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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 38276

FusionGeneSummary for TMC3_C15orf40

check button Fusion gene summary
Fusion gene informationFusion gene name: TMC3_C15orf40
Fusion gene ID: 38276
HgeneTgene
Gene symbol

TMC3

C15orf40

Gene ID

342125

123207

Gene nametransmembrane channel like 3chromosome 15 open reading frame 40
Synonyms--
Cytomap

15q25.1

15q25.2

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane channel-like protein 3UPF0235 protein C15orf40
Modification date2018052320180519
UniProtAcc

Q7Z5M5

Q8WUR7

Ensembl transtripts involved in fusion geneENST00000359440, ENST00000558726, 
ENST00000538348, ENST00000451195, 
ENST00000304177, ENST00000513601, 
ENST00000565712, 
Fusion gene scores* DoF score1 X 1 X 1=11 X 2 X 1=2
# samples 11
** MAII scorelog2(1/1*10)=3.32192809488736log2(1/2*10)=2.32192809488736
Context

PubMed: TMC3 [Title/Abstract] AND C15orf40 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLGGTCGA-DU-A7TC-01ATMC3chr15

81630996

-C15orf40chr15

83657909

-
TCGALDLGGTCGA-DU-A7TC-01ATMC3chr15

81630996

-C15orf40chr15

83660800

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000359440ENST00000538348TMC3chr15

81630996

-C15orf40chr15

83657909

-
5CDS-intronENST00000359440ENST00000451195TMC3chr15

81630996

-C15orf40chr15

83657909

-
5CDS-intronENST00000359440ENST00000304177TMC3chr15

81630996

-C15orf40chr15

83657909

-
5CDS-intronENST00000359440ENST00000513601TMC3chr15

81630996

-C15orf40chr15

83657909

-
5CDS-intronENST00000359440ENST00000565712TMC3chr15

81630996

-C15orf40chr15

83657909

-
In-frameENST00000558726ENST00000538348TMC3chr15

81630996

-C15orf40chr15

83657909

-
5CDS-intronENST00000558726ENST00000451195TMC3chr15

81630996

-C15orf40chr15

83657909

-
5CDS-intronENST00000558726ENST00000304177TMC3chr15

81630996

-C15orf40chr15

83657909

-
5CDS-intronENST00000558726ENST00000513601TMC3chr15

81630996

-C15orf40chr15

83657909

-
5CDS-intronENST00000558726ENST00000565712TMC3chr15

81630996

-C15orf40chr15

83657909

-
5CDS-intronENST00000359440ENST00000538348TMC3chr15

81630996

-C15orf40chr15

83660800

-
5CDS-intronENST00000359440ENST00000451195TMC3chr15

81630996

-C15orf40chr15

83660800

-
5CDS-intronENST00000359440ENST00000304177TMC3chr15

81630996

-C15orf40chr15

83660800

-
5CDS-intronENST00000359440ENST00000513601TMC3chr15

81630996

-C15orf40chr15

83660800

-
5CDS-intronENST00000359440ENST00000565712TMC3chr15

81630996

-C15orf40chr15

83660800

-
5CDS-intronENST00000558726ENST00000538348TMC3chr15

81630996

-C15orf40chr15

83660800

-
5CDS-intronENST00000558726ENST00000451195TMC3chr15

81630996

-C15orf40chr15

83660800

-
5CDS-intronENST00000558726ENST00000304177TMC3chr15

81630996

-C15orf40chr15

83660800

-
5CDS-intronENST00000558726ENST00000513601TMC3chr15

81630996

-C15orf40chr15

83660800

-
5CDS-intronENST00000558726ENST00000565712TMC3chr15

81630996

-C15orf40chr15

83660800

-

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FusionProtFeatures for TMC3_C15orf40


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TMC3

Q7Z5M5

C15orf40

Q8WUR7

Probable ion channel. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTMC3chr15:81630996chr15:83657909ENST00000359440-1822170_1926931101Topological domainExtracellular
HgeneTMC3chr15:81630996chr15:83657909ENST00000359440-18221_1486931101Topological domainCytoplasmic
HgeneTMC3chr15:81630996chr15:83657909ENST00000359440-1822214_2256931101Topological domainCytoplasmic
HgeneTMC3chr15:81630996chr15:83657909ENST00000359440-1822247_3196931101Topological domainExtracellular
HgeneTMC3chr15:81630996chr15:83657909ENST00000359440-1822341_3616931101Topological domainCytoplasmic
HgeneTMC3chr15:81630996chr15:83657909ENST00000359440-1822383_3936931101Topological domainExtracellular
HgeneTMC3chr15:81630996chr15:83657909ENST00000359440-1822415_5086931101Topological domainCytoplasmic
HgeneTMC3chr15:81630996chr15:83657909ENST00000359440-1822530_5696931101Topological domainExtracellular
HgeneTMC3chr15:81630996chr15:83657909ENST00000359440-1822591_6186931101Topological domainCytoplasmic
HgeneTMC3chr15:81630996chr15:83657909ENST00000359440-1822640_6796931101Topological domainExtracellular
HgeneTMC3chr15:81630996chr15:83657909ENST00000359440-1822149_1696931101TransmembraneHelical
HgeneTMC3chr15:81630996chr15:83657909ENST00000359440-1822193_2136931101TransmembraneHelical
HgeneTMC3chr15:81630996chr15:83657909ENST00000359440-1822226_2466931101TransmembraneHelical
HgeneTMC3chr15:81630996chr15:83657909ENST00000359440-1822320_3406931101TransmembraneHelical
HgeneTMC3chr15:81630996chr15:83657909ENST00000359440-1822362_3826931101TransmembraneHelical
HgeneTMC3chr15:81630996chr15:83657909ENST00000359440-1822394_4146931101TransmembraneHelical
HgeneTMC3chr15:81630996chr15:83657909ENST00000359440-1822509_5296931101TransmembraneHelical
HgeneTMC3chr15:81630996chr15:83657909ENST00000359440-1822570_5906931101TransmembraneHelical
HgeneTMC3chr15:81630996chr15:83657909ENST00000359440-1822619_6396931101TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTMC3chr15:81630996chr15:83657909ENST00000359440-1822701_11006931101Topological domainCytoplasmic
HgeneTMC3chr15:81630996chr15:83657909ENST00000359440-1822680_7006931101TransmembraneHelical


Top

FusionGeneSequence for TMC3_C15orf40


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_TMC3_ENST00000359440_chr15_81630996_-_C15orf40_ENST00000538348_chr15_83657909_-_721aa
MKTSKASQRYRGIRRNASQCYLYQESLLLSNLDDSFSADETGDSNDPEQIFQNIQFQKDLMANIRCRPWTMGQKLRALRQAKNIVLKFEG
RLTRTRGYQAAGAELWRKFARLACNFVVIFIPWEMRIKKIESHFGSGVASYFIFLRWLFGINIVLTIMTGAFIVIPELIAGQPFGSTARK
TIPKEQVSSAQDLDTVWSLGGYLQYSVLFYGYYGRERKIGRAGYRLPLAYFLVGMAVFAYSFIILLKKMAKNSRTSLASASNENYTFCWR
VFCAWDYLIGNPEAAESKTAAIVNSIREAILEEQEKKKSKNLAVTICLRIIANILVLLSLAGSIYLIYFVVDRSQKLEQSKKELTLWEKN
EVSVVVSLVTMIAPSAFDLIAALEMYHPRTTLRFQLARVLVLYLGNLYSLIIALLDKVNSMSIEEMATKNNTSHWIDSTTFFATRTAPEE
EKWSTSRPGMGLRRNNTWALEETSISAYTMPLIKANKTSLHTQSPQDQCWETYVGQEMLKLSIIDMLFTVASILLIDFFRGLFVRYLSDY
WCWDLESKFPEYGEFKIAENVLHLVYNQGMIWMGAFFSPCLPAFNVLKLIGLMYLRSWAVLTCNVPHQQVFRASRSNNFYLAMLLFMLFL
CMLPTIFAIVRYKPSLNCGPFSGQEKIYDIVSETIEKDFPVWFGSVVGHISSPVVILPAVLLLFSAIPFLNNWRRLRRAFQVFLILLVIF

