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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 38165

FusionGeneSummary for TLDC2_DYNLRB1

check button Fusion gene summary
Fusion gene informationFusion gene name: TLDC2_DYNLRB1
Fusion gene ID: 38165
HgeneTgene
Gene symbol

TLDC2

DYNLRB1

Gene ID

140711

83658

Gene nameTBC/LysM-associated domain containing 2dynein light chain roadblock-type 1
SynonymsC20orf118BITH|BLP|DNCL2A|DNLC2A|ROBLD1
Cytomap

20q11.23

20q11.22

Type of geneprotein-codingprotein-coding
DescriptionTLD domain-containing protein 2TBC/LysM-associated domain-containing protein 2dynein light chain roadblock-type 1ROBL/LC7-like 1bithoraxoid-like proteindynein, cytoplasmic, light polypeptide 2Adynein-associated protein Km23roadblock domain-containing protein 1
Modification date2018051920180523
UniProtAcc

A0PJX2

Q9NP97

Ensembl transtripts involved in fusion geneENST00000217320, ENST00000602922, 
ENST00000357156, ENST00000480759, 
ENST00000417166, ENST00000300469, 
ENST00000374846, 
Fusion gene scores* DoF score1 X 1 X 1=16 X 5 X 4=120
# samples 16
** MAII scorelog2(1/1*10)=3.32192809488736log2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TLDC2 [Title/Abstract] AND DYNLRB1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUADTCGA-55-1594-01ATLDC2chr20

35517806

+DYNLRB1chr20

33122432

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000217320ENST00000357156TLDC2chr20

35517806

+DYNLRB1chr20

33122432

+
3UTR-3UTRENST00000217320ENST00000480759TLDC2chr20

35517806

+DYNLRB1chr20

33122432

+
3UTR-3UTRENST00000217320ENST00000417166TLDC2chr20

35517806

+DYNLRB1chr20

33122432

+
3UTR-intronENST00000217320ENST00000300469TLDC2chr20

35517806

+DYNLRB1chr20

33122432

+
3UTR-intronENST00000217320ENST00000374846TLDC2chr20

35517806

+DYNLRB1chr20

33122432

+
3UTR-3CDSENST00000602922ENST00000357156TLDC2chr20

35517806

+DYNLRB1chr20

33122432

+
3UTR-3UTRENST00000602922ENST00000480759TLDC2chr20

35517806

+DYNLRB1chr20

33122432

+
3UTR-3UTRENST00000602922ENST00000417166TLDC2chr20

35517806

+DYNLRB1chr20

33122432

+
3UTR-intronENST00000602922ENST00000300469TLDC2chr20

35517806

+DYNLRB1chr20

33122432

+
3UTR-intronENST00000602922ENST00000374846TLDC2chr20

35517806

+DYNLRB1chr20

33122432

+

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FusionProtFeatures for TLDC2_DYNLRB1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TLDC2

A0PJX2

DYNLRB1

Q9NP97

Acts as one of several non-catalytic accessorycomponents of the cytoplasmic dynein 1 complex that are thought tobe involved in linking dynein to cargos and to adapter proteinsthat regulate dynein function. Cytoplasmic dynein 1 acts as amotor for the intracellular retrograde motility of vesicles andorganelles along microtubules.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TLDC2_DYNLRB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TLDC2_DYNLRB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TLDC2ATP6V1C1, ATP6V1D, ATP6V1E1, ATP6V1B2, KLHL15, TRIM25DYNLRB1DYNC1I1, HSPH1, CUL3, DYNC1H1, DYNLL1, FLNC, DYNLT1, DCTN2, PLOD3, SEPT2, LAMTOR2, SAFB, MRPS26, MPP6, DYNC1I2, DYNC1LI1, DYNC1LI2, AKAP12, KIF11, MAPRE1, MPHOSPH8, CCDC88A, CENPJ, WDR34, TCTEX1D2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TLDC2_DYNLRB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TLDC2_DYNLRB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource