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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 38204

FusionGeneSummary for TLN2_RBPMS2

check button Fusion gene summary
Fusion gene informationFusion gene name: TLN2_RBPMS2
Fusion gene ID: 38204
HgeneTgene
Gene symbol

TLN2

RBPMS2

Gene ID

83660

348093

Gene nametalin 2RNA binding protein, mRNA processing factor 2
SynonymsILWEQ-
Cytomap

15q22.2

15q22.31

Type of geneprotein-codingprotein-coding
Descriptiontalin-2RNA-binding protein with multiple splicing 2RNA binding protein with multiple splicing 2
Modification date2018051920180523
UniProtAcc

Q9Y4G6

Q6ZRY4

Ensembl transtripts involved in fusion geneENST00000561311, ENST00000306829, 
ENST00000559908, ENST00000472902, 
ENST00000560606, ENST00000300069, 
Fusion gene scores* DoF score7 X 4 X 7=1967 X 6 X 4=168
# samples 78
** MAII scorelog2(7/196*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/168*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TLN2 [Title/Abstract] AND RBPMS2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUADTCGA-91-7771-01ATLN2chr15

62682884

+RBPMS2chr15

65043837

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000561311ENST00000560606TLN2chr15

62682884

+RBPMS2chr15

65043837

-
intron-5UTRENST00000561311ENST00000300069TLN2chr15

62682884

+RBPMS2chr15

65043837

-
intron-5UTRENST00000306829ENST00000560606TLN2chr15

62682884

+RBPMS2chr15

65043837

-
intron-5UTRENST00000306829ENST00000300069TLN2chr15

62682884

+RBPMS2chr15

65043837

-
intron-5UTRENST00000559908ENST00000560606TLN2chr15

62682884

+RBPMS2chr15

65043837

-
intron-5UTRENST00000559908ENST00000300069TLN2chr15

62682884

+RBPMS2chr15

65043837

-
intron-5UTRENST00000472902ENST00000560606TLN2chr15

62682884

+RBPMS2chr15

65043837

-
intron-5UTRENST00000472902ENST00000300069TLN2chr15

62682884

+RBPMS2chr15

65043837

-

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FusionProtFeatures for TLN2_RBPMS2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TLN2

Q9Y4G6

RBPMS2

Q6ZRY4

As a major component of focal adhesion plaques thatlinks integrin to the actin cytoskeleton, may play an importantrole in cell adhesion. Recruits PIP5K1C to focal adhesion plaquesand strongly activates its kinase activity (By similarity).{ECO:0000250}. Contributes to the regulation of smooth muscle celldifferentiation and proliferation in the gastrointestinal system.Binds NOG mRNA. Mediates an increase of NOG mRNA levels, andthereby contributes to the negative regulation of the BMPsignaling pathway. This promotes reversible dedifferentiation ofsmooth muscle cells and promotes smooth muscle cell proliferation.{ECO:0000250|UniProtKB:Q9W6I1}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TLN2_RBPMS2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TLN2_RBPMS2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TLN2PIP5K1C, TWF2, EXOC8, NUP93, ALB, SHFM1, RGCC, DCUN1D5, DDI2, DIAPH1, HAT1, SNF8, TRMT6, TRMT61A, TTC4, UBL7, CLK1, HNRNPD, SKP1, SYNCRIP, DGCR8, SGTB, CHMP4B, CDC5L, KANK4, CCND2RBPMS2VHL, RBFOX2, RBPMS, HAO2, DEFA6, ESRP1, TRIM11


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TLN2_RBPMS2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TLN2_RBPMS2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource