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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 38281

FusionGeneSummary for TMC5_HN1

check button Fusion gene summary
Fusion gene informationFusion gene name: TMC5_HN1
Fusion gene ID: 38281
HgeneTgene
Gene symbol

TMC5

HN1

Gene ID

79838

Gene nametransmembrane channel like 5
Synonyms-
Cytomap

16p12.3

Type of geneprotein-coding
Descriptiontransmembrane channel-like protein 5
Modification date20180523
UniProtAcc

Q6UXY8

Ensembl transtripts involved in fusion geneENST00000563675, ENST00000541464, 
ENST00000381414, ENST00000396229, 
ENST00000542583, ENST00000219821, 
ENST00000561503, ENST00000564959, 
ENST00000476258, ENST00000405458, 
ENST00000409753, ENST00000482348, 
ENST00000356033, ENST00000470924, 
ENST00000481647, ENST00000392566, 
ENST00000581874, ENST00000465454, 
Fusion gene scores* DoF score5 X 4 X 4=807 X 4 X 6=168
# samples 67
** MAII scorelog2(6/80*10)=-0.415037499278844
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TMC5 [Title/Abstract] AND HN1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUADTCGA-55-A493-01ATMC5chr16

19441962

+HN1chr17

73144766

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000563675ENST00000476258TMC5chr16

19441962

+HN1chr17

73144766

-
5CDS-5UTRENST00000563675ENST00000405458TMC5chr16

19441962

+HN1chr17

73144766

-
5CDS-5UTRENST00000563675ENST00000409753TMC5chr16

19441962

+HN1chr17

73144766

-
5CDS-5UTRENST00000563675ENST00000482348TMC5chr16

19441962

+HN1chr17

73144766

-
5CDS-5UTRENST00000563675ENST00000356033TMC5chr16

19441962

+HN1chr17

73144766

-
5CDS-5UTRENST00000563675ENST00000470924TMC5chr16

19441962

+HN1chr17

73144766

-
5CDS-5UTRENST00000563675ENST00000481647TMC5chr16

19441962

+HN1chr17

73144766

-
5CDS-5UTRENST00000563675ENST00000392566TMC5chr16

19441962

+HN1chr17

73144766

-
5CDS-5UTRENST00000563675ENST00000581874TMC5chr16

19441962

+HN1chr17

73144766

-
5CDS-5UTRENST00000563675ENST00000465454TMC5chr16

19441962

+HN1chr17

73144766

-
5UTR-5UTRENST00000541464ENST00000476258TMC5chr16

19441962

+HN1chr17

73144766

-
5UTR-5UTRENST00000541464ENST00000405458TMC5chr16

19441962

+HN1chr17

73144766

-
5UTR-5UTRENST00000541464ENST00000409753TMC5chr16

19441962

+HN1chr17

73144766

-
5UTR-5UTRENST00000541464ENST00000482348TMC5chr16

19441962

+HN1chr17

73144766

-
5UTR-5UTRENST00000541464ENST00000356033TMC5chr16

19441962

+HN1chr17

73144766

-
5UTR-5UTRENST00000541464ENST00000470924TMC5chr16

19441962

+HN1chr17

73144766

-
5UTR-5UTRENST00000541464ENST00000481647TMC5chr16

19441962

+HN1chr17

73144766

-
5UTR-5UTRENST00000541464ENST00000392566TMC5chr16

19441962

+HN1chr17

73144766

-
5UTR-5UTRENST00000541464ENST00000581874TMC5chr16

19441962

+HN1chr17

73144766

-
5UTR-5UTRENST00000541464ENST00000465454TMC5chr16

19441962

+HN1chr17

73144766

-
5UTR-5UTRENST00000381414ENST00000476258TMC5chr16

19441962

+HN1chr17

73144766

-
5UTR-5UTRENST00000381414ENST00000405458TMC5chr16

19441962

+HN1chr17

73144766

-
5UTR-5UTRENST00000381414ENST00000409753TMC5chr16

19441962

+HN1chr17

73144766

-
5UTR-5UTRENST00000381414ENST00000482348TMC5chr16

19441962

+HN1chr17

73144766

-
5UTR-5UTRENST00000381414ENST00000356033TMC5chr16

19441962

+HN1chr17

73144766

-
5UTR-5UTRENST00000381414ENST00000470924TMC5chr16

19441962

+HN1chr17

73144766

-
5UTR-5UTRENST00000381414ENST00000481647TMC5chr16

19441962

+HN1chr17

73144766

-
5UTR-5UTRENST00000381414ENST00000392566TMC5chr16

19441962

+HN1chr17

73144766

-
5UTR-5UTRENST00000381414ENST00000581874TMC5chr16

19441962

+HN1chr17

73144766

-
5UTR-5UTRENST00000381414ENST00000465454TMC5chr16

19441962

+HN1chr17

73144766

-
5UTR-5UTRENST00000396229ENST00000476258TMC5chr16

19441962

+HN1chr17

73144766

-
5UTR-5UTRENST00000396229ENST00000405458TMC5chr16

19441962

+HN1chr17

73144766

-
5UTR-5UTRENST00000396229ENST00000409753TMC5chr16

19441962

+HN1chr17

73144766

-
5UTR-5UTRENST00000396229ENST00000482348TMC5chr16

19441962

+HN1chr17

73144766

-
5UTR-5UTRENST00000396229ENST00000356033TMC5chr16

19441962

+HN1chr17

73144766

-
5UTR-5UTRENST00000396229ENST00000470924TMC5chr16

19441962

+HN1chr17

73144766

-
5UTR-5UTRENST00000396229ENST00000481647TMC5chr16

19441962

+HN1chr17

73144766

-
5UTR-5UTRENST00000396229ENST00000392566TMC5chr16

19441962

+HN1chr17

73144766

-
5UTR-5UTRENST00000396229ENST00000581874TMC5chr16

19441962

+HN1chr17

73144766

-
5UTR-5UTRENST00000396229ENST00000465454TMC5chr16

19441962

+HN1chr17

73144766

-
5UTR-5UTRENST00000542583ENST00000476258TMC5chr16

19441962

+HN1chr17

73144766

-
5UTR-5UTRENST00000542583ENST00000405458TMC5chr16

19441962

+HN1chr17

73144766

-
5UTR-5UTRENST00000542583ENST00000409753TMC5chr16

19441962

+HN1chr17

73144766

-
5UTR-5UTRENST00000542583ENST00000482348TMC5chr16

19441962

+HN1chr17

73144766

-
5UTR-5UTRENST00000542583ENST00000356033TMC5chr16

19441962

+HN1chr17

73144766

-
5UTR-5UTRENST00000542583ENST00000470924TMC5chr16

19441962

+HN1chr17

73144766

-
5UTR-5UTRENST00000542583ENST00000481647TMC5chr16

19441962

+HN1chr17

73144766

-
5UTR-5UTRENST00000542583ENST00000392566TMC5chr16

19441962

+HN1chr17

73144766

-
5UTR-5UTRENST00000542583ENST00000581874TMC5chr16

19441962

+HN1chr17

73144766

-
5UTR-5UTRENST00000542583ENST00000465454TMC5chr16

19441962

+HN1chr17

73144766

-
intron-5UTRENST00000219821ENST00000476258TMC5chr16

19441962

+HN1chr17

73144766

-
intron-5UTRENST00000219821ENST00000405458TMC5chr16

19441962

+HN1chr17

73144766

-
intron-5UTRENST00000219821ENST00000409753TMC5chr16

19441962

+HN1chr17

73144766

-
intron-5UTRENST00000219821ENST00000482348TMC5chr16

19441962

+HN1chr17

73144766

-
intron-5UTRENST00000219821ENST00000356033TMC5chr16

19441962

+HN1chr17

73144766

-
intron-5UTRENST00000219821ENST00000470924TMC5chr16

19441962

+HN1chr17

73144766

-
intron-5UTRENST00000219821ENST00000481647TMC5chr16

19441962

+HN1chr17

73144766

-
intron-5UTRENST00000219821ENST00000392566TMC5chr16

19441962

+HN1chr17

73144766

-
intron-5UTRENST00000219821ENST00000581874TMC5chr16

19441962

+HN1chr17

73144766

-
intron-5UTRENST00000219821ENST00000465454TMC5chr16

19441962

+HN1chr17

73144766

-
intron-5UTRENST00000561503ENST00000476258TMC5chr16

19441962

+HN1chr17

73144766

-
intron-5UTRENST00000561503ENST00000405458TMC5chr16

19441962

+HN1chr17

73144766

-
intron-5UTRENST00000561503ENST00000409753TMC5chr16

19441962

+HN1chr17

73144766

-
intron-5UTRENST00000561503ENST00000482348TMC5chr16

19441962

+HN1chr17

73144766

-
intron-5UTRENST00000561503ENST00000356033TMC5chr16

19441962

+HN1chr17

73144766

-
intron-5UTRENST00000561503ENST00000470924TMC5chr16

19441962

+HN1chr17

73144766

-
intron-5UTRENST00000561503ENST00000481647TMC5chr16

19441962

+HN1chr17

73144766

-
intron-5UTRENST00000561503ENST00000392566TMC5chr16

19441962

+HN1chr17

73144766

-
intron-5UTRENST00000561503ENST00000581874TMC5chr16

19441962

+HN1chr17

73144766

-
intron-5UTRENST00000561503ENST00000465454TMC5chr16

19441962

+HN1chr17

73144766

-
intron-5UTRENST00000564959ENST00000476258TMC5chr16

19441962

+HN1chr17

73144766

-
intron-5UTRENST00000564959ENST00000405458TMC5chr16

19441962

+HN1chr17

73144766

-
intron-5UTRENST00000564959ENST00000409753TMC5chr16

19441962

+HN1chr17

73144766

-
intron-5UTRENST00000564959ENST00000482348TMC5chr16

19441962

+HN1chr17

73144766

-
intron-5UTRENST00000564959ENST00000356033TMC5chr16

19441962

+HN1chr17

73144766

-
intron-5UTRENST00000564959ENST00000470924TMC5chr16

19441962

+HN1chr17

73144766

-
intron-5UTRENST00000564959ENST00000481647TMC5chr16

19441962

+HN1chr17

73144766

-
intron-5UTRENST00000564959ENST00000392566TMC5chr16

19441962

+HN1chr17

73144766

-
intron-5UTRENST00000564959ENST00000581874TMC5chr16

19441962

+HN1chr17

73144766

-
intron-5UTRENST00000564959ENST00000465454TMC5chr16

19441962

+HN1chr17

73144766

-

Top

FusionProtFeatures for TMC5_HN1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TMC5

Q6UXY8

HN1

Probable ion channel. {ECO:0000250}. Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TMC5_HN1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for TMC5_HN1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TMC5NUMBL, TRIM25HN1ARHGAP44, SFPQ, KPNA2, CPLX1, PMPCB, SEPT9, UNK, CFL1, COTL1, HSPB1, PLIN3, SNCG, STMN1, TRIM28, CDH1, EGFR


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for TMC5_HN1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for TMC5_HN1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource