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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 38200

FusionGeneSummary for TLN1_TLN1

check button Fusion gene summary
Fusion gene informationFusion gene name: TLN1_TLN1
Fusion gene ID: 38200
HgeneTgene
Gene symbol

TLN1

TLN1

Gene ID

7094

7094

Gene nametalin 1talin 1
SynonymsILWEQ|TLN|talin-1ILWEQ|TLN|talin-1
Cytomap

9p13.3

9p13.3

Type of geneprotein-codingprotein-coding
Descriptiontalin-1talin-1
Modification date2018052220180522
UniProtAcc

Q9Y490

Q9Y490

Ensembl transtripts involved in fusion geneENST00000314888, ENST00000540444, 
ENST00000464379, 		ENST00000314888, 
ENST00000540444, ENST00000464379, 
Fusion gene scores* DoF score7 X 10 X 3=2108 X 8 X 5=320
# samples 1010
** MAII scorelog2(10/210*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/320*10)=-1.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TLN1 [Title/Abstract] AND TLN1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BI116596TLN1chr9

35700362

+TLN1chr9

35700308

-
ChiTaRS3.1BE695654TLN1chr9

35710651

-TLN1chr9

35710606

+
ChiTaRS3.1W28594TLN1chr9

35704070

+TLN1chr9

35704172

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000314888ENST00000314888TLN1chr9

35700362

+TLN1chr9

35700308

-
intron-3CDSENST00000314888ENST00000540444TLN1chr9

35700362

+TLN1chr9

35700308

-
intron-intronENST00000314888ENST00000464379TLN1chr9

35700362

+TLN1chr9

35700308

-
intron-3CDSENST00000540444ENST00000314888TLN1chr9

35700362

+TLN1chr9

35700308

-
intron-3CDSENST00000540444ENST00000540444TLN1chr9

35700362

+TLN1chr9

35700308

-
intron-intronENST00000540444ENST00000464379TLN1chr9

35700362

+TLN1chr9

35700308

-
intron-3CDSENST00000464379ENST00000314888TLN1chr9

35700362

+TLN1chr9

35700308

-
intron-3CDSENST00000464379ENST00000540444TLN1chr9

35700362

+TLN1chr9

35700308

-
intron-intronENST00000464379ENST00000464379TLN1chr9

35700362

+TLN1chr9

35700308

-
intron-3CDSENST00000314888ENST00000314888TLN1chr9

35710651

-TLN1chr9

35710606

+
intron-3CDSENST00000314888ENST00000540444TLN1chr9

35710651

-TLN1chr9

35710606

+
intron-intronENST00000314888ENST00000464379TLN1chr9

35710651

-TLN1chr9

35710606

+
intron-3CDSENST00000540444ENST00000314888TLN1chr9

35710651

-TLN1chr9

35710606

+
intron-3CDSENST00000540444ENST00000540444TLN1chr9

35710651

-TLN1chr9

35710606

+
intron-intronENST00000540444ENST00000464379TLN1chr9

35710651

-TLN1chr9

35710606

+
intron-3CDSENST00000464379ENST00000314888TLN1chr9

35710651

-TLN1chr9

35710606

+
intron-3CDSENST00000464379ENST00000540444TLN1chr9

35710651

-TLN1chr9

35710606

+
intron-intronENST00000464379ENST00000464379TLN1chr9

35710651

-TLN1chr9

35710606

+
intron-3CDSENST00000314888ENST00000314888TLN1chr9

35704070

+TLN1chr9

35704172

-
intron-3CDSENST00000314888ENST00000540444TLN1chr9

35704070

+TLN1chr9

35704172

-
intron-5UTRENST00000314888ENST00000464379TLN1chr9

35704070

+TLN1chr9

35704172

-
intron-3CDSENST00000540444ENST00000314888TLN1chr9

35704070

+TLN1chr9

35704172

-
intron-3CDSENST00000540444ENST00000540444TLN1chr9

35704070

+TLN1chr9

35704172

-
intron-5UTRENST00000540444ENST00000464379TLN1chr9

35704070

+TLN1chr9

35704172

-
intron-3CDSENST00000464379ENST00000314888TLN1chr9

35704070

+TLN1chr9

35704172

-
intron-3CDSENST00000464379ENST00000540444TLN1chr9

35704070

+TLN1chr9

35704172

-
intron-5UTRENST00000464379ENST00000464379TLN1chr9

35704070

+TLN1chr9

35704172

-

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FusionProtFeatures for TLN1_TLN1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TLN1

Q9Y490

TLN1

Q9Y490

Probably involved in connections of major cytoskeletalstructures to the plasma membrane. High molecular weightcytoskeletal protein concentrated at regions of cell-substratumcontact and, in lymphocytes, at cell-cell contacts (Bysimilarity). {ECO:0000250}. Probably involved in connections of major cytoskeletalstructures to the plasma membrane. High molecular weightcytoskeletal protein concentrated at regions of cell-substratumcontact and, in lymphocytes, at cell-cell contacts (Bysimilarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TLN1_TLN1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TLN1_TLN1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TLN1ITGB3, PXN, PTK2, ITGA1, PTK2B, ITGB1, TERF2, CDK5, SMURF1, DAG1, TUBA1A, SIRT7, BLNK, CDK2, UBA1, TRIP6, IARS, NAB2, DARS, USP19, TXLNG, TXNDC12, FN1, VCAM1, EGFR, ERBB2, ITGA4, PIP5K1C, YWHAQ, FAM114A1, CC2D1B, FAF1, NUDC, PRDX4, ASB9, SHMT2, MOV10, NXF1, CUL7, OBSL1, BLVRA, CYP1A1, RGCC, NMD3, RNASEH2C, GPKOW, TTC37, WAC, NTRK1, MED4, HNRNPD, KIF11, RBM4, SORT1, VCL, SYNCRIP, MRPL50, SGTB, SAMD1, BAG6, MCM2, SNW1, CDC5L, U2AF2, SRC, CDH1, KANK4, GTF2E2, FGB, SNRNP27, MTNR1A, MTNR1B, DNM1L, DOK1, ITGB7, BRCA1, TESTLN1ITGB3, PXN, PTK2, ITGA1, PTK2B, ITGB1, TERF2, CDK5, SMURF1, DAG1, TUBA1A, SIRT7, BLNK, CDK2, UBA1, TRIP6, IARS, NAB2, DARS, USP19, TXLNG, TXNDC12, FN1, VCAM1, EGFR, ERBB2, ITGA4, PIP5K1C, YWHAQ, FAM114A1, CC2D1B, FAF1, NUDC, PRDX4, ASB9, SHMT2, MOV10, NXF1, CUL7, OBSL1, BLVRA, CYP1A1, RGCC, NMD3, RNASEH2C, GPKOW, TTC37, WAC, NTRK1, MED4, HNRNPD, KIF11, RBM4, SORT1, VCL, SYNCRIP, MRPL50, SGTB, SAMD1, BAG6, MCM2, SNW1, CDC5L, U2AF2, SRC, CDH1, KANK4, GTF2E2, FGB, SNRNP27, MTNR1A, MTNR1B, DNM1L, DOK1, ITGB7, BRCA1, TES


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TLN1_TLN1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TLN1_TLN1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTLN1C0027626Neoplasm Invasiveness1CTD_human
HgeneTLN1C0029456Osteoporosis1CTD_human
TgeneTLN1C0027626Neoplasm Invasiveness1CTD_human
TgeneTLN1C0029456Osteoporosis1CTD_human