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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 38219

FusionGeneSummary for TM4SF19_BAZ2A

check button Fusion gene summary
Fusion gene informationFusion gene name: TM4SF19_BAZ2A
Fusion gene ID: 38219
HgeneTgene
Gene symbol

TM4SF19

BAZ2A

Gene ID

116211

11176

Gene nametransmembrane 4 L six family member 19bromodomain adjacent to zinc finger domain 2A
SynonymsOCTM4TIP5|WALp3
Cytomap

3q29

12q13.3

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane 4 L6 family member 19osteoclast maturation-associated gene 4 proteintetraspan membrane protein OCTM4bromodomain adjacent to zinc finger domain protein 2ATTF-I interacting peptide 5TTF-I-interacting protein 5transcription termination factor I-interacting protein 5
Modification date2018052320180519
UniProtAcc

Q96DZ7

Q9UIF9

Ensembl transtripts involved in fusion geneENST00000442633, ENST00000446879, 
ENST00000454715, ENST00000273695, 
ENST00000379441, ENST00000179765, 
ENST00000551812, ENST00000549884, 
ENST00000553222, 
Fusion gene scores* DoF score1 X 1 X 1=17 X 7 X 2=98
# samples 18
** MAII scorelog2(1/1*10)=3.32192809488736log2(8/98*10)=-0.292781749227846
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TM4SF19 [Title/Abstract] AND BAZ2A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF900417TM4SF19chr3

196048794

-BAZ2Achr12

57011271

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000442633ENST00000379441TM4SF19chr3

196048794

-BAZ2Achr12

57011271

-
intron-3CDSENST00000442633ENST00000179765TM4SF19chr3

196048794

-BAZ2Achr12

57011271

-
intron-3CDSENST00000442633ENST00000551812TM4SF19chr3

196048794

-BAZ2Achr12

57011271

-
intron-3CDSENST00000442633ENST00000549884TM4SF19chr3

196048794

-BAZ2Achr12

57011271

-
intron-intronENST00000442633ENST00000553222TM4SF19chr3

196048794

-BAZ2Achr12

57011271

-
intron-3CDSENST00000446879ENST00000379441TM4SF19chr3

196048794

-BAZ2Achr12

57011271

-
intron-3CDSENST00000446879ENST00000179765TM4SF19chr3

196048794

-BAZ2Achr12

57011271

-
intron-3CDSENST00000446879ENST00000551812TM4SF19chr3

196048794

-BAZ2Achr12

57011271

-
intron-3CDSENST00000446879ENST00000549884TM4SF19chr3

196048794

-BAZ2Achr12

57011271

-
intron-intronENST00000446879ENST00000553222TM4SF19chr3

196048794

-BAZ2Achr12

57011271

-
intron-3CDSENST00000454715ENST00000379441TM4SF19chr3

196048794

-BAZ2Achr12

57011271

-
intron-3CDSENST00000454715ENST00000179765TM4SF19chr3

196048794

-BAZ2Achr12

57011271

-
intron-3CDSENST00000454715ENST00000551812TM4SF19chr3

196048794

-BAZ2Achr12

57011271

-
intron-3CDSENST00000454715ENST00000549884TM4SF19chr3

196048794

-BAZ2Achr12

57011271

-
intron-intronENST00000454715ENST00000553222TM4SF19chr3

196048794

-BAZ2Achr12

57011271

-
intron-3CDSENST00000273695ENST00000379441TM4SF19chr3

196048794

-BAZ2Achr12

57011271

-
intron-3CDSENST00000273695ENST00000179765TM4SF19chr3

196048794

-BAZ2Achr12

57011271

-
intron-3CDSENST00000273695ENST00000551812TM4SF19chr3

196048794

-BAZ2Achr12

57011271

-
intron-3CDSENST00000273695ENST00000549884TM4SF19chr3

196048794

-BAZ2Achr12

57011271

-
intron-intronENST00000273695ENST00000553222TM4SF19chr3

196048794

-BAZ2Achr12

57011271

-

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FusionProtFeatures for TM4SF19_BAZ2A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TM4SF19

Q96DZ7

BAZ2A

Q9UIF9

Essential component of the NoRC (nucleolar remodelingcomplex) complex, a complex that mediates silencing of a fractionof rDNA by recruiting histone-modifying enzymes and DNAmethyltransferases, leading to heterochromatin formation andtranscriptional silencing. In the complex, it plays a central roleby being recruited to rDNA and by targeting chromatin modifyingenzymes such as HDAC1, leading to repress RNA polymerase Itranscription. Recruited to rDNA via its interaction with TTF1 andits ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12acbut not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAsthat are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNAsilencing (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TM4SF19_BAZ2A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TM4SF19_BAZ2A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TM4SF19_BAZ2A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TM4SF19_BAZ2A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneBAZ2AC0033578Prostatic Neoplasms1CTD_human