|
Fusion gene ID: 38208 |
FusionGeneSummary for TLR4_SLC31A1 |
Fusion gene summary |
Fusion gene information | Fusion gene name: TLR4_SLC31A1 | Fusion gene ID: 38208 | Hgene | Tgene | Gene symbol | TLR4 | SLC31A1 | Gene ID | 7099 | 1317 |
Gene name | toll like receptor 4 | solute carrier family 31 member 1 | |
Synonyms | ARMD10|CD284|TLR-4|TOLL | COPT1|CTR1 | |
Cytomap | 9q33.1 | 9q32 | |
Type of gene | protein-coding | protein-coding | |
Description | toll-like receptor 4hTollhomolog of Drosophila toll | high affinity copper uptake protein 1copper transport 1 homologcopper transporter 1solute carrier family 31 (copper transporter), member 1solute carrier family 31 (copper transporters), member 1 | |
Modification date | 20180527 | 20180519 | |
UniProtAcc | O00206 | O15431 | |
Ensembl transtripts involved in fusion gene | ENST00000394487, ENST00000355622, ENST00000472304, | ENST00000374210, ENST00000374212, ENST00000496650, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 3 X 1 X 3=9 |
# samples | 1 | 3 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: TLR4 [Title/Abstract] AND SLC31A1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | TLR4 | GO:0007252 | I-kappaB phosphorylation | 19740627 |
Hgene | TLR4 | GO:0031663 | lipopolysaccharide-mediated signaling pathway | 10880523 |
Hgene | TLR4 | GO:0032496 | response to lipopolysaccharide | 12594207 |
Hgene | TLR4 | GO:0032497 | detection of lipopolysaccharide | 19252480 |
Hgene | TLR4 | GO:0032722 | positive regulation of chemokine production | 19740627 |
Hgene | TLR4 | GO:0032755 | positive regulation of interleukin-6 production | 19740627 |
Hgene | TLR4 | GO:0032757 | positive regulation of interleukin-8 production | 19740627 |
Hgene | TLR4 | GO:0042535 | positive regulation of tumor necrosis factor biosynthetic process | 17951129 |
Hgene | TLR4 | GO:0045084 | positive regulation of interleukin-12 biosynthetic process | 15027902 |
Hgene | TLR4 | GO:0045416 | positive regulation of interleukin-8 biosynthetic process | 17951129 |
Hgene | TLR4 | GO:0050718 | positive regulation of interleukin-1 beta secretion | 11432859 |
Hgene | TLR4 | GO:0051092 | positive regulation of NF-kappaB transcription factor activity | 12594207 |
Hgene | TLR4 | GO:0071222 | cellular response to lipopolysaccharide | 11432859 |
Hgene | TLR4 | GO:0071346 | cellular response to interferon-gamma | 11672593 |
Hgene | TLR4 | GO:1901224 | positive regulation of NIK/NF-kappaB signaling | 19740627 |
Hgene | TLR4 | GO:1903974 | positive regulation of cellular response to macrophage colony-stimulating factor stimulus | 11672593 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | SARC | TCGA-DX-A8BV-01A | TLR4 | chr9 | 120471007 | + | SLC31A1 | chr9 | 116018394 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000394487 | ENST00000374210 | TLR4 | chr9 | 120471007 | + | SLC31A1 | chr9 | 116018394 | + |
5CDS-5UTR | ENST00000394487 | ENST00000374212 | TLR4 | chr9 | 120471007 | + | SLC31A1 | chr9 | 116018394 | + |
5CDS-intron | ENST00000394487 | ENST00000496650 | TLR4 | chr9 | 120471007 | + | SLC31A1 | chr9 | 116018394 | + |
5CDS-5UTR | ENST00000355622 | ENST00000374210 | TLR4 | chr9 | 120471007 | + | SLC31A1 | chr9 | 116018394 | + |
5CDS-5UTR | ENST00000355622 | ENST00000374212 | TLR4 | chr9 | 120471007 | + | SLC31A1 | chr9 | 116018394 | + |
5CDS-intron | ENST00000355622 | ENST00000496650 | TLR4 | chr9 | 120471007 | + | SLC31A1 | chr9 | 116018394 | + |
intron-5UTR | ENST00000472304 | ENST00000374210 | TLR4 | chr9 | 120471007 | + | SLC31A1 | chr9 | 116018394 | + |
intron-5UTR | ENST00000472304 | ENST00000374212 | TLR4 | chr9 | 120471007 | + | SLC31A1 | chr9 | 116018394 | + |
intron-intron | ENST00000472304 | ENST00000496650 | TLR4 | chr9 | 120471007 | + | SLC31A1 | chr9 | 116018394 | + |
Top |
FusionProtFeatures for TLR4_SLC31A1 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
TLR4 | SLC31A1 |
High-affinity, saturable copper transporter involved indietary copper uptake. {ECO:0000269|PubMed:11734551}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for TLR4_SLC31A1 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for TLR4_SLC31A1 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
TLR4 | RNF216, MYD88, SIGIRR, LY96, TOLLIP, TIRAP, TLR1, ECSIT, PPP4C, TICAM2, STUB1, IRAK1, TRIM69, TBK1, TRAF6, HSPA8, SRC, PRKCZ, IRAK4, STK11IP, TRAF3, HSPA4, TICAM1, HGS, BTK, SYK, SMAD3, SERTAD1, TNFSF9, UBQLN1, CAV1 | SLC31A1 | SLC31A1, CCS, MOV10, NXF1, STX7, LGALS8, ERBB3, PLXDC2, CD70, TMPRSS11B, NCR3LG1, TRIM25 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for TLR4_SLC31A1 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | TLR4 | O00206 | DB13615 | Mifamurtide | Toll-like receptor 4 | small molecule | approved|experimental |
Hgene | TLR4 | O00206 | DB01183 | Naloxone | Toll-like receptor 4 | small molecule | approved|vet_approved |
Top |
RelatedDiseases for TLR4_SLC31A1 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | TLR4 | C0021368 | Inflammation | 4 | CTD_human |
Hgene | TLR4 | C0009404 | Colorectal Neoplasms | 2 | CTD_human |
Hgene | TLR4 | C0015695 | Fatty Liver | 2 | CTD_human |
Hgene | TLR4 | C0035126 | Reperfusion Injury | 2 | CTD_human |
Hgene | TLR4 | C0085762 | Alcohol abuse | 2 | PSYGENET |
Hgene | TLR4 | C0004153 | Atherosclerosis | 1 | CTD_human |
Hgene | TLR4 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
Hgene | TLR4 | C0010346 | Crohn Disease | 1 | CTD_human |
Hgene | TLR4 | C0011616 | Contact Dermatitis | 1 | CTD_human |
Hgene | TLR4 | C0011882 | Diabetic Neuropathies | 1 | CTD_human |
Hgene | TLR4 | C0014457 | Eosinophilia | 1 | CTD_human |
Hgene | TLR4 | C0020538 | Hypertensive disease | 1 | CTD_human |
Hgene | TLR4 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Hgene | TLR4 | C0024121 | Lung Neoplasms | 1 | CTD_human |
Hgene | TLR4 | C0025202 | melanoma | 1 | CTD_human |
Hgene | TLR4 | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
Hgene | TLR4 | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
Hgene | TLR4 | C0032285 | Pneumonia | 1 | CTD_human |
Hgene | TLR4 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Hgene | TLR4 | C0035228 | Respiratory Hypersensitivity | 1 | CTD_human |
Hgene | TLR4 | C0036341 | Schizophrenia | 1 | PSYGENET |
Hgene | TLR4 | C0242383 | Age related macular degeneration | 1 | CTD_human |
Hgene | TLR4 | C0243026 | Sepsis | 1 | CTD_human |
Hgene | TLR4 | C0273115 | Lung Injury | 1 | CTD_human |
Hgene | TLR4 | C0279628 | Adenocarcinoma Of Esophagus | 1 | CTD_human |
Hgene | TLR4 | C0340288 | Stable angina | 1 | CTD_human |
Hgene | TLR4 | C0520459 | Necrotizing Enterocolitis | 1 | CTD_human |
Hgene | TLR4 | C0919267 | ovarian neoplasm | 1 | CTD_human |
Hgene | TLR4 | C0948089 | Acute Coronary Syndrome | 1 | CTD_human |
Hgene | TLR4 | C1384666 | hearing impairment | 1 | CTD_human |
Hgene | TLR4 | C1956346 | Coronary Artery Disease | 1 | CTD_human |
Hgene | TLR4 | C2239176 | Liver carcinoma | 1 | CTD_human |
Tgene | SLC31A1 | C0000768 | Congenital Abnormality | 1 | CTD_human |
Tgene | SLC31A1 | C0020542 | Pulmonary Hypertension | 1 | CTD_human |
Tgene | SLC31A1 | C0023904 | Liver Neoplasms, Experimental | 1 | CTD_human |
Tgene | SLC31A1 | C0027540 | Necrosis | 1 | CTD_human |
Tgene | SLC31A1 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Tgene | SLC31A1 | C0677050 | Manganese Poisoning | 1 | CTD_human |
Tgene | SLC31A1 | C0752351 | Embryo Loss | 1 | CTD_human |
Tgene | SLC31A1 | C3714756 | Intellectual Disability | 1 | CTD_human |