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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 38064

FusionGeneSummary for TIA1_MRPL33

check button Fusion gene summary
Fusion gene informationFusion gene name: TIA1_MRPL33
Fusion gene ID: 38064
HgeneTgene
Gene symbol

TIA1

MRPL33

Gene ID

7072

9553

Gene nameTIA1 cytotoxic granule associated RNA binding proteinmitochondrial ribosomal protein L33
SynonymsTIA-1|WDMC2orf1|L33mt|MRP-L33|RPL33L
Cytomap

2p13.3

2p23.2

Type of geneprotein-codingprotein-coding
Descriptionnucleolysin TIA-1 isoform p40nucleolysin TIA-1T-cell-restricted intracellular antigen-1p40-TIA-1 (containing p15-TIA-1)39S ribosomal protein L33, mitochondrialmitochondrial large ribosomal subunit protein bL33m
Modification date2018051920180522
UniProtAcc

P31483

O75394

Ensembl transtripts involved in fusion geneENST00000433529, ENST00000415783, 
ENST00000282574, ENST00000445587, 
ENST00000482876, ENST00000416149, 
ENST00000379666, ENST00000296102, 
ENST00000483992, 
Fusion gene scores* DoF score8 X 5 X 7=2803 X 2 X 2=12
# samples 82
** MAII scorelog2(8/280*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/12*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TIA1 [Title/Abstract] AND MRPL33 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTIA1

GO:0048024

regulation of mRNA splicing, via spliceosome

11106748


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLGGTCGA-QH-A6XC-01ATIA1chr2

70475537

-MRPL33chr2

28002300

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000433529ENST00000379666TIA1chr2

70475537

-MRPL33chr2

28002300

+
Frame-shiftENST00000433529ENST00000296102TIA1chr2

70475537

-MRPL33chr2

28002300

+
5CDS-3UTRENST00000433529ENST00000483992TIA1chr2

70475537

-MRPL33chr2

28002300

+
Frame-shiftENST00000415783ENST00000379666TIA1chr2

70475537

-MRPL33chr2

28002300

+
Frame-shiftENST00000415783ENST00000296102TIA1chr2

70475537

-MRPL33chr2

28002300

+
5CDS-3UTRENST00000415783ENST00000483992TIA1chr2

70475537

-MRPL33chr2

28002300

+
Frame-shiftENST00000282574ENST00000379666TIA1chr2

70475537

-MRPL33chr2

28002300

+
Frame-shiftENST00000282574ENST00000296102TIA1chr2

70475537

-MRPL33chr2

28002300

+
5CDS-3UTRENST00000282574ENST00000483992TIA1chr2

70475537

-MRPL33chr2

28002300

+
Frame-shiftENST00000445587ENST00000379666TIA1chr2

70475537

-MRPL33chr2

28002300

+
Frame-shiftENST00000445587ENST00000296102TIA1chr2

70475537

-MRPL33chr2

28002300

+
5CDS-3UTRENST00000445587ENST00000483992TIA1chr2

70475537

-MRPL33chr2

28002300

+
intron-3CDSENST00000482876ENST00000379666TIA1chr2

70475537

-MRPL33chr2

28002300

+
intron-3CDSENST00000482876ENST00000296102TIA1chr2

70475537

-MRPL33chr2

28002300

+
intron-3UTRENST00000482876ENST00000483992TIA1chr2

70475537

-MRPL33chr2

28002300

+
Frame-shiftENST00000416149ENST00000379666TIA1chr2

70475537

-MRPL33chr2

28002300

+
Frame-shiftENST00000416149ENST00000296102TIA1chr2

70475537

-MRPL33chr2

28002300

+
5CDS-3UTRENST00000416149ENST00000483992TIA1chr2

70475537

-MRPL33chr2

28002300

+

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FusionProtFeatures for TIA1_MRPL33


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TIA1

P31483

MRPL33

O75394

Involved in alternative pre-RNA splicing and regulationof mRNA translation by binding to AU-rich elements (AREs) locatedin mRNA 3' untranslated regions (3' UTRs). Possesses nucleolyticactivity against cytotoxic lymphocyte target cells. May beinvolved in apoptosis.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TIA1_MRPL33


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TIA1_MRPL33


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TIA1FASTK, RICTOR, CUL3, CUL4A, CUL5, CUL2, CUL1, COPS5, DCUN1D1, CAND1, SRSF3, WDR6, FMNL1, FN1, VCAM1, ITGA4, SOX2, BMI1, LUC7L2, MPI, PCBP1, PCBP2, PITPNB, SNRPD1, DAZAP1, DDX58, HTRA2, PIR, NTRK1, AK1, ELL2, POLK, CXXC4, NETO2, ESR1, DPPA4, BCOR, NANOG, POU5F1, G3BP1MRPL33PAXIP1, MRPL4, MRPS30, MRPL47, SYNCRIP, MRPL50, MRPL9, MRPL1, FAM134A, CNTROB, C6orf203, MRPL10, MRPL12, MRPL42


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TIA1_MRPL33


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TIA1_MRPL33


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTIA1C0221054Welander Distal Myopathy1UNIPROT