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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 38208

FusionGeneSummary for TLR4_SLC31A1

check button Fusion gene summary
Fusion gene informationFusion gene name: TLR4_SLC31A1
Fusion gene ID: 38208
HgeneTgene
Gene symbol

TLR4

SLC31A1

Gene ID

7099

1317

Gene nametoll like receptor 4solute carrier family 31 member 1
SynonymsARMD10|CD284|TLR-4|TOLLCOPT1|CTR1
Cytomap

9q33.1

9q32

Type of geneprotein-codingprotein-coding
Descriptiontoll-like receptor 4hTollhomolog of Drosophila tollhigh affinity copper uptake protein 1copper transport 1 homologcopper transporter 1solute carrier family 31 (copper transporter), member 1solute carrier family 31 (copper transporters), member 1
Modification date2018052720180519
UniProtAcc

O00206

O15431

Ensembl transtripts involved in fusion geneENST00000394487, ENST00000355622, 
ENST00000472304, 
ENST00000374210, 
ENST00000374212, ENST00000496650, 
Fusion gene scores* DoF score1 X 1 X 1=13 X 1 X 3=9
# samples 13
** MAII scorelog2(1/1*10)=3.32192809488736log2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TLR4 [Title/Abstract] AND SLC31A1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTLR4

GO:0007252

I-kappaB phosphorylation

19740627

HgeneTLR4

GO:0031663

lipopolysaccharide-mediated signaling pathway

10880523

HgeneTLR4

GO:0032496

response to lipopolysaccharide

12594207

HgeneTLR4

GO:0032497

detection of lipopolysaccharide

19252480

HgeneTLR4

GO:0032722

positive regulation of chemokine production

19740627

HgeneTLR4

GO:0032755

positive regulation of interleukin-6 production

19740627

HgeneTLR4

GO:0032757

positive regulation of interleukin-8 production

19740627

HgeneTLR4

GO:0042535

positive regulation of tumor necrosis factor biosynthetic process

17951129

HgeneTLR4

GO:0045084

positive regulation of interleukin-12 biosynthetic process

15027902

HgeneTLR4

GO:0045416

positive regulation of interleukin-8 biosynthetic process

17951129

HgeneTLR4

GO:0050718

positive regulation of interleukin-1 beta secretion

11432859

HgeneTLR4

GO:0051092

positive regulation of NF-kappaB transcription factor activity

12594207

HgeneTLR4

GO:0071222

cellular response to lipopolysaccharide

11432859

HgeneTLR4

GO:0071346

cellular response to interferon-gamma

11672593

HgeneTLR4

GO:1901224

positive regulation of NIK/NF-kappaB signaling

19740627

HgeneTLR4

GO:1903974

positive regulation of cellular response to macrophage colony-stimulating factor stimulus

11672593


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-DX-A8BV-01ATLR4chr9

120471007

+SLC31A1chr9

116018394

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000394487ENST00000374210TLR4chr9

120471007

+SLC31A1chr9

116018394

+
5CDS-5UTRENST00000394487ENST00000374212TLR4chr9

120471007

+SLC31A1chr9

116018394

+
5CDS-intronENST00000394487ENST00000496650TLR4chr9

120471007

+SLC31A1chr9

116018394

+
5CDS-5UTRENST00000355622ENST00000374210TLR4chr9

120471007

+SLC31A1chr9

116018394

+
5CDS-5UTRENST00000355622ENST00000374212TLR4chr9

120471007

+SLC31A1chr9

116018394

+
5CDS-intronENST00000355622ENST00000496650TLR4chr9

120471007

+SLC31A1chr9

116018394

+
intron-5UTRENST00000472304ENST00000374210TLR4chr9

120471007

+SLC31A1chr9

116018394

+
intron-5UTRENST00000472304ENST00000374212TLR4chr9

120471007

+SLC31A1chr9

116018394

+
intron-intronENST00000472304ENST00000496650TLR4chr9

120471007

+SLC31A1chr9

116018394

+

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FusionProtFeatures for TLR4_SLC31A1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TLR4

O00206

SLC31A1

O15431

High-affinity, saturable copper transporter involved indietary copper uptake. {ECO:0000269|PubMed:11734551}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TLR4_SLC31A1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TLR4_SLC31A1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TLR4RNF216, MYD88, SIGIRR, LY96, TOLLIP, TIRAP, TLR1, ECSIT, PPP4C, TICAM2, STUB1, IRAK1, TRIM69, TBK1, TRAF6, HSPA8, SRC, PRKCZ, IRAK4, STK11IP, TRAF3, HSPA4, TICAM1, HGS, BTK, SYK, SMAD3, SERTAD1, TNFSF9, UBQLN1, CAV1SLC31A1SLC31A1, CCS, MOV10, NXF1, STX7, LGALS8, ERBB3, PLXDC2, CD70, TMPRSS11B, NCR3LG1, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TLR4_SLC31A1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneTLR4O00206DB13615MifamurtideToll-like receptor 4small moleculeapproved|experimental
HgeneTLR4O00206DB01183NaloxoneToll-like receptor 4small moleculeapproved|vet_approved

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RelatedDiseases for TLR4_SLC31A1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTLR4C0021368Inflammation4CTD_human
HgeneTLR4C0009404Colorectal Neoplasms2CTD_human
HgeneTLR4C0015695Fatty Liver2CTD_human
HgeneTLR4C0035126Reperfusion Injury2CTD_human
HgeneTLR4C0085762Alcohol abuse2PSYGENET
HgeneTLR4C0004153Atherosclerosis1CTD_human
HgeneTLR4C0005586Bipolar Disorder1PSYGENET
HgeneTLR4C0010346Crohn Disease1CTD_human
HgeneTLR4C0011616Contact Dermatitis1CTD_human
HgeneTLR4C0011882Diabetic Neuropathies1CTD_human
HgeneTLR4C0014457Eosinophilia1CTD_human
HgeneTLR4C0020538Hypertensive disease1CTD_human
HgeneTLR4C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneTLR4C0024121Lung Neoplasms1CTD_human
HgeneTLR4C0025202melanoma1CTD_human
HgeneTLR4C0027626Neoplasm Invasiveness1CTD_human
HgeneTLR4C0027627Neoplasm Metastasis1CTD_human
HgeneTLR4C0032285Pneumonia1CTD_human
HgeneTLR4C0033578Prostatic Neoplasms1CTD_human
HgeneTLR4C0035228Respiratory Hypersensitivity1CTD_human
HgeneTLR4C0036341Schizophrenia1PSYGENET
HgeneTLR4C0242383Age related macular degeneration1CTD_human
HgeneTLR4C0243026Sepsis1CTD_human
HgeneTLR4C0273115Lung Injury1CTD_human
HgeneTLR4C0279628Adenocarcinoma Of Esophagus1CTD_human
HgeneTLR4C0340288Stable angina1CTD_human
HgeneTLR4C0520459Necrotizing Enterocolitis1CTD_human
HgeneTLR4C0919267ovarian neoplasm1CTD_human
HgeneTLR4C0948089Acute Coronary Syndrome1CTD_human
HgeneTLR4C1384666hearing impairment1CTD_human
HgeneTLR4C1956346Coronary Artery Disease1CTD_human
HgeneTLR4C2239176Liver carcinoma1CTD_human
TgeneSLC31A1C0000768Congenital Abnormality1CTD_human
TgeneSLC31A1C0020542Pulmonary Hypertension1CTD_human
TgeneSLC31A1C0023904Liver Neoplasms, Experimental1CTD_human
TgeneSLC31A1C0027540Necrosis1CTD_human
TgeneSLC31A1C0033578Prostatic Neoplasms1CTD_human
TgeneSLC31A1C0677050Manganese Poisoning1CTD_human
TgeneSLC31A1C0752351Embryo Loss1CTD_human
TgeneSLC31A1C3714756Intellectual Disability1CTD_human