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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 38319

FusionGeneSummary for TMED10_IL6

check button Fusion gene summary
Fusion gene informationFusion gene name: TMED10_IL6
Fusion gene ID: 38319
HgeneTgene
Gene symbol

TMED10

IL6

Gene ID

10972

3569

Gene nametransmembrane p24 trafficking protein 10interleukin 6
SynonymsP24(DELTA)|S31I125|S31III125|TMP21|Tmp-21-I|p23|p24d1BSF-2|BSF2|CDF|HGF|HSF|IFN-beta-2|IFNB2|IL-6
Cytomap

14q24.3

7p15.3

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane emp24 domain-containing protein 1021 kDa transmembrane trafficking proteinp24 family protein delta-1p24deltap24delta1testicular tissue protein Li 206transmembrane emp24-like trafficking protein 10transmembrane protein Tmp21interleukin-6B-cell differentiation factorB-cell stimulatory factor 2CTL differentiation factorhybridoma growth factorinterferon beta-2interleukin BSF-2
Modification date2018052320180527
UniProtAcc

P49755

P05231

Ensembl transtripts involved in fusion geneENST00000303575, ENST00000557670, 
ENST00000404625, ENST00000401651, 
ENST00000258743, ENST00000420258, 
ENST00000407492, ENST00000401630, 
ENST00000406575, 
Fusion gene scores* DoF score6 X 5 X 4=1201 X 1 X 1=1
# samples 61
** MAII scorelog2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: TMED10 [Title/Abstract] AND IL6 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTMED10

GO:0006886

intracellular protein transport

20427317

HgeneTMED10

GO:0035964

COPI-coated vesicle budding

10052452

TgeneIL6

GO:0001781

neutrophil apoptotic process

7595060

TgeneIL6

GO:0002384

hepatic immune response

2444978

TgeneIL6

GO:0002675

positive regulation of acute inflammatory response

2444978

TgeneIL6

GO:0006954

inflammatory response

10443688

TgeneIL6

GO:0008284

positive regulation of cell proliferation

2261637

TgeneIL6

GO:0010574

regulation of vascular endothelial growth factor production

8557680

TgeneIL6

GO:0010628

positive regulation of gene expression

19390056

TgeneIL6

GO:0019221

cytokine-mediated signaling pathway

2261637|12643274

TgeneIL6

GO:0032722

positive regulation of chemokine production

10510402

TgeneIL6

GO:0032755

positive regulation of interleukin-6 production

10510402

TgeneIL6

GO:0032966

negative regulation of collagen biosynthetic process

12419823

TgeneIL6

GO:0033138

positive regulation of peptidyl-serine phosphorylation

7508917

TgeneIL6

GO:0042102

positive regulation of T cell proliferation

3130269

TgeneIL6

GO:0042531

positive regulation of tyrosine phosphorylation of STAT protein

12643274|19390056

TgeneIL6

GO:0043065

positive regulation of apoptotic process

9949178

TgeneIL6

GO:0043066

negative regulation of apoptotic process

7595060

TgeneIL6

GO:0043410

positive regulation of MAPK cascade

7508917|12419823

TgeneIL6

GO:0045727

positive regulation of translation

16732314

TgeneIL6

GO:0045893

positive regulation of transcription, DNA-templated

7749983|16606666

TgeneIL6

GO:0045944

positive regulation of transcription by RNA polymerase II

7508917|16946298|17324931

TgeneIL6

GO:0046427

positive regulation of JAK-STAT cascade

12419823|12552091|17324931

TgeneIL6

GO:0048661

positive regulation of smooth muscle cell proliferation

10510402

TgeneIL6

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

7508917

TgeneIL6

GO:0050871

positive regulation of B cell activation

3491322

TgeneIL6

GO:0051024

positive regulation of immunoglobulin secretion

3491322

TgeneIL6

GO:0051091

positive regulation of DNA binding transcription factor activity

7749983

TgeneIL6

GO:0051092

positive regulation of NF-kappaB transcription factor activity

12419823

TgeneIL6

GO:0051384

response to glucocorticoid

10443688

TgeneIL6

GO:0051607

defense response to virus

3023045

TgeneIL6

GO:0070102

interleukin-6-mediated signaling pathway

12552091|16946298

TgeneIL6

GO:0070301

cellular response to hydrogen peroxide

19168699


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE619899TMED10chr14

75598821

+IL6chr7

22771050

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000303575ENST00000404625TMED10chr14