>In-frame_TMC3_ENST00000558726_chr15_81630996_-_C15orf40_ENST00000538348_chr15_83657909_-_722aa
MKTSKASQRYRGIRRNASQCYLYQESLLLSNLDDSFSADETGDSNDPEQIFQNIQFQKDLMANIRCRPWTMGQKLRALRQAKNIVLKFEG
RLTRTRGYQAAGAELWRKFARLACNFVVIFIPWEMRIKKIESHFGSGVASYFIFLRWLFGINIVLTIMTGAFIVIPELIAGQPFGSTARK
TIPKEQVSSAQDLDTVWSLGGYLQYSVLFYGYYGRERKIGRAGYRLPLAYFLVGMAVFAYSFIILLKKMAKNSRTSLASASNENYTFCWR
VFCAWDYLIGNPEAAESKTAAIVNSIREAILEEQEKKKSKNLAVTICLRIIANILVLLSLAGSIYLIYFVVDRSQKLEQSKKELTLWEKN
EQVSVVVSLVTMIAPSAFDLIAALEMYHPRTTLRFQLARVLVLYLGNLYSLIIALLDKVNSMSIEEMATKNNTSHWIDSTTFFATRTAPE
EEKWSTSRPGMGLRRNNTWALEETSISAYTMPLIKANKTSLHTQSPQDQCWETYVGQEMLKLSIIDMLFTVASILLIDFFRGLFVRYLSD
YWCWDLESKFPEYGEFKIAENVLHLVYNQGMIWMGAFFSPCLPAFNVLKLIGLMYLRSWAVLTCNVPHQQVFRASRSNNFYLAMLLFMLF
LCMLPTIFAIVRYKPSLNCGPFSGQEKIYDIVSETIEKDFPVWFGSVVGHISSPVVILPAVLLLFSAIPFLNNWRRLRRAFQVFLILLVI


