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Fusion gene ID: 38187 |
FusionGeneSummary for TLK2_FN3KRP |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TLK2_FN3KRP | Fusion gene ID: 38187 | Hgene | Tgene | Gene symbol | TLK2 | FN3KRP | Gene ID | 11011 | 79672 |
| Gene name | tousled like kinase 2 | fructosamine 3 kinase related protein | |
| Synonyms | HsHPK|PKU-ALPHA | FN3KL | |
| Cytomap | 17q23.2 | 17q25.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | serine/threonine-protein kinase tousled-like 2 | ketosamine-3-kinaseFN3K-related proteintestis secretory sperm-binding protein Li 211a | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q86UE8 | Q9HA64 | |
| Ensembl transtripts involved in fusion gene | ENST00000582809, ENST00000577616, ENST00000326270, ENST00000346027, ENST00000343388, ENST00000542523, | ENST00000269373, ENST00000535965, | |
| Fusion gene scores | * DoF score | 10 X 6 X 6=360 | 7 X 5 X 6=210 |
| # samples | 10 | 8 | |
| ** MAII score | log2(10/360*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/210*10)=-1.39231742277876 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TLK2 [Title/Abstract] AND FN3KRP [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TLK2 | GO:0001672 | regulation of chromatin assembly or disassembly | 12660173 |
| Hgene | TLK2 | GO:0006468 | protein phosphorylation | 12660173 |
| Hgene | TLK2 | GO:0006974 | cellular response to DNA damage stimulus | 12660173 |
| Hgene | TLK2 | GO:0018105 | peptidyl-serine phosphorylation | 20016786 |
| Hgene | TLK2 | GO:0035556 | intracellular signal transduction | 12660173 |
| Hgene | TLK2 | GO:0071480 | cellular response to gamma radiation | 12660173 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | UCS | TCGA-N8-A4PQ-01A | TLK2 | chr17 | 60558567 | + | FN3KRP | chr17 | 80676782 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000582809 | ENST00000269373 | TLK2 | chr17 | 60558567 | + | FN3KRP | chr17 | 80676782 | + |
| 5UTR-5UTR | ENST00000582809 | ENST00000535965 | TLK2 | chr17 | 60558567 | + | FN3KRP | chr17 | 80676782 | + |
| 3UTR-3CDS | ENST00000577616 | ENST00000269373 | TLK2 | chr17 | 60558567 | + | FN3KRP | chr17 | 80676782 | + |
| 3UTR-5UTR | ENST00000577616 | ENST00000535965 | TLK2 | chr17 | 60558567 | + | FN3KRP | chr17 | 80676782 | + |
