FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 38112

FusionGeneSummary for TIMM9_FCF1

check button Fusion gene summary
Fusion gene informationFusion gene name: TIMM9_FCF1
Fusion gene ID: 38112
HgeneTgene
Gene symbol

TIMM9

FCF1

Gene ID

26520

51077

Gene nametranslocase of inner mitochondrial membrane 9FCF1, rRNA-processing protein
SynonymsTIM9|TIM9ABka|C14orf111|CGI-35|UTP24
Cytomap

14q23.1

14q24.3

Type of geneprotein-codingprotein-coding
Descriptionmitochondrial import inner membrane translocase subunit Tim9translocase of inner mitochondrial membrane 9 homologrRNA-processing protein FCF1 homologFCF1 small subunit
Modification date2018052220180523
UniProtAcc

Q9Y5J7

Q9Y324

Ensembl transtripts involved in fusion geneENST00000395159, ENST00000216463, 
ENST00000555593, ENST00000556007, 
ENST00000555061, ENST00000555404, 
ENST00000341162, ENST00000534938, 
ENST00000553615, 
Fusion gene scores* DoF score1 X 1 X 1=13 X 3 X 2=18
# samples 13
** MAII scorelog2(1/1*10)=3.32192809488736log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TIMM9 [Title/Abstract] AND FCF1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTIMM9

GO:0045039

protein import into mitochondrial inner membrane

16387659

HgeneTIMM9

GO:0072321

chaperone-mediated protein transport

16387659


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLGGTCGA-DU-7006-01ATIMM9chr14

58890726

-FCF1chr14

75189975

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000395159ENST00000341162TIMM9chr14

58890726

-FCF1chr14

75189975

+
5UTR-3CDSENST00000395159ENST00000534938TIMM9chr14

58890726

-FCF1chr14

75189975

+
5UTR-3CDSENST00000395159ENST00000553615TIMM9chr14

58890726

-FCF1chr14

75189975

+
5UTR-3CDSENST00000216463ENST00000341162TIMM9chr14

58890726

-FCF1chr14

75189975

+
5UTR-3CDSENST00000216463ENST00000534938TIMM9chr14

58890726

-FCF1chr14

75189975

+
5UTR-3CDSENST00000216463ENST00000553615TIMM9chr14

58890726

-FCF1chr14

75189975

+
intron-3CDSENST00000555593ENST00000341162TIMM9chr14

58890726

-FCF1chr14

75189975

+
intron-3CDSENST00000555593ENST00000534938TIMM9chr14

58890726

-FCF1chr14

75189975

+
intron-3CDSENST00000555593ENST00000553615TIMM9chr14

58890726

-FCF1chr14

75189975

+
5UTR-3CDSENST00000556007ENST00000341162TIMM9chr14

58890726

-FCF1chr14

75189975

+
5UTR-3CDSENST00000556007ENST00000534938TIMM9chr14

58890726

-FCF1chr14

75189975

+
5UTR-3CDSENST00000556007ENST00000553615TIMM9chr14

58890726

-FCF1chr14

75189975

+
intron-3CDSENST00000555061ENST00000341162TIMM9chr14

58890726

-FCF1chr14

75189975

+
intron-3CDSENST00000555061ENST00000534938TIMM9chr14

58890726

-FCF1chr14

75189975

+
intron-3CDSENST00000555061ENST00000553615TIMM9chr14

58890726

-FCF1chr14

75189975

+
intron-3CDSENST00000555404ENST00000341162TIMM9chr14

58890726

-FCF1chr14

75189975

+
intron-3CDSENST00000555404ENST00000534938TIMM9chr14

58890726

-FCF1chr14

75189975

+
intron-3CDSENST00000555404ENST00000553615TIMM9chr14

58890726

-FCF1chr14

75189975

+

Top

FusionProtFeatures for TIMM9_FCF1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TIMM9

Q9Y5J7

FCF1

Q9Y324

Mitochondrial intermembrane chaperone that participatesin the import and insertion of multi-pass transmembrane proteinsinto the mitochondrial inner membrane. May also be required forthe transfer of beta-barrel precursors from the TOM complex to thesorting and assembly machinery (SAM complex) of the outermembrane. Acts as a chaperone-like protein that protects thehydrophobic precursors from aggregation and guide them through themitochondrial intermembrane space. {ECO:0000269|PubMed:14726512}. Essential protein involved in pre-rRNA processing and40S ribosomal subunit assembly. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for TIMM9_FCF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for TIMM9_FCF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TIMM9TIMM10, PRDX6, NADK2, NIT2, HTRA2, SLC25A6, UQCRFS1, NDUFV1, MPST, THOP1, OXCT1, SART1, DHX9, SFPQ, HNRNPM, SEC22B, ATF2, BAG3, COX5A, NUDC, PTGES3, TIMM13, TIMM8A, TIMM8B, CTSA, ANKS6, C19orf52FCF1RPS2, RBM4B, APP, IFI16, HNRNPU, MYH9, TM9SF4, PPL, TREX2, SULT2B1, ENDOU, EVPL, IVL, SERPINB5, TRIM29, SERPINA12, ME1, KLK7, LGALSL, RAB5B, IL1RN, YOD1, CALML5, PKP3, DMKN, PYCARD, SERPINB8, SDR9C7, KLK10, FLG, POF1B, HAL, SERPINB2, CRABP2, EPPK1, ASPRV1, RNASE7, KPRP, SART3, SBSN, NCCRP1, MECP2, CRYAB, GPATCH4, MYH14, IGHG2, NEFH, RPL18, RPL30, DGCR8, LYPLA1, ACPP, CALML3, ARG1, PKP1, CASP14, CST6, CNBP, LGALS3, LGALS7B, UTP23, FOXA1, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for TIMM9_FCF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for TIMM9_FCF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource