGAGGCACCGTGGAACTCATCCAGGGCCGGGCGG
CCAAGGGCAACTGTGTGAGCCTGCTGTCCCCAAGCCCCGAGGGTGACCCGCGCTTCAGCTTCCTCCTCCACTTCTACACAGTACCCATAC
CCAAAACCGGCACCCTCAGCTGCACGGTAGCCCTGCGTCCCAAGACCGGGTCTCAAGACCAGGAAGTCCATAGGACTGTCTTCATGCGCT
TGAACATCATCAGCCCTGACCTGTCTGGTTGCACAAGCAAAGGCCTCGTCCTGCCCGCCGTGCTGGGCATCACCTTTGGTGCCTTCCTCA
TCGGGGCCCTGCTCACTGCTGCACTCTGGTACATCTACTCGCACACGCGTTCCCCCAGCAAGCGGGAGCCCGTGGTGGCGGTGGCTGCCC
CGGCCTCCTCGGAGAGCAGCAGCACCAACCACAGCATCGGGAGCACCCAGAGCACCCCCTGCTCCACCAGCAGCATGGCATAGCCCCGGC
CCCCCGCGCTCGCCCAGCAGGAGAGACTGAGCAGCCGCCAGCTGGGAGCACTGGTGTGAACTCACCCTGGGAGCCAGTCCTCCACTCGAC
CCAGAATGGAGCCTGCTCTCCGCGCCTACCCTTCCCGCCTCCCTCTCAGAGGCCTGCTGCCAGTGCAGCCACTGGCTTGGAACACCTTGG
GGTCCCTCCACCCCACAGAACCTTCAACCCAGTGGGTCTGGGATATGGCTGCCCAGGAGACAGACCACTTGCCACGCTGTTGTAAAAACC
CAAGTCCCTGTCATTTGAACCTGGATCCAGCACTGGTGAACTGAGCTGGGCAGGAAGGGAGAACTTGAAACAGATTCAGGCCAGCCCAGC
CAGGCCAACAGCACCTCCCCGCTGGGAAGAGAAGAGGGCCCAGCCCAGAGCCACCTGGATCTATCCCTGCGGCCTCCACACCTGAACTTG
CCTAACTAACTGGCAGGGGAGACAGGAGCCTAGCGGAGCCCAGCCTGGGAGCCCAGAGGGTGGCAAGAACAGTGGGCGTTGGGAGCCTAG
CTCCTGCCACATGGAGCCCCCTCTGCCGGTCGGGCAGCCAGCAGAGGGGGAGTAGCCAAGCTGCTTGTCCTGGGCCTGCCCCTGTGTATT

>In-frame_TMED4_ENST00000457408_chr7_44620692_-_ENG_ENST00000344849_chr9_130581112_-_2054nt
GCAGGCGCAGAGCGATGCGCAAATGTGCGCAGGCGCTTAGGGGCTGAGGCGCGATGGCAGGTGTCGGGGCTGGGCCTCTGCGGGCGATGG
GGCGGCAGGCCCTGCTGCTTCTCGCGCTGTGCGCCACAGGCGCCCAGGGGCTCTACTTCCACATCGGCGAGACCGAGAAGCGCTGTTTCA
TCGAGGAAATCCCCGACGAGACCATGGTCATCGGCAACTATCGTACCCAGATGTGGGATAAGCAGAAGGAGGTCTTCCTGCCCTCGACCC
CTGGCCTGGGCATGCACGTGGAAGTGAAGGACCCCGACGGCAAGGTGGTGCTGTCCCGGCAGTACGGCTCGGAGGGCCGCTTCACGTTCA
CCTCCCACACGCCCGGTGACCATCAAATCTGTCTGCACTCCAATTCTACCAGGATGGCTCTCTTCGCTGGTGGCAAACTGCGGGTGCATC
TCGACATCCAGGTTGGGGAGCATGCCAACAACTACCCTGAGATTGCTGCAAAAGATAAGCTGACGGAGCTACAGCTCCGCGCCCGCCAGT
TGCTTGATCAGGTGGAACAGATTCAGAAGGAGCAGGATTACCAAAGGAAAAAGGTGCACTGCCTCAACATGGACAGCCTCTCTTTCCAGC
TGGGCCTCTACCTCAGCCCACACTTCCTCCAGGCCTCCAACACCATCGAGCCGGGGCAGCAGAGCTTTGTGCAGGTCAGAGTGTCCCCAT
CCGTCTCCGAGTTCCTGCTCCAGTTAGACAGCTGCCACCTGGACTTGGGGCCTGAGGGAGGCACCGTGGAACTCATCCAGGGCCGGGCGG
CCAAGGGCAACTGTGTGAGCCTGCTGTCCCCAAGCCCCGAGGGTGACCCGCGCTTCAGCTTCCTCCTCCACTTCTACACAGTACCCATAC
CCAAAACCGGCACCCTCAGCTGCACGGTAGCCCTGCGTCCCAAGACCGGGTCTCAAGACCAGGAAGTCCATAGGACTGTCTTCATGCGCT
TGAACATCATCAGCCCTGACCTGTCTGGTTGCACAAGCAAAGGCCTCGTCCTGCCCGCCGTGCTGGGCATCACCTTTGGTGCCTTCCTCA
TCGGGGCCCTGCTCACTGCTGCACTCTGGTACATCTACTCGCACACGCGTGAGTACCCCAGGCCCCCACAGTGAGCATGCCGGGCCCCTC
CATCCACCCGGGGGAGCCCAGTGAAGCCTCTGAGGGATTGAGGGGCCCTGGCCAGGACCCTGACCTCCGCCCCTGCCCCCGCTCCCGCTC
CCAGGTTCCCCCAGCAAGCGGGAGCCCGTGGTGGCGGTGGCTGCCCCGGCCTCCTCGGAGAGCAGCAGCACCAACCACAGCATCGGGAGC
ACCCAGAGCACCCCCTGCTCCACCAGCAGCATGGCATAGCCCCGGCCCCCCGCGCTCGCCCAGCAGGAGAGACTGAGCAGCCGCCAGCTG
GGAGCACTGGTGTGAACTCACCCTGGGAGCCAGTCCTCCACTCGACCCAGAATGGAGCCTGCTCTCCGCGCCTACCCTTCCCGCCTCCCT
CTCAGAGGCCTGCTGCCAGTGCAGCCACTGGCTTGGAACACCTTGGGGTCCCTCCACCCCACAGAACCTTCAACCCAGTGGGTCTGGGAT
ATGGCTGCCCAGGAGACAGACCACTTGCCACGCTGTTGTAAAAACCCAAGTCCCTGTCATTTGAACCTGGATCCAGCACTGGTGAACTGA
GCTGGGCAGGAAGGGAGAACTTGAAACAGATTCAGGCCAGCCCAGCCAGGCCAACAGCACCTCCCCGCTGGGAAGAGAAGAGGGCCCAGC
CCAGAGCCACCTGGATCTATCCCTGCGGCCTCCACACCTGAACTTGCCTAACTAACTGGCAGGGGAGACAGGAGCCTAGCGGAGCCCAGC
CTGGGAGCCCAGAGGGTGGCAAGAACAGTGGGCGTTGGGAGCCTAGCTCCTGCCACATGGAGCCCCCTCTGCCGGTCGGGCAGCCAGCAG


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FusionGenePPI for TMED4_ENG


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TMED4ELAVL1, KIAA0368, CHCHD6, TMED2, SF1, PPIC, SLC25A3, SRPRB, IKBIP, MOV10, NXF1, TMED10, TMED3, CHST8, HTR3C, LMAN1, NAGLU, LIPG, SCN3B, CDK5RAP3, FGF3, GORASP2, IL13RA2, SPPL2B, RFX3, PDHA1ENGTGFBR2, TGFBR1, ACVR1, ACVR2B, BMP7, BMP2, ACVR2A, TUFM, ACVRL1, TGFB3, TGFB1, ENG


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TMED4_ENG


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TMED4_ENG


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneENGC0039445Hereditary hemorrhagic telangiectasia12CTD_human;ORPHANET;UNIPROT