| In-frame | ENST00000326270 | ENST00000269373 | TLK2 | chr17 | 60558567 | + | FN3KRP | chr17 | 80676782 | + |
| 5CDS-5UTR | ENST00000326270 | ENST00000535965 | TLK2 | chr17 | 60558567 | + | FN3KRP | chr17 | 80676782 | + |
| In-frame | ENST00000346027 | ENST00000269373 | TLK2 | chr17 | 60558567 | + | FN3KRP | chr17 | 80676782 | + |
| 5CDS-5UTR | ENST00000346027 | ENST00000535965 | TLK2 | chr17 | 60558567 | + | FN3KRP | chr17 | 80676782 | + |
| In-frame | ENST00000343388 | ENST00000269373 | TLK2 | chr17 | 60558567 | + | FN3KRP | chr17 | 80676782 | + |
| 5CDS-5UTR | ENST00000343388 | ENST00000535965 | TLK2 | chr17 | 60558567 | + | FN3KRP | chr17 | 80676782 | + |
| In-frame | ENST00000542523 | ENST00000269373 | TLK2 | chr17 | 60558567 | + | FN3KRP | chr17 | 80676782 | + |
| 5CDS-5UTR | ENST00000542523 | ENST00000535965 | TLK2 | chr17 | 60558567 | + | FN3KRP | chr17 | 80676782 | + |
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FusionProtFeatures for TLK2_FN3KRP |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TLK2 | FN3KRP |
| Serine/threonine-protein kinase involved in the processof chromatin assembly and probably also DNA replication,transcription, repair, and chromosome segregation. Phosphorylatesthe chromatin assembly factors ASF1A AND ASF1B. Phosphorylation ofASF1A prevents its proteasome-mediated degradation, therebyenhancing chromatin assembly. Negative regulator of amino acidstarvation-induced autophagy. {ECO:0000269|PubMed:10523312,ECO:0000269|PubMed:11470414, ECO:0000269|PubMed:12660173,ECO:0000269|PubMed:12955071, ECO:0000269|PubMed:20016786,ECO:0000269|PubMed:22354037, ECO:0000269|PubMed:9427565}. | Phosphorylates psicosamines and ribulosamines, but notfructosamines, on the third carbon of the sugar moiety. Protein-bound psicosamine 3-phosphates and ribulosamine 3-phosphates areunstable and decompose under physiological conditions. Thusphosphorylation leads to deglycation.