FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 38173

FusionGeneSummary for TLE4_UBC

check button Fusion gene summary
Fusion gene informationFusion gene name: TLE4_UBC
Fusion gene ID: 38173
HgeneTgene
Gene symbol

TLE4

UBC

Gene ID

7091

7316

Gene nametransducin like enhancer of split 4ubiquitin C
SynonymsBCE-1|BCE1|E(spI)|ESG|ESG4|GRG4|Grg-4HMG20
Cytomap

9q21.31

12q24.31

Type of geneprotein-codingprotein-coding
Descriptiontransducin-like enhancer protein 4B lymphocyte gene 1enhancer of split groucho 4groucho-related protein 4transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)transducin-like enhancer of split 4, homolog of Drosophila E(sp1)polyubiquitin-C
Modification date2018052320180523
UniProtAcc

Q04727

P0CG48

Ensembl transtripts involved in fusion geneENST00000376552, ENST00000376520, 
ENST00000376544, ENST00000376537, 
ENST00000376534, ENST00000265284, 
ENST00000455913, 
ENST00000536769, 
ENST00000538617, ENST00000546120, 
ENST00000339647, ENST00000536661, 
Fusion gene scores* DoF score1 X 1 X 1=114 X 14 X 3=588
# samples 115
** MAII scorelog2(1/1*10)=3.32192809488736log2(15/588*10)=-1.97085365434048
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TLE4 [Title/Abstract] AND UBC [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA362969TLE4chr9

82291611

+UBCchr12

125399201

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000376552ENST00000536769TLE4chr9

82291611

+UBCchr12

125399201

-
intron-5UTRENST00000376552ENST00000538617TLE4chr9

82291611

+UBCchr12

125399201

-
intron-5UTRENST00000376552ENST00000546120TLE4chr9

82291611

+UBCchr12

125399201

-
intron-5UTRENST00000376552ENST00000339647TLE4chr9

82291611

+UBCchr12

125399201

-
intron-5UTRENST00000376552ENST00000536661TLE4chr9

82291611

+UBCchr12

125399201

-
intron-5UTRENST00000376520ENST00000536769TLE4chr9

82291611

+UBCchr12

125399201

-
intron-5UTRENST00000376520ENST00000538617TLE4chr9

82291611

+UBCchr12

125399201

-
intron-5UTRENST00000376520ENST00000546120TLE4chr9

82291611

+UBCchr12

125399201

-
intron-5UTRENST00000376520ENST00000339647TLE4chr9

82291611

+UBCchr12

125399201

-
intron-5UTRENST00000376520ENST00000536661TLE4chr9

82291611

+UBCchr12

125399201

-
intron-5UTRENST00000376544ENST00000536769TLE4chr9

82291611

+UBCchr12

125399201

-
intron-5UTRENST00000376544ENST00000538617TLE4chr9

82291611

+UBCchr12

125399201

-
intron-5UTRENST00000376544ENST00000546120TLE4chr9

82291611

+UBCchr12

125399201

-
intron-5UTRENST00000376544ENST00000339647TLE4chr9

82291611

+UBCchr12

125399201

-
intron-5UTRENST00000376544ENST00000536661TLE4chr9

82291611

+UBCchr12

125399201

-
intron-5UTRENST00000376537ENST00000536769TLE4chr9

82291611

+UBCchr12

125399201

-
intron-5UTRENST00000376537ENST00000538617TLE4chr9

82291611

+UBCchr12

125399201

-
intron-5UTRENST00000376537ENST00000546120TLE4chr9

82291611

+UBCchr12

125399201

-
intron-5UTRENST00000376537ENST00000339647TLE4chr9

82291611

+UBCchr12

125399201

-
intron-5UTRENST00000376537ENST00000536661TLE4chr9

82291611

+UBCchr12

125399201

-
intron-5UTRENST00000376534ENST00000536769TLE4chr9

82291611

+UBCchr12

125399201

-
intron-5UTRENST00000376534ENST00000538617TLE4chr9

82291611

+UBCchr12

125399201

-
intron-5UTRENST00000376534ENST00000546120TLE4chr9

82291611

+UBCchr12

125399201

-
intron-5UTRENST00000376534ENST00000339647TLE4chr9

82291611

+UBCchr12

125399201

-
intron-5UTRENST00000376534ENST00000536661TLE4chr9

82291611

+UBCchr12

125399201

-
intron-5UTRENST00000265284ENST00000536769TLE4chr9

82291611

+UBCchr12

125399201

-
intron-5UTRENST00000265284ENST00000538617TLE4chr9

82291611

+UBCchr12

125399201

-
intron-5UTRENST00000265284ENST00000546120TLE4chr9

82291611

+UBCchr12

125399201

-
intron-5UTRENST00000265284ENST00000339647TLE4chr9

82291611

+UBCchr12

125399201

-
intron-5UTRENST00000265284ENST00000536661TLE4chr9

82291611

+UBCchr12

125399201

-
intron-5UTRENST00000455913ENST00000536769TLE4chr9

82291611

+UBCchr12

125399201

-
intron-5UTRENST00000455913ENST00000538617TLE4chr9

82291611

+UBCchr12

125399201

-
intron-5UTRENST00000455913ENST00000546120TLE4chr9

82291611

+UBCchr12

125399201

-
intron-5UTRENST00000455913ENST00000339647TLE4chr9

82291611

+UBCchr12

125399201

-
intron-5UTRENST00000455913ENST00000536661TLE4chr9

82291611

+UBCchr12

125399201

-

Top

FusionProtFeatures for TLE4_UBC


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TLE4

Q04727

UBC

P0CG48


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for TLE4_UBC


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for TLE4_UBC


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for TLE4_UBC


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for TLE4_UBC


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTLE4C0024667Animal Mammary Neoplasms1CTD_human
HgeneTLE4C0024668Mammary Neoplasms, Experimental1CTD_human
HgeneTLE4C0151744Myocardial Ischemia1CTD_human