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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 38229

FusionGeneSummary for TM9SF1_TSSK4

check button Fusion gene summary
Fusion gene informationFusion gene name: TM9SF1_TSSK4
Fusion gene ID: 38229
HgeneTgene
Gene symbol

TM9SF1

TSSK4

Gene ID

10548

283629

Gene nametransmembrane 9 superfamily member 1testis specific serine kinase 4
SynonymsHMP70|MP70C14orf20|STK22E|TSK-4|TSK4|TSSK5
Cytomap

14q12

14q12

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane 9 superfamily member 1MP70 protein family membermultispanning membrane protein (70kD)transmembrane protein 9 superfamily member 1testis-specific serine/threonine-protein kinase 4serine/threonine kinase 22Eserine/threonine-protein kinase 22E
Modification date2018052320180523
UniProtAcc

O15321

Q6SA08

Ensembl transtripts involved in fusion geneENST00000261789, ENST00000528669, 
ENST00000556387, ENST00000530611, 
ENST00000524835, ENST00000396854, 
ENST00000339917, ENST00000556621, 
ENST00000287913, ENST00000428351, 
Fusion gene scores* DoF score3 X 3 X 3=271 X 1 X 1=1
# samples 31
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(1/1*10)=3.32192809488736
Context

PubMed: TM9SF1 [Title/Abstract] AND TSSK4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTSSK4

GO:0006468

protein phosphorylation

15964553

TgeneTSSK4

GO:0032793

positive regulation of CREB transcription factor activity

15964553


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-C8-A1HG-01ATM9SF1chr14

24664552

-TSSK4chr14

24677170

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000261789ENST00000339917TM9SF1chr14

24664552

-TSSK4chr14

24677170

+
5UTR-3CDSENST00000261789ENST00000556621TM9SF1chr14

24664552

-TSSK4chr14

24677170

+
5UTR-3CDSENST00000261789ENST00000287913TM9SF1chr14

24664552

-TSSK4chr14

24677170

+
5UTR-3CDSENST00000261789ENST00000428351TM9SF1chr14

24664552

-TSSK4chr14

24677170

+
intron-3CDSENST00000528669ENST00000339917TM9SF1chr14

24664552

-TSSK4chr14

24677170

+
intron-3CDSENST00000528669ENST00000556621TM9SF1chr14

24664552

-TSSK4chr14

24677170

+
intron-3CDSENST00000528669ENST00000287913TM9SF1chr14

24664552

-TSSK4chr14

24677170

+
intron-3CDSENST00000528669ENST00000428351TM9SF1chr14

24664552

-TSSK4chr14

24677170

+
intron-3CDSENST00000556387ENST00000339917TM9SF1chr14

24664552

-TSSK4chr14

24677170

+
intron-3CDSENST00000556387ENST00000556621TM9SF1chr14

24664552

-TSSK4chr14

24677170

+
intron-3CDSENST00000556387ENST00000287913TM9SF1chr14

24664552

-TSSK4chr14

24677170

+
intron-3CDSENST00000556387ENST00000428351TM9SF1chr14

24664552

-TSSK4chr14

24677170

+
intron-3CDSENST00000530611ENST00000339917TM9SF1chr14

24664552

-TSSK4chr14

24677170

+
intron-3CDSENST00000530611ENST00000556621TM9SF1chr14

24664552

-TSSK4chr14

24677170

+
intron-3CDSENST00000530611ENST00000287913TM9SF1chr14

24664552

-TSSK4chr14

24677170

+
intron-3CDSENST00000530611ENST00000428351TM9SF1chr14

24664552

-TSSK4chr14

24677170

+
5UTR-3CDSENST00000524835ENST00000339917TM9SF1chr14

24664552

-TSSK4chr14

24677170

+
5UTR-3CDSENST00000524835ENST00000556621TM9SF1chr14

24664552

-TSSK4chr14

24677170

+
5UTR-3CDSENST00000524835ENST00000287913TM9SF1chr14

24664552

-TSSK4chr14

24677170

+
5UTR-3CDSENST00000524835ENST00000428351TM9SF1chr14

24664552

-TSSK4chr14

24677170

+
5UTR-3CDSENST00000396854ENST00000339917TM9SF1chr14

24664552

-TSSK4chr14

24677170

+
5UTR-3CDSENST00000396854ENST00000556621TM9SF1chr14

24664552

-TSSK4chr14

24677170

+
5UTR-3CDSENST00000396854ENST00000287913TM9SF1chr14

24664552

-TSSK4chr14

24677170

+
5UTR-3CDSENST00000396854ENST00000428351TM9SF1chr14

24664552

-TSSK4chr14

24677170

+

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FusionProtFeatures for TM9SF1_TSSK4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TM9SF1

O15321

TSSK4

Q6SA08

Plays an essential role in autophagy.{ECO:0000269|PubMed:19029833}. May be involved in a signaling pathway during male germcell development or mature sperm function (By similarity).Phosphorylates CREB1 on Ser-133 and stimulates downstreamsignaling. {ECO:0000250, ECO:0000269|PubMed:15964553}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TM9SF1_TSSK4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TM9SF1_TSSK4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TM9SF1MME, ATP6V1B1, P2RX7, TCOF1, RNASEH1, CHMP4B, CLEC2D, MTNR1ATSSK4CREB1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TM9SF1_TSSK4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TM9SF1_TSSK4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource