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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 38169

FusionGeneSummary for TLE3_MLKL

check button Fusion gene summary
Fusion gene informationFusion gene name: TLE3_MLKL
Fusion gene ID: 38169
HgeneTgene
Gene symbol

TLE3

MLKL

Gene ID

7090

197259

Gene nametransducin like enhancer of split 3mixed lineage kinase domain like pseudokinase
SynonymsESG|ESG3|GRG3|HsT18976hMLKL
Cytomap

15q23

16q23.1

Type of geneprotein-codingprotein-coding
Descriptiontransducin-like enhancer protein 3enhancer of split groucho 3enhancer of split groucho-like protein 3transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)transducin-like enhancer of split 3 short isoformtransducin-like enhancer of split 3,mixed lineage kinase domain-like protein
Modification date2018052320180523
UniProtAcc

Q04726

Q8NB16

Ensembl transtripts involved in fusion geneENST00000558939, ENST00000442299, 
ENST00000317509, ENST00000560589, 
ENST00000559929, ENST00000559048, 
ENST00000560939, ENST00000557997, 
ENST00000539550, ENST00000558201, 
ENST00000440567, ENST00000559191, 
ENST00000558379, ENST00000557907, 
ENST00000451782, ENST00000559574, 
ENST00000306247, ENST00000308807, 
Fusion gene scores* DoF score6 X 5 X 4=1201 X 1 X 1=1
# samples 61
** MAII scorelog2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: TLE3 [Title/Abstract] AND MLKL [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMLKL

GO:0070207

protein homotrimerization

24316671


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF895963TLE3chr15

70344732

+MLKLchr16

74729448

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000558939ENST00000306247TLE3chr15

70344732

+MLKLchr16

74729448

-
intron-3CDSENST00000558939ENST00000308807TLE3chr15

70344732

+MLKLchr16

74729448

-
intron-3CDSENST00000442299ENST00000306247TLE3chr15

70344732

+MLKLchr16

74729448

-
intron-3CDSENST00000442299ENST00000308807TLE3chr15

70344732

+MLKLchr16

74729448

-
intron-3CDSENST00000317509ENST00000306247TLE3chr15

70344732

+MLKLchr16

74729448

-
intron-3CDSENST00000317509ENST00000308807TLE3chr15

70344732

+MLKLchr16

74729448

-
intron-3CDSENST00000560589ENST00000306247TLE3chr15

70344732

+MLKLchr16

74729448

-
intron-3CDSENST00000560589ENST00000308807TLE3chr15

70344732

+MLKLchr16

74729448

-
intron-3CDSENST00000559929ENST00000306247TLE3chr15

70344732

+MLKLchr16

74729448

-
intron-3CDSENST00000559929ENST00000308807TLE3chr15

70344732

+MLKLchr16

74729448

-
intron-3CDSENST00000559048ENST00000306247TLE3chr15

70344732

+MLKLchr16

74729448

-
intron-3CDSENST00000559048ENST00000308807TLE3chr15

70344732

+MLKLchr16

74729448

-
intron-3CDSENST00000560939ENST00000306247TLE3chr15

70344732

+MLKLchr16

74729448

-
intron-3CDSENST00000560939ENST00000308807TLE3chr15

70344732

+MLKLchr16

74729448

-
intron-3CDSENST00000557997ENST00000306247TLE3chr15

70344732

+MLKLchr16

74729448

-
intron-3CDSENST00000557997ENST00000308807TLE3chr15

70344732

+MLKLchr16

74729448

-
intron-3CDSENST00000539550ENST00000306247TLE3chr15

70344732

+MLKLchr16

74729448

-
intron-3CDSENST00000539550ENST00000308807TLE3chr15

70344732

+MLKLchr16

74729448

-
intron-3CDSENST00000558201ENST00000306247TLE3chr15

70344732

+MLKLchr16

74729448

-
intron-3CDSENST00000558201ENST00000308807TLE3chr15

70344732

+MLKLchr16

74729448

-
intron-3CDSENST00000440567ENST00000306247TLE3chr15

70344732

+MLKLchr16

74729448

-
intron-3CDSENST00000440567ENST00000308807TLE3chr15

70344732

+MLKLchr16

74729448

-
intron-3CDSENST00000559191ENST00000306247TLE3chr15

70344732

+MLKLchr16

74729448

-
intron-3CDSENST00000559191ENST00000308807TLE3chr15

70344732

+MLKLchr16

74729448

-
intron-3CDSENST00000558379ENST00000306247TLE3chr15

70344732

+MLKLchr16

74729448

-
intron-3CDSENST00000558379ENST00000308807TLE3chr15

70344732

+MLKLchr16

74729448

-
intron-3CDSENST00000557907ENST00000306247TLE3chr15

70344732

+MLKLchr16

74729448

-
intron-3CDSENST00000557907ENST00000308807TLE3chr15

70344732

+MLKLchr16

74729448

-
intron-3CDSENST00000451782ENST00000306247TLE3chr15

70344732

+MLKLchr16

74729448

-
intron-3CDSENST00000451782ENST00000308807TLE3chr15

70344732

+MLKLchr16

74729448

-
intron-3CDSENST00000559574ENST00000306247TLE3chr15

70344732

+MLKLchr16

74729448

-
intron-3CDSENST00000559574ENST00000308807TLE3chr15

70344732

+MLKLchr16

74729448

-

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FusionProtFeatures for TLE3_MLKL


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TLE3

Q04726

MLKL

Q8NB16

Transcriptional corepressor that binds to a number oftranscription factors. Inhibits the transcriptional activationmediated by CTNNB1 and TCF family members in Wnt signaling. Theeffects of full-length TLE family members may be modulated byassociation with dominant-negative AES (By similarity).{ECO:0000250}. Pseudokinase that plays a key role in TNF-inducednecroptosis, a programmed cell death process. Activated followingphosphorylation by RIPK3, leading to homotrimerization,localization to the plasma membrane and execution of programmednecrosis characterized by calcium influx and plasma membranedamage. Does not have protein kinase activity.{ECO:0000269|PubMed:22265413, ECO:0000269|PubMed:22265414,ECO:0000269|PubMed:22421439, ECO:0000269|PubMed:24316671}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TLE3_MLKL


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TLE3_MLKL


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TLE3_MLKL


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TLE3_MLKL


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTLE3C0003873Rheumatoid Arthritis1CTD_human
HgeneTLE3C1458155Mammary Neoplasms1CTD_human
HgeneTLE3C1862939AMYOTROPHIC LATERAL SCLEROSIS 11CTD_human