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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 3817

FusionGeneSummary for BAIAP2L2_TMEM184B

check button Fusion gene summary
Fusion gene informationFusion gene name: BAIAP2L2_TMEM184B
Fusion gene ID: 3817
HgeneTgene
Gene symbol

BAIAP2L2

TMEM184B

Gene ID

80115

25829

Gene nameBAI1 associated protein 2 like 2transmembrane protein 184B
Synonyms-C22orf5|FM08|HS5O6A|HSPC256
Cytomap

22q13.1

22q13.1

Type of geneprotein-codingprotein-coding
Descriptionbrain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2BAI1-associated protein 2-like protein 2pinkbarplanar intestinal- and kidney-specific BAR domain proteintransmembrane protein 184Bputative MAPK-activating protein FM08
Modification date2018052320180523
UniProtAcc

Q6UXY1

Q9Y519

Ensembl transtripts involved in fusion geneENST00000381669, ENST00000332536, 
ENST00000361906, ENST00000361684, 
ENST00000504337, 
Fusion gene scores* DoF score2 X 2 X 3=126 X 5 X 7=210
# samples 38
** MAII scorelog2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(8/210*10)=-1.39231742277876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BAIAP2L2 [Title/Abstract] AND TMEM184B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVESCATCGA-L5-A4OQ-01ABAIAP2L2chr22

38493039

-TMEM184Bchr22

38627340

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000381669ENST00000361906BAIAP2L2chr22

38493039

-TMEM184Bchr22

38627340

-
Frame-shiftENST00000381669ENST00000361684BAIAP2L2chr22

38493039

-TMEM184Bchr22

38627340

-
5CDS-intronENST00000381669ENST00000504337BAIAP2L2chr22

38493039

-TMEM184Bchr22

38627340

-
Frame-shiftENST00000332536ENST00000361906BAIAP2L2chr22

38493039

-TMEM184Bchr22

38627340

-
Frame-shiftENST00000332536ENST00000361684BAIAP2L2chr22

38493039

-TMEM184Bchr22

38627340

-
5CDS-intronENST00000332536ENST00000504337BAIAP2L2chr22

38493039

-TMEM184Bchr22

38627340

-

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FusionProtFeatures for BAIAP2L2_TMEM184B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BAIAP2L2

Q6UXY1

TMEM184B

Q9Y519

Phosphoinositides-binding protein that induces theformation of planar or gently curved membrane structures. Binds tophosphoinositides, including to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) headgroups. There seems to be noclear preference for a specific phosphoinositide (By similarity).{ECO:0000250}. May activate the MAP kinase signaling pathway.{ECO:0000269|PubMed:12761501}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for BAIAP2L2_TMEM184B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for BAIAP2L2_TMEM184B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
BAIAP2L2TMEM184BLPAR6, ERGIC3, SNIP1, REN, CLASRP, CCDC9, ACIN1, INPPL1, TIMM23, FPR2, GPR21, C17orf85, SLC22A9, CLEC2D, YTHDF1, ZFYVE27, PDCD1, ABCG8, BBS4


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for BAIAP2L2_TMEM184B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for BAIAP2L2_TMEM184B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTMEM184BC0023893Liver Cirrhosis, Experimental1CTD_human