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_TMC3_ENST00000359440_chr15_81630996_-_C15orf40_ENST00000538348_chr15_83657909_-_2165nt
ATGAAAACCTCGAAGGCATCCCAGCGCTATAGAGGCATCCGGAGAAATGCCAGCCAGTGCTACCTCTACCAGGAATCTCTGCTGCTCAGC
AACTTGGATGACAGCTTTAGTGCTGATGAAACAGGGGACAGCAATGATCCGGAACAAATCTTCCAGAATATACAGTTCCAGAAAGATCTC
ATGGCAAACATTCGCTGCAGACCCTGGACTATGGGACAGAAGCTGAGGGCATTGAGACAAGCGAAGAACATTGTGCTGAAGTTTGAAGGG
AGGCTGACCAGGACCCGAGGCTACCAAGCAGCAGGTGCAGAGCTCTGGCGGAAATTTGCTCGTCTCGCCTGTAACTTTGTGGTCATCTTC
ATTCCCTGGGAAATGAGGATAAAGAAAATCGAGAGTCATTTTGGATCTGGCGTTGCCTCCTATTTCATATTCTTGAGATGGTTATTTGGA
ATTAATATTGTGCTCACCATTATGACAGGTGCTTTTATTGTCATTCCAGAGCTGATTGCAGGCCAGCCCTTTGGAAGCACAGCCAGGAAG
ACCATCCCCAAGGAGCAGGTTTCGTCTGCCCAAGACCTGGACACCGTCTGGTCTCTGGGGGGCTACCTCCAGTACTCTGTCCTCTTCTAC
GGATATTACGGCAGGGAGAGGAAGATCGGGAGAGCTGGCTACCGGCTGCCCTTGGCGTATTTCCTAGTGGGGATGGCAGTGTTTGCTTAC
AGCTTCATCATTCTTTTAAAAAAGATGGCTAAGAACTCCCGCACGAGTCTTGCCAGTGCTTCCAATGAAAACTATACCTTCTGCTGGCGG
GTGTTCTGTGCCTGGGATTACCTCATTGGAAACCCAGAGGCTGCAGAGAGCAAAACAGCTGCCATAGTGAACAGCATCAGGGAAGCTATA
TTGGAAGAACAGGAGAAAAAGAAAAGCAAAAACCTGGCAGTGACCATCTGCCTGAGGATTATTGCCAACATCCTGGTGCTTCTCTCACTG
GCTGGGAGCATTTATCTCATCTACTTTGTGGTGGACCGGTCCCAGAAGCTGGAGCAGTCGAAGAAGGAGCTGACACTTTGGGAAAAGAAT
GAGGTCAGTGTGGTGGTCTCCCTCGTCACCATGATAGCACCATCAGCCTTTGACCTCATTGCTGCCTTAGAGATGTACCACCCCAGGACC
ACGCTGCGCTTCCAGCTTGCAAGGGTCCTTGTGCTGTATTTGGGAAATCTCTACAGCCTGATCATTGCTCTCCTGGACAAAGTTAACAGC
ATGAGCATTGAGGAAATGGCTACCAAAAATAACACAAGTCATTGGATAGATTCCACCACCTTCTTTGCAACCAGGACAGCCCCTGAAGAA
GAGAAATGGTCCACATCTCGGCCTGGAATGGGGCTCAGGAGAAACAACACATGGGCCTTGGAAGAGACCAGCATTTCAGCTTATACCATG
CCTCTTATAAAGGCCAACAAGACTAGCCTCCACACTCAGAGTCCACAAGACCAGTGCTGGGAGACATACGTTGGTCAGGAGATGCTGAAG
CTCTCCATCATTGACATGCTCTTCACCGTGGCGAGCATTCTGCTCATAGACTTCTTCCGAGGACTTTTCGTGCGGTACTTAAGTGACTAC
TGGTGTTGGGATCTGGAGAGCAAGTTTCCTGAATATGGAGAATTCAAAATAGCTGAGAATGTGCTACATTTAGTCTACAACCAAGGAATG
ATTTGGATGGGGGCCTTCTTCTCCCCATGTCTCCCAGCGTTCAACGTTCTCAAACTCATTGGGCTCATGTACCTGAGAAGCTGGGCTGTG
CTGACCTGCAATGTGCCCCACCAGCAAGTATTTCGAGCCTCAAGATCCAACAACTTCTACTTGGCAATGCTCCTGTTTATGCTGTTTCTG
TGCATGCTGCCAACCATTTTTGCTATTGTCCGATACAAGCCATCTCTAAACTGTGGGCCATTCAGTGGACAAGAGAAAATTTATGACATT
GTGTCAGAAACGATTGAGAAAGACTTTCCTGTGTGGTTTGGCTCCGTGGTTGGACACATCAGTAGCCCCGTGGTCATCCTGCCCGCAGTA
CTCCTGCTTTTCTCTGCTATTCCATTCCTCAACAATTGGAGGAGACTCAGGAGGGCGTTTCAGGTATTCCTGATACTCCTTGTCATTTTC

>In-frame_TMC3_ENST00000558726_chr15_81630996_-_C15orf40_ENST00000538348_chr15_83657909_-_2168nt
ATGAAAACCTCGAAGGCATCCCAGCGCTATAGAGGCATCCGGAGAAATGCCAGCCAGTGCTACCTCTACCAGGAATCTCTGCTGCTCAGC
AACTTGGATGACAGCTTTAGTGCTGATGAAACAGGGGACAGCAATGATCCGGAACAAATCTTCCAGAATATACAGTTCCAGAAAGATCTC
ATGGCAAACATTCGCTGCAGACCCTGGACTATGGGACAGAAGCTGAGGGCATTGAGACAAGCGAAGAACATTGTGCTGAAGTTTGAAGGG
AGGCTGACCAGGACCCGAGGCTACCAAGCAGCAGGTGCAGAGCTCTGGCGGAAATTTGCTCGTCTCGCCTGTAACTTTGTGGTCATCTTC
ATTCCCTGGGAAATGAGGATAAAGAAAATCGAGAGTCATTTTGGATCTGGCGTTGCCTCCTATTTCATATTCTTGAGATGGTTATTTGGA
ATTAATATTGTGCTCACCATTATGACAGGTGCTTTTATTGTCATTCCAGAGCTGATTGCAGGCCAGCCCTTTGGAAGCACAGCCAGGAAG
ACCATCCCCAAGGAGCAGGTTTCGTCTGCCCAAGACCTGGACACCGTCTGGTCTCTGGGGGGCTACCTCCAGTACTCTGTCCTCTTCTAC
GGATATTACGGCAGGGAGAGGAAGATCGGGAGAGCTGGCTACCGGCTGCCCTTGGCGTATTTCCTAGTGGGGATGGCAGTGTTTGCTTAC
AGCTTCATCATTCTTTTAAAAAAGATGGCTAAGAACTCCCGCACGAGTCTTGCCAGTGCTTCCAATGAAAACTATACCTTCTGCTGGCGG
GTGTTCTGTGCCTGGGATTACCTCATTGGAAACCCAGAGGCTGCAGAGAGCAAAACAGCTGCCATAGTGAACAGCATCAGGGAAGCTATA
TTGGAAGAACAGGAGAAAAAGAAAAGCAAAAACCTGGCAGTGACCATCTGCCTGAGGATTATTGCCAACATCCTGGTGCTTCTCTCACTG
GCTGGGAGCATTTATCTCATCTACTTTGTGGTGGACCGGTCCCAGAAGCTGGAGCAGTCGAAGAAGGAGCTGACACTTTGGGAAAAGAAT
GAGCAGGTCAGTGTGGTGGTCTCCCTCGTCACCATGATAGCACCATCAGCCTTTGACCTCATTGCTGCCTTAGAGATGTACCACCCCAGG
ACCACGCTGCGCTTCCAGCTTGCAAGGGTCCTTGTGCTGTATTTGGGAAATCTCTACAGCCTGATCATTGCTCTCCTGGACAAAGTTAAC
AGCATGAGCATTGAGGAAATGGCTACCAAAAATAACACAAGTCATTGGATAGATTCCACCACCTTCTTTGCAACCAGGACAGCCCCTGAA
GAAGAGAAATGGTCCACATCTCGGCCTGGAATGGGGCTCAGGAGAAACAACACATGGGCCTTGGAAGAGACCAGCATTTCAGCTTATACC
ATGCCTCTTATAAAGGCCAACAAGACTAGCCTCCACACTCAGAGTCCACAAGACCAGTGCTGGGAGACATACGTTGGTCAGGAGATGCTG
AAGCTCTCCATCATTGACATGCTCTTCACCGTGGCGAGCATTCTGCTCATAGACTTCTTCCGAGGACTTTTCGTGCGGTACTTAAGTGAC
TACTGGTGTTGGGATCTGGAGAGCAAGTTTCCTGAATATGGAGAATTCAAAATAGCTGAGAATGTGCTACATTTAGTCTACAACCAAGGA
ATGATTTGGATGGGGGCCTTCTTCTCCCCATGTCTCCCAGCGTTCAACGTTCTCAAACTCATTGGGCTCATGTACCTGAGAAGCTGGGCT
GTGCTGACCTGCAATGTGCCCCACCAGCAAGTATTTCGAGCCTCAAGATCCAACAACTTCTACTTGGCAATGCTCCTGTTTATGCTGTTT
CTGTGCATGCTGCCAACCATTTTTGCTATTGTCCGATACAAGCCATCTCTAAACTGTGGGCCATTCAGTGGACAAGAGAAAATTTATGAC
ATTGTGTCAGAAACGATTGAGAAAGACTTTCCTGTGTGGTTTGGCTCCGTGGTTGGACACATCAGTAGCCCCGTGGTCATCCTGCCCGCA
GTACTCCTGCTTTTCTCTGCTATTCCATTCCTCAACAATTGGAGGAGACTCAGGAGGGCGTTTCAGGTATTCCTGATACTCCTTGTCATT


