FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 38184

FusionGeneSummary for TLK2_BCAS3

check button Fusion gene summary
Fusion gene informationFusion gene name: TLK2_BCAS3
Fusion gene ID: 38184
HgeneTgene
Gene symbol

TLK2

BCAS3

Gene ID

11011

54828

Gene nametousled like kinase 2BCAS3, microtubule associated cell migration factor
SynonymsHsHPK|PKU-ALPHAGAOB1|MAAB
Cytomap

17q23.2

17q23.2

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase tousled-like 2breast carcinoma-amplified sequence 3BCAS4/BCAS3 fusionRudhirabreast carcinoma amplified sequence 4/3 fusion proteinmetastasis associated antigen of breast cancerprotein Maab1
Modification date2018051920180523
UniProtAcc

Q86UE8

Q9H6U6

Ensembl transtripts involved in fusion geneENST00000582809, ENST00000577616, 
ENST00000326270, ENST00000346027, 
ENST00000343388, ENST00000542523, 
ENST00000589222, ENST00000407086, 
ENST00000390652, ENST00000408905, 
ENST00000588462, ENST00000585744, 
ENST00000588874, ENST00000585812, 
Fusion gene scores* DoF score10 X 6 X 6=36026 X 15 X 15=5850
# samples 1041
** MAII scorelog2(10/360*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(41/5850*10)=-3.83474080985268
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TLK2 [Title/Abstract] AND BCAS3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Kinase involved fusion gene, inframe and retained kinase domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTLK2

GO:0001672

regulation of chromatin assembly or disassembly

12660173

HgeneTLK2

GO:0006468

protein phosphorylation

12660173

HgeneTLK2

GO:0006974

cellular response to DNA damage stimulus

12660173

HgeneTLK2

GO:0018105

peptidyl-serine phosphorylation

20016786

HgeneTLK2

GO:0035556

intracellular signal transduction

12660173

HgeneTLK2

GO:0071480

cellular response to gamma radiation

12660173

TgeneBCAS3

GO:0043085

positive regulation of catalytic activity

17505058

TgeneBCAS3

GO:0045944

positive regulation of transcription by RNA polymerase II

17505058

TgeneBCAS3

GO:0071391

cellular response to estrogen stimulus

17505058


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUSCTCGA-94-7943-01ATLK2chr17

60558567

+BCAS3chr17

58945937

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000582809ENST00000589222TLK2chr17

60558567

+BCAS3chr17

58945937

+
5UTR-3CDSENST00000582809ENST00000407086TLK2chr17

60558567

+BCAS3chr17

58945937

+
5UTR-3CDSENST00000582809ENST00000390652TLK2chr17

60558567

+BCAS3chr17

58945937

+
5UTR-3CDSENST00000582809ENST00000408905TLK2chr17

60558567

+BCAS3chr17

58945937

+
5UTR-3CDSENST00000582809ENST00000588462TLK2chr17

60558567

+BCAS3chr17

58945937

+
5UTR-intronENST00000582809ENST00000585744TLK2chr17

60558567

+BCAS3chr17

58945937

+
5UTR-intronENST00000582809ENST00000588874TLK2chr17

60558567

+BCAS3chr17

58945937

+
5UTR-intronENST00000582809ENST00000585812TLK2chr17

60558567

+BCAS3chr17

58945937

+
3UTR-3CDSENST00000577616ENST00000589222TLK2chr17

60558567

+BCAS3chr17

58945937

+
3UTR-3CDSENST00000577616ENST00000407086TLK2chr17

60558567

+BCAS3chr17

58945937

+
3UTR-3CDSENST00000577616ENST00000390652TLK2chr17

60558567

+BCAS3chr17

58945937

+
3UTR-3CDSENST00000577616ENST00000408905TLK2chr17

60558567

+BCAS3chr17

58945937

+
3UTR-3CDSENST00000577616ENST00000588462TLK2chr17

60558567

+BCAS3chr17

58945937

+
3UTR-intronENST00000577616ENST00000585744TLK2chr17

60558567

+BCAS3chr17

58945937

+
3UTR-intronENST00000577616ENST00000588874TLK2chr17

60558567

+BCAS3chr17

58945937

+
3UTR-intronENST00000577616ENST00000585812TLK2chr17

60558567

+BCAS3chr17

58945937

+
Frame-shitENST00000326270ENST00000589222TLK2chr17

60558567

+BCAS3chr17

58945937

+
Frame-shitENST00000326270ENST00000407086TLK2chr17

60558567

+BCAS3chr17

58945937

+
Frame-shitENST00000326270ENST00000390652TLK2chr17

60558567

+BCAS3chr17

58945937

+
Frame-shitENST00000326270ENST00000408905TLK2chr17

60558567

+BCAS3chr17

58945937

+
Frame-shitENST00000326270ENST00000588462TLK2chr17

60558567

+BCAS3chr17

58945937

+
5CDS-intronENST00000326270ENST00000585744TLK2chr17

60558567

+BCAS3chr17

58945937

+
5CDS-intronENST00000326270ENST00000588874TLK2chr17

60558567

+BCAS3chr17

58945937

+
5CDS-intronENST00000326270ENST00000585812TLK2chr17

60558567

+BCAS3chr17

58945937

+
Frame-shitENST00000346027ENST00000589222TLK2chr17

60558567

+BCAS3chr17

58945937

+
Frame-shitENST00000346027ENST00000407086TLK2chr17

60558567

+BCAS3chr17

58945937

+
Frame-shitENST00000346027ENST00000390652TLK2chr17

60558567

+BCAS3chr17

58945937

+
Frame-shitENST00000346027ENST00000408905TLK2chr17

60558567

+BCAS3chr17

58945937

+
Frame-shitENST00000346027ENST00000588462TLK2chr17

60558567

+BCAS3chr17

58945937

+
5CDS-intronENST00000346027ENST00000585744TLK2chr17

60558567

+BCAS3chr17

58945937

+
5CDS-intronENST00000346027ENST00000588874TLK2chr17

60558567

+BCAS3chr17

58945937

+
5CDS-intronENST00000346027ENST00000585812TLK2chr17

60558567

+BCAS3chr17

58945937

+
Frame-shitENST00000343388ENST00000589222TLK2chr17

60558567

+BCAS3chr17

58945937

+
Frame-shitENST00000343388ENST00000407086TLK2chr17

60558567

+BCAS3chr17

58945937

+
Frame-shitENST00000343388ENST00000390652TLK2chr17

60558567

+BCAS3chr17

58945937

+
Frame-shitENST00000343388ENST00000408905TLK2chr17

60558567

+BCAS3chr17

58945937

+
Frame-shitENST00000343388ENST00000588462TLK2chr17

60558567

+BCAS3chr17

58945937

+
5CDS-intronENST00000343388ENST00000585744TLK2chr17

60558567

+BCAS3chr17

58945937

+
5CDS-intronENST00000343388ENST00000588874TLK2chr17

60558567

+BCAS3chr17

58945937

+
5CDS-intronENST00000343388ENST00000585812TLK2chr17

60558567

+BCAS3chr17

58945937

+
Frame-shitENST00000542523ENST00000589222TLK2chr17

60558567

+BCAS3chr17

58945937

+
Frame-shitENST00000542523ENST00000407086TLK2chr17

60558567

+BCAS3chr17

58945937

+
Frame-shitENST00000542523ENST00000390652TLK2chr17

60558567

+BCAS3chr17

58945937

+
Frame-shitENST00000542523ENST00000408905TLK2chr17

60558567

+BCAS3chr17

58945937

+
Frame-shitENST00000542523ENST00000588462TLK2chr17

60558567

+BCAS3chr17

58945937

+
5CDS-intronENST00000542523ENST00000585744TLK2chr17

60558567

+BCAS3chr17

58945937

+
5CDS-intronENST00000542523ENST00000588874TLK2chr17

60558567

+BCAS3chr17

58945937

+
5CDS-intronENST00000542523ENST00000585812TLK2chr17

60558567

+BCAS3chr17

58945937

+

Top

FusionProtFeatures for TLK2_BCAS3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TLK2

Q86UE8

BCAS3

Q9H6U6

Serine/threonine-protein kinase involved in the processof chromatin assembly and probably also DNA replication,transcription, repair, and chromosome segregation. Phosphorylatesthe chromatin assembly factors ASF1A AND ASF1B. Phosphorylation ofASF1A prevents its proteasome-mediated degradation, therebyenhancing chromatin assembly. Negative regulator of amino acidstarvation-induced autophagy. {ECO:0000269|PubMed:10523312,ECO:0000269|PubMed:11470414, ECO:0000269|PubMed:12660173,ECO:0000269|PubMed:12955071, ECO:0000269|PubMed:20016786,ECO:0000269|PubMed:22354037, ECO:0000269|PubMed:9427565}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for TLK2_BCAS3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for TLK2_BCAS3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TLK2ASF1B, ASF1A, TLK1, FEZ1, FEZ2, AURKA, IRF4, IRF7, ELAVL1, XPO7, XPO1, RPS6KA1, RFPL3, EID3, LHX6, STK24, NTRK1, DYNLL1, NFATC2, SPATA1, RPS27A, CABIN1, IL36A, DYNLL2, AMOTL1, IFFO1, CDADC1, SCML1, COBLL1BCAS3CTBP1, CTBP2, CDC23, C16orf70, ZDHHC17, ESR1, PELP1, HIST1H3A, KAT2B, WIPI2, ATM, BAG4, CCND1, FBXW7, KRAS, PALB2, PHB, PTPN1, SMAD4, STK11, TGFB1, TSG101, XRCC3, OFD1, CEP128, FBF1, NPHP1, SCLT1, XPO1, CD14, HDAC1, IRF3, MAGEE1, IL17RA, DOCK5, VWA5A, RAB2B


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for TLK2_BCAS3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for TLK2_BCAS3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource