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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 38150

FusionGeneSummary for TK1_CAMTA1

check button Fusion gene summary
Fusion gene informationFusion gene name: TK1_CAMTA1
Fusion gene ID: 38150
HgeneTgene
Gene symbol

TK1

CAMTA1

Gene ID

7083

23261

Gene namethymidine kinase 1calmodulin binding transcription activator 1
SynonymsTK2CANPMR
Cytomap

17q25.3

1p36.31-p36.23

Type of geneprotein-codingprotein-coding
Descriptionthymidine kinase, cytosolicthymidine kinase 1 soluble isoformcalmodulin-binding transcription activator 1
Modification date2018052320180523
UniProtAcc

P04183

Q9Y6Y1

Ensembl transtripts involved in fusion geneENST00000301634, ENST00000405273, 
ENST00000588734, ENST00000590862, 
ENST00000590430, 		ENST00000303635, 
ENST00000439411, ENST00000476163, 
ENST00000557126, ENST00000473578, 
ENST00000467404, ENST00000476864, 
Fusion gene scores* DoF score5 X 4 X 4=8015 X 13 X 5=975
# samples 516
** MAII scorelog2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/975*10)=-2.60733031374961
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TK1 [Title/Abstract] AND CAMTA1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BG118054TK1chr17

76170734

+CAMTA1chr1

7100596

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000301634ENST00000303635TK1chr17

76170734

+CAMTA1chr1

7100596

+
intron-intronENST00000301634ENST00000439411TK1chr17

76170734

+CAMTA1chr1

7100596

+
intron-intronENST00000301634ENST00000476163TK1chr17

76170734

+CAMTA1chr1

7100596

+
intron-intronENST00000301634ENST00000557126TK1chr17

76170734

+CAMTA1chr1

7100596

+
intron-intronENST00000301634ENST00000473578TK1chr17

76170734

+CAMTA1chr1

7100596

+
intron-intronENST00000301634ENST00000467404TK1chr17

76170734

+CAMTA1chr1

7100596

+
intron-intronENST00000301634ENST00000476864TK1chr17

76170734

+CAMTA1chr1

7100596

+
intron-intronENST00000405273ENST00000303635TK1chr17

76170734

+CAMTA1chr1

7100596

+
intron-intronENST00000405273ENST00000439411TK1chr17

76170734

+CAMTA1chr1

7100596

+
intron-intronENST00000405273ENST00000476163TK1chr17

76170734

+CAMTA1chr1

7100596

+
intron-intronENST00000405273ENST00000557126TK1chr17

76170734

+CAMTA1chr1

7100596

+
intron-intronENST00000405273ENST00000473578TK1chr17

76170734

+CAMTA1chr1

7100596

+
intron-intronENST00000405273ENST00000467404TK1chr17

76170734

+CAMTA1chr1

7100596

+
intron-intronENST00000405273ENST00000476864TK1chr17

76170734

+CAMTA1chr1

7100596

+
intron-intronENST00000588734ENST00000303635TK1chr17

76170734

+CAMTA1chr1

7100596

+
intron-intronENST00000588734ENST00000439411TK1chr17

76170734

+CAMTA1chr1

7100596

+
intron-intronENST00000588734ENST00000476163TK1chr17

76170734

+CAMTA1chr1

7100596

+
intron-intronENST00000588734ENST00000557126TK1chr17

76170734

+CAMTA1chr1

7100596

+
intron-intronENST00000588734ENST00000473578TK1chr17

76170734

+CAMTA1chr1

7100596

+
intron-intronENST00000588734ENST00000467404TK1chr17

76170734

+CAMTA1chr1

7100596

+
intron-intronENST00000588734ENST00000476864TK1chr17

76170734

+CAMTA1chr1

7100596

+
intron-intronENST00000590862ENST00000303635TK1chr17

76170734

+CAMTA1chr1

7100596

+
intron-intronENST00000590862ENST00000439411TK1chr17

76170734

+CAMTA1chr1

7100596

+
intron-intronENST00000590862ENST00000476163TK1chr17

76170734

+CAMTA1chr1

7100596

+
intron-intronENST00000590862ENST00000557126TK1chr17

76170734

+CAMTA1chr1

7100596

+
intron-intronENST00000590862ENST00000473578TK1chr17

76170734

+CAMTA1chr1

7100596

+
intron-intronENST00000590862ENST00000467404TK1chr17

76170734

+CAMTA1chr1

7100596

+
intron-intronENST00000590862ENST00000476864TK1chr17

76170734

+CAMTA1chr1

7100596

+
intron-intronENST00000590430ENST00000303635TK1chr17

76170734

+CAMTA1chr1

7100596

+
intron-intronENST00000590430ENST00000439411TK1chr17

76170734

+CAMTA1chr1

7100596

+
intron-intronENST00000590430ENST00000476163TK1chr17

76170734

+CAMTA1chr1

7100596

+
intron-intronENST00000590430ENST00000557126TK1chr17

76170734

+CAMTA1chr1

7100596

+
intron-intronENST00000590430ENST00000473578TK1chr17

76170734

+CAMTA1chr1

7100596

+
intron-intronENST00000590430ENST00000467404TK1chr17

76170734

+CAMTA1chr1

7100596

+
intron-intronENST00000590430ENST00000476864TK1chr17

76170734

+CAMTA1chr1

7100596

+

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FusionProtFeatures for TK1_CAMTA1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TK1

P04183

CAMTA1

Q9Y6Y1

Transcriptional activator. May act as a tumorsuppressor. {ECO:0000269|PubMed:11925432,ECO:0000269|PubMed:15709179}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TK1_CAMTA1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TK1_CAMTA1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TK1_CAMTA1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TK1_CAMTA1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTK1C0009404Colorectal Neoplasms1CTD_human
HgeneTK1C0023904Liver Neoplasms, Experimental1CTD_human