* Fusion transcript sequences (Full-length transcript).
>In-frame_TMC3_ENST00000359440_chr15_81630996_-_C15orf40_ENST00000538348_chr15_83657909_-_2412nt
ACACAGTCTTCTTCCTGAGAACTAGCGGGCAGAGCAAACTCCGCTGCTTCCATTCAGAAACCTCGGAACAGACCTTTGCCTGCCAACTTC
CTAGCTCTCTGGCCAGCTTCTGATTGTTAGCAGTGGGTTAGCTCCCATGAAAACCTCGAAGGCATCCCAGCGCTATAGAGGCATCCGGAG
AAATGCCAGCCAGTGCTACCTCTACCAGGAATCTCTGCTGCTCAGCAACTTGGATGACAGCTTTAGTGCTGATGAAACAGGGGACAGCAA
TGATCCGGAACAAATCTTCCAGAATATACAGTTCCAGAAAGATCTCATGGCAAACATTCGCTGCAGACCCTGGACTATGGGACAGAAGCT
GAGGGCATTGAGACAAGCGAAGAACATTGTGCTGAAGTTTGAAGGGAGGCTGACCAGGACCCGAGGCTACCAAGCAGCAGGTGCAGAGCT
CTGGCGGAAATTTGCTCGTCTCGCCTGTAACTTTGTGGTCATCTTCATTCCCTGGGAAATGAGGATAAAGAAAATCGAGAGTCATTTTGG
ATCTGGCGTTGCCTCCTATTTCATATTCTTGAGATGGTTATTTGGAATTAATATTGTGCTCACCATTATGACAGGTGCTTTTATTGTCAT
TCCAGAGCTGATTGCAGGCCAGCCCTTTGGAAGCACAGCCAGGAAGACCATCCCCAAGGAGCAGGTTTCGTCTGCCCAAGACCTGGACAC
CGTCTGGTCTCTGGGGGGCTACCTCCAGTACTCTGTCCTCTTCTACGGATATTACGGCAGGGAGAGGAAGATCGGGAGAGCTGGCTACCG
GCTGCCCTTGGCGTATTTCCTAGTGGGGATGGCAGTGTTTGCTTACAGCTTCATCATTCTTTTAAAAAAGATGGCTAAGAACTCCCGCAC
GAGTCTTGCCAGTGCTTCCAATGAAAACTATACCTTCTGCTGGCGGGTGTTCTGTGCCTGGGATTACCTCATTGGAAACCCAGAGGCTGC
AGAGAGCAAAACAGCTGCCATAGTGAACAGCATCAGGGAAGCTATATTGGAAGAACAGGAGAAAAAGAAAAGCAAAAACCTGGCAGTGAC
CATCTGCCTGAGGATTATTGCCAACATCCTGGTGCTTCTCTCACTGGCTGGGAGCATTTATCTCATCTACTTTGTGGTGGACCGGTCCCA
GAAGCTGGAGCAGTCGAAGAAGGAGCTGACACTTTGGGAAAAGAATGAGGTCAGTGTGGTGGTCTCCCTCGTCACCATGATAGCACCATC
AGCCTTTGACCTCATTGCTGCCTTAGAGATGTACCACCCCAGGACCACGCTGCGCTTCCAGCTTGCAAGGGTCCTTGTGCTGTATTTGGG
AAATCTCTACAGCCTGATCATTGCTCTCCTGGACAAAGTTAACAGCATGAGCATTGAGGAAATGGCTACCAAAAATAACACAAGTCATTG
GATAGATTCCACCACCTTCTTTGCAACCAGGACAGCCCCTGAAGAAGAGAAATGGTCCACATCTCGGCCTGGAATGGGGCTCAGGAGAAA
CAACACATGGGCCTTGGAAGAGACCAGCATTTCAGCTTATACCATGCCTCTTATAAAGGCCAACAAGACTAGCCTCCACACTCAGAGTCC
ACAAGACCAGTGCTGGGAGACATACGTTGGTCAGGAGATGCTGAAGCTCTCCATCATTGACATGCTCTTCACCGTGGCGAGCATTCTGCT
CATAGACTTCTTCCGAGGACTTTTCGTGCGGTACTTAAGTGACTACTGGTGTTGGGATCTGGAGAGCAAGTTTCCTGAATATGGAGAATT
CAAAATAGCTGAGAATGTGCTACATTTAGTCTACAACCAAGGAATGATTTGGATGGGGGCCTTCTTCTCCCCATGTCTCCCAGCGTTCAA
CGTTCTCAAACTCATTGGGCTCATGTACCTGAGAAGCTGGGCTGTGCTGACCTGCAATGTGCCCCACCAGCAAGTATTTCGAGCCTCAAG
ATCCAACAACTTCTACTTGGCAATGCTCCTGTTTATGCTGTTTCTGTGCATGCTGCCAACCATTTTTGCTATTGTCCGATACAAGCCATC
TCTAAACTGTGGGCCATTCAGTGGACAAGAGAAAATTTATGACATTGTGTCAGAAACGATTGAGAAAGACTTTCCTGTGTGGTTTGGCTC
CGTGGTTGGACACATCAGTAGCCCCGTGGTCATCCTGCCCGCAGTACTCCTGCTTTTCTCTGCTATTCCATTCCTCAACAATTGGAGGAG
ACTCAGGAGGGCGTTTCAGGTATTCCTGATACTCCTTGTCATTTTCTGTGAATCTACTAGCAAACATCTCTTCAAACTTTGGAACAGCTT

>In-frame_TMC3_ENST00000558726_chr15_81630996_-_C15orf40_ENST00000538348_chr15_83657909_-_2415nt
ACACAGTCTTCTTCCTGAGAACTAGCGGGCAGAGCAAACTCCGCTGCTTCCATTCAGAAACCTCGGAACAGACCTTTGCCTGCCAACTTC
CTAGCTCTCTGGCCAGCTTCTGATTGTTAGCAGTGGGTTAGCTCCCATGAAAACCTCGAAGGCATCCCAGCGCTATAGAGGCATCCGGAG
AAATGCCAGCCAGTGCTACCTCTACCAGGAATCTCTGCTGCTCAGCAACTTGGATGACAGCTTTAGTGCTGATGAAACAGGGGACAGCAA
TGATCCGGAACAAATCTTCCAGAATATACAGTTCCAGAAAGATCTCATGGCAAACATTCGCTGCAGACCCTGGACTATGGGACAGAAGCT
GAGGGCATTGAGACAAGCGAAGAACATTGTGCTGAAGTTTGAAGGGAGGCTGACCAGGACCCGAGGCTACCAAGCAGCAGGTGCAGAGCT
CTGGCGGAAATTTGCTCGTCTCGCCTGTAACTTTGTGGTCATCTTCATTCCCTGGGAAATGAGGATAAAGAAAATCGAGAGTCATTTTGG
ATCTGGCGTTGCCTCCTATTTCATATTCTTGAGATGGTTATTTGGAATTAATATTGTGCTCACCATTATGACAGGTGCTTTTATTGTCAT
TCCAGAGCTGATTGCAGGCCAGCCCTTTGGAAGCACAGCCAGGAAGACCATCCCCAAGGAGCAGGTTTCGTCTGCCCAAGACCTGGACAC
CGTCTGGTCTCTGGGGGGCTACCTCCAGTACTCTGTCCTCTTCTACGGATATTACGGCAGGGAGAGGAAGATCGGGAGAGCTGGCTACCG
GCTGCCCTTGGCGTATTTCCTAGTGGGGATGGCAGTGTTTGCTTACAGCTTCATCATTCTTTTAAAAAAGATGGCTAAGAACTCCCGCAC
GAGTCTTGCCAGTGCTTCCAATGAAAACTATACCTTCTGCTGGCGGGTGTTCTGTGCCTGGGATTACCTCATTGGAAACCCAGAGGCTGC
AGAGAGCAAAACAGCTGCCATAGTGAACAGCATCAGGGAAGCTATATTGGAAGAACAGGAGAAAAAGAAAAGCAAAAACCTGGCAGTGAC
CATCTGCCTGAGGATTATTGCCAACATCCTGGTGCTTCTCTCACTGGCTGGGAGCATTTATCTCATCTACTTTGTGGTGGACCGGTCCCA
GAAGCTGGAGCAGTCGAAGAAGGAGCTGACACTTTGGGAAAAGAATGAGCAGGTCAGTGTGGTGGTCTCCCTCGTCACCATGATAGCACC
ATCAGCCTTTGACCTCATTGCTGCCTTAGAGATGTACCACCCCAGGACCACGCTGCGCTTCCAGCTTGCAAGGGTCCTTGTGCTGTATTT
GGGAAATCTCTACAGCCTGATCATTGCTCTCCTGGACAAAGTTAACAGCATGAGCATTGAGGAAATGGCTACCAAAAATAACACAAGTCA
TTGGATAGATTCCACCACCTTCTTTGCAACCAGGACAGCCCCTGAAGAAGAGAAATGGTCCACATCTCGGCCTGGAATGGGGCTCAGGAG
AAACAACACATGGGCCTTGGAAGAGACCAGCATTTCAGCTTATACCATGCCTCTTATAAAGGCCAACAAGACTAGCCTCCACACTCAGAG
TCCACAAGACCAGTGCTGGGAGACATACGTTGGTCAGGAGATGCTGAAGCTCTCCATCATTGACATGCTCTTCACCGTGGCGAGCATTCT
GCTCATAGACTTCTTCCGAGGACTTTTCGTGCGGTACTTAAGTGACTACTGGTGTTGGGATCTGGAGAGCAAGTTTCCTGAATATGGAGA
ATTCAAAATAGCTGAGAATGTGCTACATTTAGTCTACAACCAAGGAATGATTTGGATGGGGGCCTTCTTCTCCCCATGTCTCCCAGCGTT
CAACGTTCTCAAACTCATTGGGCTCATGTACCTGAGAAGCTGGGCTGTGCTGACCTGCAATGTGCCCCACCAGCAAGTATTTCGAGCCTC
AAGATCCAACAACTTCTACTTGGCAATGCTCCTGTTTATGCTGTTTCTGTGCATGCTGCCAACCATTTTTGCTATTGTCCGATACAAGCC
ATCTCTAAACTGTGGGCCATTCAGTGGACAAGAGAAAATTTATGACATTGTGTCAGAAACGATTGAGAAAGACTTTCCTGTGTGGTTTGG
CTCCGTGGTTGGACACATCAGTAGCCCCGTGGTCATCCTGCCCGCAGTACTCCTGCTTTTCTCTGCTATTCCATTCCTCAACAATTGGAG
GAGACTCAGGAGGGCGTTTCAGGTATTCCTGATACTCCTTGTCATTTTCTGTGAATCTACTAGCAAACATCTCTTCAAACTTTGGAACAG


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FusionGenePPI for TMC3_C15orf40


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TMC3C15orf40ERCC1, METTL1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TMC3_C15orf40


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TMC3_C15orf40


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource