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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 38092

FusionGeneSummary for TICAM1_VMP1

check button Fusion gene summary
Fusion gene informationFusion gene name: TICAM1_VMP1
Fusion gene ID: 38092
HgeneTgene
Gene symbol

TICAM1

VMP1

Gene ID

148022

81671

Gene nametoll like receptor adaptor molecule 1vacuole membrane protein 1
SynonymsIIAE6|MyD88-3|PRVTIRB|TICAM-1|TRIFEPG3|TANGO5|TMEM49
Cytomap

19p13.3

17q23.1

Type of geneprotein-codingprotein-coding
DescriptionTIR domain-containing adapter molecule 1TIR domain containing adaptor inducing interferon-betaTIR domain-containing adapter protein inducing IFN-betaproline-rich, vinculin and TIR domain-containing protein Bputative NF-kappa-B-activating protein 502Hvacuole membrane protein 1ectopic P-granules autophagy protein 3 homologtransmembrane protein 49transport and golgi organization 5 homolog
Modification date2018051920180523
UniProtAcc

Q8IUC6

Q96GC9

Ensembl transtripts involved in fusion geneENST00000248244, ENST00000262291, 
ENST00000537567, ENST00000539763, 
ENST00000536180, ENST00000545362, 
ENST00000588617, 
Fusion gene scores* DoF score5 X 2 X 5=5024 X 11 X 12=3168
# samples 527
** MAII scorelog2(5/50*10)=0log2(27/3168*10)=-3.55254102302878
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TICAM1 [Title/Abstract] AND VMP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDKIRCTCGA-CJ-4901-01ATICAM1chr19

4831626

-VMP1chr17

57889031

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000248244ENST00000262291TICAM1chr19

4831626

-VMP1chr17

57889031

+
5UTR-3CDSENST00000248244ENST00000537567TICAM1chr19

4831626

-VMP1chr17

57889031

+
5UTR-3CDSENST00000248244ENST00000539763TICAM1chr19

4831626

-VMP1chr17

57889031

+
5UTR-3CDSENST00000248244ENST00000536180TICAM1chr19

4831626

-VMP1chr17

57889031

+
5UTR-3CDSENST00000248244ENST00000545362TICAM1chr19

4831626

-VMP1chr17

57889031

+
5UTR-intronENST00000248244ENST00000588617TICAM1chr19

4831626

-VMP1chr17

57889031

+

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FusionProtFeatures for TICAM1_VMP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TICAM1

Q8IUC6

VMP1

Q96GC9

Involved in innate immunity against invading pathogens.Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and toinduce apoptosis. Ligand binding to these receptors results inTRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteinsTBK1, TRAF6 and RIPK1, which in turn, lead to the activation oftranscription factors IRF3 and IRF7, NF-kappa-B and FADDrespectively. {ECO:0000269|PubMed:12471095,ECO:0000269|PubMed:12539043, ECO:0000269|PubMed:14739303}. Stress-induced protein that, when overexpressed,promotes formation of intracellular vacuoles followed by celldeath. May be involved in the cytoplasmic vacuolization of acinarcells during the early stage of acute pancreatitis. Plays a rolein the initial stages of the autophagic process through itsinteraction with BECN1 (By similarity). Involved in cell-celladhesion. Plays an essential role in formation of cell junctions.{ECO:0000250, ECO:0000269|PubMed:17724469}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TICAM1_VMP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TICAM1_VMP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TICAM1RIPK1, RIPK3, RNF216, TRAF2, TRAF6, TANK, TBK1, UBQLN1, TLR4, CBLB, TRAF1, TRAF3, TRAF5, TLR3, TNFAIP3, TRIM56, TRAF4, TICAM2, MAVS, PIAS4, TRIM38, SYK, SRSF4, TICAM1, CASP8, CFLAR, CARM1, IRF3, XPO1, MKNK2, KIF21B, CDCA5, CEP170P1, FOSL1, TRIM25VMP1HGS, ELAVL1, TJP1, KLK11, LPAR6, ERGIC3, FAF2, KRAS, TCTN2, TCTN3, TMEM216, DPEP1, CDH13, MAS1, LMNA


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TICAM1_VMP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TICAM1_VMP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTICAM1C0032273Pneumoconiosis1CTD_human
HgeneTICAM1C0035126Reperfusion Injury1CTD_human
HgeneTICAM1C0035235Respiratory Syncytial Virus Infections1CTD_human
HgeneTICAM1C3553869HERPES SIMPLEX ENCEPHALITIS, SUSCEPTIBILITY TO, 41UNIPROT