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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 38254

FusionGeneSummary for TM9SF4_TPX2

check button Fusion gene summary
Fusion gene informationFusion gene name: TM9SF4_TPX2
Fusion gene ID: 38254
HgeneTgene
Gene symbol

TM9SF4

TPX2

Gene ID

9777

22974

Gene nametransmembrane 9 superfamily member 4TPX2, microtubule nucleation factor
SynonymsdJ836N17.2C20orf1|C20orf2|DIL-2|DIL2|FLS353|GD:C20orf1|HCA519|HCTP4|REPP86|p100
Cytomap

20q11.21

20q11.21

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane 9 superfamily member 4dinucleotide oxidase disulfide thiol exchanger 3 superfamily member 4transmembrane 9 superfamily protein member 4tumor cannibalism associated protein 1targeting protein for Xklp2TPX2, microtubule-associated protein homologTPX2, microtubule-associated, homologdifferentially expressed in cancerous and non-cancerous lung cells 2differentially expressed in lung cellshepatocellular carcinoma-associated
Modification date2018052920180519
UniProtAcc

Q92544

Q9ULW0

Ensembl transtripts involved in fusion geneENST00000398022, ENST00000217315, 
ENST00000340513, ENST00000300403, 
Fusion gene scores* DoF score14 X 13 X 8=14566 X 6 X 5=180
# samples 146
** MAII scorelog2(14/1456*10)=-3.37851162325373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/180*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TM9SF4 [Title/Abstract] AND TPX2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTM9SF4

GO:0001666

response to hypoxia

25961573

TgeneTPX2

GO:0032147

activation of protein kinase activity

14580337|19801554

TgeneTPX2

GO:0090307

mitotic spindle assembly

26165940


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-E2-A1LK-01ATM9SF4chr20

30697842

+TPX2chr20

30354359

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000398022ENST00000340513TM9SF4chr20

30697842

+TPX2chr20

30354359

+
intron-3CDSENST00000398022ENST00000300403TM9SF4chr20

30697842

+TPX2chr20

30354359

+
5UTR-3CDSENST00000217315ENST00000340513TM9SF4chr20

30697842

+TPX2chr20

30354359

+
5UTR-3CDSENST00000217315ENST00000300403TM9SF4chr20

30697842

+TPX2chr20

30354359

+

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FusionProtFeatures for TM9SF4_TPX2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TM9SF4

Q92544

TPX2

Q9ULW0

Associates with proteins harboring glycine-richtransmembrane domains and ensures their efficient localization tothe cell surface (PubMed:25999474). Regulates the assembly andactivity of V-ATPase in colon cancer cells via its interactionwith V-type proton ATPase subunit H (ATP6V1H) and contributes toV-ATPase-mediated pH alterations in cancer cells which play animportant role in drug resistance and invasiveness of colon cancercells (PubMed:25659576). Plays an important role in an atypicalphagocytic activity of metastatic melanoma cells calledcannibalism and is involved in the pH regulation of theintracellular vesicles in tumor cells (PubMed:19893578).{ECO:0000269|PubMed:19893578, ECO:0000269|PubMed:25659576,ECO:0000269|PubMed:25999474}. Spindle assembly factor required for normal assembly ofmitotic spindles. Required for normal assembly of microtubulesduring apoptosis. Required for chromatin and/or kinetochoredependent microtubule nucleation. Mediates AURKA localization tospindle microtubules (PubMed:18663142, PubMed:19208764). ActivatesAURKA by promoting its autophosphorylation at 'Thr-288' andprotects this residue against dephosphorylation (PubMed:18663142,PubMed:19208764). TPX2 is inactivated upon binding to importin-alpha (PubMed:26165940). At the onset of mitosis, GOLGA2 interactswith importin-alpha, liberating TPX2 from importin-alpha, allowingTPX2 to activates AURKA kinase and stimulates local microtubulenucleation (PubMed:26165940). {ECO:0000269|PubMed:18663142,ECO:0000269|PubMed:19208764, ECO:0000269|PubMed:26165940}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TM9SF4_TPX2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TM9SF4_TPX2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TM9SF4ELAVL1, IGF2R, SPCS2, TMX2, FAM162A, LAMP1, UQCRFS1, ATP1B3, F3, ERMP1, LMAN2, RAB1A, STX12, STX7, SGPL1, TMED2, CALD1, HIST1H1B, KDM5A, RPN2, S100A6, SLC25A12, OASL, RIOK3, H1FX, PHF14, ABCF2, SCAMP3, ATP5H, SACM1L, MKRN2, ITSN2, FCF1, SIRT6, TMEM161A, CDCA7L, ZC3H15, RPAP3, CEP44, RNF170, SP140L, H2AFV, ZNF800, NSMCE2, FAM3B, TSPAN11, TRIM25TPX2AURKA, FZR1, KPNA1, KPNB1, HMMR, BRCA1, SIAH2, ZNF598, NDUFA7, THUMPD2, DNAJC8, MRPL53, SERPINH1, UBE2S, PPIF, SARNP, TWF1, SCAMP3, CDK6, IKBKB, CHUK, IKBKG, AURKB, LMNA, HDAC9, THAP11, NAP1L1, RPA3, RPA2, RPA1, GOLGA2, MAPK14, GSTM3, HIST1H2BG, AFAP1, SAP130, RBPJ, CDC5L, RNF111


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TM9SF4_TPX2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TM9SF4_TPX2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource