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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 3811

FusionGeneSummary for BAIAP2L1_DMTF1

check button Fusion gene summary
Fusion gene informationFusion gene name: BAIAP2L1_DMTF1
Fusion gene ID: 3811
HgeneTgene
Gene symbol

BAIAP2L1

DMTF1

Gene ID

55971

9988

Gene nameBAI1 associated protein 2 like 1cyclin D binding myb like transcription factor 1
SynonymsIRTKSDMP1|DMTF|MRUL|hDMP1
Cytomap

7q21.3-q22.1

7q21.12

Type of geneprotein-codingprotein-coding
Descriptionbrain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1BAI1-associated protein 2-like protein 1insulin receptor tyrosine kinase substratecyclin-D-binding Myb-like transcription factor 1cyclin D-binding Myb-like proteincyclin-D-interacting Myb-like protein 1hDMTF1
Modification date2018052320180523
UniProtAcc

Q9UHR4

Q9Y222

Ensembl transtripts involved in fusion geneENST00000005260, ENST00000462558, 
ENST00000394702, ENST00000331242, 
ENST00000413276, ENST00000411766, 
ENST00000432937, ENST00000394703, 
ENST00000580710, ENST00000414194, 
Fusion gene scores* DoF score7 X 4 X 6=1684 X 4 X 3=48
# samples 74
** MAII scorelog2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BAIAP2L1 [Title/Abstract] AND DMTF1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneBAIAP2L1

GO:0009617

response to bacterium

19366662

HgeneBAIAP2L1

GO:0030838

positive regulation of actin filament polymerization

21098279


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDCOADTCGA-A6-5667-01ABAIAP2L1chr7

98030114

-DMTF1chr7

86800311

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000005260ENST00000394702BAIAP2L1chr7

98030114

-DMTF1chr7

86800311

+
Frame-shitENST00000005260ENST00000331242BAIAP2L1chr7

98030114

-DMTF1chr7

86800311

+
Frame-shitENST00000005260ENST00000413276BAIAP2L1chr7

98030114

-DMTF1chr7

86800311

+
Frame-shitENST00000005260ENST00000411766BAIAP2L1chr7

98030114

-DMTF1chr7

86800311

+
5CDS-5UTRENST00000005260ENST00000432937BAIAP2L1chr7

98030114

-DMTF1chr7

86800311

+
5CDS-5UTRENST00000005260ENST00000394703BAIAP2L1chr7

98030114

-DMTF1chr7

86800311

+
5CDS-intronENST00000005260ENST00000580710BAIAP2L1chr7

98030114

-DMTF1chr7

86800311

+
5CDS-5UTRENST00000005260ENST00000414194BAIAP2L1chr7

98030114

-DMTF1chr7

86800311

+
5UTR-3CDSENST00000462558ENST00000394702BAIAP2L1chr7

98030114

-DMTF1chr7

86800311

+
5UTR-3CDSENST00000462558ENST00000331242BAIAP2L1chr7

98030114

-DMTF1chr7

86800311

+
5UTR-3CDSENST00000462558ENST00000413276BAIAP2L1chr7

98030114

-DMTF1chr7

86800311

+
5UTR-3CDSENST00000462558ENST00000411766BAIAP2L1chr7

98030114

-DMTF1chr7

86800311

+
5UTR-5UTRENST00000462558ENST00000432937BAIAP2L1chr7

98030114

-DMTF1chr7

86800311

+
5UTR-5UTRENST00000462558ENST00000394703BAIAP2L1chr7

98030114

-DMTF1chr7

86800311

+
5UTR-intronENST00000462558ENST00000580710BAIAP2L1chr7

98030114

-DMTF1chr7

86800311

+
5UTR-5UTRENST00000462558ENST00000414194BAIAP2L1chr7

98030114

-DMTF1chr7

86800311

+

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FusionProtFeatures for BAIAP2L1_DMTF1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BAIAP2L1

Q9UHR4

DMTF1

Q9Y222

May function as adapter protein. Involved in theformation of clusters of actin bundles. Plays a role in thereorganization of the actin cytoskeleton in response to bacterialinfection. {ECO:0000269|PubMed:17430976,ECO:0000269|PubMed:19366662, ECO:0000269|PubMed:22921828}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for BAIAP2L1_DMTF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for BAIAP2L1_DMTF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
BAIAP2L1PRKAA2, PRKAB2, TERF1, TERF2, TP53, MDM2, BRD4, KHDRBS1, FASLG, VCP, EPS8, WAS, HECW2, BAIAP2, NPHP1, TMEM17, CENPJ, SORT1, TACC1, PSMD14, ZWINT, SGTB, IP6K3, BAG6, CDH1, GPRC5C, MUM1, TMEM184A, MARVELD2DMTF1TP53, SRA1, DNMT3L, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for BAIAP2L1_DMTF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for BAIAP2L1_DMTF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneBAIAP2L1C0003873Rheumatoid Arthritis1CTD_human