{ECO:0000269|PubMed:14633848, ECO:0000269|PubMed:15137908}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TLK2_FN3KRP |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_TLK2_ENST00000326270_chr17_60558567_+_FN3KRP_ENST00000269373_chr17_80676782_+_290aa MMEELHSLDPRRQELLEARFTGVGVSKARRMFEGEMASLTAILKTNTVKVPKPIKVLDAPGGGSVLVMEHMDMRHLSSHAAKLGAQLADL HLDNKKLGEMRLKEAGTVGRGGGQEERPFVARFGFDVVTCCGYLPQVNDWQEDWVVFYARQRIQPQMDMVEKESGDREALQLWSALQLKI PDLFRDLEIIPALLHGDLWGGNVAEDSSGPVIFDPASFYGHSEYELAIAGMFGGFSSSFYSAYHGKIPKAPGFEKRLQLYQLFHYLNHWN >In-frame_TLK2_ENST00000346027_chr17_60558567_+_FN3KRP_ENST00000269373_chr17_80676782_+_290aa MMEELHSLDPRRQELLEARFTGVGVSKARRMFEGEMASLTAILKTNTVKVPKPIKVLDAPGGGSVLVMEHMDMRHLSSHAAKLGAQLADL HLDNKKLGEMRLKEAGTVGRGGGQEERPFVARFGFDVVTCCGYLPQVNDWQEDWVVFYARQRIQPQMDMVEKESGDREALQLWSALQLKI PDLFRDLEIIPALLHGDLWGGNVAEDSSGPVIFDPASFYGHSEYELAIAGMFGGFSSSFYSAYHGKIPKAPGFEKRLQLYQLFHYLNHWN >In-frame_TLK2_ENST00000343388_chr17_60558567_+_FN3KRP_ENST00000269373_chr17_80676782_+_290aa MMEELHSLDPRRQELLEARFTGVGVSKARRMFEGEMASLTAILKTNTVKVPKPIKVLDAPGGGSVLVMEHMDMRHLSSHAAKLGAQLADL HLDNKKLGEMRLKEAGTVGRGGGQEERPFVARFGFDVVTCCGYLPQVNDWQEDWVVFYARQRIQPQMDMVEKESGDREALQLWSALQLKI PDLFRDLEIIPALLHGDLWGGNVAEDSSGPVIFDPASFYGHSEYELAIAGMFGGFSSSFYSAYHGKIPKAPGFEKRLQLYQLFHYLNHWN >In-frame_TLK2_ENST00000542523_chr17_60558567_+_FN3KRP_ENST00000269373_chr17_80676782_+_290aa MMEELHSLDPRRQELLEARFTGVGVSKARRMFEGEMASLTAILKTNTVKVPKPIKVLDAPGGGSVLVMEHMDMRHLSSHAAKLGAQLADL HLDNKKLGEMRLKEAGTVGRGGGQEERPFVARFGFDVVTCCGYLPQVNDWQEDWVVFYARQRIQPQMDMVEKESGDREALQLWSALQLKI PDLFRDLEIIPALLHGDLWGGNVAEDSSGPVIFDPASFYGHSEYELAIAGMFGGFSSSFYSAYHGKIPKAPGFEKRLQLYQLFHYLNHWN |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_TLK2_ENST00000326270_chr17_60558567_+_FN3KRP_ENST00000269373_chr17_80676782_+_870nt ATGATGGAAGAATTGCATAGCCTGGACCCACGACGGCAGGAATTATTGGAGGCCAGGTTTACTGGAGTAGGTGTTAGTAAGGCCAGAAGA ATGTTTGAAGGTGAGATGGCAAGTTTAACTGCCATCCTGAAAACAAACACGGTGAAAGTGCCCAAGCCCATCAAGGTTCTGGATGCCCCA GGCGGCGGGAGCGTGCTGGTGATGGAGCACATGGACATGAGGCATCTGAGCAGTCATGCTGCAAAGCTTGGAGCCCAGCTGGCCGATTTA CACCTTGATAACAAGAAGCTTGGAGAGATGCGCCTGAAGGAGGCGGGCACAGTGGGGAGAGGAGGTGGGCAGGAGGAACGGCCCTTTGTG GCCCGGTTTGGATTTGACGTGGTGACGTGCTGTGGATACCTCCCCCAGGTGAATGACTGGCAGGAGGACTGGGTCGTGTTCTATGCCCGG CAGCGCATTCAGCCCCAGATGGACATGGTGGAGAAGGAGTCTGGGGACAGGGAGGCCCTCCAGCTTTGGTCTGCTCTGCAGTTAAAGATC CCTGACCTGTTCCGTGACCTGGAGATCATCCCAGCCTTACTCCACGGGGACCTCTGGGGTGGAAACGTAGCAGAGGATTCCTCTGGGCCG GTGATTTTTGACCCAGCTTCTTTCTACGGCCACTCGGAATATGAGCTGGCAATAGCTGGCATGTTTGGGGGCTTTAGCAGCTCCTTTTAC TCCGCCTACCACGGCAAAATCCCCAAGGCCCCAGGATTCGAGAAGCGCCTTCAGTTGTATCAGCTCTTTCACTACTTGAACCACTGGAAT >In-frame_TLK2_ENST00000346027_chr17_60558567_+_FN3KRP_ENST00000269373_chr17_80676782_+_870nt ATGATGGAAGAATTGCATAGCCTGGACCCACGACGGCAGGAATTATTGGAGGCCAGGTTTACTGGAGTAGGTGTTAGTAAGGCCAGAAGA ATGTTTGAAGGTGAGATGGCAAGTTTAACTGCCATCCTGAAAACAAACACGGTGAAAGTGCCCAAGCCCATCAAGGTTCTGGATGCCCCA GGCGGCGGGAGCGTGCTGGTGATGGAGCACATGGACATGAGGCATCTGAGCAGTCATGCTGCAAAGCTTGGAGCCCAGCTGGCCGATTTA CACCTTGATAACAAGAAGCTTGGAGAGATGCGCCTGAAGGAGGCGGGCACAGTGGGGAGAGGAGGTGGGCAGGAGGAACGGCCCTTTGTG GCCCGGTTTGGATTTGACGTGGTGACGTGCTGTGGATACCTCCCCCAGGTGAATGACTGGCAGGAGGACTGGGTCGTGTTCTATGCCCGG CAGCGCATTCAGCCCCAGATGGACATGGTGGAGAAGGAGTCTGGGGACAGGGAGGCCCTCCAGCTTTGGTCTGCTCTGCAGTTAAAGATC CCTGACCTGTTCCGTGACCTGGAGATCATCCCAGCCTTACTCCACGGGGACCTCTGGGGTGGAAACGTAGCAGAGGATTCCTCTGGGCCG GTGATTTTTGACCCAGCTTCTTTCTACGGCCACTCGGAATATGAGCTGGCAATAGCTGGCATGTTTGGGGGCTTTAGCAGCTCCTTTTAC TCCGCCTACCACGGCAAAATCCCCAAGGCCCCAGGATTCGAGAAGCGCCTTCAGTTGTATCAGCTCTTTCACTACTTGAACCACTGGAAT >In-frame_TLK2_ENST00000343388_chr17_60558567_+_FN3KRP_ENST00000269373_chr17_80676782_+_870nt ATGATGGAAGAATTGCATAGCCTGGACCCACGACGGCAGGAATTATTGGAGGCCAGGTTTACTGGAGTAGGTGTTAGTAAGGCCAGAAGA ATGTTTGAAGGTGAGATGGCAAGTTTAACTGCCATCCTGAAAACAAACACGGTGAAAGTGCCCAAGCCCATCAAGGTTCTGGATGCCCCA GGCGGCGGGAGCGTGCTGGTGATGGAGCACATGGACATGAGGCATCTGAGCAGTCATGCTGCAAAGCTTGGAGCCCAGCTGGCCGATTTA CACCTTGATAACAAGAAGCTTGGAGAGATGCGCCTGAAGGAGGCGGGCACAGTGGGGAGAGGAGGTGGGCAGGAGGAACGGCCCTTTGTG GCCCGGTTTGGATTTGACGTGGTGACGTGCTGTGGATACCTCCCCCAGGTGAATGACTGGCAGGAGGACTGGGTCGTGTTCTATGCCCGG CAGCGCATTCAGCCCCAGATGGACATGGTGGAGAAGGAGTCTGGGGACAGGGAGGCCCTCCAGCTTTGGTCTGCTCTGCAGTTAAAGATC CCTGACCTGTTCCGTGACCTGGAGATCATCCCAGCCTTACTCCACGGGGACCTCTGGGGTGGAAACGTAGCAGAGGATTCCTCTGGGCCG GTGATTTTTGACCCAGCTTCTTTCTACGGCCACTCGGAATATGAGCTGGCAATAGCTGGCATGTTTGGGGGCTTTAGCAGCTCCTTTTAC TCCGCCTACCACGGCAAAATCCCCAAGGCCCCAGGATTCGAGAAGCGCCTTCAGTTGTATCAGCTCTTTCACTACTTGAACCACTGGAAT >In-frame_TLK2_ENST00000542523_chr17_60558567_+_FN3KRP_ENST00000269373_chr17_80676782_+_870nt ATGATGGAAGAATTGCATAGCCTGGACCCACGACGGCAGGAATTATTGGAGGCCAGGTTTACTGGAGTAGGTGTTAGTAAGGCCAGAAGA ATGTTTGAAGGTGAGATGGCAAGTTTAACTGCCATCCTGAAAACAAACACGGTGAAAGTGCCCAAGCCCATCAAGGTTCTGGATGCCCCA GGCGGCGGGAGCGTGCTGGTGATGGAGCACATGGACATGAGGCATCTGAGCAGTCATGCTGCAAAGCTTGGAGCCCAGCTGGCCGATTTA CACCTTGATAACAAGAAGCTTGGAGAGATGCGCCTGAAGGAGGCGGGCACAGTGGGGAGAGGAGGTGGGCAGGAGGAACGGCCCTTTGTG GCCCGGTTTGGATTTGACGTGGTGACGTGCTGTGGATACCTCCCCCAGGTGAATGACTGGCAGGAGGACTGGGTCGTGTTCTATGCCCGG CAGCGCATTCAGCCCCAGATGGACATGGTGGAGAAGGAGTCTGGGGACAGGGAGGCCCTCCAGCTTTGGTCTGCTCTGCAGTTAAAGATC CCTGACCTGTTCCGTGACCTGGAGATCATCCCAGCCTTACTCCACGGGGACCTCTGGGGTGGAAACGTAGCAGAGGATTCCTCTGGGCCG GTGATTTTTGACCCAGCTTCTTTCTACGGCCACTCGGAATATGAGCTGGCAATAGCTGGCATGTTTGGGGGCTTTAGCAGCTCCTTTTAC TCCGCCTACCACGGCAAAATCCCCAAGGCCCCAGGATTCGAGAAGCGCCTTCAGTTGTATCAGCTCTTTCACTACTTGAACCACTGGAAT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_TLK2_ENST00000326270_chr17_60558567_+_FN3KRP_ENST00000269373_chr17_80676782_+_1984nt GCGGCCGCCCGGGCCCGGGCCCGCGTCGGGCGCCTGGCTCTGTACGCGAGCCCGGGGATCTGCGGCCTTCGTGCCCCCCCTCCCCCGCCC GCCCTCTCGTGGAGCCCGGCGCCGGCGGCGGCTGCCCGGGCGGGGGGTTGCGGCGCTCAGGAGAGGCCCCGGCTCCGCCCCGGGCCTGCC CAGGGGGAGAGCGGAGCGGTCCGCAGCCGGGTCGGGTCGGGGCCCCTCCCGGGAGGAGCGTGGAGCGGCGGCGGCGGCGGCGGCAGAAAT GATGGAAGAATTGCATAGCCTGGACCCACGACGGCAGGAATTATTGGAGGCCAGGTTTACTGGAGTAGGTGTTAGTAAGGCCAGAAGAAT GTTTGAAGGTGAGATGGCAAGTTTAACTGCCATCCTGAAAACAAACACGGTGAAAGTGCCCAAGCCCATCAAGGTTCTGGATGCCCCAGG CGGCGGGAGCGTGCTGGTGATGGAGCACATGGACATGAGGCATCTGAGCAGTCATGCTGCAAAGCTTGGAGCCCAGCTGGCCGATTTACA CCTTGATAACAAGAAGCTTGGAGAGATGCGCCTGAAGGAGGCGGGCACAGTGGGGAGAGGAGGTGGGCAGGAGGAACGGCCCTTTGTGGC CCGGTTTGGATTTGACGTGGTGACGTGCTGTGGATACCTCCCCCAGGTGAATGACTGGCAGGAGGACTGGGTCGTGTTCTATGCCCGGCA GCGCATTCAGCCCCAGATGGACATGGTGGAGAAGGAGTCTGGGGACAGGGAGGCCCTCCAGCTTTGGTCTGCTCTGCAGTTAAAGATCCC TGACCTGTTCCGTGACCTGGAGATCATCCCAGCCTTACTCCACGGGGACCTCTGGGGTGGAAACGTAGCAGAGGATTCCTCTGGGCCGGT GATTTTTGACCCAGCTTCTTTCTACGGCCACTCGGAATATGAGCTGGCAATAGCTGGCATGTTTGGGGGCTTTAGCAGCTCCTTTTACTC CGCCTACCACGGCAAAATCCCCAAGGCCCCAGGATTCGAGAAGCGCCTTCAGTTGTATCAGCTCTTTCACTACTTGAACCACTGGAATCA TTTTGGATCGGGGTACAGAGGATCCTCCCTGAACATCATGAGGAATCTGGTCAAGTGAGCGGGCCTTACTCTGGAAGGAGGCCTCAGAGG TTTCTCCACAGTCCTCTTCTGGGCAAATTCTTGTTTCTTCACATGCTGGACTAGCTTAAGACCAATGCAGTAGCTTATTTCCAAGCCTTG CAAAGTATATAATATCTAAGAGGAAAGGTTTTGTCATCCCAGCGTTGTCCACTTTGTGGGGCTTTGTAGGTAGACGGAGCCACACTACAG GCAGGGTATGAGCAGAGGGATGTATGGAGTGTGGGTGACTCTGAGCCTCACTGCTGCTGCAAGGTGGGGAAACTGTAAGTGAACCCCTGT GGGTGCGGGGGAGGGTATCCGGTGCGCAGGGAGGTGGCCAGCGCCCCCGGGCACTGCTGCTCATAGGTACCTTTCCACTGCCTCCTCCCT GCTCTCCTGTGCAGGAATGTCTCTGAGCTGTTCACGTTGATGCTTCTTGGTTGGCAAGACTTGGGTGTAGACATGAAACCATCTTACTAA AAGCGTCTTAAAATGACCAATTCCAGAATCAAGCGTATTCCGTTTTCTTCCTGCATGATCCCTGGGCCCTCCCGCAGGCTGAGCAAGTCT GTAAACTGATTCTGGGAGAAACCAAGCTGCTGGCCATAGGGTGTCCTTGGGTACATCCAGGAGTCTTCATTGCTTCTGTTATTACCCCGT CTCCTCTGCCATTTTCTACAGCTTGCTGAGTTGTCATTCCTTTGCAACATTAAAATACATGCTGAACTCATATTTTTCCTTCCTTCACTG TTGTAGTAAAGAGACATATTTCATGAATGGCATTGATGCTAATAAATCCTTTGCACAAAAATTTGAATAAACTTCCAGTGGTTTCGATAA >In-frame_TLK2_ENST00000346027_chr17_60558567_+_FN3KRP_ENST00000269373_chr17_80676782_+_1987nt GCGGCCGCCCGGGCCCGGGCCCGCGTCGGGCGCCTGGCTCTGTACGCGAGCCCGGGGATCTGCGGCCTTCGTGCCCCCCCTCCCCCGCCC GCCCTCTCGTGGAGCCCGGCGCCGGCGGCGGCTGCCCGGGCGGGGGGTTGCGGCGCTCAGGAGAGGCCCCGGCTCCGCCCCGGGCCTGCC CAGGGGGAGAGCGGAGCGGTCCGCAGCCGGGTCGGGTCGGGGCCCCTCCCGGGAGGAGCGTGGAGCGGCGGCGGCGGCGGCGGCAGCAGA AATGATGGAAGAATTGCATAGCCTGGACCCACGACGGCAGGAATTATTGGAGGCCAGGTTTACTGGAGTAGGTGTTAGTAAGGCCAGAAG AATGTTTGAAGGTGAGATGGCAAGTTTAACTGCCATCCTGAAAACAAACACGGTGAAAGTGCCCAAGCCCATCAAGGTTCTGGATGCCCC AGGCGGCGGGAGCGTGCTGGTGATGGAGCACATGGACATGAGGCATCTGAGCAGTCATGCTGCAAAGCTTGGAGCCCAGCTGGCCGATTT ACACCTTGATAACAAGAAGCTTGGAGAGATGCGCCTGAAGGAGGCGGGCACAGTGGGGAGAGGAGGTGGGCAGGAGGAACGGCCCTTTGT GGCCCGGTTTGGATTTGACGTGGTGACGTGCTGTGGATACCTCCCCCAGGTGAATGACTGGCAGGAGGACTGGGTCGTGTTCTATGCCCG GCAGCGCATTCAGCCCCAGATGGACATGGTGGAGAAGGAGTCTGGGGACAGGGAGGCCCTCCAGCTTTGGTCTGCTCTGCAGTTAAAGAT CCCTGACCTGTTCCGTGACCTGGAGATCATCCCAGCCTTACTCCACGGGGACCTCTGGGGTGGAAACGTAGCAGAGGATTCCTCTGGGCC GGTGATTTTTGACCCAGCTTCTTTCTACGGCCACTCGGAATATGAGCTGGCAATAGCTGGCATGTTTGGGGGCTTTAGCAGCTCCTTTTA CTCCGCCTACCACGGCAAAATCCCCAAGGCCCCAGGATTCGAGAAGCGCCTTCAGTTGTATCAGCTCTTTCACTACTTGAACCACTGGAA TCATTTTGGATCGGGGTACAGAGGATCCTCCCTGAACATCATGAGGAATCTGGTCAAGTGAGCGGGCCTTACTCTGGAAGGAGGCCTCAG AGGTTTCTCCACAGTCCTCTTCTGGGCAAATTCTTGTTTCTTCACATGCTGGACTAGCTTAAGACCAATGCAGTAGCTTATTTCCAAGCC TTGCAAAGTATATAATATCTAAGAGGAAAGGTTTTGTCATCCCAGCGTTGTCCACTTTGTGGGGCTTTGTAGGTAGACGGAGCCACACTA CAGGCAGGGTATGAGCAGAGGGATGTATGGAGTGTGGGTGACTCTGAGCCTCACTGCTGCTGCAAGGTGGGGAAACTGTAAGTGAACCCC TGTGGGTGCGGGGGAGGGTATCCGGTGCGCAGGGAGGTGGCCAGCGCCCCCGGGCACTGCTGCTCATAGGTACCTTTCCACTGCCTCCTC CCTGCTCTCCTGTGCAGGAATGTCTCTGAGCTGTTCACGTTGATGCTTCTTGGTTGGCAAGACTTGGGTGTAGACATGAAACCATCTTAC TAAAAGCGTCTTAAAATGACCAATTCCAGAATCAAGCGTATTCCGTTTTCTTCCTGCATGATCCCTGGGCCCTCCCGCAGGCTGAGCAAG TCTGTAAACTGATTCTGGGAGAAACCAAGCTGCTGGCCATAGGGTGTCCTTGGGTACATCCAGGAGTCTTCATTGCTTCTGTTATTACCC CGTCTCCTCTGCCATTTTCTACAGCTTGCTGAGTTGTCATTCCTTTGCAACATTAAAATACATGCTGAACTCATATTTTTCCTTCCTTCA CTGTTGTAGTAAAGAGACATATTTCATGAATGGCATTGATGCTAATAAATCCTTTGCACAAAAATTTGAATAAACTTCCAGTGGTTTCGA >In-frame_TLK2_ENST00000343388_chr17_60558567_+_FN3KRP_ENST00000269373_chr17_80676782_+_1862nt CCGGGCGGGGGGTTGCGGCGCTCAGGAGAGGCCCCGGCTCCGCCCCGGGCCTGCCCAGGGGGAGAGCGGAGCGGTCCGCAGCCGGGTCGG GTCGGGGCCCCTCCCGGGAGGAGCGTGGAGCGGCGGCGGCGGCGGCGGCAGCAGAAATGATGGAAGAATTGCATAGCCTGGACCCACGAC GGCAGGAATTATTGGAGGCCAGGTTTACTGGAGTAGGTGTTAGTAAGGCCAGAAGAATGTTTGAAGGTGAGATGGCAAGTTTAACTGCCA TCCTGAAAACAAACACGGTGAAAGTGCCCAAGCCCATCAAGGTTCTGGATGCCCCAGGCGGCGGGAGCGTGCTGGTGATGGAGCACATGG ACATGAGGCATCTGAGCAGTCATGCTGCAAAGCTTGGAGCCCAGCTGGCCGATTTACACCTTGATAACAAGAAGCTTGGAGAGATGCGCC TGAAGGAGGCGGGCACAGTGGGGAGAGGAGGTGGGCAGGAGGAACGGCCCTTTGTGGCCCGGTTTGGATTTGACGTGGTGACGTGCTGTG GATACCTCCCCCAGGTGAATGACTGGCAGGAGGACTGGGTCGTGTTCTATGCCCGGCAGCGCATTCAGCCCCAGATGGACATGGTGGAGA AGGAGTCTGGGGACAGGGAGGCCCTCCAGCTTTGGTCTGCTCTGCAGTTAAAGATCCCTGACCTGTTCCGTGACCTGGAGATCATCCCAG CCTTACTCCACGGGGACCTCTGGGGTGGAAACGTAGCAGAGGATTCCTCTGGGCCGGTGATTTTTGACCCAGCTTCTTTCTACGGCCACT CGGAATATGAGCTGGCAATAGCTGGCATGTTTGGGGGCTTTAGCAGCTCCTTTTACTCCGCCTACCACGGCAAAATCCCCAAGGCCCCAG GATTCGAGAAGCGCCTTCAGTTGTATCAGCTCTTTCACTACTTGAACCACTGGAATCATTTTGGATCGGGGTACAGAGGATCCTCCCTGA ACATCATGAGGAATCTGGTCAAGTGAGCGGGCCTTACTCTGGAAGGAGGCCTCAGAGGTTTCTCCACAGTCCTCTTCTGGGCAAATTCTT GTTTCTTCACATGCTGGACTAGCTTAAGACCAATGCAGTAGCTTATTTCCAAGCCTTGCAAAGTATATAATATCTAAGAGGAAAGGTTTT GTCATCCCAGCGTTGTCCACTTTGTGGGGCTTTGTAGGTAGACGGAGCCACACTACAGGCAGGGTATGAGCAGAGGGATGTATGGAGTGT GGGTGACTCTGAGCCTCACTGCTGCTGCAAGGTGGGGAAACTGTAAGTGAACCCCTGTGGGTGCGGGGGAGGGTATCCGGTGCGCAGGGA GGTGGCCAGCGCCCCCGGGCACTGCTGCTCATAGGTACCTTTCCACTGCCTCCTCCCTGCTCTCCTGTGCAGGAATGTCTCTGAGCTGTT CACGTTGATGCTTCTTGGTTGGCAAGACTTGGGTGTAGACATGAAACCATCTTACTAAAAGCGTCTTAAAATGACCAATTCCAGAATCAA GCGTATTCCGTTTTCTTCCTGCATGATCCCTGGGCCCTCCCGCAGGCTGAGCAAGTCTGTAAACTGATTCTGGGAGAAACCAAGCTGCTG GCCATAGGGTGTCCTTGGGTACATCCAGGAGTCTTCATTGCTTCTGTTATTACCCCGTCTCCTCTGCCATTTTCTACAGCTTGCTGAGTT GTCATTCCTTTGCAACATTAAAATACATGCTGAACTCATATTTTTCCTTCCTTCACTGTTGTAGTAAAGAGACATATTTCATGAATGGCA >In-frame_TLK2_ENST00000542523_chr17_60558567_+_FN3KRP_ENST00000269373_chr17_80676782_+_1741nt AAGGAATTTTCTTTTTGCAGCAGAAATGATGGAAGAATTGCATAGCCTGGACCCACGACGGCAGGAATTATTGGAGGCCAGGTTTACTGG AGTAGGTGTTAGTAAGGCCAGAAGAATGTTTGAAGGTGAGATGGCAAGTTTAACTGCCATCCTGAAAACAAACACGGTGAAAGTGCCCAA GCCCATCAAGGTTCTGGATGCCCCAGGCGGCGGGAGCGTGCTGGTGATGGAGCACATGGACATGAGGCATCTGAGCAGTCATGCTGCAAA GCTTGGAGCCCAGCTGGCCGATTTACACCTTGATAACAAGAAGCTTGGAGAGATGCGCCTGAAGGAGGCGGGCACAGTGGGGAGAGGAGG TGGGCAGGAGGAACGGCCCTTTGTGGCCCGGTTTGGATTTGACGTGGTGACGTGCTGTGGATACCTCCCCCAGGTGAATGACTGGCAGGA GGACTGGGTCGTGTTCTATGCCCGGCAGCGCATTCAGCCCCAGATGGACATGGTGGAGAAGGAGTCTGGGGACAGGGAGGCCCTCCAGCT TTGGTCTGCTCTGCAGTTAAAGATCCCTGACCTGTTCCGTGACCTGGAGATCATCCCAGCCTTACTCCACGGGGACCTCTGGGGTGGAAA CGTAGCAGAGGATTCCTCTGGGCCGGTGATTTTTGACCCAGCTTCTTTCTACGGCCACTCGGAATATGAGCTGGCAATAGCTGGCATGTT TGGGGGCTTTAGCAGCTCCTTTTACTCCGCCTACCACGGCAAAATCCCCAAGGCCCCAGGATTCGAGAAGCGCCTTCAGTTGTATCAGCT CTTTCACTACTTGAACCACTGGAATCATTTTGGATCGGGGTACAGAGGATCCTCCCTGAACATCATGAGGAATCTGGTCAAGTGAGCGGG CCTTACTCTGGAAGGAGGCCTCAGAGGTTTCTCCACAGTCCTCTTCTGGGCAAATTCTTGTTTCTTCACATGCTGGACTAGCTTAAGACC AATGCAGTAGCTTATTTCCAAGCCTTGCAAAGTATATAATATCTAAGAGGAAAGGTTTTGTCATCCCAGCGTTGTCCACTTTGTGGGGCT TTGTAGGTAGACGGAGCCACACTACAGGCAGGGTATGAGCAGAGGGATGTATGGAGTGTGGGTGACTCTGAGCCTCACTGCTGCTGCAAG GTGGGGAAACTGTAAGTGAACCCCTGTGGGTGCGGGGGAGGGTATCCGGTGCGCAGGGAGGTGGCCAGCGCCCCCGGGCACTGCTGCTCA TAGGTACCTTTCCACTGCCTCCTCCCTGCTCTCCTGTGCAGGAATGTCTCTGAGCTGTTCACGTTGATGCTTCTTGGTTGGCAAGACTTG GGTGTAGACATGAAACCATCTTACTAAAAGCGTCTTAAAATGACCAATTCCAGAATCAAGCGTATTCCGTTTTCTTCCTGCATGATCCCT GGGCCCTCCCGCAGGCTGAGCAAGTCTGTAAACTGATTCTGGGAGAAACCAAGCTGCTGGCCATAGGGTGTCCTTGGGTACATCCAGGAG TCTTCATTGCTTCTGTTATTACCCCGTCTCCTCTGCCATTTTCTACAGCTTGCTGAGTTGTCATTCCTTTGCAACATTAAAATACATGCT GAACTCATATTTTTCCTTCCTTCACTGTTGTAGTAAAGAGACATATTTCATGAATGGCATTGATGCTAATAAATCCTTTGCACAAAAATT |
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FusionGenePPI for TLK2_FN3KRP |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TLK2 | ASF1B, ASF1A, TLK1, FEZ1, FEZ2, AURKA, IRF4, IRF7, ELAVL1, XPO7, XPO1, RPS6KA1, RFPL3, EID3, LHX6, STK24, NTRK1, DYNLL1, NFATC2, SPATA1, RPS27A, CABIN1, IL36A, DYNLL2, AMOTL1, IFFO1, CDADC1, SCML1, COBLL1 | FN3KRP | USP43, CUL3, CUL4B, APP, EGFR, LTF, LACRT, PIGR, IGHA1, MCM2, DUSP23, DOHH, BRCA1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TLK2_FN3KRP |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TLK2_FN3KRP |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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