75598821

+IL6chr7

22771050

-
intron-intronENST00000303575ENST00000401651TMED10chr14

75598821

+IL6chr7

22771050

-
intron-intronENST00000303575ENST00000258743TMED10chr14

75598821

+IL6chr7

22771050

-
intron-intronENST00000303575ENST00000420258TMED10chr14

75598821

+IL6chr7

22771050

-
intron-intronENST00000303575ENST00000407492TMED10chr14

75598821

+IL6chr7

22771050

-
intron-intronENST00000303575ENST00000401630TMED10chr14

75598821

+IL6chr7

22771050

-
intron-intronENST00000303575ENST00000406575TMED10chr14

75598821

+IL6chr7

22771050

-
intron-3CDSENST00000557670ENST00000404625TMED10chr14

75598821

+IL6chr7

22771050

-
intron-intronENST00000557670ENST00000401651TMED10chr14

75598821

+IL6chr7

22771050

-
intron-intronENST00000557670ENST00000258743TMED10chr14

75598821

+IL6chr7

22771050

-
intron-intronENST00000557670ENST00000420258TMED10chr14

75598821

+IL6chr7

22771050

-
intron-intronENST00000557670ENST00000407492TMED10chr14

75598821

+IL6chr7

22771050

-
intron-intronENST00000557670ENST00000401630TMED10chr14

75598821

+IL6chr7

22771050

-
intron-intronENST00000557670ENST00000406575TMED10chr14

75598821

+IL6chr7

22771050

-

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FusionProtFeatures for TMED10_IL6


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TMED10

P49755

IL6

P05231

Involved in vesicular protein trafficking. Mainlyfunctions in the early secretory pathway. Thought to act as cargoreceptor at the lumenal side for incorporation of secretory cargomolecules into transport vesicles and to be involved in vesiclecoat formation at the cytoplasmic side. In COPII vesicle-mediatedanterograde transport involved in the transport of GPI-anchoredproteins and proposed to act together with TMED2 as their cargoreceptor; the function specifically implies SEC24C and SEC24D ofthe COPII vesicle coat and lipid raft-like microdomains of the ER.Recognizes GPI anchors structural remodeled in the ER by PGAP1 andMPPE1 (By similarity). In COPI vesicle-mediated retrogradetransport involved in the biogenesis of COPI vesicles and vesiclecoat recruitment. On Golgi membranes, acts as primary receptor forARF1-GDP which is involved in COPI-vesicle formation. Increasescoatomer-dependent GTPase-activating activity of ARFGAP2. Involvedin trafficking of G protein-coupled receptors (GPCRs). RegulatesF2LR1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to theplasma membrane thus contributing to receptor resensitization.Involved in trafficking of amyloid beta A4 protein and solubleAPP-beta release (independent of modulation of gamma-secretaseactivity). As part of the presenilin-dependent gamma-secretasecomplex regulates gamma-cleavages of the amyloid beta A4 proteinto yield amyloid-beta 40 (Abeta40). Involved in organization ofthe Golgi apparatus. {ECO:0000250, ECO:0000269|PubMed:10052452,ECO:0000269|PubMed:11726511, ECO:0000269|PubMed:16641999,ECO:0000269|PubMed:17288597, ECO:0000269|PubMed:19296914,ECO:0000269|PubMed:20427317, ECO:0000269|PubMed:21219331}. Cytokine with a wide variety of biological functions. Itis a potent inducer of the acute phase response. Plays anessential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocytedifferentiation. Acts on B-cells, T-cells, hepatocytes,hematopoietic progenitor cells and cells of the CNS. Required forthe generation of T(H)17 cells. Also acts as a myokine. It isdischarged into the bloodstream after muscle contraction and actsto increase the breakdown of fats and to improve insulinresistance. It induces myeloma and plasmacytoma growth and inducesnerve cells differentiation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TMED10_IL6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TMED10_IL6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TMED10_IL6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneIL6P05231DB09036SiltuximabInterleukin-6biotechapproved|investigational

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RelatedDiseases for TMED10_IL6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneIL6C0021368Inflammation10CTD_human
TgeneIL6C0011581Depressive disorder6CTD_human;PSYGENET
TgeneIL6C0011206Delirium5PSYGENET
TgeneIL6C0011570Mental Depression5PSYGENET
TgeneIL6C0033578Prostatic Neoplasms5CTD_human
TgeneIL6C0035126Reperfusion Injury5CTD_human
TgeneIL6C0041696Unipolar Depression5PSYGENET
TgeneIL6C1269683Major Depressive Disorder5PSYGENET
TgeneIL6C1458155Mammary Neoplasms4CTD_human
TgeneIL6C0015967Fever3CTD_human;HPO
TgeneIL6C0020429Hyperalgesia3CTD_human
TgeneIL6C0023290Leishmaniasis, Visceral3CTD_human
TgeneIL6C0026764Multiple Myeloma3CTD_human
TgeneIL6C0740392Infarction, Middle Cerebral Artery3CTD_human
TgeneIL6C0993582Arthritis, Experimental3CTD_human
TgeneIL6C2239176Liver carcinoma3CTD_human
TgeneIL6C0001973Alcoholic Intoxication, Chronic2PSYGENET
TgeneIL6C0003873Rheumatoid Arthritis2CTD_human
TgeneIL6C0005586Bipolar Disorder2PSYGENET
TgeneIL6C0007786Brain Ischemia2CTD_human
TgeneIL6C0009319Colitis2CTD_human
TgeneIL6C0010346Crohn Disease2CTD_human
TgeneIL6C0018801Heart failure2CTD_human
TgeneIL6C0020649Hypotension2CTD_human
TgeneIL6C0022876Premature Obstetric Labor2CTD_human
TgeneIL6C0027051Myocardial Infarction2CTD_human
TgeneIL6C0028754Obesity2CTD_human
TgeneIL6C0034069Pulmonary Fibrosis2CTD_human
TgeneIL6C4277682Chemical and Drug Induced Liver Injury2CTD_human
TgeneIL6C0000786Spontaneous abortion1CTD_human
TgeneIL6C0001925Albuminuria1CTD_human
TgeneIL6C0002622Amnesia1CTD_human
TgeneIL6C0004153Atherosclerosis1CTD_human
TgeneIL6C0004352Autistic Disorder1CTD_human
TgeneIL6C0004364Autoimmune Diseases1CTD_human;HPO
TgeneIL6C0005138Berylliosis1CTD_human
TgeneIL6C0006625Cachexia1CTD_human
TgeneIL6C0007117Basal cell carcinoma1CTD_human
TgeneIL6C0007134Renal Cell Carcinoma1CTD_human
TgeneIL6C0007137Squamous cell carcinoma1CTD_human
TgeneIL6C0007621Neoplastic Cell Transformation1CTD_human
TgeneIL6C0008370Cholestasis1CTD_human
TgeneIL6C0011615Dermatitis, Atopic1CTD_human
TgeneIL6C0011853Diabetes Mellitus, Experimental1CTD_human
TgeneIL6C0013604Edema1CTD_human
TgeneIL6C0014324Entamoebiasis1CTD_human
TgeneIL6C0017531Angiolymphoid hyperplasia1CTD_human
TgeneIL6C0017658Glomerulonephritis1CTD_human
TgeneIL6C0018681Headache1CTD_human
TgeneIL6C0018843Heat Stroke1CTD_human
TgeneIL6C0019061Hemolytic-Uremic Syndrome1CTD_human
TgeneIL6C0019202Hepatolenticular Degeneration1CTD_human
TgeneIL6C0019284Diaphragmatic Hernia1CTD_human
TgeneIL6C0020437Hypercalcemia1CTD_human
TgeneIL6C0020500Hyperoxaluria1CTD_human
TgeneIL6C0020503Hyperparathyroidism, Secondary1CTD_human
TgeneIL6C0020517Hypersensitivity1CTD_human
TgeneIL6C0020538Hypertensive disease1CTD_human
TgeneIL6C0022116Ischemia1CTD_human
TgeneIL6C0022661Kidney Failure, Chronic1CTD_human
TgeneIL6C0023281Leishmaniasis1CTD_human
TgeneIL6C0023434Chronic Lymphocytic Leukemia1CTD_human
TgeneIL6C0023890Liver Cirrhosis1CTD_human
TgeneIL6C0023891Liver Cirrhosis, Alcoholic1CTD_human
TgeneIL6C0024121Lung Neoplasms1CTD_human
TgeneIL6C0024141Lupus Erythematosus, Systemic1CTD_human
TgeneIL6C0025290Aseptic Meningitis1CTD_human
TgeneIL6C0027540Necrosis1CTD_human
TgeneIL6C0027626Neoplasm Invasiveness1CTD_human
TgeneIL6C0027627Neoplasm Metastasis1CTD_human
TgeneIL6C0029456Osteoporosis1CTD_human
TgeneIL6C0029458Osteoporosis, Postmenopausal1CTD_human
TgeneIL6C0030567Parkinson Disease1CTD_human
TgeneIL6C0031117Peripheral Neuropathy1CTD_human
TgeneIL6C0032226Pleural Diseases1CTD_human
TgeneIL6C0032231Pleurisy1CTD_human
TgeneIL6C0032285Pneumonia1CTD_human
TgeneIL6C0032963Pregnancy Complications, Cardiovascular1CTD_human
TgeneIL6C0033860Psoriasis1CTD_human
TgeneIL6C0035228Respiratory Hypersensitivity1CTD_human
TgeneIL6C0036341Schizophrenia1CTD_human
TgeneIL6C0036572Seizures1CTD_human
TgeneIL6C0036982Shock, Hemorrhagic1CTD_human
TgeneIL6C0037274Dermatologic disorders1CTD_human
TgeneIL6C0038356Stomach Neoplasms1CTD_human
TgeneIL6C0038454Cerebrovascular accident1CTD_human
TgeneIL6C0040136Thyroid Neoplasm1CTD_human
TgeneIL6C0085655Polymyositis1CTD_human
TgeneIL6C0151526Premature Birth1CTD_human
TgeneIL6C0151744Myocardial Ischemia1CTD_human
TgeneIL6C0162670Mitochondrial Myopathies1CTD_human
TgeneIL6C0162848Lichenoid Eruptions1CTD_human
TgeneIL6C0206698Cholangiocarcinoma1CTD_human
TgeneIL6C0239981Hypoalbuminemia1CTD_human
TgeneIL6C0241910Hepatitis, Autoimmune1CTD_human
TgeneIL6C0242698Ventricular Dysfunction, Left1CTD_human
TgeneIL6C0273115Lung Injury1CTD_human
TgeneIL6C0338715Drug-induced depressive state1PSYGENET
TgeneIL6C0343755HIV Wasting Syndrome1CTD_human
TgeneIL6C0345967Malignant mesothelioma1CTD_human
TgeneIL6C0524620Metabolic Syndrome X1CTD_human
TgeneIL6C0524851Neurodegenerative Disorders1CTD_human
TgeneIL6C0878544Cardiomyopathies1CTD_human
TgeneIL6C0919267ovarian neoplasm1CTD_human
TgeneIL6C0948089Acute Coronary Syndrome1CTD_human
TgeneIL6C2609414Acute kidney injury1CTD_human