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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 38130

FusionGeneSummary for TINAGL1_TINAGL1

check button Fusion gene summary
Fusion gene informationFusion gene name: TINAGL1_TINAGL1
Fusion gene ID: 38130
HgeneTgene
Gene symbol

TINAGL1

TINAGL1

Gene ID

64129

64129

Gene nametubulointerstitial nephritis antigen like 1tubulointerstitial nephritis antigen like 1
SynonymsARG1|LCN7|LIECG3|TINAGRPARG1|LCN7|LIECG3|TINAGRP
Cytomap

1p35.2

1p35.2

Type of geneprotein-codingprotein-coding
Descriptiontubulointerstitial nephritis antigen-likeOLRG-2P3ECSLTIN Ag-related proteinTIN-Ag-RPTINAG-like 1androgen-regulated gene 1glucocorticoid-inducible protein 5lipocalin 7oxidized-LDL responsive gene 2tubulointerstitial nephritis antigen-related prottubulointerstitial nephritis antigen-likeOLRG-2P3ECSLTIN Ag-related proteinTIN-Ag-RPTINAG-like 1androgen-regulated gene 1glucocorticoid-inducible protein 5lipocalin 7oxidized-LDL responsive gene 2tubulointerstitial nephritis antigen-related prot
Modification date2018052320180523
UniProtAcc

Q9GZM7

Q9GZM7

Ensembl transtripts involved in fusion geneENST00000441210, ENST00000457433, 
ENST00000271064, ENST00000537531, 
ENST00000481165, 
ENST00000441210, 
ENST00000457433, ENST00000271064, 
ENST00000537531, ENST00000481165, 
Fusion gene scores* DoF score2 X 2 X 1=44 X 4 X 3=48
# samples 35
** MAII scorelog2(3/4*10)=2.90689059560852log2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TINAGL1 [Title/Abstract] AND TINAGL1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF368733TINAGL1chr1

32049159

+TINAGL1chr1

32050363

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000441210ENST00000441210TINAGL1chr1

32049159

+TINAGL1chr1

32050363

-
intron-intronENST00000441210ENST00000457433TINAGL1chr1

32049159

+TINAGL1chr1

32050363

-
intron-intronENST00000441210ENST00000271064TINAGL1chr1

32049159

+TINAGL1chr1

32050363

-
intron-3UTRENST00000441210ENST00000537531TINAGL1chr1

32049159

+TINAGL1chr1

32050363

-
intron-3UTRENST00000441210ENST00000481165TINAGL1chr1

32049159

+TINAGL1chr1

32050363

-
5CDS-intronENST00000457433ENST00000441210TINAGL1chr1

32049159

+TINAGL1chr1

32050363

-
5CDS-intronENST00000457433ENST00000457433TINAGL1chr1

32049159

+TINAGL1chr1

32050363

-
5CDS-intronENST00000457433ENST00000271064TINAGL1chr1

32049159

+TINAGL1chr1

32050363

-
5CDS-3UTRENST00000457433ENST00000537531TINAGL1chr1

32049159

+TINAGL1chr1

32050363

-
5CDS-3UTRENST00000457433ENST00000481165TINAGL1chr1

32049159

+TINAGL1chr1

32050363

-
5CDS-intronENST00000271064ENST00000441210TINAGL1chr1

32049159

+TINAGL1chr1

32050363

-
5CDS-intronENST00000271064ENST00000457433TINAGL1chr1

32049159

+TINAGL1chr1

32050363

-
5CDS-intronENST00000271064ENST00000271064TINAGL1chr1

32049159

+TINAGL1chr1

32050363

-
5CDS-3UTRENST00000271064ENST00000537531TINAGL1chr1

32049159

+TINAGL1chr1

32050363

-
5CDS-3UTRENST00000271064ENST00000481165TINAGL1chr1

32049159

+TINAGL1chr1

32050363

-
3UTR-intronENST00000537531ENST00000441210TINAGL1chr1

32049159

+TINAGL1chr1

32050363

-
3UTR-intronENST00000537531ENST00000457433TINAGL1chr1

32049159

+TINAGL1chr1

32050363

-
3UTR-intronENST00000537531ENST00000271064TINAGL1chr1

32049159

+TINAGL1chr1

32050363

-
3UTR-3UTRENST00000537531ENST00000537531TINAGL1chr1

32049159

+TINAGL1chr1

32050363

-
3UTR-3UTRENST00000537531ENST00000481165TINAGL1chr1

32049159

+TINAGL1chr1

32050363

-
3UTR-intronENST00000481165ENST00000441210TINAGL1chr1

32049159

+TINAGL1chr1

32050363

-
3UTR-intronENST00000481165ENST00000457433TINAGL1chr1

32049159

+TINAGL1chr1

32050363

-
3UTR-intronENST00000481165ENST00000271064TINAGL1chr1

32049159

+TINAGL1chr1

32050363

-
3UTR-3UTRENST00000481165ENST00000537531TINAGL1chr1

32049159

+TINAGL1chr1

32050363

-
3UTR-3UTRENST00000481165ENST00000481165TINAGL1chr1

32049159

+TINAGL1chr1

32050363

-

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FusionProtFeatures for TINAGL1_TINAGL1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TINAGL1

Q9GZM7

TINAGL1

Q9GZM7

May be implicated in the adrenocortical zonation and inmechanisms for repressing the CYP11B1 gene expression inadrenocortical cells. This is a non catalytic peptidase C1 familyprotein (By similarity). {ECO:0000250}. May be implicated in the adrenocortical zonation and inmechanisms for repressing the CYP11B1 gene expression inadrenocortical cells. This is a non catalytic peptidase C1 familyprotein (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TINAGL1_TINAGL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TINAGL1_TINAGL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TINAGL1_TINAGL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TINAGL1_TINAGL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource